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Light-Weight Design Method for Force-Performa.ce-Structure of Complex Structura. Pa.t Ba.ed Co-opera.ive Optimiza.ion

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Chinese Journa. of Mecha.ica. Engineering 2018年第2期31卷 115-123页

作者： ya-Li Ma.Jia.-Rong Ta. De-Lun Wa.g Zi-Zhe Liu School of Mecha.ica. Engineering Dalian University of Technology School of Mecha.ica. Engineering Zhejiang University

a.light?weight design method of integra.ed structura. topology a.d size co?optimiza.ion for the force?performa.ce?structure of complex structura. pa.ts is presented in this pa.er. Firstly, the supporting function of a.complex structura. pa.t is built to ma. the force tra.smission, where the force exerted a.ea. a.d constra.nts a.e considered a. connecting structure a.d the structura. configura.ion, to determine the pa.t performa.ce a. well a. the force routines. Then the connecting structure design model, a.ming to optimize the sta.ic a.d dyna.ic performa.ces on connection configura.ion, is developed, a.d the optimum design of the cha.a.teristic pa.a.eters is ca.ried out by mea.s of the colla.ora.ive optimiza.ion method, na.ely, the integra.ed structura. topology optimiza.ion a.d size optimiza.ion. In this design model, the objective is to ma.imize the connecting stiffness. Ba.ed on the rela.ionship between the force a.d the structura. configura.ion of a.pa.t, the optima. force tra.smission routine tha. ca. meet the performa.ce requirements is obta.ned using the structura. topology optimiza.ion technology. a.cordingly, the light?weight design of conceptua. configura.ion for complex pa.ts under multi?objective a.d multi?condition ca. be realized. Fina.ly, ba.ed on the proposed colla.ora.ive optimiza.ion design method, the optima. performa.ce a.d optima. structure of the complex pa.ts with light weight a.e realized, a.d the rea.ona.le structura. unit configura.ion a.d size cha.a.?teristic pa.a.eters a.e obta.ned. a.bed structure of ga.try?type ma.hining center is designed by using the proposed light?weight structure design method in this pa.er, a. a. illustra.ive exa.ple. The bed a.ter the design optimiza.ion is lighter 8% tha. origina. one, a.d the ra.l deforma.ion is reduced by 5%. Moreover, the lightweight design of the bed is a.hieved with enha.ced performa.ce to show the effectiveness of the proposed method.

关键词： Light?weight design Pa.t structure Topology optimiza.ion Size optimiza.ion Force Performa.ce

a.novel high precision Doppler frequency estima.ion method ba.ed on the third-order pha.e-locked loop

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Resea.ch in a.tronomy a.d a.trophysics 2021年第9期21卷 83-90页

作者： Ta. Deng Ma.-Li Ma.Qing-Hui Liu ya-Jun Wu Sha.gha. a.tronomica. Observa.ory Chinese Academy of SciencesShanghai 200030China University of Chinese a.a.emy of Sciences Beijing 100049China

In deep spa.e explora.ion,ma.y engineering a.d scientific requirements require the a.cura.y of the mea.ured Doppler frequency to be a. high a. *** our pa.er,we a.a.yze the possible frequency mea.urement points of the third-order pha.e-locked loop(PLL)a.d find a.new Doppler mea.urement *** on this finding,a.Doppler frequency mea.urement a.gorithm with significa.tly higher mea.urement a.cura.y is *** the a.tua. da.a.processing,compa.ed with the existing engineering softwa.e,the a.cura.y of frequency of 1 second integra.ion is a.out 5.5 times higher when using the new *** improved a.gorithm is simple a.d ea.y to *** improvement ca. be ea.ily combined with other improvement methods of PLL,so tha. the performa.ce of PLL ca. be further improved.

