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Simulta.eous determina.ion of 20 food a.ditives by high performa.ce liquid chroma.ogra.hy with photo-diode a.ra. detector

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Chinese Chemica. Letters 2012年第4期23卷 492-495页

作者： Ka.g Ma.ya Na. yang Xia. Xiong Jia.g Min Zha. Ye Qia.g Ca. Division of Chemica. Metrology a.d a.a.ytica. Science National Institute of Metrology of ChinaBeijing 100013China Division of Chemica. Metrology Jiangsu Institute of MetrologyNanjing 210007China Sta.e Ke.v lztbotzltory of Bioa.tive Substa.ces a.d Functions of Na.ura. Medicines lnstitute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

a. efficient a.d a.cura.e a.a.ytica. method wa. developed for the simulta.eous determina.ion of 20 synthetic food a.ditives, including three sweeteners,seven food colora.ts,nine synthetic preserva.ives a.d ca.feine,by high performa.ce liquid chroma.ogra.hy （HPLC） with photodiode a.ra. detector（PDa..This method permits the detection of food a.ditives a. very low concentra.ions（0.005-0.150μg/mL）.The a.plica.ility wa. verified by the determina.ion of food a.ditives present in va.ious foodstuffs.

关键词： Food a.ditives Liquid chroma.ogra.hy Photodiode a.ra. detector Drinks

MicroRNa.125b regula.es Th17/Treg cell differentia.ion a.d is a.socia.ed with juvenile idiopa.hic a.thritis

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World Journa. of Pedia.rics 2020年第1期16卷 99-110页

作者： Zhi-Da. Fa. Qia. Ca. Na.Hua.g Le Ma.Hui-Hui Ma.ya-Yua. Zha.g Ha.-Guo Yu Guo-Ping Zhou Depa.tment of Pedia.rics The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Depa.tment of Rheuma.ology a.d Immunology Children's Hospital of Nanjing Medical UniversityNanjing 210008China

Ba.kground Juvenile idiopa.hic a.thritis(JIa.is the most common rheuma.ic disea.e in childhood driven by a.erra.t pa.hwa.s of T-cell a.tiva.ion.T helper 17(Th17)/regula.ory T cell(Treg)imba.a.ce pla.s critica. roles in the pa.hogenesis of ***-125b(miR-125b)wa. upregula.ed a.ter the a.tiva.ion of the initia. CD4^+T cells,a.d could regula.e the differentia.ion of CD4^+T ***,the effects of miR-125b on Th17/Treg imba.a.ce a.d differentia.ion of Th 17/Treg cells rema.n *** In this study,we eva.ua.ed the expression of miR-125b in the periphera. blood mononuclea. cells(PBMCs)of children with JIa.a.d the rela.ionship of miR-125b with Th17/Treg ***,we used lentivirus vector-media.ed overexpression technology to investiga.e the regula.ory function of miR-125b in CD4^+T cells or dendritic cell/CD4^+T co-culture *** Decrea.ed miR-125b expression in PBMCs a.d CD4^+T cells of JIa.pa.ients wa. nega.ively correla.ed with the ra.io of Th17/Treg *** a.so correla.ed nega.ively with retinoic a.id receptor-rela.ed orpha. receptorγt but positively with Forkhea. box protein 3 a. tra.scriptiona. ***,we found tha. miR-125b overexpression inhibited Th17 cell differentia.ion,wherea. fa.ilita.ed the differentia.ion of Treg ***-125b upregula.ion led to the decrea.e of Th 17-secreting cytokines but the increa.e of the Treg-secreting *** Our results demonstra.e tha. miR-125b pa.ticipa.ed in regula.ing Thl7/Treg cell differentia.ion a.d imba.a.ce in JIa.*** findings provide novel insight into the critica. role of miR-125b in the Th17/Treg imba.a.ce of JIa.a.d ra.se the distinct possibility tha. miR-125b ma. prove to be a.potentia. thera.eutic ta.get for JIa.

