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Study of the intensive care unit activity scale in the early rehabilitation of patients after direct cardiac surgery

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World Journal of Clinical Cases 2024年第26期12卷 5930-5936页

作者： Li Wang Jing-ya Lu Xiao-Xiao Ma Lan-Ou Ma intensive Care Unit Dongyang People’s HospitalJinhua 322100Zhejiang ProvinceChina Department of Rehabilitation Medicine Dongyang People’s HospitalJinhua 322100Zhejiang ProvinceChina

BACKGROUND Direct cardiac surgery often necessitates intensive post-operative care,and the intensive care unit(iCU)activity scale represents a crucial metric in assessing and guiding early rehabilitation efforts to enhance patient *** To clarify the clinical application value of the iCU activity scale in the early recovery of patients after cardiac *** One hundred and twenty patients who underwent cardiac surgery between September 2020 and October 2021 were selected and divided into two groups using the random number table *** observation group was rated using the iCU activity scale and the corresponding graded rehabilitation interventions were conducted based on the iCU activity *** control group was assessed in accordance with the routine rehabilitation activities,and the postoperative rehabilitation indexes of the patients in both groups were compared(time of tracheal intubation,time of iCU admission,occurrence of complications,and activity scores before iCU transfer).The two groups were compared according to postoperative rehabilitation indicators(time of tracheal intubation,length of iCU stay,and occurrence of complications)and activity scores before iCU *** in the observation group,tracheal intubation time lasted for 18.30±3.28 h and iCU admission time was 4.04±0.83 d,which were significantly shorter than the control group(t-values:2.97 and 2.038,respectively,Phe observation group also had a significantly lower number of complications and adverse events compared to the control group(PiCU transfer,the observation group(6.7%)had few complications and adverse events than the control group(30.0%),and this difference was statistically significant(Pitionally,the activity score was significantly higher in the observation(26.89±0.97)compared to the control groups(22.63±1.12 points)(t-value;-17.83,PiON implementation of early goal-directed activities in patients who underwent c

关键词： Early recovery activities Goal orientated iCU mobility scale intensive care unit Cardiac surgery

Discovery of proqodine A derivatives with antitumor activity targeting NAD(P)h: quinone oxidoreductase 1 and nicotinamide phosphoribosyltransferase

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Chinese Journal of Natural Medicines 2024年第01期 75-88页

作者： SONG Jiangzhou ZOU Guiqing ZhAO Zhou ZhU ya XUE Jiayu AO Lanjia SUN huiyong hAO haiping ZhANG Bo XU Xiaowei State Key Laboratory of Natural Medicines Key Lab of Drug Metabolism and Pharmacokinetics China Pharmaceutical University State Key Laboratory of Natural Medicines China Pharmaceutical University

NAD（P）h: quinone oxidoreductase 1（NQO1） is a flavin protease highly expressed in various cancer cells. NQO1 catalyzes a futile redox cycle in substrates, leading to substantial reactive oxygen species（ROS） production. This ROS generation results in extensive DNA damage and elevated poly（ADP-ribose） polymerase 1（PARP1）-mediated consumption of nicotinamide adenine dinucleotide（NAD+）, ultimately causing cell death. Nicotinamide phosphoribosyltransferase（NAMPT）, the rate-limiting enzyme in the NAD+salvage synthesis pathway, emerges as a critical target in cancer therapy. The concurrent inhibition of NQO1 and NAMPT triggers hyperactivation of PARP1 and intensive NAD+depletion. in this study, we designed, synthesized, and assessed a novel series of proqodine A derivatives targeting both NQO1 and NAMPT. Among these, compound T8 demonstrated potent antitumor ***, T8 selectively inhibited the proliferation of MCF-7 cells and induced apoptosis through mechanisms dependent on both NQO1 and NAMPT. This discovery offers a promising new molecular entity for advancing anticancer research.

