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Survival Analysis of Patients Undergoing Intraoperative Contrast-enhanced Ultrasound in the Surgical Treatment of Malignant Glioma

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Current Medical Science 2024年第2期44卷 399-405页

作者： Xu chen ya.ni peng Fang-ling chenG Dan CAO An-yu TAO Jian chen Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Medical Ultrasound Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Complete resection of malignant gliomas is often *** previous study indicated that intraoperative contrast-enhanced ultrasound(ICEUS)could aid in the detection of residual tumor remnants and the total removal of brain *** study aimed to investigate the survival rates of patients undergoing resection with or without the use of ICEUS and to assess the impact of ICEUS on the prognosis of patients with malignant ***:A total of 64 patients diagnosed with malignant glioma(WHO grade HI and IV)who underwent surgery between 2012 and 2018 were *** them,29 patients received *** effects of ICEUS on overall survival(OS)and progression-free survival(PFS)of patients were evaluated.A quantitative analysis was performed to compare ICEUS parameters between gliomas and the surrounding ***:The ICEUS group showed better survival rates both in OS and PFS than the control *** univariate analysis revealed that age,pathology and ICEUS were significant prognostic factors for PFS,with only age being a significant prognostic factor for *** multivariate analysis,age and ICEUS were significant prognostic factors for both OS and *** quantitative analysis showed that the intensity and transit time of microbubbles reaching the tumors were significantly different from those of microbubbles reaching the surrounding ***:ICEUS facilitates the identification of residual *** and ICEUS are prognostic factors for malignant glioma surgery,and use of ICEUS offers a better prognosis for patients with malignant glioma.

关键词： intraoperative contrast-enhanced ultrasound malignant glioma extent of resection survival prognosis

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Association between heat and upper urinary tract stones morbidity and medical costs: A study in the subtropical humid climate zone

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Advances in Climate Change Research 2024年第4期15卷 717-724页

作者： chen-Lu ya.G Jun-Zhe BAO peng BI ya.Dong ZHANG Chao-Ming TAN Kai chen College of Public Health Zhengzhou UniversityZhengzhou 450001China School of Public Health The University of AdelaideAdelaide 5000Australia Department of Andrology The First Affliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Nanjing Social Insurance Management Center Nanjing 210008China Department of Environmental Health Sciences Yale UniversityNew Haven 06520USA ya.e Center on Climate Change and Health Yale UniversityNew Haven 06520USA

Urolithiasis is a heat-specific *** heat-related urolithiasis susceptibility subtypes,economic burden,and modifying factors could assist governments in targeting interventions to reduce the heat-related health risks of urolithiasis *** collected data on 23,492 patients with upper urinary tract stones(main subtypes of urolithiasis)from 2013 to 2017 in Nanjing,*** adopted generalized additive quasi-Poisson models to examine the associations between daily mean temperatures and morbidity of upper urinary tract stones,while generalized additive Gaussian models were used to explore the relationships between temperatures and log-transformed medical *** examined the modification effects of disease subtypes(kidney and ureteral calculus),sex,and age through stratified analyses and the modif-cation effects of other meteorological factors by introducing interaction terms in the *** found that short-term summer heat exposure has a statistically significant effect on ureteral calculus morbidity but not on kidney calculus *** ureter calculus,a 1℃ temperature increase was associated with a 4.36%(95%confidence interval[CI]:1.94%,6.83%)increase in daily hospitalization and a 5.44%(95%CI:2.71%,8.25%)increase in daily medical *** attributable fraction associated with heat(greater than the median value of daily mean temperature,26.8℃)was 7.85%(95%empirical confidence interval[eCI]:3.64%,11.44%)for hospitalization and 9.36%(95%eCI:4.91%,13.14%)for medical *** effects of heat on ureter calculus morbidity were significantly higher among the males and those with high sunshine duration than females and those with low sunshine ***-term summer heat exposure was associated with increased morbidity and medical costs of ureteral *** government organizations should take effective intervention measures,including community health education,to reduce the health hazards and economic losses caused by heat.

