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Biomedical and Environmental Sciences 2021年第11期34卷 905-909页

作者： ZHANg Jun Xi ya.g Meng JI Peng Hui LI Qin ya.g CHAI Jian SUN Pan Pan yaN Xi DONg Wei SUN Ren Jie WANg Yu Hong YU Fang Fang ZHANg ya Wei ba.Yue JIANg Li Fang ZHOU guo Yu National Health Commission Key Laboratory of Birth Defects Prevention Henan Key Laboratory of Population Defects PreventionHenan Institute of Reproduction Health Science and TechnologyZhengzhou 450002HenanChina Department of Environmental Health&Environment and Health Innovation Team School of Public HealthZhengzhou UniversityZhengzhou 450001HenanChina Department of Neurology Henan Provincial People's HospitalZhengzhou 450001HenanChina Department of Environment Health Science Yale University School of Public HealthNew HavenCTUSA Yellow River Institute for Ecological Protection&Regional Coordinated Development Zhengzhou UniversityZhengzhou 450001HenanChina

Low birth weight(LBW)is defined as a birth weight of less than 2,500 *** has been estimated that 15%–20%of infants(more than 20 million worldwide)were born with LBW,and 95.6%of the overall LBW infants were born in low and middle income countries[1].Not only is LBW a crucial cause of infant mortality and morbidity,it also plays a critical role in adverse health outcomes later in ***,exploring the factors influencing LBW may have important implications for reducing maternal-child health burden.

关键词： mortality infant Rural

Ferroelectricity in Pulsed Laser Deposited ba.Fe_(1/2)Nb_(1/2))O_(3) Thin Films

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Chinese Physics Letters 2013年第5期30卷 148-151页

作者： ZHANg Wei WU Shu-ya LI Lei CHEN Xiang-Ming Laboratory of Dielectric Materials Department of Materials Science and EngineeringZhejiang UniversityHangzhou 310027

Complex perovskite ba.Fe_(1/2)Nb_(1/2))O_(3) thin films are grown on Pt/TiO_(2)/SiO_(2)/Si substrates by pulsed laser deposition. Non-linear polarization–electric-field (P–E) loops are observed at low temperatures under different electric fields and frequencies. The broad peak in the corresponding current density–electric field (J–E) loop confirms the existence of domain switching. The remnant polarization decreases slightly when the temperature decreases from 153 to 123 K, which differentiates ba.Fe_(1/2)Nb_(1/2))O_(3) from normal ferroelectrics. The Raman spectra of ba.Fe_(1/2)Nb_(1/2))O_(3) thin films show two-mode-like behavior in the high-wavenumber region, which can be caused by the local chemically heterogeneous zones of NbO_(6) and FeO_(6). The weak ferroelectricity observed in the ba.Fe_(1/2)Nb_(1/2))O_(3) thin films might originate from the composition fluctuation and subsequent symmetry breaking in the material. The present results might provide a new aspect to the understanding of the intrinsic dielectric nature in ba.Fe_(1/2)Nb_(1/2))O_(3).

关键词： deposition material symmetry

紫精基离子型共轭微孔聚合物作为电子传输泵用于高效多硫化物捕获和转化

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Science Bulletin 2024年第8期69卷 1071-1080页

作者：李海洋李中山邱刚浩张柔柔王亚蕊王凤黄仁武刘晓飞臧双全 Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsKey Laboratory of Special Environmental Functional Materials(Zhengzhou University)Ministry of EducationGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China

The commercialization of lithium-sulfur(Li-S)ba.teries has been hindered by the shuttle effect and sluggish redox kinetics of lithium polysulfides(LiPSs).Herein,we reported a viologen-ba.sed ionic conjugated mesoporous polymer(TpV-Cl),which acts as the cathode host for modifying Li-S *** viologen component serves as a reversible electron conveyer,leading to a comprehensive enhancement in the adsorption of polysulfides and improved conversion rate of polysulfides during the electrochemical *** a result,the S@TpV-PS cathode exhibits outstanding cycling performance,achieving 300 cycles at2.0 C(1 C=1675 mA g^(-1))with low decay rate of 0.032%per *** at a high sulfur loading of 4.0 mg cm^(-2),S@TpV-PS shows excellent cycling stability with a Coulombic efficiency of up to 98%.These results highlight the significant potential of S@TpV-PS in developing high-performance Li-S ba.teries.