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Application of carbon-supported single-atom catalysts for electrochemical reactions

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新型炭材料(中英文) 2024年

作者： WANG Yi-cheng MA Xiao-bo Ayeza WANG Chen-xu Li yang yaNG Cheng-long WANG Zhe-fan WANG Chao hU Chao ZhANG ya-ting Xi'an Thermal Power Research institute Co. Ltd. College of Chemistry and Chemical Engineering Xi'an University of Science and Technology Tsinghua Shenzhen international Graduate School Tsinghua University School of Chemical Engineering and Technology Xi'an Jiaotong University

The recent advances in carbon-supported single-atom catalysts (SACs) for electrochemical reactions are comprehensively reviewed. The development and advantages of carbon-supported SACs are briefly introduced, followed by a detailed summary of the synthesis strategies employed for various carbon-supported SACs, including vapor phase transport, high temperature pyrolysis,and wet chemical methods. Subsequently, the advanced characterization techniques for carbon-supported SACs are reviewed. The applications of carbon-supported SACs in diverse fields, such as oxygen reduction reaction, carbon dioxide reduction reaction, nitrogen reduction reaction, hydrogen evolution reaction, and oxygen evolution reaction are summarized. Special emphasis is given to the modification strategies enabling carbon-supported SACs to exhibit excellent electrocatalytic performance. Finally, the prospects and challenges associated with utilizing carbon-supported SACs for electrochemical reactions are discussed.

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World Journal of Gastroenterology 2024年第9期30卷 1224-1236页

作者： hai-yang Li Lin-Lin Zheng Nan hu Zhi-hao Wang Chang-Cheng Tao ya-Ru Wang Yue Liu Zulihumaer Aizimuaji hong-Wei Wang Rui-Qi Zheng Ting Xiao Wei-Qi Rong Department of hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of hepatobiliary hernia Surgery Liaocheng Dongcangfu People’s HospitalLiaocheng 252000Shandong ProvinceChina State Key Laboratory of Molecular Oncology Department of Etiology and CarcinogenesisNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND As a critical early event in hepatocellular carcinogenesis,telomerase activation might be a promising and critical biomarker for hepatocellular carcinoma(hCC)patients,and its function in the genesis and treatment of hCC has gained much attention over the past two *** To perform a bibliometric analysis to systematically assess the current state of research on hCC-related *** The Web of Science Core Collection and PubMed were systematically searched to retrieve publications pertaining to hCC/telomerase limited to“articles”and“reviews”published in English.A total of 873 relevant publications related to hCC and telomerase were *** employed the Bibliometrix package in R to extract and analyze the fundamental information of the publications,such as the trends in the publications,citation counts,most prolific or influential writers,and most popular journals;to screen for keywords occurring at high frequency;and to draw collaboration and cluster analysis charts on the basis of coauthorship and *** was utilized to compile and visualize the bibliometric *** A surge of 51 publications on hCC/telomerase research occurred in 2016,the most productive year from 1996 to 2023,accompanied by the peak citation count recorded in *** to December 2023,35226 citations were made to all publications,an average of 46.6 citations to each *** United States received the most citations(n=13531),followed by China(n=7427)and Japan(n=5754).in terms of national cooperation,China presented the highest centrality,its strongest bonds being to the United States and *** the 20 academic institutions with the most publications,ten came from China and the rest of Asia,though the University of Paris Cité,Public Assistance-hospitals of Paris,and the National institute of health and Medical Research(iNSERM)were the most *** for individual contributions,hisatomi h,Kaneko S,and ide T were the three most prolific a

关键词： Telomerase Bibliometric analysis Telomerase reverse transcriptase Prognosis Treatment hepatocellular carcinoma

The dynamics beamline at SSRF

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Nuclear Science and Techniques 2024年第09期 98-109页

作者： Zhen Liu Li-hua Wang Yong Jiang ya-Jun Tong hua-Chun Zhu Te Ji Min Chen Zheng Jiang Xiang-Jun Wei Shanghai Advanced Research institute Chinese Academy of Sciences Shanghai Tech University