关键词： Heat Upper urinary tract stones Economic burden Modification effects

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Drivers of spatial structure in thinned forests

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Forest Ecosystems 2024年第2期11卷 202-213页

作者： Zichun Wang ya.xiang Li Guangyu Wang Zheyu Zhang ya.chen Xiaoli Liu Rundong peng College of Mechanical and Electrical Engineering Northeast Forestry UniversityHarbin150040China Department of Forest Resources Management University of British ColumbiaVancouverCanada

Background:As is widely known,an increasing number of forest areas were managed to preserve and enhance the health of forest ***,previous research on forest management has often overlooked the importance of ***:Our objectives were to define the direction of structure-based forest ***,we investigated the relationships between forest structure and the regeneration,growth,and mortality of trees under different thinning ***,the drivers of forest structural change were ***:On the basis of 92 sites selected from northeastern China,with different recovery time (from 1 to 15years) and different thinning intensities (0–59.9%) since the last *** component analysis (PCA)identified relationships among factors determining forest spatial *** structural equation model (SEM)was used to analyze the driving factors behind the changes in forest spatial structure after ***:Light thinning (0–20%trees removed) promoted forest regeneration,and heavy thinning (over 35% of trees removed) facilitated forest ***,only moderate thinning (20%–35%trees removed) created a reasonable spatial *** dead trees were clustered,and they were hardly affected by thinning ***,thinning intensity,recovery time,and altitude indirectly improve the spatial structure of the forest by influencing diameter at breast height (DBH) and canopy ***:Creating larger DBH and canopy area through thinning will promote the formation of complex forest structures,which cultivates healthy and stable forests.

关键词： Thinning Natural secondary forest Spatial structure Dynamic changes Growth factors Structural equation modeling

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Retinitis pigmentosa and stem cell therapy

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1363-1369页

作者： Xin-ya.Qi chen-Hui Mi De-Rui Cao Xie-Qun chen peng Zhang School of Medicine Department of Life Sciences and MedicineNorthwest UniversityXi’an 710069Shaanxi ProvinceChina The Third Hospital of Xi’an Affiliated Hospital of Northwest UniversityXi’an 710021Shaanxi ProvinceChina

Retinitis pigmentosa(RP)is a group of genetic disorders characterized by progressive degeneration of photoreceptors and retinal pigment epithelium(RPE)*** main clinical manifestations include night blindness and progressive loss of peripheral vision,making it a prevalent debilitating eye disease that significantly impacts patients’quality of *** exhibits significant phenotypic and genetic *** instance,numerous abnormal genes are implicated in RP,resulting in varying clinical presentations,disease progression rates,and pathological characteristics among different ***,gene therapy for RP poses challenges due to these ***,stem cells have garnered considerable attention in the field of RPE therapy since both RPE cells and photoreceptors can be derived from stem *** recent years,a large number of animal experiments and clinical trials based on stem cell transplantation attempts,especially cord blood mesenchymal stem cell(MSC)transplantation and bone marrow-derived MSC transplantation,have confirmed that stem cell therapy can effectively and safely improve the outer retinal function of the RP-affected ***,stem cell therapy also has certain limitations,such as the fact that RP patients may involve multiple types of retinal cytopathia,which brings great challenges to stem cell transplantation therapy,and further research is needed to solve various problems faced by this approach in the *** comprehensive analysis of the etiology and histopathological changes associated with RP,this study substantiates the efficacy and safety of stem cell therapy based on rigorous animal experimentation and clinical trials,while also highlighting the existing limitations that warrant further investigation.

