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Ora. a.ministra.ion of hyperoxygena.ed solution for the prophyla.is of ga.tric ulcera.ion induced by stress or Helicoba.ter pylori

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医学争鸣 2015年第6期6卷 28-34页

作者： Ma.Hong-Wei WU ya-Qiong ZHa.G Ha.-Feng Experiment Tea.hing Center School of Basic Medicine Fourth Military Medical University School of Life Sciences Shaanxi Normal University

Oxygen wa. first discovered by Sweden chemist Scheele in 1773 a.d convinced a. a. essentia. fa.tor for living by French scientists in *** ta.kle with different hypoxic emergencies,corresponding medica. a.proa.hes,*** or na.a. ca.heter oxygen inha.a.ion,brea.hing ma.hine,hyperba.ic oxygen thera.y etc.,ha.e been contrived in ***,one morta. trouble exists in a.l these conventiona. wa.s,*** must rely on the ventila.ion a.d ga. excha.ge via.lungs,thus not being a.le to promptly render oxygen to specific hypoxia.*** solution(HOS),a.new kind of medica. liquid which ca. be ora.ly ta.en or intra.enously a.ministra.ed,ha. been widely a.plied a. a. a.xilia.y method of offering oxygen in China.a.la.ge number of experiments ha.e proved its validity in the trea.ment of myoca.dia. a.d cerebra. ischemia.reperfusion injury,nerve lesions,shock,respira.ory disea.es,neona.a. hypoxia.a.d so *** findings suggest tha. HOS might not only pla. a.role of increa.ing oxygen pressure in loca. region,but a.so conspicuously contribute to improving the pa.hologic process of hypoxia.which coincidently is the vita. link in stress-induced lesions in the ga.trointestina. ***,Helicoba.ter pylori(***),a.kind of microa.rophilic(a.a.robic)ba.terium which ca. ha.dly survive in a. a.robic a.mosphere,ha. a.so been identified a. a. independent risk fa.tor for the occurrence a.d development of *** the etiology of peptic ulcera.ion a.d the fea.ures of HOS,we hypothesize tha. drinking HOS might prevent ga.tric ulcera.ion ca.sed by stress or a.a.robic ***.

关键词： hyperoxygena.ed solution ga.tric ulcera.ion prophyla.is stress Helicoba.ter pylori

The Loca.ion-influenced Fluorescence of a.Egens in the Micropha.esepa.a.ed Structures

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Chinese Journa. of Polymer Science 2019年第11期37卷 1060-1064页

作者： ya-Fa.g Zhi Cha. Li Ze-Hua.Song Zhong-Jia.yang Hong-Wei Ma.Long-Cheng Ga. La.ora.ory of Bio-Inspired Sma.t Interfa.ia. Science a.d Technology of Ministry of Educa.ion School of Chemistry Beihang UniversityBeijing 100191China Depa.tment of Polymer Science a.d Engineering School of Chemical Engineering Dalian University of Technology Dalian 116024 China

The fluorescent probe techniques ha.e been widely *** the fluorescence probes a.e selectively loca.ed in na.ostructures,the fluorescence properties a.e highly influenced by the ***,we systema.ica.ly studied the loca.ion-influenced fluorescence of a.Egens in the micropha.e-sepa.a.ed *** a.Egen tetra.henylethene (TPE) wa. doped into polystyrene-bpolyisoprene (PS-b-Pl).TPE wa. selectively loca.ed in the PS *** TPE fluorenscence wa. a.fected by the structura. rela.a.ion of PS when investiga.ed in a.wide ra.ge of tempera.ures,including the gla.s tra.siton a.d seconda.y *** TPE groups were selectively loca.ed in the PI na.odoma.ns,the fluorenscence wa. a.fected by the gla.s tra.sitons of PI a.d PS *** TPE deriva.ive wa. loca.ed a. the interfa.e of the *** fluorescence emission wa. influenced by the ma.n tra.sition a.d seconda.y tra.siton of PS blocks,a. well a. the ma.n tra.sition of PI *** results would give new understa.ding of the interrela.ion between fluorescence probes a.d the na.ostructures.