The dynamics beamline （D-Line）,which combines synchrotron radiation infrared spectroscopy （SR-iR） and energy-dispersive X-ray absorption spectroscopy （ED-XAS）,is the first beamline in the world to realize concurrent ED-XAS and SR-iR measurements at the same sample position on a millisecond time-resolved *** combined technique is effective for investigating rapid structural changes in atoms,electrons,and molecules in complicated disorder systems,such as those used in physics,chemistry,materials science,and extreme ***,ED-XAS and SR-iR can be used independently in the two branches of the *** ED-XAS branch is the first ED-XAS beamline in China,which uses a tapered undulator light source and can achieve approximately 2.5×1012photons/s·300 eV BW@7.2 keV at the sample *** exchangeable polychromator operating in the Bragg-reflection or Laue-transmission configuration is used in different energy ranges to satisfy the requirements for beam size and energy *** focused beam size is approximately 3.5μm （h）×21.5μm（V）,and the X-ray energy range is 5–25 *** one-and two-dimensional position-sensitive detectors with frame rates of up to 400 khz enables time resolutions of tens of microseconds to be *** distinctive techniques,such as the concurrent measurement of in situ ED-XAS and infrared spectroscopy,time-resolved ED-XAS,high-pressure ED-XAS,XMCD,and pump-probe ED-XAS,can be applied to achieve different scientific goals.

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World Journal of Clinical Cases 2024年第24期12卷 5589-5595页

作者： Zhi-Nian Wu Ru Ji Ying Xiao ya-Dong Wang Cai-yan Zhao Department of infectious Diseases The Hebei Medical University Third HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND The complexity of immunoglobulin G4(igG4)-related diseases and their potential connection to hematologic malignancies remains *** article provided a review of the diagnosis and treatment of a patient with igG4-related sclerosing cholangitis(SC)and essential thrombocythemia(ET),along with an analysis of relevant literature to enhance comprehension of this *** SUMMARY A 56-year-old male was admitted to two hospitals with deteriorating jaundice and pruritus prior to *** our expectations,the patient was first diagnosed with igG4-SC and ET with the Janus kinase 2 V617F ***,the administration of acetate prednisone significantly resulted in improvements in both igG4-SC and *** need to pay attention to immune disorders and inflammation as they contribute to the development of various disease *** When igG4-SC is suspected without histopathological evidence,diagnostic therapy and long-term regular follow-up can lead to positive treatment *** should be mindful of the potential presence of concurrent hematologic diseases in patients with immune disorders.

关键词： immunoglobulin G4-related sclerosing cholangitis Essential thrombocythemia Autoimmune pancreatitis Janus kinase 2 mutation Glucocorticoids Case report

ChatGPT应用于中国特色话语翻译的有效性研究

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上海翻译 2024年第2期 27-34,94,F0003页

作者：文旭田亚灵西南大学重庆400715

随着中国综合国力的不断提升和国际交流的日益频繁,政治文献中“中国特色话语”翻译的准确性成为传播中国声音和塑造中国国际形象的关键因素。本研究以党的二十大报告为语料,聚焦ChatGPT生成的译文,并将其与市场上主流的三种机器翻译工... 详细信息

随着中国综合国力的不断提升和国际交流的日益频繁,政治文献中“中国特色话语”翻译的准确性成为传播中国声音和塑造中国国际形象的关键因素。本研究以党的二十大报告为语料,聚焦ChatGPT生成的译文,并将其与市场上主流的三种机器翻译工具——Google翻译、有道翻译和DeepL翻译进行对比分析,旨在评估ChatGPT在政治文献翻译中的有效性。本研究首先使用BLEU和TER两种自动评估指标以量化翻译质量,然后进一步增加人工评估环节,以更全面地洞察其性能表现。结果显示,ChatGPT相对于其他三个翻译工具表现出一定的优势。然而,该模型在处理涉及意识形态、复杂结构、文化负载词、隐转喻等内容以及在翻译准确性上的局限性仍然明显。最后,本研究探讨了翻译在人工智能时代的未来发展趋势。翻译需要在整合现代技术、研究翻译伦理、深入跨文化研究、促进机器与人的协同工作等方面不断发展,以满足翻译实践新的需求,为塑造中国的国际形象提供更全面的支持。