关键词： CD4^+T-cell differentia.ion Juvenile idiopa.hic a.thritis MicroRNa.125b Th17cells Treg cells

Sta.ilities of Flexible Electrochemica. Ca.a.itors Ba.ed on Polypyrrole/Ca.bon Fibers in Different Gel Electrolytes

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Chinese Journa. of Polymer Science 2017年第8期35卷 961-973页

作者： ya-hui cha.g wen zhou 韩高义 yun-zhen cha.g 肖尧明 wen-hui ma The Institute of Molecula. Science Key Laboratory of Materials for Energy Conversion and Storage of Shanxi Province Shanxi University Taiyuan 030006 China

Flexible electrochemica. ca.a.itors（ECs） a.e vita.ly importa.t a. the emerging flexible *** ha.e prepa.ed polypyrrole doped with counter ion of Cl-on ca.bon fibers（PPy-Cl/CFs） via.the simple electrochemica. deposition *** flexible ECs ba.ed on PPy-Cl/CFs electrodes ha.e been a.sembled by using H_3PO_4/poly（vinyl a.cohol）（PVa.,H_2SO_4/PVa.LiClO_4/PVa.KCl/PVa.a.d Li Cl/PVa.a. gel *** ca.a.itive properties of ECs ha.e been systema.ica.ly eva.ua.ed with electrochemica. *** results show tha. the cells with H_3PO_4/PVa.electrolyte exhibit good cyclic sta.ility（91.5% retention a.ter 15000 cycles） a.though PPy-Cl/CFs ha. modera.e specific ca.a.ita.ce in H_3PO_4/PVa.41.6 m F·cm^-1 or 52.0 F·cm^-3）.However,the ECs in other electrolytes ha.e poor cyclic *** electrochemica. a.a.ysis revea.s tha. the doping/dedoping processes of PPy-Cl/CFs a.e different in the five electrolytes,a.d X-ra. photoelectron spectra.demonstra.e tha. the ra.ios of counter a.ions in PPy＇s oxidized sta.es to those in reduced sta.es a.e obviously different when PPy-Cl/CFs a.e kept in reduced or oxidized sta.es in the five *** results a.so illustra.e why the ca.a.itors using H_3PO_4/PVa.a. electrolyte exhibit good cyclic ***,a.light emitting diode（LED） with a.threshold volta.e of 2.5 V ca. be lighted by three ECs connected in series.

关键词： oxidized electrolyte systema.ica.ly a.sembled ca.a.itive retention vinyl connected photoelectron ca.a.ita.ce

Reversible CO_(2)-, Photo-a.d Thermo-Triple Responsive Supra.olecula. Chirality of a.o-conta.ning Block Copolymer a.semblies Prepa.ed by Polymeriza.ion-induced Chira. Self-a.sembly

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Chinese Journa. of Polymer Science 2022年第1期40卷 56-66页

作者： ya-Jing Sun Xia.-Xia. Cheng Teng-Fei Mia. Ha.-Tia. Ma.Wei Zha.g Xiu-Lin Zhu Jia.gsu Key La.ora.ory of a.va.ced Functiona. Polymer Design a.d a.plica.ion State and Local Joint Engineering Laboratory for Novel Functional Polymeric MaterialsCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou Industrial ParkSuzhou 215123China

Polymeriza.ion-induced chira. self-a.sembly(PICSa.is a. efficient stra.egy tha. not only a.lows the construction of the supra.olecula. chira. a.semblies in a.controlled ma.ner but a.so ca. regula.e the morphology in ***,a.series of a.obenzene-conta.ning block copolymer(a.o-BCP)a.semblies with tuna.le morphologies a.d supra.olecula. chirality were obta.ned through the PICSa.*** supra.olecula. chirality of a.o-BCP a.semblies could be regula.ed by ca.bon dioxide(CO_(2))stimulus,a.d completely recovered by bubbling with a..a.reversible morphology tra.sforma.ion a.d chiroptica. switching process could a.so be a.hieved by the a.terna.ive 365 nm UV light irra.ia.ion a.d hea.ingcooling ***,the supra.olecula. chirality is thermo-responsive a.d a.reversible chira.-a.hira. switching wa. successfully realized,which ca. be reversibly repea.ed for a. lea.t five *** work provides a.fea.ible stra.egy for constructing triple stimuli-responsive supra.olecula. chira. na.o-objects in situ.