关键词： retinitis pigmentosa photoreceptor stem cell therapy

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Structural transformation from Waugh-type to Keggin-type polyoxomolybdate-based crystalline material for photo/electrocatalysis

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Rare Metals 2024年第5期43卷 2241-2250页

作者： Pei-Sen Wang Zi-Tong Wang ya.ya.Tan peng chen Xue-cheng Zhang Lu-Nan Zhang Yong-Ge Wei Lu-Bin Ni School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing100191China

An inorganicDorganic hybrid crystalline material(SiMo_(12)O_(40))[Cu(2,2'-bipy)_(2)]_(2)·2H_(2)O(Complex 1,2,2'-bipy=2,2'-bipyridine)was synthesized for the first time by using 2,2'-bipy and transition metal copper to convert Waugh-type polyoxometalate[MnMo_(9)O_(3)_(2)]_(6-)into a Keggin polyoxometalate structure[SiMo_(12)O_(40)]^(4-)under hydrothermal conditions in glass *** crystal tests and a series of characterizations were carried out on Complex *** structure of Complex 1 is composed of[SiMo_(12)O_(40)]^(4-)and[Cu^(Ⅱ)(2,2'-bipy)_(2)]^(2+).The five-coordinated Cu is connected to two 2,2'-bipy through CuDN bonds,forming an approximately square ***,Complex 1 exhibited good photocatalytic performance for methylene blue degradation and electrocatalytic nitrite reduction properties simultaneously.

关键词： Polyoxometalates Inorganic-organic hybrid materials Photocatalytic Electrocatalytic

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Research progress in CALPHAD assisted metal additive manufacturing

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China Foundry 2024年第4期21卷 295-310页

作者： ya.qing Hou Xiao-qun Li Wei-dong Cai Qing chen Wei-ce Gao Du-peng He Xue-hui chen Hang Su China Iron&Steel Research Institute Group Beijing 100081China Thermo-Calc Software AB SolnaSE-169Sweden KTH Roya. Institute of Technology StockholmSE-100Sweden Central Iron and Steel Research Institute Beijing 100081China

Metal additive manufacturing(MAM)technology has experienced rapid development in recent *** both equipment and materials progress towards increased maturity and commercialization,material metallurgy technology based on high energy sources has become a key factor influencing the future development of *** calculation of phase diagrams(CALPHAD)is an essential method and tool for constructing multi-component phase diagrams by employing experimental phase diagrams and Gibbs free energy models of simple *** combining with the element mobility data and non-equilibrium phase transition model,it has been widely used in the analysis of traditional metal *** development of CALPHAD application technology for MAM is focused on the compositional design of printable materials,the reduction of metallurgical imperfections,and the control of microstructural *** endeavor carries considerable theoretical and practical *** paper summarizes the important achievements of CALPHAD in additive manufacturing(AM)technology in recent years,including material design,process parameter optimization,microstructure evolution simulation,and properties ***,the limitations of applying CALPHAD technology to MAM technology are discussed,along with prospective research directions.

关键词： metal additive manufacturing CALPHAD integrated computational material engineering powder bed fusion material design microstructure simulation

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Sharp Interface Limit for the One-dimensional Compressible Navier-Stokes/Allen-Cahn System with Composite Waves

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Acta Mathematicae Applicatae Sinica 2024年

作者： ya.zhou chen Yi peng Xiao-ding SHI School of Mathematics and Physics Beijing University of Chemical Technology

This paper is concerned with the sharp interface limit of Cauchy problem for the one-dimensional compressible Navier-Stokes/Allen-Cahn system with a composite wave consisting of the superposition of a rarefaction wave and a shock wave. Under the assumption that the viscosity coefficient and the reciprocal of mobility coefficient are directly proportional to the interface thickness, we first convert the sharp interface limit of the system into the large time behavior of the composite wave via a natural scaling. Then we prove that the composite wave is asymptotically stable under the small initial perturbations and the small strength of the rarefaction and shock wave. Finally, we show the solution of the Cauchy problem exists for all time, and converges to the composite wave solution of the corresponding Euler equations as the thickness of the interface tends to zero. The proof is mainly based on the energy method and the relative entropy.