关键词： ChatGPT 二十大报告译文质量评估翻译学

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Guicao Baidu decoction in mitigating chemotherapy-induced myocardial injury:case report and mechanism investigation

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Natural Therapy Advances 2024年第3期7卷 29-36页

作者： Jia-Qi Fu Run-Jie Sun Man-ya Yu Mu-Yun Wu Xing Cui The First School of Clinical Medicine Shandong University of Traditional Chinese MedicineJinan 250014China Center of Oncology and hematology The Second Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250001China

To observe the effects of GuiCaoBaiDu Decoction(GCBD)on chemotherapy especially doxorubicin(DOX)-induced myocardial cardiotoxicity(DiC)and explore the *** present study presents a case demonstrating the preventive and therapeutic effects of GCBD on myocardial injury following *** network pharmacology was employed to predict the targets of ***,a DOX-induced apoptosis model of h9C2 cardiomyocytes was established and co-cultured with serum containing GCBD *** viability and myocardial enzyme levels were evaluated using CCK8 assay and ELiSA assay,TUNEL was using for apoptosis *** GCBD effect was confirmed by tests of ROS andα-actinin levels,evaluation of mitochondrial morphology,and BAX co-localization with ***,the expression levels of apoptosis-related molecules were determined via Western ***,a mouse model exhibiting DOX-induced cardiac functional impairment was generated and subsequently treated with *** enzyme level was tested at first,then echocardiography was tested,myocardial apoptosis in mice was observed through hE staining while related proteins were detected using *** pharmacological analyses revealed that GCBD exerts its effects on BAX,Caspase7,and other related ***,we demonstrated the effective amelioration of DiC in cardiomyocyte viability,LDh/CK levels,α-actinin and ROS levels,and apoptosis by GCBD through improvements in TUNEL test,mitochondrial morphology and *** efficacy of GCBD in enhancing cardiac function in DiC mice has been validated through animal *** together,our study showed that GCBD could significantly alleviate DOX induced myocardial injury by regulating mitochondrial *** utilization of GCBD can effectively contribute to the prevention and treatment of chemotherapy-induced myocardial injury when anthracycline chemotherapy is employed in clinical practice.

关键词： Guicao Baidu decoction chemotherapy-induced myocardial injury case report angiogenesis

溶剂热合成的锌(Ⅱ)MOF、晶体结构及其性质

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化学研究与应用 2024年第5期36卷 1078-1083页

作者：乔雅楠山西工学院通识教育学院山西朔州036000

在溶剂热的条件下,以1,3-双(咪唑)丙烷与均苯三酸作为混合配体,合成了一例锌(Ⅱ)的有机框架材料。即{[Zn_(2)(μ2-Oh)L_(1)L_(2)]·DMAc·_(2)h_(2)O}n其中L_(1)为1,3-双(咪唑)丙烷,L2为1,3,5-苯三羧酸用表示,DMAc为N,N-二甲基乙酰胺。... 详细信息

在溶剂热的条件下,以1,3-双(咪唑)丙烷与均苯三酸作为混合配体,合成了一例锌(Ⅱ)的有机框架材料。即{[Zn_(2)(μ2-Oh)L_(1)L_(2)]·DMAc·_(2)h_(2)O}n其中L_(1)为1,3-双(咪唑)丙烷,L2为1,3,5-苯三羧酸用表示,DMAc为N,N-二甲基乙酰胺。经X射线单晶衍射仪、红外光谱仪、粉末XRD、热重分析仪和元素分析仪表征,该MOF为3D→3D二重穿插三维骨架结构。此外,室温下固体荧光的测试结果表明:该MOF对苯胺有明显猝灭作用,所以MOF可以用在荧光分光光度计检测苯胺的传感器方面的应用。

关键词： Zn(Ⅱ)有机骨架材料混合配体溶剂热拓扑结构 X射线衍射荧光性能

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