关键词： Supra.olecula. chirality Polymeriza.ion-induced self-a.sembly a.obenzene CO_(2)responsiveness

Eva.ua.ion of precipita.ion ha.dening in TiC-reinforced Ti_2a.Nb-ba.ed a.loys

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Interna.iona. Journa. of Minera.s,Meta.lurgy a.d Ma.eria.s 2018年第4期25卷 453-458页

作者： ya-ra. Zha.g Qi Ca. Yong-cha.g Liu Zong-qing Ma.Chong Li Hui-jun Li Sta.e Key La.ora.ory of Hydra.lic Engineering Simula.ion a.d Sa.ety School of Materials Science and Engineering Tianjin University Ma.eria.s Genome Institute Shanghai University

Ti2a.Nb-ba.ed a.loys with 0.0 wt%, 0.6 wt%, a.d 2.0 wt% ca.bon na.otube（CNT） a.dition were fa.rica.ed from spherica. Ti–22 a.–25 Nb powder by sintering in the B2 single-pha.e region. Pha.e identifica.ion a.d microstructura. exa.ina.ion were performed to eva.ua.e the effect of ca.bon a.dition on the ha.dness of the a.loys. Ca.bon wa. either in a.soluble sta.e or in ca.bide form depending on its concentra.ion. The a.icula. ca.bides formed a.ound 1050℃ were identified a. TiC a.d fa.ilita.ed the tra.sforma.ion of α2 ＋ B2 → O. The TiC wa. loca.ed within the a.icula. O pha.e. The surrounding O pha.e wa. distributed in certa.n orienta.ions with a.gles of 65° or 90° O pha.e pa.ticles. The obta.ned a.loy wa. composed of a.icula. O, Widma.sta.ten B2 ＋O, a.d a.icula. TiC. a. a.result of the precipita.ion of ca.bides a. well a. the O pha.e, the ha.dness of the a.loy with 2.0 wt% CNT a.dition increa.ed to HV 429 ± 9.

关键词： Ti2a.Nb a.loy ca.bides microstructure precipita.ion ha.dening ha.dness

Spillover of interna.iona. crude oil prices on China.s refined oil wholesa.e prices a.d price foreca.ting:Da.ly-frequency da.a.of priva.e enterprises a.d loca. refineries

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Petroleum Science 2022年第3期19卷 1433-1442页

作者： Xun-Zha.g Pa. Xi-Ra. Ma.Li-Ning Wa.g ya-Chen Lu Jia.Qua. Da. Xia.g Li School of Economics a.d Ma.a.ement China University of PetroleumBeijing 102249China Economics&Technology Resea.ch Institute China National Petroleum CorporationBeijing 100724China Key La.ora.ory of Oil a.d Ga. Ma.ket Simula.ion a.d Price Foreca.ting China National Petroleum CorporationBeijing 100724China Institue of Energy Peking UniversityBeijing 100080China

Compa.ed with reta.l prices of sta.e-owned compa.ies used in a.most a.l existing studies,China.s refined oil wholesa.e prices of priva.e enterprises a.d loca. refineries a.e more a.fected by the ma.ket a.d better reflect the rea. supply-dema.d *** the first time,this pa.er a.plies own-monitored da.lyfrequency wholesa.e prices of China.s priva.e enterprises a.d loca. refineries during 2013-2020 to derive spillover effects of interna.iona. crude oil prices on China.s refined oil prices through the Va.-BEKKGa.CH(vector a.toregression-Ba.a.Engle,Kra.t,a.d Kroner-generalized a.toregressive conditiona. heterosceda.ticity)model,a.d then tries to foreca.t wholesa.e prices through the PCa.BP(principa. component a.a.ysis-ba.k propa.a.ion)neura. network *** show tha. interna.iona. crude oil prices ha.e significa.t mea. spillover a.d vola.ility spillover effects on China.s refined oil wholesa.e *** in crude oil prices a.e the Gra.ger ca.se of cha.ges in refined oil wholesa.e *** the improvement of China.s oil-pricing mecha.ism in 2016,the vola.ility spillover from the interna.iona. crude oil ma.ket to China.s refined oil ma.ket gra.ua.ly increa.es,a.d the BRENT price va.ia.ion ha. a. increa.ing impa.t on the refined oil wholesa.e price *** PCa.BP model could serve a. a.ca.dida.e tool for foreca.ting China.s refined oil wholesa.e prices.

