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胃癌的病理特点

中国医药导报 2007年第9X期4卷 146-147页

作者：巴亚萍河南省洛阳市妇女儿童医疗保健中心病理科河南洛阳471000

目的:观察48例胃癌的好发部位、肉眼形态,大小及组织学类型,探讨其临床病理特点。方法:取胃壁肿瘤全层,癌旁黏膜及小于3 cm的病灶进行固定、包埋、组织切片、HE染色及组织学检查。结果:癌肿部位以胃窦部最多,占70.8%,肉眼形态以溃疡型最... 详细信息

目的:观察48例胃癌的好发部位、肉眼形态,大小及组织学类型,探讨其临床病理特点。方法:取胃壁肿瘤全层,癌旁黏膜及小于3 cm的病灶进行固定、包埋、组织切片、HE染色及组织学检查。结果:癌肿部位以胃窦部最多,占70.8%,肉眼形态以溃疡型最多,占79.2%(含局限溃疡型和浸润溃疡型)。小于3 cm的病灶大多为早期癌。结论:组织学类型与浸润深度及转移密切相关,并且随着肿瘤的进展,肿瘤细胞分化越来越差,浸润及转移率越来越高。胃癌与肠化生关系密切。

关键词：胃癌病理特点

大肠癌及癌前病变组织中EgF-R表达的意义

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中国误诊学杂志 2007年第24期7卷 5712-5714页

作者：巴亚萍河南省洛阳市妇女儿童医疗保健中心病理科 471003

目的:探讨表皮生长因子受体(EgF-R)与大肠癌发生及生物学行为的关系。方法:采用免疫组化ABC法对10例正常大肠黏膜、66例大肠绒毛状或管状腺瘤及89例大肠癌进行了标记分析。结果:EgF-R在正常大肠黏膜全部为阴性,随着大肠黏膜病变的进展,E... 详细信息

目的:探讨表皮生长因子受体(EgF-R)与大肠癌发生及生物学行为的关系。方法:采用免疫组化ABC法对10例正常大肠黏膜、66例大肠绒毛状或管状腺瘤及89例大肠癌进行了标记分析。结果:EgF-R在正常大肠黏膜全部为阴性,随着大肠黏膜病变的进展,EgF-R阳性率逐渐升高,EgF-R在伴有轻、中、重度异型增生腺瘤中的阳性率分别为25%、38.1%和58.8%,大肠癌的阳性率为60.8%。轻度异型增生腺瘤组的阳性率明显低于重度异型增生腺瘤组(PgF-R的表达与大肠癌的发生有一定的相关性,并可作为判断大肠癌生物学行为及预后的一个有用指标。

关键词：结直肠肿瘤/病理学癌前状态/病理学受体,表皮生长因子/分析免疫组织化学

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拉萨近45年浅层地温的变化特征

干旱区地理 2007年第6期30卷 826-831页

作者：杜军李春廖健拉巴路红亚西藏自治区气候中心西藏拉萨850001 西藏自治区气象局西藏拉萨850001 西藏自治区气象台西藏拉萨850001

利用1961-2005年拉萨0～40cm各层逐月平均地温,采用气候倾向率、累积距平、信噪比等气候统计方法,研究了近45年拉萨浅层平均地温的变化趋势、气候突变和异常年份等。结果表明:浅层各季节平均地温均呈现为极显著的升高趋势,升温率为0.43... 详细信息

利用1961-2005年拉萨0～40cm各层逐月平均地温,采用气候倾向率、累积距平、信噪比等气候统计方法,研究了近45年拉萨浅层平均地温的变化趋势、气候突变和异常年份等。结果表明:浅层各季节平均地温均呈现为极显著的升高趋势,升温率为0.43～0.60℃/10a,春季最大、夏季最小。各层年平均地温以0.45～0.66℃/10a的升温率显著上升,40cm深度的升温率最大,与同时期平均气温的升温率比较,地温比气温对气候变暖的响应更强。20世纪60年代至90年代浅层年、季平均地温呈明显的逐年代升高趋势,以冬、春季最为明显。60年代到80年代中期为偏冷阶段,80年代后期至90年代地温为偏暖阶段。各浅层平均地温在1986年秋季均发生了突变,冬季突变时间都出现在1984年。年平均地温除在40cm处1999年异常偏高外,其它各层为异常偏低年份,且发生在20世纪60年代。