关键词： Doppler frequency mea.urement:deep spa.e explora.ion:ca.rier tra.king:pha.e locked loop:high precision

Liquid Crysta.line Microdroplets of Gra.hene Oxide via.Microfluidics

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Chinese Journa. of Polymer Science 2021年第12期39卷 1657-1664页

作者： Pia. Ma.Peng Li ya Wa.g Da. Cha.g Wei-Wei Ga. Cha. Ga. MOE Key La.ora.ory of Ma.romolecula. Synthesis a.d Functionaliza.ion Department of Polymer Science and EngineeringKey Laboratory of Adsorption and Separation Materials Technologies of Zhejiang ProvinceZhejiang UniversityHangzhou 310027China

Study of sta.le liquid crysta.(LC)microdroplets is of grea. significa.ce for LC dyna.ics in con fined spa.e or a. topologica. ***,the fa.rica.ion of LC microdroplets with diverse sha.e without ionic gela.i on a.ents still rema. ns cha.le nging due to the fluid ***,we utilize the microfluidic tech no logy to prepa.e gra.he ne oxide(GO)LC microdroplets with va.ious morphologies ba.ed on the a.oma.ous rheologica. property of GO a.ueous *** from LC of one-dimensiona. polymer,LC conta.ning two-dimensiona. GO sheets exhibits considera.le viscoela.ticity a.d wea. extensibility,resulting from the pla.a. molecula. conforma.ion a.d the a.sence of intermolecula. enta.gleme *** low exte risibility ensures tha. GO a.ueous suspension is discretized into mono dispersed microdroplets ra.her tha. thin threa. in the microfluidic *** la.ge viscoela.ticity a.d ultra.1 ong rela.a.ion time of GO LC ena.le the diverse sta.le morphologies of *** droplet morphology is well con trolled from sphere to tea.drop by modula.i ng the competition between GO viscoela.ticity a.d in terfa.ia. ten *** two-dimensiona. GO LC fea.uri ng unique rheologica. property provides a.novel system for the microfluidic field,a.d corresponding topologica. sta.ility enriches the LC dyn a.ics a.d ope ns a.new pa.hwa. for desig ning gra.he ne-ba.ed ma.eria.s.

关键词： Gra.hene oxide Liquid crysta. Microdroplets Microfluidics

白头翁汤通过HMGB1调控Nrf-2/HO-1信号通路缓解溃疡性结肠炎

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中国药理学通报 2025年第1期41卷 186-192页

作者：朱维娜马春华阮杰周芙琼张亚杰隆红艳南京中医药大学附属南京中医院南京210022 南京中医药大学附属南京中医院生物样本库南京210022

目的探讨白头翁汤对葡聚糖硫酸钠所致小鼠炎症性肠病的干预作用,并初步阐明其作用机制。方法将50只C57BL/6小鼠随机分为正常组、模型组、白头翁汤高、中、低剂量组(20、10、5 g·kg^(-1)),美沙拉嗪组(5-a.a.(800 mg·kg^(-1)),采用3%葡... 详细信息

目的探讨白头翁汤对葡聚糖硫酸钠所致小鼠炎症性肠病的干预作用,并初步阐明其作用机制。方法将50只C57BL/6小鼠随机分为正常组、模型组、白头翁汤高、中、低剂量组(20、10、5 g·kg^(-1)),美沙拉嗪组(5-a.a.(800 mg·kg^(-1)),采用3%葡聚糖硫酸钠(DSS)7 d构建UC模型,造模d 5开始灌胃给药,连续7 d。观察小鼠体质量,肠道大体观形态、结肠长度、生存率、结肠质量、HE染色观察结肠组织病理学改变,ELISa.测小鼠血清IL-6、IL-1β、高迁移率族蛋白B1(HMGB1)含量;比色法检测髓过氧化物酶(MPO)含量,超氧化物歧化酶(SOD)活性、丙二醛(MDa.含量,Western blot检测肠道HMGB1、免疫球蛋白血管细胞粘附分子1(VCa.)、细胞间粘附分子(ICa.)、金属蛋白酶基质金属肽酶9(MMP-9)、核因子相关因子2(Nrf2)、血红素加氧酶1(HO-1)蛋白表达。结果白头翁汤有效减轻UC小鼠的症状和组织病理学评分。下调炎症因子IL-6和IL-1β、VCa.和ICa.、MMP-9,下调HMGB1。此外,它还抑制核Nrf2/HO-1通路。结论白头翁汤对炎症性肠病模型小鼠的一般情况、炎症指标及氧化应激水平有较好的改善作用,其作用机制可能与抑制HMGB1水平调控Nrf-2/HO-1信号通路,增强结肠黏膜的屏障作用有关。

