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nNOS and Neurological, Neuropsychiatric Disorders: A 20-Year Story

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Neuroscience Bulletin 2023年第9期39卷 1439-1453页

作者： Li-Juan zhu Fei Li Dong-ya.zhu Key Laboratory of Developmental Genes and Human Diseases Ministry of EducationDepartment of Histology and EmbryologySchool of MedicineSoutheast UniversityNanjing210009China Department of Pharmacology School of PharmacyNanjing Medical UniversityNanjing211166China Department of Medicinal Chemistry School of PharmacyNanjing Medical UniversityNanjing211166China

In the central nervous system,nitric oxide(NO),a free gas with multitudinous bioactivities,is mainly produced from the oxidation of L-arginine by neuronal nitric oxide synthase(nNOS).In the past 20 years,the studies in our group and other laboratories have suggested a significant involvement of nNOS in a variety of neurological and neuropsychiatric *** particular,the interactions between the PDZ domain of nNOS and its adaptor proteins,including post-synaptic density 95,the carboxy-terminal PDZ ligand of nNOS,and the serotonin transporter,significantly influence the subcellular localization and functions of nNOS in the *** nNOS-mediated protein-protein interactions provide new attractive targets and guide the discovery of therapeutic drugs for neurological and neuropsychiatric ***,we summarize the work on the roles of nNOS and its association with multiple adaptor proteins on neurological and neuropsychiatric disorders.

关键词： nNOS nNOS-PSD95 nNOS-CAPON nNOS-SERT Neurological and neuropsychiatric disorder

One-dimensional metallic, magnetic, and dielectric nanomaterialsbased composites for electromagnetic wave interference shielding

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Nano Research 2022年第10期15卷 9595-9613页

作者： ya.Cheng Wendong zhu Xiaofeng Lu Ce Wang Alan G.MacDiarmid Institute College of ChemistryJilin UniversityChangchun 130012China

The excrescent electromagnetic(EM)radiation exposure in the air threatens human health and electronic equipment due to the abuse of EM waves in wireless telecommunication technology and electronic ***,electromagnetic interference(EMI)shielding materials are provided to solve the EM waves pollution *** particular,the appearance of onedimensional(1D)metallic,magnetic,and dielectric nanofillers will extremely reduce the density of EMI composite and enhance EMI protection performance because they can easily assemble to form complete two-dimensional(2D)or three-dimensional(3D)EMI network based on their high aspect ratio,large specific surface area,and additional attenuated *** review focuses on the EMI shielding composites with 1D metallic,magnetic,and dielectric nanofillers,which could be constructed in the final form of membrane-or aerogel/sponge-like shielding *** to the structural features,1D metallic,magnetic,and dielectric nanofillers are classified into nanowires,nanorods,nanospindles,nanochains,nanofibers,nanotubes,nanorings,nanocoils,and quasi-one-dimensional(1D)van der Waals ***,the fabricated routes,shielding performances,and EM waves attenuation mechanism of the 1D metallic,magnetic,and dielectric nanofiller-based composites are *** is found that the dominant shielding mechanism of most of the 1D metal-based EMI composites is reflection loss,while that of 1D magnetic and dielectric nanomaterials-based EMI composites is absorption loss caused by interfacial polarization,natural resonance,eddy current,and multiple ***,the challenges and prospects of 1D nanofiller-based composites with a tunable architecture and composition are put forward,aiming to give a guideline for the next generation of high-performance EMI shielding materials.

关键词： one-dimensional nanofillers composites electromagnetic interference(EMI)shielding mechanism

Concentration-dependent effects of reductive pulmonary inhalants on ultrafine particle-induced oxidative stress:Insights for health risk assessment

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Environmental Science and Ecotechnology 2024年第3期19卷 118-124页

作者： ya.qi Yu Tong zhu BIC-ESAT and SKL-ESPC College of Environmental Sciences and EngineeringPeking UniversityBeijing100871PR China School of Environmental Science and Engineering Qingdao UniversityQingdao266071PR China

The impact of reductive pulmonary inhalants on ultrafine particles(UFPs)-induced pulmonary oxidative stress remains a crucial consideration,yet the concentration-dependent effects of these inhalants have remained *** we synthesized composite UFPs simulating atmospheric UFPs,primarily composed of metals and *** subjected these UFPs to varying concentrations(0e7000 mM)of two reductive pulmonary inhalants,N-acetylcysteine and salbutamol,to assess their influence on oxidative potential,measured through the dithiothreitol assay(OP^(DTT)).Simultaneously,we analysed the soluble metal content of UFPs to uncover potential relationships between oxidative potential and metal *** results unveil a dual role played by these inhalants in shaping the OPDTT of composite ***,OP^(DTT) generally increased as inhalant concentrations rose from 0 to 300 ***,an intriguing reversal occurred when concentrations exceeded 500 mM,resulting in a decline in *** to untreated UFPs,these inhalants induced promotion and inhibition effects within concentration ranges of 100e500 and>1000 mM,*** no significant correlation emerged between OP^(DTT) and soluble metal content as inhalant concentrations ranged from 0 to 7000 mM,noteworthy positive correlations emerged at lower inhalant concentrations(e.g.,N-acetylcysteine at 0 e300 mM).These findings provide insights into the potential influence of reductive pulmonary inhalants on health risks associated with UFP exposure,further underscoring the need for continued research in this critical area.