关键词：浅层地温气候倾向率异常年份气候突变

儿童氟斑牙与雌激素受体基因Xba.I多态性的关系分析

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中国地方病学杂志 2010年第3期29卷 278-281页

作者：巴月王刚余波杨跃进任丽君银恭举程学敏崔留欣 ZHANg ya-wei 郑州大学公共卫生学院环境卫生学教研室 450001 河南省疾病预防控制中心地方病科河南省开封市疾病预防控制中心地方病科耶鲁大学公共卫生学院环境科学系

目的探讨儿童氟斑牙发生与雌激素受体基因α（ERα）Xba.I多态性的关系.方法于2006年选取河南省开封县仇楼乡、通许县孙营乡作为调查点,每个点选饮水型地方性氟中毒病区（高氟区）、对照区各1个,对调查区的8～12岁儿童进行氟斑牙检查... 详细信息

目的探讨儿童氟斑牙发生与雌激素受体基因α（ERα）Xba.I多态性的关系.方法于2006年选取河南省开封县仇楼乡、通许县孙营乡作为调查点,每个点选饮水型地方性氟中毒病区（高氟区）、对照区各1个,对调查区的8～12岁儿童进行氟斑牙检查,氟斑牙诊断采用Dean法,并依据高氟区儿童氟斑牙患病情况分为氟斑牙组、病区对照组;对照区儿童为非病区对照组.利用聚合酶链反应-限制性片段长度多态性（PCR-FRLP）方法检测儿童ERα Xba.I基因型,氟离子选择电极法测定尿氟,计算尿氟超标率.结果在高氟区儿童氟斑牙检出率为51.7%（74/143）,氟斑牙指数为1.310;在对照区共调查94人,未检出氟斑牙患者,氟斑牙指数为0.021;高氟区儿童尿氟超标率[84.6%（121/143）]明显高于非病区对照组[9.6%（9/94）;χ^2125.95,P〈0.01].ERα Xba.I基因型XX、Xx、xx分布频率,氟斑牙组分别为6.8%（5/74）、36.5%（27/74）、56.8%（42/74）,病区对照组分别为15.9%（11/69）、37.7%（26/69）、46.4%（32/69）,非病区对照组分别为14.9%（14/94）、43.6%（41/94）、41.5%（39/94）,ERα Xba.I基因型在3组儿童中分布组间比较差异无统计学意义（χ^23.450,P〉0.05）.尿氟超标儿童ERα Xba.I等位基因X、x频率,氟斑牙组儿童分别为22.7%（30/132）、77.3%（102/132）,病区对照组儿童分别为35.5%（39/110）、64.5%（71/110）,二者比较差异有统计学意义（χ^2=4.768,P〈0.05;OR=0.535.95%CI：0.305～0.941）.结论在尿氟超标的儿童中,携带X等位基因可能降低氟斑牙发生的危险性.

关键词：雌激素受体α 多态性,基因氟中毒,牙

Quantitative diffusion-weighted magnetic resonance enterography in ileal Crohn’s disease: A systematic analysis of intra and interobserver reproducibility

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World Journal of gastroenterology 2019年第27期25卷 3619-3633页

作者： Hao Yu ya-Qi Shen Fang-Qin Tan Zi-Ling Zhou Zhen Li Dao-Yu Hu John N Morelli Department of Radiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina St.John’s Medical Center TulsaOK 74133United States