关键词：白头翁汤溃疡性结肠炎 Nrf-2/HO-1信号通路 HMGB1 氧化应激葡聚糖硫酸钠

Electronic Excita.ion of H_(2) by Electron Impa.t Using Multicha.nel Sta.ic-Excha.ge-Optica. Method

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Chinese Physics Letters 2013年第7期30卷 64-67页

作者： Wa.G Yua.-Cheng Ma.Jia.ZHOU ya-Jun Center for Theoretica. a.omic a.d Molecula. Physics Academy of Fundamental and Interdisciplinary SciencesHarbin Institute of TechnologyHarbin 150081

The momentum-spa.e multicha.nel sta.ic-excha.ge-optica. model is a.plied to the electron-H_(2) collision a. the two-sta.e close-coupling *** cross sections for X^(1)Σ_(g) to b^(3)Σ_(u) tra.sition a. the energies of 20 a.d 30 eV a.e *** a.e compa.ed with other theoretica. results a.d experimenta. *** sca.tering cross sections a.e a.so presented a.d compa.ed with other work.

关键词： level. Electron momentum

Meta.a.a.ysis of Polymera.e Cha.n Rea.tion in the Detection of Huma. Leptospirosis

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Wuha. University Journa. of Na.ura. Sciences 2020年第5期25卷 387-394页

作者： Ma.Lina.Ma.ya LUO Ba.ling Ma.Bishu yaN Jie LIN Xu'a. School of Medicine Zhejiang UniversityHangzhou 310058ZhejiangChina Depa.tment of Medica. Tea.hing in Dingxi Ca.pus Gansu University of Chinese MedicineDingxi 743000GansuChina Depa.tment of Petroleum Chemica. Engineering Lanzhou Petrochemical College of Vocational TechnologyLanzhou 730060GansuChina Depa.tment of Medica. Microbiology a.d Immunology Haiyuan School of Kunming Medical UniversityKunming 650106YunnanChina

Leptospirosis,a.ma.or zoonotic disea.e widesprea. in the world,would infect huma.s a.d other a.ima.s by direct conta.ting with the soil or wa.er conta.ina.ed by the pa.hogenic *** report a.a.yzes the a.cura.y of polymera.e cha.n rea.tion(PCR)a.sa. used in the detection of leptospira.specific genes in *** published a.ticles which included 2526 sa.ples sa.isfied a.l inclusion sta.da.ds a.d were a.plied to *** sensitivity a.d specificity were 0.73(95%CI 0.70-0.76)a.d 0.94(95%CI 0.93-0.95),*** wa. sta.istica.ly significa.t a.ong studies,but none of the sources for heterogeneity(disea.e sta.e,PCR type,ta.geted genes)could a.equa.ely interpret this ***-regression a.vised tha. rea.-time PCR(qPCR)ta.geted 16 s rRNa.would be the best choice for ea.ly detection of ca.es during the a.ute sta.e of the disea.e a.d wa. a.counted a. a.good screening tool in a.l sta.es of the disea.e.

关键词： huma. leptospirosis polymera.e cha.n rea.tion meta.a.a.ysis sensitivity specificity

Comment on “Outcomes of different minima.ly inva.ive surgica. trea.ments for vertebra. compression fra.tures: a. observa.iona. study”

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World Journa. of Clinica. Ca.es 2022年第12期10卷 3966-3968页

作者： Long Ma.Zhi-Wen Luo ya-Ying Sun Depa.tment of Orthopedics The First People's Hospital of Pindingshan CityPingdingshan 467000Henan ProvinceChina Depa.tment of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

Recently we rea. the a.ticle entitled“Outcomes of different minima.ly inva.ive surgica. trea.ments for vertebra. compression fra.tures:a. observa.iona. study”.This wa. a. observa.iona. study tha. reviewed the sa.ety a.d effica.y of different cement a.gmenta.ion modalities for vertebra. compression fra.tures under osteoporotic ***,this is a.va.ua.le study tha. ca. provide a.reference for clinica. *** the other ha.d,we a.so noticed some points in the a.ticle a.d a.e willing to sha.e our *** studies with a.higher level of evidence ca. a.d more knowledge rega.ding releva.t concerns.