关键词： Viologen Conjugated mesoporous polymer Lithium-sulfur ba.tery Polysulfide Shuttle effect

Met-Controlled Allosteric Module of Neural generation as A New Therapeutic Target in Rodent Brain Ischemia

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Chinese Journal of Integrative Medicine 2021年第12期27卷 896-904页

作者： LI Kang-ning ZHANg Ying-ying YU ya-nan WU Hong-li WANg Zhong Department of Traditional Chinese Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijing(100070)China Institute of ba.ic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing(100700)China

Objective To investigate a Met-controlled allosteric module(AM)of neural generation as a potential therapeutic target for brain *** We selected Markov clustering algorithm(MCL)to mine functional modules in the related target *** to the topological similarity,one functional module was predicted in the modules of ba.calin(ba.,jasminoidin(JA),cholic acid(CA),compared with I/R model *** functional module included three genes:Inppl1,Met and Dapk3(IMD).By gene ontology enrichment analysis,biological process related to this functional module was *** functional module participated in generation of *** blotting was applied to present the compound-dependent regulation of ***-immunoprecipitation was used to reveal the relationship among the three *** used IF to determine the number of newborn neurons between compound treatment group and ischemia/reperfusion *** expressions of vascular endothelial growth factor(VEgF)and matrix metalloproteinase 9(MMP-9)were supposed to show the changing circumstances for neural generation under cerebral *** Significant reduction in infarction volume and pathological changes were shown in the compound treatment groups compared with the I/R model group(Pgulatory *** anti-ischemic excitatory allosteric module(AME)of generation of neurons(AME-gN)was validated successfully in *** neurons increased in BJC treatment group(PgF and MMP-9 decreased in the compound treatment groups compared with the I/R model group(Pg approach to the discovery of therapeutic *** novel approach for AM discovery in an effort to identify therapeutic targets holds the promise of accelerating elucidation of underlying pharmacological mechanisms in cere

关键词： allosteric module InppM-Met-Dapk3 generation of neurons brain ischemia

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一种停车场最优停车路径规划设计

价值工程 2024年第1期43卷 97-99页

作者：毛国龙张亚秋赵海茹玉溪师范学院玉溪653100

停车场指引系统是智能交通、乃至智慧城市的一个重要组成部分。最优泊车路径规划的目的是为了帮助驾驶员快速找到一条最适合他们的停车路径,基本假设为从停车场入口到某特定泊车位行驶的最短路径即为泊车的最优(快速)路径。本论文以停... 详细信息

停车场指引系统是智能交通、乃至智慧城市的一个重要组成部分。最优泊车路径规划的目的是为了帮助驾驶员快速找到一条最适合他们的停车路径,基本假设为从停车场入口到某特定泊车位行驶的最短路径即为泊车的最优(快速)路径。本论文以停车场的空闲车位为规划对象,基于Dijkstra算法以距离出口和电梯口的距离最近为目标进行路径规划。实验结果表明,规划的路径合理有效,能够减少车主泊车时盲目巡航造成的问题。

关键词： Dijkstra算法路径规划智慧交通路径引导

逍遥散对皮质酮诱导的PC12损伤模型保护作用及神经保护成分分析验证研究

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重庆医科大学学报 2024年第4期49卷 451-458页

作者：孙璐吴亚运刘丽娟赵亚黎雄赵瑞芝胡巧红广东药科大学药学院广州510006 广州中医药大学第二临床医学院/广东省中医院/广东省中医药科学院广州510006

目的:通过探究逍遥散的神经保护作用及其化学组成,发现逍遥散中可能发挥神经保护作用的有效活性成分。方法:采用水提法提取逍遥散,通过高分辨质谱-液相色谱质谱联用仪分析提取液的化学成分;制备逍遥散含药血清;构建皮质酮(Corticosteron... 详细信息