关键词： a.E Block copolymer Seconda.y rela.a.ion

Tuna.le ba.dga.s a.d fla. ba.ds in twisted bila.er biphenylene ca.bon

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Chinese Physics B 2021年第7期30卷 451-455页

作者： ya-Bin Ma.Ta. Ouyang Yua.-Ping Chen Yue-E Xie School of Physics a.d Optoelectronics Xiangtan UniversityXiangtan 411105China Fa.ulty of Science Jiangsu UniversityZhenjiang 212013China

Owing to the intera.tion between the la.ers,the twisted bila.er two-dimensiona.(2 D)ma.eria.s exhibit numerous unique optica. a.d electronic properties different from the monola.er counterpa.t,a.d ha.e a.tra.ted tremendous interests in current physica. resea.ch *** mea.s of first-principles a.d tight-binding model ca.cula.ions,the electronic properties of twisted bila.er biphenylene ca.bon(BPC)a.e systema.ica.ly investiga.ed in this *** results indica.e tha. the effect of twist will not only lea.s to a.pha.e tra.sition from semiconductor to meta.,but a.so a. a.justa.le ba.d ga. in BPC(0 me V to 120 me V depending on the twist a.gle).Moreover,unlike the twisted bila.er gra.hene(TBG),the fla. ba.ds in twisted BPC a.e no longer restricted by"ma.ic a.gles",i.e.,a.norma. fla. ba.ds could be a.pea.ed a. well a. severa. specific la.ge a.gles in a.dition to the sma.l *** cha.ge density of these fla. ba.ds possesses different loca. modes,indica.ing tha. they might be derived from different sta.ked modes a.d host different *** exotic physica. properties presented in this work foreshow twisted BPC a.promising ma.eria. for the a.plica.ion of tera.ertz a.d infra.ed photodetectors a.d the explora.ion of strong correla.ion.

关键词： twisted bila.er biphenylene ca.bon a.justa.le ba.d ga. fla. ba.ds

Intera.tions of ginsenosides with DNa.duplexes: a.study by electrospra. ioniza.ion ma.s spectrometry a.d UV a.sorption spectroscopy

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Chinese Chemica. Letters 2014年第8期25卷 1179-1184页

作者： Lei Ma.Shu Liu Niu-Sheng Xu ya-Qiu Jia.g Feng-Rui Song Zhi-Qia.g Liu Cha.g’a. University Cha.gchun Institute of a.plied Chemistry Chinese Academy of Sciences Changchun Center of Mass Spectrometry The First Hospita. of Jilin University

The non-cova.ent complexes of duplexes DNa.a.d 9 ginsenosides（1 a.lycone a.d 8 glycosides） were investiga.ed using electrospra. ioniza.ion ma.s spectrometry（ESI-MS） in the ga. pha.e. The results of rela.ive binding a.finities in nega.ive ion mode revea.ed tha. severa. fa.tors impa.t on the duplexbinding properties of ginsenosides. Glycosyla.ions of 20（S）-protopa.a.a.iol ginsenosides a. the position C-20 a.d 20（S）-protopa.a.a.riol cla.sifica.ion a. the position C-6 enha.ced the fra.tion of bound DNa.sha.ply. a.rha.nose moiety shows little lower binding intensities tha. glucose a. the sa.e *** of 20（S）-protopa.a.a.riol result in subtle higher binding a.finities towa.d the duplex DNa.tha. 20（S）-protopa.a.a.iol fa.ily. However, glycosyla.ion with two suga. moieties does not show a.higher binding a.finity tha. with only one moiety. The collision-induced dissocia.ion experimenta. da.a.demonstra.e the ga.-pha.e sta.ility a.d fra.menta.ion pa.terns of the ginsenoside/DNa.complexes a.e rela.ed to the glycoside number. Positive ion ESI ma.s spectra.of the complexes were a.so recorded. The result of ESI-MS suggests tha. hydrogen bonds a.e the domina.e intera.tion between ginsenosides a.d DNa. Simila. results were obta.ned in solution-pha.e by UV spectroscopy, which exhibit a.hyperchromism a.d blue-shift effect when DNa.solution wa. titra.ed by individua. ginsenoside.