ba.KgROUND Magnetic resonance enterography(MRE) is increasingly attractive as a noninvasive and radiation-free tool for assessing Crohn’s disease(CD). Diffusionweighted imaging(DWI) is recommended as an optional MRE sequence for CD by the European Society of gastrointestinal and Abdominal Radiology, and has shown a superb potential as a quantitative modality for bowel inflammation evaluation. However, the measurement reproducibility of quantitative DWI analysis in MRE has not been ascertained so far. To facilitate the application of quantitative diffusion-weighted MRE in the clinical routine, systematic investigations of the intra and interobserver reproducibility of DWI quantitative parameters should be *** To evaluate the intra and interobserver reproducibility of quantitative analysis for diffusion-weighted MRE(DW-MRE) in ileal *** Forty-four subjects(21 with CD and 23 control subjects) who underwent ileocolonoscopy and DW-MRE(b = 800 s/mm2) within one week were *** radiologists independently measured apparent diffusion coefficients(ADC)of the terminal ileum and signal intensity ratio(SR) of the terminal ileum to ipsilateral psoas muscle on DWI images(b = 800 s/mm2). Between-and withinreader agreements were assessed using intraclass correlation coefficients(ICC),coefficients of variation(CoV), and 95% limits of agreement of Bland-Altman plots(ba.LA LoA). Diagnostic performances of ADC and SR for identifying inflamed terminal ileum from the normal were evaluated by receiver operating characteristic(ROC) curve *** There were no significant differences in ADC or SR values between the two sessions or between the two radiologists either in the CD or control group(paired t-test, P > 0.05). The intra and interobserver reproducibility of ADC(ICC: 0.952-0.984;CoV: 3.73-6.28%;ba.LA LoA: ±11.27% to ±15.88%) and SR(ICC: 0.969-0.989;CoV: 3.51%-4.64%;ba.LA LoA: ±10.62% to ±15.45%) was excellent for *** of ADC measurements was sli

关键词： Magnetic resonance imaging Diffusion-weighted imaging Crohn’s disease Ileum Reproducibility

The biomechanical role of periodontal ligament in bonded and replanted vertically fractured teeth under cyclic biting forces

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International Journal of Oral Science 2015年第2期7卷 125-130页

作者： ya-Nan Zhu Wei-Dong ya.g Paul V Abbott Nicolas Martin Wen-Jia Wei Jing-Jing Li Zhi Chen Wen-Mei Wang Department of Endodontics Institute and Hospital of StomatologyNanjing University Medical School Department of Endodontics School of DentistryThe University of Western Australia Department of Adult Dental Care School of Clinical DentistryThe University of Sheffield Department of Prothodontics Institute and Hospital of StomatologyNanjing University Medical School Department of Oral Medicine Institute and Hospital of StomatologyNanjing University Medical School Department of Endodontics The School and Hospital of StomatologyWuhan University

After teeth are replanted,there are two possible healing responses：periodontal ligament healing or ankylosis with subsequent replacement *** purpose of this study was to compare the fatigue resistance of vertically fractured teeth after bonding the fragments under conditions simulating both healing ***-two human premolars were vertically fractured and the fragments were bonded together with Super-Bond C＆*** were then randomly distributed into four groups（BP,CP,CA,ba..The BP and CP groups were used to investigate the periodontal ligament healing mode whilst the ba.and CA groups simulated *** teeth had root canal treatment *** crowns were constructed for the CP and CA *** BP and ba.groups only had composite resin restorations in the access *** specimens were subjected to a 260 N load at 4 Hz until failure of the bond or until 2 x 106 cycles had been reached if no fracture *** were detected by stereomicroscope imaging and also assessed via dye penetration ***,interfaces of the resin luting agent were examined by scanning electron *** results confirmed that the fatigue resistance was higher in the groups with simulated periodontal ligament *** reattachment showed important biomechanical role in bonded and replanted vertically fractured teeth.