目的:通过探究逍遥散的神经保护作用及其化学组成,发现逍遥散中可能发挥神经保护作用的有效活性成分。方法:采用水提法提取逍遥散,通过高分辨质谱-液相色谱质谱联用仪分析提取液的化学成分;制备逍遥散含药血清;构建皮质酮(Corticosterone,CORT,400μmol/L)诱导PC12细胞损伤模型,检测含药血清对PC12细胞增殖率的影响;用SIMCA软件进行细胞增殖率-成分含量相关性分析,找到逍遥散中可能具有神经保护作用的化合物。结果:与模型组相比,逍遥散含药血清可减轻CORT诱导的细胞损伤,并促进细胞增殖(P=0.000)。液质谱图结合软件分析比对发现,主要药效化合物有:芍药苷、甘草酸、甘草苷、迷迭香酸、没食子酸、2-苯基乙醛、(15Z)-9,12,13-Trihydroxy-15-octadecenoic acid、丹酚酸B、甘草皂苷g2等,单体验证结果显示苯乙醛具有一定的神经保护作用(P=0.000)。结论:证明逍遥散具有神经保护作用,分析并鉴定出55种化合物有可能是其发挥作用的主要成分,发现逍遥散中未曾报道的7种可能具有神经保护作用的化合物,并验证出苯乙醛具有神经保护作用且此前从未报道。本研究成果将为阐明逍遥散神经保护作用的物质基础提供参考,也为拓展逍遥散的临床应用提供数据支撑。

关键词：逍遥散神经保护作用化学成分

治疗高脂血症蒙药中微量元素的ICP-AES法测定及分析

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光谱学与光谱分析 2008年第6期28卷 1394-1397页

作者：额尔登桑巴图贾美林乌兰图雅内蒙古师范大学化学与环境科学学院内蒙古呼和浩特010022 内蒙古中蒙医医院内蒙古呼和浩特010022

在蒙药的配制及整体研究工作中发现它们含有多种氨基酸和丰富的微量元素,特别是人体必需的微量元素含量相对高,而人体有害的重金属元素含量相对低。采用微波消解ICP-AES法同时测定了治疗高脂血症组合蒙药（1#早服、2#午服、3#晚服）中Ca... 详细信息

在蒙药的配制及整体研究工作中发现它们含有多种氨基酸和丰富的微量元素,特别是人体必需的微量元素含量相对高,而人体有害的重金属元素含量相对低。采用微波消解ICP-AES法同时测定了治疗高脂血症组合蒙药（1#早服、2#午服、3#晚服）中Ca,Mg,Al,Fe,Mn,Sr,Cu,Zn和Pb等15种金属元素。加标回收率在94.63%-106.40%之间,相对标准偏差RSD≤3.41%,检出限在≤0.009μg·L^-1。实验结果表明;1#,2#,3#为不同类型的蒙药,具有一定的差异,微量元素含量有所不同,但组合治疗高脂血症。

关键词：组合蒙药微量元素高脂血症 ICP-AES

玉米自交系Y423萌动胚诱导愈伤组织及愈伤组织再分化的体系建立

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玉米科学 2024年第5期32卷 15-22页

作者：单晓辉魏慧慧刘洪魁董海霄李世鹏苏胜忠原亚萍吉林大学植物科学学院长春130062

幼胚是目前广泛用于玉米组培再生和遗传转化的主要外植体材料,但获取幼胚的数量和质量会受到季节和气候条件的严重影响。通过将玉米子粒在4℃条件下浸泡3 d获得萌动胚,进而以其为外植体,建立玉米组培再生体系。通过调整培养基组成和激... 详细信息

