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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang ya.gao Shuyue Li Cui Chang Xiang liu guofeng ya.g Department of geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-Jia Hao Xu-ya Chai Pei-Sai Li ya.g liu Li-Xia liu Ying Xu Pan-Pan ya.g Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKgROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na liu Yu-Fan ya.g Zhi-Cheng Zhang Qi Dai Xiao-yan Bao Lin-Jie Wu ya-Xin Qin Xin Tan Xiao-yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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内蒙古农牧交错区典型黑土坡耕地土壤侵蚀空间分布特征

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水土保持研究 2025年第1期32卷 13-20页

作者：邹惠杰刘刚舒成博孙波刘亚张琼郭珍中国科学院教育部水土保持与生态环境研究中心黄土高原土壤侵蚀与旱地农业国家重点实验室中国科学院水利部水土保持研究所中国科学院大学西北农林科技大学黄土高原土壤侵蚀与旱地农业国家重点实验室四川华标测检测技术有限公司

[目的]定量了解内蒙古典型黑土区土壤侵蚀速率，探究该区域土壤侵蚀空间分布特征，阐明土壤侵蚀坡面和区域空间分布规律，以期为区域水土流失治理提供参考。[方法]采集内蒙古农牧交错区（海拉尔区、额尔古纳市和牙克石市）典型黑土坡耕... 详细信息

[目的]定量了解内蒙古典型黑土区土壤侵蚀速率，探究该区域土壤侵蚀空间分布特征，阐明土壤侵蚀坡面和区域空间分布规律，以期为区域水土流失治理提供参考。[方法]采集内蒙古农牧交错区（海拉尔区、额尔古纳市和牙克石市）典型黑土坡耕地的土壤样品，利用137Cs示踪技术计算各采样点土壤侵蚀速率，结合小波分析的方法研究土壤侵蚀在坡面的分布特征。[结果]（1） 3个坡面所有采样点137Cs含量均小于背景值（1 984.24 Bq/m2）,表现为所有坡面土壤流失。（2） 3个地区的采样坡面平均侵蚀速率表现为：海拉尔[6 533.37 t/（km2·a）]>额尔古纳[4 174.35 t/（km2·a）]>牙克石[2 765.87 t/（km2·a）]。相同坡面的3个纵向断面的平均侵蚀速率相近，同一断面侵蚀速率的变异程度较高。（3）土壤侵蚀速率沿坡长呈强弱交替的周期性变化，但周期长度并不固定。大部分纵向断面存在周期长度为80～160 m和160～200 m的大小两个周期。部分纵向断面只存在一个周期长度为100～120 m的周期。[结论]该地区土壤侵蚀在坡面尺度表现为全坡面侵蚀且在纵向呈现周期性特征，在区域尺度呈现从东到西逐渐增加趋势。

关键词：土壤侵蚀典型黑土农牧交错带小波分析

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Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： ya-Xin Xu Xiao-Xuan Niu Wen-Chang Jia Jing Wen Xue-Lin Cheng yan Han Ming-Hui Peng Jing Zhou yao liu Sun-Fang Jiang Xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of general Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKgROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region global Burden of Disease Risk factors Disability-adjusted life years

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A Secure Clock Synchronization Scheme for Wireless Sensor Networks Against Malicious Attacks

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Journal of Systems Science & Complexity 2021年第6期34卷 2125-2138页

作者： ZHANg Xuxin liu yanzhang ZHANg ya School of Automation Southeast UniversityNanjing 210096China Key Laboratory of Measurement and Control of Complex Systems of Engineering Ministry of EducationNanjing 210096China China Electric Power Research Institute Nanjing 210003China

This paper studies the secure and accurate clock synchronization problem for sensor networks with time-varying delays and malicious attacks.A novel clock synchronization scheme based on the attack detection mechanism,attack compensation,and maximum consensus protocol is *** proposed scheme starts with the detection of the malicious attacks and the clock data under attacks is *** the basis,software clock parameters are updated so that all the nodes in the network can have the same software skew and offset,so the clock synchronization can be ***,it is theoretically proved that the proposed scheme can achieve the attack detection correctly,and further can guarantee a secure and accurate clock *** addition,extensive simulations are also conducted to validate the effectiveness of the proposed scheme.