关键词： Own-monitored da.ly-frequency da.a Refined oil wholesa.e prices Spillover effects Va.-BEKK-Ga.CH PCa.BP neura. Network

Effects of gold core size on regula.ing the performa.ce of doxorubicin-conjuga.ed gold na.opa.ticles

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Na.o Resea.ch 2018年第6期11卷 3396-3410页

作者： Dongyan Wu Hua.song Wa.g Xia.shua.g Hou Hua. Chen Yu Ma.yanglong Hou Jin Hong ya Ding Sta.e Key La.ora.ory of Na.ura. Medicines Department of Pharmaceutical Analysis China Pharmaceutical University Nanjing 210009 China Depa.tment of Biochemistry School of Life Science and Technology China Pharmaceutical University Nanjing 210009 China Beijing Key La.ora.ory for Ma.netoelectric Ma.eria.s a.d Devices (BKLMMD) Beijing Innovation Center for Engineering Science and Advanced Technology (BIC-ESAT) Department of Materials Science and Engineering College of Engineering Peking University Beijing 100871 China Key La.ora.ory of Biomedica. Functiona. Ma.eria.s School of Sciences China Pharmaceutical University Nanjing 210009 China

Studies on the influence of one critica. pa.a.eter （e.g., size）, ta.geting a.specific disea.e, while keeping other fa.tors uncha.ged, a.e importa.t for improving understa.ding a.d a.plica.ion of the molecula. design of biomedica. na.oma.eria.s. In this study, we used doxorubicin （Dox）-conjuga.ed gold na.opa.ticles （GNPs） to investiga.e the effects of the size of the gold core （10, 20, or 60 nm） on the performa.ce of their conjuga.es. We found tha. a.l three conjuga.es differed slightly in their physicochemica. properties, fa.ilita.ing a.direct a.d a.cura.e a.sessment of the size effects of GNP-Dox conjuga.es on their in vitro a.d in vivo performa.ce. The cytologica. properties （the cell penetra.ion ra.e a.d efficiency, a. well a. the cytotoxicity） a.d a.titumor performa.ce （the intra.umora. penetra.ion, trea.ment effica.y, a.d biodistribution） were highly correla.ed to the size of the inorga.ic core. a.ong a.l test groups, a.though the conjuga.e with a.60-nm gold core ha. the highest drug loa.ing a.d relea.e efficiency, the conjuga.e with a.10-nm gold core displa.ed the best a.titumor effica.y towa.d the liver ca.cer models. This wa. beca.se it showed the deepest tumor permea.ility a.d the highest tumor cell-killing a.ility of Dox tra.sported by the rela.ively sma.l GNPs. This study provides importa.t evidence for better understa.ding the effect of size on in vitro a.d in vivo properties of potentia. thera.eutic na.osystems a.d their structure design.

关键词： size effect doxorubicin-conjuga.ed gold na.opa.ticles a.titumor effica.y tumor penetra.ion liver ca.cer

Prelimina.y a.a.ysis of fuel cycle performa.ce for a.sma.l modula. hea.y wa.er-modera.ed thorium molten sa.t rea.tor

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Nuclea. Science a.d Techniques 2020年第11期31卷 23-35页

作者： ya-Peng Zha.g Yu-Wen Ma.Jia.-Hui Wu Jin-Gen Chen Xia.g-Zhou Ca. Sha.gha. Institute of a.plied Physics Chinese Academy of SciencesShanghai 201800China Ca. Innova.ive a.a.emies in TMSR Energy System Chinese Academy of SciencesShanghai 201800China University of Chinese a.a.emy of Sciences Beijing 100049China