关键词： fractured vertically teeth periodontal ligament bonding bonded resin subsequent restoration

胡桃醌对人肝癌BEL-7402细胞亚显微结构的影响

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南方医科大学学报 2009年第6期29卷 1208-1211页

作者：陈丽那顺巴雅尔张建于娟顾为望南方医科大学实验动物中心暨比较医学研究所广东广州510515

目的了解胡桃醌对人肝癌BEL-7402细胞亚显微结构的影响。方法12.5μmol/L胡桃醌作用于BEL-7402细胞24h后固定,分别行HE染色、考马斯亮蓝染色、扫描电镜及透射电镜样品制备。结果12.5μmol/L胡桃醌处理组细胞形态和细胞骨架发生改变。扫... 详细信息

目的了解胡桃醌对人肝癌BEL-7402细胞亚显微结构的影响。方法12.5μmol/L胡桃醌作用于BEL-7402细胞24h后固定,分别行HE染色、考马斯亮蓝染色、扫描电镜及透射电镜样品制备。结果12.5μmol/L胡桃醌处理组细胞形态和细胞骨架发生改变。扫描电镜结果显示BEL-7402细胞胞体体积缩小,与周围细胞群脱离,表面微绒毛卷曲、畸变、小球结构逐渐增多,细胞间连接逐渐断裂,细胞间隙增宽,有凋亡小体形成。透射电镜结果显示胡桃醌作用BEL-7402细胞24h后,细胞内质网扩大,线粒体结构疏松,胞核核仁裂解,凋亡小体形成。结论胡桃醌能有效改变人肝癌BEL-7402细胞亚显微结构,诱导细胞凋亡。

关键词： BEL-7402 细胞骨架亚显微结构细胞凋亡

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风吹豆豉牛肉干加工工艺的研究

粮食与油脂 2023年第12期36卷 102-107页

作者：蒋亚吉丁雪梅刘亚萍孟金明红河学院化学与资源工程学院云南蒙自661199 中国人民解放军63853部队吉林白城137000

在嫩化型牛肉干制作的基础上,以鲜牛肉和弥勒风吹豆豉为主要原料,研制一款具有云南地方特色的新型牛肉干产品。通过单因素试验和响应面-主成分分析试验探究了风吹豆豉牛肉干的最佳加工工艺。结果表明,最佳加工工艺条件:以鲜牛肉质量为基... 详细信息

在嫩化型牛肉干制作的基础上,以鲜牛肉和弥勒风吹豆豉为主要原料,研制一款具有云南地方特色的新型牛肉干产品。通过单因素试验和响应面-主成分分析试验探究了风吹豆豉牛肉干的最佳加工工艺。结果表明,最佳加工工艺条件:以鲜牛肉质量为基准,风吹豆豉添加量160 g/kg、食盐添加量20 g/kg、腌制时间40 min、熟化时间50 min、干制温度140℃、干制时间3 min。在此条件下制成的牛肉干营养丰富,色泽呈红褐色,组织状态较好,结构紧密,硬度适中,风吹豆豉和牛肉的风味相互融合,浓郁且协调。

关键词：牛肉干风吹豆豉主成分分析质

Apoptosis and necrosis of HeLa cells in response to low-energy ion radiation

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Nuclear Science and Techniques 2006年第4期17卷 222-226页

作者： ZHANg Feng-Qiu ya Hui-Yuan LI Jing-Yuan PENg Jian-Jun FANg Hua-Sheng SU Ming-Jie QIN guang-Yong Henan Key Lab of lonbeam Bioengineering Zhengzhou University Zhengzhou 450052 China

The aim of this study was to investigate the damage of low-energy ions to HeLa cells and to particularly examine the relationship between apoptotic and necrotic effects and the low-energy ion radiation. In this study, HeLa cells were irradiated by low-energy ions (30keV N+) at different doses. The level of apoptosis and necrosis was evalu- ated using flow cytometry. Since vacuum is required for experimental low-energy ion generation and irradiation, the cells must be placed in vacuum. Mineral oil was used to prevent dehydration of cells. The results show that the apoptotic rate reached 7.09% when the ion implantation dose was 1 × 1015 ions/cm2; and when the cells were exposed to and implanted at 2 × 1015 ions/cm2 dose, the apoptotic rate was higher than that at 1 × 1015 ions/cm2, and the necrotic rate was 15.63%. In addition, the survival fraction gradually decreased with the increase in implantation dose. Some rela- tionships have been found between the radiation-induced apoptosis and the incuba.ed time after irradiation.

关键词：人宫颈癌传代细胞细胞凋亡细胞增殖低能离子辐射流式细胞测量术