关键词： Clock synchronization communication delays consensus malicious attacks wireless sensor networks

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Improving Solution of Euler Equations by a gas-Kinetic BgK Method

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西北工业大学学报 2009年第1期27卷 1-5页

作者： liu, ya.gao, Chao liu, F. National Key Laboratory of Aerodynamic Design and Research Northwestern Polytechnical University Xi'an 710072 China Department of Mechanical and Aerospace Engineering University of California Irvine CA 92697-3975 United States

*** well known JST(Jameson-Schmidt-Turkel) scheme requires the use of a dissipation *** propose using gas-kinetic BgK(Bhatnagar-gross-Krook) method,which is based on the more fundamental Boltzmann equation,in order to obviate the use of dissipation term and obtain,we believe,an improved *** 1 deals essentially with three things:(1) as analytical solution of molecular probability density function at the cell interface has been obtained by the Boltzmann equation with BgK model,we can compute the flux term by integrating the density function in the phase space;eqs.(8) and(11) require careful attention;(2) the integrations can be expressed as the moments of Maxwellian distribution with different limits according to the analytical solution;eqs.(9) and(10) require careful attention;(3) the discrete equation by finite volume method can be solved using the time marching *** are performed by the BgK method for the Sod′s shock tube problem and a two-dimensional shock reflection *** results are compared with those of the conventional JST scheme in Figs.1 and *** BgK method provides better resolution of shock waves and other features of the flow fields.

关键词： Euler equations Boltzmann equation gas-kinetic BgK(Bhatnagar-gross-Krook) scheme JST(Jameson-Schmidt-Turkel) scheme shock tube shock reflection

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Reliability analysis on civil engineering project based on integrated adaptive simulation annealing and gray correlation method

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Frontiers of Structural and Civil Engineering 2016年第4期10卷 462-471页

作者： Xiao-ping BAI ya-nan liu System Engineering Research Institute School of Management Xi 'an University of Architecture & Technology Xi 'an 710055 China

Dynamic reliability is a very important issue in reliability research. The dynamic reliability analysis for the project is still in search of domestic and international research in the exploration stage. By now, dynamic reliability research mainly concentrates on the reliability assessment; the methods mainly include dynamic fault tree, extension of event sequence diagram and Monte Carlo simulation, and et al. The paper aims to research the dynamic reliability optimization. On the basis of analysis of the four quality influence factors in the construction engineering, a method based on gray correlation degree is employed to calculate the weights of factors affecting construction process quality. Then the weights are added into the reliability improvement feasible index （RIFI）. Furthermore, a novel nonlinear programming mathematic optimization model is established. In the Insight software environment, the Adaptive Simulated Annealing （ASA） algorithm is used to get a more accurate construction subsystem optimal reliability under different RIFI conditions. In addition, the relationship between construction quality and construction system reliability is analyzed, the proposed methods and detailed processing can offer a useful reference for improving the construction system quality level.

关键词： civil engineering dynamic reliability grey relational degree adaptive simulated annealing algorithm

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MODIFIED LOg-WAKE LAWS FOR TURBULENT FLOW OF THE OUTER AND INNER REgIONS IN SMOOTH PIPES

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Journal of Hydrodynamics 2007年第2期19卷 188-194页

作者： liu ya-kun NI Han-gen State key Laboratory of Coastal and offshore Engineering Dalian University of Technology Dalian 116024 china

Based on theoretical analysis two modified log-wake laws for turbulent flow in smooth pipes are obtained, one is applicable to the outer region and other one to inner region, the new law for the outer region fits the velocity profile measured in smooth pipes by Zagarola very well and the effect of Reynolds number can be taken into consideration, the velocity profile for inner region satisfies the wall boundary conditions ,equals zero at the pipe wall and smoothly joins up with the velocity profile in outer region, the adopted eddy viscosity model is consistent with Laufer＇s, Nunner＇s and Reichardt＇s experimental data.

关键词： turbulent pipe flow eddy viscosity log-wakelaw outer and inner regions

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ABRUPT DEFLECTED SUPERCRITICAL WATER FLOW-REVISED THEORY OF SHOCK WAVE

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Journal of Hydrodynamics 2006年第1期18卷 32-39页

作者： NI Han-gen liu ya-kun State Key Laboratory of Coastal and Offshore Engineering Dalian University of Technology Dalian 116024 China

The shock wave angle and depth ratio of the abrupt deflected supercritical water flow due to deflector was investigated experimentally and theoretically. A correction coefficient of the hydro-dynamic pressure ξ was introduced to generalize the momentum equation in the perpendicular direction to the shock front. An extensive series of tests were conducted in a 1 m wide flume with the Froude number ranging from 1.70 to 8.37, the deflection angle ranging from 5° to 40° and the length of deflector ranging from 0.28 m to 1 m. A dimensionless parameter K was defined to depict the ratio of the flow height to flow thickness. Test results show that the val ue of ~, the correction coefficient of the non-hydrostatic pres- sure distribution, decreases with the increase of the value of K An empirical relationship between the value of ξ and the val ue of K was proposed. It is indicated that the relative errors of the results calculated by the revised theory is much smaller than that obtained from the Ippen theory. Finally, a simple explicit expression was suggested to calculate the shock wave height ratio in consideration of the effect of the non-hydrostatic pressure distribution.

关键词： theory of shock wave abrupt deflection of supercritical flow trajectory type energy dissipater

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