关键词： Vertebra. compression fra.tures Osteoporosis Study design Observa.iona. study Ra.domize

High-performa.ce liquid chroma.ogra.hy utiliza.ion of ionic liquids a. mobile pha.e a.ditives for sepa.a.ion a.d determina.ion of the isomers of a.ino benzoic a.ids

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Chinese Chemica. Letters 2016年第5期27卷 749-752页

作者： ya-Jie Ma.Cha. Gua. Ying-Jie Dong Hong Yu College of Chemistry a.d Chemica. Engineering Harbin Normal University

For the isomers of a.ino benzoic a.id, including o-, m-, p-a.ino benzoic a.id, the beneficia. effects of using the ionic liquid, l-butyl-3-methylimida.olium tetra.luorobora.e （[BMIm][BF4]）, a. mobile pha.e a.ditives on retention beha.ior a.d sepa.a.ion were investiga.ed. Chroma.ogra.hic sepa.a.ion of the o-, m-, p-a.ino benzoic a.id wa. performed on a.reversed-pha.e C18 column by ultra.iolet detection a. 245 nm. The effects of severa. chroma.ogra.hic pa.a.eters, concentra.ions a.d pH va.ues of [BMIm][BF4] solutions, metha.ol concentra.ion a.d length of a.kyl cha.n on different ionic liquids, on the sepa.a.ion a.d determina.ion of the isomers were eva.ua.ed. The optimized chroma.ogra.hic conditions were esta.lished using a. a.ueous 0.5 mmol/L [BMIm][BF4] solution （pH 3.0）/metha.ol （40：60, v/v） a. mobile pha.e without need of gra.ient eiution, with sepa.a.ion of three a.ino benzoic a.ids a.hieved within four min. The calibra.ion curve showed good linea.ity over the tested ra.ge of 2 mg/L to 120 mg/L for the three isomers with a.correla.ion coefficients of 0.9999. The recoveries of the three a.ino benzoic a.ids of spiked components were between 99.8% a.d 100%. The method ha. been successfully a.plied to the determina.ion of p-a.ino benzoic a.id in the pha.ma.eutica., Bromine Mita. Proca.ne Injection.

关键词： Ionic liquid Reverse pha.e liquid chroma.ogra.hyamino benzoic a.ids Ultra.iolet detection Pha.ma.eutica.

Exothermic process of ca.t-in-pla.e pile founda.ion a.d its therma. a.ita.ion of the frozen ground under a.long dry bridge on the Qingha.-Tibet Ra.lwa.

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Journa. of Zhejia.g University-Science a.a.plied Physics & Engineering) 2010年第2期11卷 88-96页

作者： ya-ping WU Jia. GUO Chun-xia.g GUO Wei Ma.Xia.-jun Wa.G School of Civil a.d a.ehiteeture Engineering Ningbo Institute of Technology Zhejiang University Ningbo 315100 China School of Civil Engineering Lanzhou Jiaotong University Lanzhou 730070 China Sta.e Key La.ora.ory of Frozen Soil Engineering Cold and Arid Regions Environment and Engineering Research Institute Chinese Aeademy of Sciences Lanzhou 730000 China

a.number of dry bridges ha.e been built to substitute for the roa.bed on the Qingha.-Tibet Ra.lwa.,*** a.m of this study wa. to investiga.e the exothermic process of ca.t-in-pla.e (CIP) pile founda.ion of a.dry bridge a.d its ha.m to the sta.ility of nea.by frozen *** present 3D hea. conduction functions of a.concrete pile a.d of frozen ground with rela.ed *** a.a.ysis is ba.ed on the theory of hea. conduction a.d the exponent la. describing the a.ia.a.ic tempera.ure rise ca.sed by hydra.ion *** under continuous a.d initia. conditions were combined to esta.lish a.finite element model of a.CIP pile-frozen ground system for a.dry bridge under a.tua. field conditions in cold *** results indica.ed tha. the process could effectively simula.e the exothermic process of CIP pile *** disturba.ce to frozen ground under a.long dry bridge ca.sed by the ca.ting tempera.ure a.d hydra.ion hea. of CIP piles wa. substa.tia. a.d *** simula.ed therma. a.a.ysis results a.reed with field mea.urements a.d some significa.t rules rela.ing to the problem were deduced a.d conclusions rea.hed.

关键词： Exothermic process of hydra.ion hea. Ca.t-in-pla.e (CIP) pile founda.ion Dry bridge Therma. a.ita.ion Frozen ground Qingha.-Tibet Ra.lwa.