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Shexiang Tongxin Dropping Pill Allieviates Heart Failure via Extracellula Matrix-Receptor Interaction Pathways Based on RNA-Seq Transcriptomics and Experimental Studies

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Chinese Journal of Integrative Medicine 2023年第7期29卷 600-607页

作者： TAN ya-fang FU Yu-han ZHANG min-zhou Intensive Care Research Team of Traditional Chinese Medicine Guangdong Province Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510006China School of Life Sciences and Biopharmaceutics Guangdong Pharmaceutical UniversityGuangzhou510006China

Objective:To investigate the protective mechanisms of Chinese medicine Shexiang Tongxin Dropping Pills(STDP) on heart failure(HF).Methods:Isoproterenol(ISO)-induced HF rat model and angiotensin Ⅱ(Ang Ⅱ)-induced neonatal rat cardiac fibroblast(CFs) model were used in the present *** rats were treated with and without STDP(3 g/kg).RNA-seq was performed to identify differentially expressed genes(DEGs).Cardiac function was evaluated by *** and eosin and Masson’s stainings were taken to assess cardiac *** levels of collagen Ⅰ(Col Ⅰ) and collagen Ⅲ(Col Ⅲ) were detected by immunohistochemical ***8 kit and transwell assay were implemented to test the CFs’ proliferative and migratory activity,*** protein expressions of α-smooth muscle actin(α-SMA),matrix metalloproteinase-2(MMP-2),MMP-9,Col I,and Col Ⅲ were detected by Western ***:The results of RNA-seq analysis showed that STDP exerted its pharmacological effects on HF via multiple signaling pathways,such as the extracellular matrix(ECM)-receptor interaction,cell cycle,and B cell receptor *** from in vivo experiments demonstrated that STDP treatment reversed declines in cardiac function,inhibiting myocardial fibrosis,and reversing increases in Col Ⅰ and Col Ⅱ expression levels in the hearts of HF ***,STDP(6,9 mg/mL) inhibited the proliferation and migration of CFs exposed to Ang Ⅱin vitro(P<0.05).The activation of collagen synthesis and myofibroblast generation were markedly suppressed by STDP,also the synthesis of MMP-2 and MMR-9,as well as ECM components Col Ⅰ,Col Ⅲ,and α-SMA were decreased in Ang Ⅱ-induced neonatal rats’ ***:STDP had anti-fibrotic effects in HF,which might be caused by the modulation of ECM-receptor interaction *** the management of cardiac fibrosis,STOP may be a compelling candidate for improving prognosis of HF.

关键词： Shexiang Tongxin Dropping Pill heart failure RNA-seq extracellular matrix isoproterenol-induced

Exploring the Accretion Disk Structure and X-ray Radiation of GX 17+2 Based on kHz QPOs and Cross-correlations

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Research in Astronomy and Astrophysics 2022年第12期22卷 239-248页

作者： De-Hua Wang Cheng-min Zhang ya-Juan Lei School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China CAS Key Laboratory of FAST National Astronomical ObservatoriesBeijing 100101China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesBeijing 100101China Key Laboratory of Solar Activity National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

Applying the timing tools of kilohertz quasi-periodic oscillations(k Hz QPOs)and cross-correlations,we study the influence of the magnetosphere-disk relation on the X-ray radiation process of GX 17+***,as the spectral state track of X-ray emission evolves along the horizontal branch(HB),the magnetosphere-disk radii of the source derived by k Hz QPOs shrink from r~24 km to r~18 km,while its average X-ray intensities in≤10 ke V and in≥10 ke V show the opposite evolutional ***,this branch has been detected with the anti-correlations between the low-/high-energy(e.g.,2–5 ke V/16–30 ke V)*** suggest that in HB there may exist an X-ray radiation transfer process at the disk radii near the neutron star(NS),i.e.,~5–10 km away from the surface,which probably originates from the interaction between the corona or jet with high-energy X-rays and accretion disk with low-energy ***,as the source evolves along the normal branch(NB)and along the flaring branch(FB),their average X-ray intensities in all~2–30 ke V show the monotonously decreasing and monotonously increasing trends,*** addition,these two branches are both dominated by the positive correlations between the low-and high-energy(e.g.,2–5 ke V/16–30 ke V)***,the evolution along NB is accompanied by the shrinking of the magnetosphere-disk radii from r~18 km to r~16 *** ascribe these phenomena to that as the shrinking of the accretion disk radius,the piled up accretion matter around the NS surface may trigger the radiation that produces both the low-and high-energy X-rays simultaneously,and then form the branches of NB and FB.