关键词： Ginsenoside Duplex DNA ESI-MS Intera.tion UV spectroscopy

Intera.tion between a.ti-shea. ga.leries a.d surrounding rock in the right-ba.k slope of Da.a.gsha. hydropower sta.ion

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Journa. of Mounta.n Science 2017年第7期14卷 1428-1444页

作者： LI Lia.-chong XING ya-zi LIU Xing-zong Ma.Ke XU Nu-wen ZHa.G Fei School of Resources a.d Civil Engineering Northeastern University School of Civil Engineering Dalian University of Technology College of Wa.er Resources a.d Hydropower Sichuan University

The fight-ba.k slope of the Da.a.gsha. hydropower sta.ion loca.ed in Southwest China.is a.highly unloa.ed rock slope. Moreover, la.ge-sca.e na.ura. fa.lts were detected in the slope body; some exca.a.ion-induced unloa.ing fra.tures were discovered a. eleva.ions between lo75m a.d 1146m. Beca.se of poor tectonic sta.ility, the exca.a.ion work wa. suspended in September 2009, a.d six la.ge- sca.e a.ti-shea. ga.leries were employed to repla.e the wea. zone in the slope body to reinforce the fight- ba.k slope. In this study, ba.ed on microseismic- monitoring technology a.d a.numerica.-simula.ion method, the sta.ilities of the slope with a.d without the reinforcement a.e a.a.ysed. a. in-situ microseismic-monitofing system is used to obta.n qua.tita.ive informa.ion a.out the da.a.e loca.ion, extent, energy, a.d ma.nitude of the rocks. Thus, a.y potentia. sliding block in the fight-ba.k slope ca. be identified. By incorpora.ing the numerica. results a.ong with the microseismic-monitoring da.a. the stress concentra.ion is found to la.gely occur a.oundthe a.ti-shea. ga.leries, a.d the seismic deforma.ion nea. the a.ti-shea. ga.leries is a.pa.ent, pa.ticula.ly a. eleva.ions of 121o, 118o, 115o, a.d 112om. To understa.d the intera.tion mecha.ism between the a.ti-shea. ga.lery a.d the surrounding rock, a.2D simula.ion of the potentia. da.a.e process occurring in a. a.ti-shea. ga.lery is performed. The numerica. simula.ion helps in obta.ning a.ditiona. informa.ion a.out the stress distribution a.d fa.lure-induced stress re-distribution in the vicinity of the a.ti-shea. ga.leries tha. ca.not be directly observed in the field. Fina.ly, the potentia. sliding surfa.e of the right-ba.k slope is numerica.ly obta.ned, which genera.ly a.rees with the spa.ia. distribution of the in-situ monitored microseismic events. The sa.ety fa.tor of the slope reinforced with the a.ti-shea. ga.lery increa.es by a.proxima.ely 36.2%. Both the numerica. results a.d microseismic da.a.show tha. the a.ti-sh

关键词： Slope sta.ility Microseismic monitoring Numerica. simula.ion Sa.ety fa.tor a.ti-shea.ga.lery

Wa.ming increa.es soil ca.bon input in a.Sibira.a.a.gusta.a.domina.ed a.pine shrub ecosystem

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Journa. of Pla.t Ecology 2022年第2期15卷 335-346页

作者： Mei Liu Jia.Ha. Wen ya-Mei Chen Wen-Jua. Xu Qiong Wa.g Zhi-Lia.g ma Ecologica. Security a.d Protection Key La.ora.ory of Sichua. Province Mianyang Normal UniversityMianyang 621000China Depa.tment of Wa.ershed Sciences a.d the Ecology Center Utah State UniversityLoganUT 84321USA College of Life Sciences China West Normal UniversityNanchong 637009China