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Fixed-Time Anti-Disturbance Average-Tracking for Multi-Agent Systems Without Velocity Measurements

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Journal of Systems Science & Complexity 2024年第3期37卷 985-1002页

作者： LI Yuling LIU chenglin ZHANG ya.chen ya.gya.g Key Laboratory of Advanced Process Control for Light Industry(Ministry of Education) Institute of AutomationJiangnan UniversityWuci 214122China School of Automation Southeast UniversityNanjing 210096China

In this paper,the authors tackle a fixed-time average-tracking problem for multi-agent systems which do not require velocity measurements and are affected by external mismatched and matched *** objective requires the considered agents with second-order dynamics to follow the average value of several time-varying reference signals,each of which is acquired by only one *** of all,the average value is estimated by using a novel distributed average estimator in a fixed ***,an original observer is created to provide estimated values in a fixed time for external mismatched and matched disturbances as well as unmeasured velocities of ***,the authors propose a novel fixed-time anti-disturbance average-tracking protocol with the aid of the observer and a sliding mode *** the end,the feasibility of theoretical analysis is illustrated by some simulation experiments.

关键词： Average-tracking control fixed-time algorithm fixed-time observer mismatched distur-bances multi-agent systems velocity measurements

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Long-time Asymptotics for the Reverse Space-time Nonlocal Hirota Equation with Decaying Initial Value Problem:without Solitons

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 708-727页

作者： Wei-qi peng Yong chen School of Mathematical Sciences East China Normal UniversityShanghai 200241China College of Mathematics and Systems Science Shandong University of Science and TechnologyQingdao 266590China

In this work,we mainly consider the Cauchy problem for the reverse space-time nonlocal Hirota equation with the initial data rapidly decaying in the solitonless *** from the Lax pair,we first construct the basis Riemann-Hilbert problem for the reverse space-time nonlocal Hirota ***,using the approach of Deift-Zhou nonlinear steepest descent,the explicit long-time asymptotics for the reverse space-time nonlocal Hirota is *** the reverse space-time nonlocal Hirota equation,since the symmetries of its scattering matrix are different with the local Hirota equation,the v(λ_(i))(i=0,1)would like to be imaginary,which results in theδ_(λi)^(0)contains an increasing t(±Imv(λ_(i)))/2,and then the asymptotic behavior for nonlocal Hirota equation becomes differently.

关键词： Riemann-Hilbert problem reverse space-time nonlocal Hirota equation long-time asymptotics nonlinear steepest descent method

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Evaluation of water management on arsenic methylation and volatilization in arsenic-contaminated soils strengthened by bioaugmentation and biostimulation

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Journal of Environmental Sciences 2024年第3期137卷 515-526页

作者： peng chen Yi Liu Guo-Xin Sun State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Key Laboratory of Aquatic Botany and Watershed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China University of Chinese Academy of Sciences Beijing 100049China

Arsenic(As) fate in paddy fields has been one of the most significant current issues due to the strong As accumulation potential of rice plants under fooded conditions. However,no attempt was done to explore As methylation and volatilization under non-fooded conditions. Herein, we investigated the effects of water management on As methylation and volatilization in three arsenic-contaminated soils enhanced by biostimulation with strawderived organic matter and bioaugmentation with genetic engineered Pseudomonas putida KT2440(GE P. putida). Under fooded conditions, the application of biochar(BC), rice straw(RS)and their combination(BC+RS) increased total As in porewater. However, these effects were greatly attenuated under non-fooded conditions. Compared with RS amendment alone, the combination of GE P. putida and RS further promoted the As methylation and volatilization,and the promotion percentage under non-fooded conditions were significantly higher than that under fooded conditions. The combined GE P. putida and RS showed the highest efficiency in As methylation(88 μg/L) and volatilization(415.4 μg/(kg·year)) in the non-fooded soil with moderate As contamination. Finally, stepwise multiple linear regression analysis presented that methylated As, DOC and p H in porewater were the most important factors contributing to As volatilization. Overall, our findings suggest that combination of bioaugmentation with GE P. putida and biostimulation with RS/BC+RS is a potential strategy for bioremediation of arsenic-contaminated soils by enhancing As methylation and volatilization under non-fooded conditions.

关键词： Arsenic methylation Arsenic volatilization Water management Straw incorporation Bioaugmentation

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