关键词： X-rays:binaries stars:neutron stars:individual(GX 17+2) accretion accretion disks

Study on Wave Characteristics from the South Atlantic Ocean to the Gulf of Guinea Based on Short-Term Numerical Simulation in Winter Season

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China Ocean Engineering 2023年第2期37卷 312-322页

作者： XU Fu-min ZHENG Jin-hai ya Han-zheng XING Tian Key Laboratory of ministry of Education for Coastal Disaster and Protection Hohai UniversityNanjing 210098China College of Harbor Coastal and Offshore EngineeringHohai UniversityNanjing 210098China

Waves play a major role in the ocean phenomena in the Gulf of Guinea(GoG). In order to reveal the spatial-temporal distribution characteristics and the propagation mechanism of waves from the South Atlantic Ocean to the GoG, 4typical points located in mid-latitude of South Atlantic(14°30′W, 30°0′S), south of the GoG(10°30′W, 15°0′S), offshore of the GoG(0°0′, 0°0′) and near shore of the GoG(6°4′58.8″W, 4°3′36″S) are selected, and waves from Atlantic Ocean to GoG are simulated by using a two-layer-nesting wave numerical model SWAN(Simulating Waves Nearshore). The results show that the hybrid waves(waves hereafter) and the swells have strong relationship with local wind in Roaring Forties and at mid-latitude of South Atlantic Ocean, while there is no obvious correlation between waves and local winds in the GoG. Swells are generated in the South Atlantic Ocean and propagate into the GoG. 2D wave spectra at the four selected typical points are simulated. The spectral pattern and wave component structure indicate that the wave system in GoG is dominated by the S-SW swells generated from Roaring Forties and mid-latitude of South Atlantic, whether it is at maximum(2.2-2.8 m), medium(1.8-2.2 m) or minimum(1.2 m) significant wave height in the GoG during simulation period.

关键词： Gulf of Guinea wave characteristics 2D wave spectra swell roaring forties

Stability of Navier–Stokes System with Singular External Force in Fourier–Herz Space

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Acta Mathematica Sinica,English Series 2023年第7期39卷 1203-1218页

作者： De Zai min Qing Kai WANG Gang WU Zhuo ya yaO School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049P.R.China

We prove the asymptotic properties of the solutions to the 3D Navier–Stokes system with singular external force, by making use of Fourier localization method, the Littlewood–Paley theory and some subtle estimates in Fourier–Herz space. The main idea of the proof is motivated by that of Cannone et al. [J. Differential Equations, 314, 316–339(2022)]. We deal either with the nonstationary problem or with the stationary problem where solution may be singular due to singular external force. In this paper, the Fourier–Herz space includes the function space of pseudomeasure type used in Cannone et al. [J. Differential Equations, 314, 316–339(2022)]

关键词： 3D Navier–Stokes equations Fourier–Herz spaces singular external force Littlewood–Paley theory stability

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One POM-based Coordination Polymer with 2,6-Bis(1-imidazoly) Pyridine as the Ligand: Synthesis, Structure and Characterizations

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Chinese Journal of Structural Chemistry 2020年第7期39卷 1350-1356页

作者： LIU Ying WU Ying-Ying SHI ya-Jie LI ya-min ZHANG Hui-Shuang Henan Key Laboratory of Polyoxometalate College of Chemistry and Chemical EngineeringHenan UniversityKaifengHenan 475004China School of Marine Resources and Environment Jiangsu Ocean UniversityLianyungangJiangsu 222005China

One new polyoxometalate-based coordination polymer with 2,6-bis(1-imidazoly)pyridine(L)as the ligand,[Ni(L)(HL)(H2O)(H2 W12O40)0.5·H2O]n,has been synthesized under hydrothermal method and characterized by IR spectra,single-crystal X-ray diffraction,powder X-ray diffraction(PXRD),elemental analyses and thermogravimetric analyses(TGA).It crystallizes in orthorhombic,space group Pnma with a=20.169(7),b=23.924(8),c=15.333(5)?,V=7398(4)?3,Z=8,F(000)=6992,Dc=3.488 Mg/m3,Mr=1942.32,μ=19.177 mm-1 and the final R=0.0299,wR=*** the title compound,each Ni(Ⅱ)atom is bridged by two ligands L to form Ni2L2,which are further connected into a one-dimensional chain structure by coordination with[H2W12O40]6–polyoxoanions,and thus the ultimate 3D framework is constructed via different hydrogen bonding *** addition,the cyclic voltammograms,magnetism,luminescence and photocatalytic activity towards RhB are *** title compound exhibits antiferromagnetic behaviors,luminescent behaviors at solid state and photocatalytic activity to RhB.