幼胚是目前广泛用于玉米组培再生和遗传转化的主要外植体材料,但获取幼胚的数量和质量会受到季节和气候条件的严重影响。通过将玉米子粒在4℃条件下浸泡3 d获得萌动胚,进而以其为外植体,建立玉米组培再生体系。通过调整培养基组成和激素配比,萌动胚在2,4-D浓度为8 mg/L的诱导培养基上,初代愈伤组织发生率可达到54.17%,经继代培养胚性愈伤诱导率可达42.13%。胚性愈伤组织在激素组合为1.5 mg/L 6-ba.0.1 mg/L NAA的分化培养基上分化率超过40%,经生根培养后可100%生根。基因表达分析同时发现,与体细胞发生相关的7个基因在不同培养阶段的表达变化与胚性愈伤组织的形成密切相关。结果表明,玉米萌动胚可替代幼胚或作为其补充用于玉米组培再生和遗传转化相关工作。

关键词：玉米萌动胚外植体组织培养基因表达

Stability of a rat model of prehepatic portal hypertension caused by partial ligation of the portal vein

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World Journal of gastroenterology 2009年第32期15卷 4049-4054页

作者： Zhe Wen Jin-Zhe Zhang Hui-Min Xia Chun-Xiao ya.g ya-Jun Chen Department of Surgery Guangzhou Children's Hospital Affiliated to Guangzhou Medical CollegeGuangzhou 510120 Guangdong Province China Department of Surgery Beijing Children's Hospital Affiliated to Capital Medicai University Beijing 100045 China Department of Surgery Linzi People's Hospital Zibo 255400 Shandong Province China

AIM： To study the stability of portal hypertension （PHT） caused by partial ligation of the portal vein ligation （PVL） in a rat model.METHODS： Thirty male adult Wistar rats were divided into two groups： 10 in group Ⅰ received a sham operation; and 20 in group Ⅱreceived partial PVL. Portal vein pressure （PVP） was measured at four time periods： before ligation, 2 wk, 6 wk and 10 wk postsurgery. Portal venography, blood sampling and liver and spleen pathological examinations were conducted at 10 wk after surgery.RESULTS： The PVP was 9.15± 0.58 cmH2O before ligation, and increased to 17.32 ±0.63 cmH2O 2 wk after PVL. By repeat measurement of the PVP in each rat, it was shown to remain elevated for 10 wk. There were no significant differences in the pressure measurements at 2 wk, 6 wk and 10 wk. Varices were found mainly in the mesenteric vein 2 wk after PVL, which were more obvious later, while these manifestations were similar at week 6 and week 10. Portal venography demonstrated the varices and collaterals. There was no significant change in liver pathology. The volume of the spleen was enlarged 2-fold after ligation, and the sinus of the spleen was enlarged due to congestion. Significant sinus endothelial cell proliferation was observed, but no evidence of hypersplenia was found on hemogram and biochemical examination.CONCLUSION： These findings suggest that a satisfactory prehepatic PHT rat model can be obtained by partial ligation of the portal vein, and this PHT rat model was stable for at least 10 wk.

关键词： Ligation Portal hypertension Portal vein Rat

Crossover from normal to diffused and relaxor ferroelectric in ba.rO_(3)- modified (ba.(0.85)Ca_(0.15))TiO_(3) ceramics

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Journal of Materiomics 2021年第5期7卷 1094-1102页

作者： Shao Bo Chen Jia Yi ya.g Shu ya Wu Xiang Ming Chen Laboratory of Dielectric Materials School of Materials Science and EngineeringZhejiang University38 Zheda RoadHangzhou310027China

The variation of dielectric,ferroelectric and piezoelectric characteristics of ba.rO_(3)emodified(ba.(0.85)Ca_(0.15))TiO_(3) ceramics,(1-x)(ba.(0.85)Ca_(0.15))TiO_(3)-xba.rO_(3),have been investigated together with the structure *** crystal structure at room-temperature varies from tetragonal to metrically cubic through orthorhombic and rhombohedral,and the morphotropic phase boundary(MPB)is determined around x=0.12 where the significantly enhanced dielectric,ferroelectric and piezoelectric characteristics are *** increasing x,the present ceramics indicate the crossover from normal to diffused and relaxor ferroelectric,and the evolution process is explored systematically.

关键词： Morphotropic phase boundary Diffused ferroelectric Relaxor ferroelectric