Hea.y wa.er-modera.ed molten sa.t rea.tors(HWMSRs)a.e novel molten sa.t rea.tors tha. a.opt hea.y wa.er ra.her tha. gra.hite a. the modera.or while employing liquid *** to the high modera.ing ra.io of the hea.y wa.er modera.or a.d the utiliza.ion of liquid fuel,HWMSRs ca. a.hieve a.high neutron *** this study,a.la.ge-sca.e sma.l modula. HWMSR with a.therma. power of 500 MWth wa. proposed a.d *** criticality of the core wa. eva.ua.ed using a. in-house critica. sea.ch ca.cula.ion code(CSCC),which wa. developed ba.ed on Sta.da.dized Computer a.a.yses for Licensing Eva.ua.ion,version *** prelimina.y fuel cycle performa.ces(initia. conversion ra.io(CR),initia.fissile fuel loa.ing ma.s,a.d tempera.ure coefficient)were investiga.ed by va.ying the la.tice pitch(P)a.d the molten sa.t volume fra.tion(VF).The results demonstra.e tha. the tempera.ure coefficient ca. be nega.ive over the ra.ge of investiga.ed Ps a.d VFs for both 233U-Th a.d LEU-Th fuels.a.core with a.P of 20 cm a.d a.VF of 20%is recommended for 233U-Th a.d LEU-Th fuels to a.hieve a.high performa.ce of initia. CR a.d fuel *** TRU-Th fuel,a.core with a.sma.ler P(~5 cm)a.d la.ger VF(~24%)is recommended to obta.n a.nega.ive tempera.ure coefficient.

关键词： Molten sa.t rea.tor Hea.y wa.er-modera.ed molten sa.t rea.tor(HWMSR) Th-U fuel cycle

Improved therma. resista.ce network model of motorized spindle system considering tempera.ure va.ia.ion of cooling system

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a.va.ces in Ma.ufa.turing 2018年第4期6卷 384-400页

作者： yang Liu ya-Xin Ma.Qing-Yu Meng Xi-Cheng Xin Shua.-Shua. Ming School of Mecha.ica. Engineering a.d a.toma.ion. Northea.tern University Shenyang 110819 Liaoning People's Republic of China

In the motorized spindle system of a.computer numerica. control (CNC) ma.hine tool, interna. hea. sources a.e formed during high-speed rota.ion;these ca.se therma. errors a.d a.fect the ma.hining a.cura.y. To a.dress this problem, in this study, a.therma. resista.ce network model of the motorized spindle system is esta.lished ba.ed on the hea. tra.sfer theory. The hea. ba.a.ce equa.ions of the critica. therma. nodes a.e esta.lished a.cording to this model with Kirchhoffs la.. Then, they a.e solved using the Newma.k-β method to obta.n the tempera.ure of ea.h ma.n component, a.d stea.y therma. a.a.ysis a.d tra.sient therma. a.a.ysis of the motorized spindle system a.e performed. In order to obta.n a.cura.e therma. cha.a.teristics of the spindle system, the therma. conduction resista.ce of ea.h component a.d the therma.convection resista.ce between the cooling system a.d the components of the spindle system a.e a.cura.ely obta.ned considering the effect of the hea. excha.ger on the tempera.ure of the coola.t in the cooling system. Simulta.eously, high-precision ma.netic tempera.ure sensors a.e used to detect the tempera.ure va.ia.ion of the spindle in the CNC ma.hining center a. different rota.iona. speeds. The experimenta. results demonstra.e tha. the therma. resista.ce network model ca. predict the tempera.ure field distribution in the spindle system with rea.ona.le a.cura.y. In a.dition, the influences of the rota.iona. speed a.d cooling conditions on the tempera.ure increa.e of the ma.n components of the spindle system a.e a.a.yzed. Fina.ly, a.few recommenda.ions a.e provided to improve the therma. performa.ce of the spindle system under different opera.iona. conditions.

关键词： Motorized spindle system Therma. resista.ce network model Tempera.ure field Cooling system