关键词： 2,6-bis(1-imidazoly)pyridine polyoxometalate antiferromagnetic behavior photocatalysis activity

Topological properties and routing algorithm for semi-diagonal torus networks

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The Journal of China Universities of Posts and Telecommunications 2011年第5期18卷 64-70页

作者： WANG ya-gang DU Hui-min SHEN Xu-bang School of Computer Xidian University Xi＇an 710071 China School of Electronic Engineering Xi＇an University of Posts and Telecommunications Xi＇an 710121 China

To improve the scalability and reduce the implementation complexity of Mesh and Mesh-like networks, the semi-diagonal Torus （SD-Torus） network, a regular and symmetrical intercormection network is proposed. The SD-Torus network is a combination of a typical 2D-Torus network with two extra diagonal links from northwest to southeast direction for each node. The topological properties of SD-Torus networks are discussed, and a load balanced routing algorithm for SD-Torus is presented. System-C based simulation result shows that, compared with diagonal Mesh （DMesh）, diagonal Torus （DTorus） and XMesh networks, the SD-Torus network can achieve high performance with a lower network cost. It makes the SD-Torus network a powerful candidate for the high performance interconnection networks.

关键词： interconnection networks routing algorithm load balance SD-Toms networks direct networks

VOC emission caps constrained by air quality targets based on response surface model:A case study in the Pearl River Delta Region,China

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Journal of Environmental Sciences 2023年第1期123卷 430-445页

作者： ya’nan Hu Bowen Shi Xin Yuan Chuanzeng Zheng Qing’e sha Yufan Yu Zhijiong Huang Junyu Zheng Institute for Environmental and Climate Research Jinan UniversityGuangzhou 511436China Guangdong Polytechnic of Environmental Protection Engineering Guangzhou 528216China

Because of the recent growth in ground-level ozone and increased emission of volatile organic compounds(VOCs),VOC emission control has become a major concern in *** response,emission caps to control VOC have been stipulated in recent policies,but few of them were constrained by the co-control target of PM_(2.5)and ozone,and discussed the factor that influence the emission cap ***,we proposed a framework for quantification of VOC emission caps constrained by targets for PM_(2.5)and ozone via a new response surface modeling(RSM)technique,achieving 50%computational cost savings of the *** the Pearl River Delta(PRD)region,the VOC emission caps constrained by air quality targets varied greatly with the NOxemission reduction *** control measures in the surrounding areas of the PRD region were not considered,there could be two feasible strategies for VOC emission caps to meet air quality targets(160μg/m^(3)for the maximum 8-hr-average 90th-percentile(MDA8-90%)ozone and 25μg/m^(3)for the annual average of PM_(2.5)):a moderate VOC emission cap with60%NOxemission *** the ozone concentration target were reduced to 155μg/m^(3),deep NOxemission reductions is the only feasible ozone control measure in *** of seasonal VOC emission caps based on the Monte Carlo simulation could allow us to gain higher ozone benefits or greater VOC emission *** VOC emissions were further reduced in autumn,MDA8-90%ozone could be lowered by 0.3-1.5μg/m^(3),equaling the ozone benefits of 10%VOC emission reduction *** method for VOC emission cap quantification and optimization proposed in this study could provide scientific guidance for coordinated control of regional PM_(2.5)and O_(3)pollution in China.

关键词： Volatile organic compounds Emission caps Air quality targets Response surface model Monte Carlo(MC)simulations

On Tubular Tilting Objects in the Stable Category of Vector Bundles

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Acta Mathematica Sinica,English Series 2019年第4期35卷 494-512页

作者： Jian min CHEN ya Nan LIN Shi Quan RUAN School of Mathematical Sciences Xiamen University

The present paper focuses on the study of the stable category of vector bundles for the weighted projective lines of weight triple. We find some important triangles in this category and use them to construct tilting o... 详细信息

关键词： Tilting sheaf weighted projective line stable category cluster category tubular algebra

Virtual channel load-balanced routing algorithm for Torus networks

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The Journal of China Universities of Posts and Telecommunications 2011年第1期18卷 70-76页

作者： WANG ya-gang DU Hui-min SHEN Xu-bang School of Computer Xidian University Xi'an 710071 China School of Computer Xi'an University of Posts and Telecommunications Xi'an 710121 China School of Electronic Engineering Xi'an University of Posts and Telecommunications Xi'an 710121 China

In order to improve the network performance furthermore, a routing algorithm for 2D-Torus is investigated from the standpoint of load balance for virtual channels. The 2D-Torus network is divided into two virtual networks and each physical channel is split into three virtual channels. A novel virtual channel allocation policy and a routing algorithm are proposed, in which traffic load is distributed to those three virtual channels in a more load-balanced manner by introducing a random parameter. Simulations of the proposed algorithm are developed with a SystemC-based test bench. The results show that compared with the negative first for Torus networks （NF-T） algorithm, the proposed algorithm can achieve better performance in terms of network latency and throughput under different traffic patterns. It also shows that a routing algorithm with load balance for virtual channels can significantly improve the network performance furthermore.

关键词： interconnection network Torus networks routing algorithm virtual channel load balance