Pla.t-derived ca.bon(C)inputs via.folia. litter,root litter a.d root exuda.es a.e key drivers of soil orga.ic C ***,the responses of these three input pa.hwa.s to clima.e wa.ming ha.e ra.ely been studied in a.pine *** employing a.3-yea. wa.ming experiment(increa.ed by 1.3℃),we investiga.ed the effects of wa.ming on the rela.ive C contributions from folia. litter,root litter a.d root exuda.es from Sibira.a.a.gusta.a.a.domina.t shrub species in a. a.pine shrubla.d on the ea.tern Qingha.-Tibeta. *** soil orga.ic C inputs from folia. litter,root litter a.d root exuda.es were 77.45,90.58 a.d 26.94 g C m^(-2),*** only slightly increa.ed the soil orga.ic C inputs from folia. litter a.d root litter by 8.04 a.d 11.13 g C m^(-2),but significa.tly increa.ed the root exuda.e C input by 15.40 g C m^(-2).Wa.ming significa.tly increa.ed the rela.ive C contributions of root exuda.es to tota. C inputs by 4.6%but slightly decrea.ed those of folia. litter a.d root litter by 2.5%a.d 2.1%,*** results highlight tha. clima.e wa.ming ma. stimula.e pla.t-derived C inputs into soils ma.nly through root exuda.es ra.her tha. litter in a.pine shrubla.ds on the Qingha.-Tibeta. Pla.ea..

关键词： soil orga.ic ca.bon folia. litter root litter root exuda.es clima.e wa.ming a.pine shrub Qingha.-Tibeta. Pla.ea.

Effects of freeze-tha. cycle on engineering properties of loess used a. roa. fills in sea.ona.ly frozen ground regions,North China

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Journa. of Mounta.n Science 2017年第2期14卷 356-368页

作者： LI Guo-yu Ma.Wei MU yan-hu Wa.G Fei Fa. Sha.-zhi WU ya-hu Sta.e Key La.ora.ory of Frozen Soil Engineering Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of SciencesLanzhou 730000China

Compa.ted loess is widely used a. fills of roa. emba.kments in loess regions of northern ***, densely-compa.ted loess ca. sa.isfy the requirements of emba.kment strength a.d postconstruction deforma.ion. However, uneven subsidence, pa.ement cra.ks a.d other rela.ed da.a.es ca. a.fect the integrity of loess subgra.e a.ter severa. yea.s of opera.ion,a.d even ca.se some ha.a.ds, especia.ly in North China. where the strong freeze-tha. erosion occurs. In this study, cyclic freeze-tha. tests for both densely a.d loosely compa.ted loess sa.ples were performed to determine the va.ia.ion in engineering properties such a. volume, void ra.io, colla.sible settlement,microstructure, a.d the rela.ed mecha.isms were a.dressed. The experimenta. results showed tha. a. obvious wa.er migra.ion a.d redistribution occurred within the sa.ples during freeze-tha. cycles. Ice lenses a.d fissures could be identified in the upper frozen la.ers of the sa.ples. a.ter freeze-tha. cycles,the dry densities of the upper la.ers of sa.ples cha.ged significa.tly due to strong freeze-tha. erosion. The dry densities decrea.ed for the dense sa.ple a.d increa.ed for the loose sa.ple. It ca. be found tha. dense sa.ples become loose, while loose sa.ples beca.e dense with the increa.ing number of freeze-tha. cycles. Their rela.ed void ra.ios cha.ged reversely. Both void ra.ios tended to fa.l into a.certa.n ra.ge, which verified the concept of a.residua. void ra.io proposed by Vikla.der. The loosening process of densely compa.ted sa.ples involves the forma.ion of la.ge pores, volume increa.e a.d density reduction a. well a. the rela.ed cha.ges in mecha.ica. properties beca.se freeze-tha. cycles ma. be importa.t contribution to problems of loess roa. *** effects of freeze-tha. cycles, therefore,should be ta.en into a.count in selecting loess pa.a.eters for the sta.ility eva.ua.ion of roa. emba.kment in sea.ona.ly frozen ground regions.

关键词： Loess Freeze-tha. cycle Frost hea.e Tha. settlement Roa. engineering

Jisuika.g, a.Chinese herba. formula. increa.es neurotrophic fa.tor expression a.d promotes the recovery of neurologica. function a.ter spina. cord injury

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Neura. Regenera.ion Resea.ch 2017年第9期12卷 1519-1528页

作者： yang Guo Yong Ma.ya-la. Pa. Su-yang Zheng Jia.-wei Wa.g Gui-cheng Hua.g Institute of Tra.ma.ology & Orthopedics a.d La.ora.ory of New Techniques of Restora.ion & Reconstruction of Orthopedics a.d Tra.ma.ology Nanjing University of Chinese Medicine Depa.tment of Tra.ma.ology & Orthopedics Affiliated Hospital of Nanjing University of Chinese Medicine Depa.tment of Tra.ma.ology & Orthopedics Wuxi Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine

The Chinese medicine compound, ]isuika.g, ca. promote recovery of neurologica. function by inhibiting lipid peroxida.ion, sca.enging oxygen free ra.ica.s, a.d effectively improving the loca. microenvironment a.ter spina. cord injury. However, the mecha.ism rema.ns unclea.. Thus, we esta.lished a.ra. model of a.ute spina. cord injury using a.modified version of a.len＇s method. Jisuika.g （50, 25, a.d 12.5 g/kg/d） a.d prednis- olone were a.ministered 30 minutes a.ter a.esthesia. Ba.so, Bea.tie, a.d Bresna.a. locomotor sca.e scores a.d the oblique boa.d test showed improved motor function recovery in the prednisone group a.d modera.e-dose Jisuika.g group compa.ed with the other groups a. 3-7 da.s post-injury. The ra.s in the modera.e-dose Jisuika.g group recovered best a. 14 da.s post-injury. Hema.oxylin-eosin sta.ning a.d tra.smis- sion electron microscopy showed tha. the surviva. ra.e of neurons in trea.ment groups increa.ed a.ter 3-7 da.s of a.ministra.ion. Further, the structure of neurons a.d glia. cells wa. more distinct, especia.ly in prednisolone a.d modera.e-dose Jisuika.g groups. Western blot a.sa. a.d immunohistochemistry showed tha. expression of bra.n-derived neurotrophic fa.tor （BDNF） in injured segments wa. ma.nta.ned a. a.high level a.ter 7-14 da.s of trea.ment. In contra.t, expression of nerve growth fa.tor （NGF） wa. down-regula.ed a. 7 da.s a.ter spina. cord injury. Re- a.-time fluorescence qua.tita.ive polymera.e cha.n rea.tion showed tha. expression of BDNF a.d NGF mRNa.wa. induced in injured segments by prednisolone a.d Jisuika.g. a. 3-7 da.s a.ter injury, the effect of prednisolone wa. grea.er, while 14 da.s a.ter injury, the effect of moder- a.e-dose Jisuika.g wa. grea.er. These results confirm tha. Jisuika.g ca. upregula.e BDNF a.d NGF expression for a.prolonged period a.ter spina. cord injury a.d promote repa.r of a.ute spina. cord injury, with its effect being simila. to prednisolone.

关键词： nerve regenera.ion spina. cord injury Jisuika.g Chinese medicine prednisolone microenvironment a.on regenera.ion seconda.y cha.ges neurona. a.optosis bra.n-derived neurotrophic fa.tor nerve growth fa.tor neura. regenera.ion

Synthesis a.d in vitro cytotoxic eva.ua.ion of 2-hydra.inylpyrido[2,3-b]pyra.in-3(4H)-one deriva.ives

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Chinese Chemica. Letters 2011年第10期22卷 1223-1225页

作者： Guo Ga.g Zha.g ya Jing Liu Xia. Gua.g Ma.Ha. Dong Ju Li Ping Gong Key La.ora.ory of Origina. New Drugs Design a.d Discovery of Ministry of Educa.ion School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 China

a.series of novel 2-hydra.inylpyrido[2,3-b]pyra.in-3（4H）-one deriva.ives were synthesized a.d eva.ua.ed for their cytotoxic a.tivities a.a.nst a.49,MDa.MB-231 a.d HT-29 cell lines in *** da.a.indica.ed tha. compounds 5b,5c,10a.a.d 10g possessed ma.ked cytotoxicity,especia.ly 10a.with IC_（50） va.ues of 0.81,2.56 a.d 1.63μmol/L a.a.nst a.49,MDa.MB- 23 1 a.d HT29 cell lines,respectively）,which ha. emerged a. a.lea. compound.

关键词： 2-Hydra.inylpyrido[2 3-b]pyra.in-3(4H)-ones Synthesis Cytotoxicity