关键词： Concentration-dependent effects Oxidative potential Reductive pulmonary inhalants Soluble metals Simulated atmospheric ultrafine particles

Life-cycle assessment and techno-economic analysis of the production of wood vinegar from Eucommia stem: a case study

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Frontiers of Chemical Science and Engineering 2023年第8期17卷 1109-1121页

作者： Ji-Lu Zheng ya.Hong zhu ya.-ya. Dong Ming-Qiang zhu College of Forestry Northwest A&F UniversityYangling 712100China College of Mechanical and Electronic Engineering Northwest A&F UniversityYangling 712100China Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China

This research undertook a case study of the life-cycle assessment and techno-economic analysis of the slow pyrolysis of Eucommia stem for the production of wood vinegar and activated *** results showed that the production of one ton of wood vinegar via the slow pyrolysis of Eucommia stem show comparatively low global warming potential(2.37×10^(2) kg CO_(2) eq),primary energy demand(3.16×10^(3) MJ),acidification potential(2.19 kg SO2 eq),antimony depletion potential(3.86×10^(–4) kg antimony eq),and ozone depletion potential(7.46×10^(–6) kg CFC-11 eq)and was more environmentally friendly than the production of dilute acetic acid(12 wt%)via petrochemical ***,the total capital investment,total product cost,and cash flowsheet were provided in the techno-economic ***,the net present value,internal rate of return,and dynamic payback period of the production process were *** findings indicated that while this production process is cost-effective,it might not be economically attractive or could generate investment *** increase in the added value of the wood vinegar and the activated carbon could remarkably improve the economic feasibility of this production process.

关键词： life-cycle assessment techno-economic analysis wood vinegar activated carbon Eucommia

Accumulation and elimination of iron oxide nanomaterials in zebrafish(Danio rerio) upon chronic aqueous exposure

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Journal of Environmental Sciences 2015年第4期27卷 223-230页

作者： ya.g Zhang Lin zhu ya.Zhou Jimiao Chen Key Laboratory of Pollution Processes and Environmental Criteria Ministry of Education Tianjin Key Laboratory of Environmental Remediation and Pollution Control College of Environmental Science and Engineering Nankai University

A 52-day continuous semi-static waterborne exposure（test media renewed daily） regimen was employed to investigate the accumulation and elimination profiles of two iron oxide nanomaterials（nano-Fe2O3 and nano-Fe3O4） in zebrafish（Danio rerio）. Adult zebrafish were exposed to nanomaterial suspensions with initial concentrations of 4.0 and 10.0 mg/L for28 days and then were moved to clean water for 24 days to perform the elimination experiment. Fe content was measured in fish body and feces to provide data on accumulation and elimination of the two iron oxide nanomaterials in zebrafish. The experiment revealed that：（1） high accumulation of nano-Fe2O3 and nano-Fe3O4 were found in zebrafish, with maximum Fe contents, respectively, of 1.32 and 1.25 mg/g for 4.0 mg/L treatment groups and 1.15 and 0.90 mg/g for 10.0 mg/L treatment groups;（2） accumulated nanoparticles in zebrafish can be eliminated efficiently（the decrease of body burden of Fe conforms to a first-order decay equation） when fish were moved to nanoparticle-free water,and the elimination rates ranged from 86% to 100% by 24 days post-exposure; and（3）according to analysis of Fe content in fish excrement in the elimination phase, iron oxide nanomaterials may be adsorbed via the gastrointestinal tract, and stored for more than12 days.

关键词： Iron oxide nanomaterials Zebrafish Chronic exposure Accumulation Elimination

Properties of ten-year-aged argon oxygen decarburization stainless steel slag

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Journal of Iron and Steel Research International 2021年第10期28卷 1233-1242页

作者： ya.jun Wang ya.nan Zeng Jun-guo Li Yu-zhu Zhang Wei Wang College of Metallurgy and Energy North China University of Science and TechnologyTangshan063210HebeiChina School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina

The characteristics of argon oxygen decarburization slag(AODS)for smelting stainless steel that has been aged for 10 years were *** types of AODSs distributed at three positions in a slag heap were sampled for comparison *** analysis,mineral phase identification,thermogravimetric analysis,and micromorphology analysis were used to study the element migration trends and carbonation behavior of AODS after long-term *** leaching tests were performed to study the chromium leachability of the aged *** results show that during the long-term aging process,the AODS heap had undergone oxidation and carbonation,accompanied by element migration and mineralogical *** surface slag had the highest degree of carbonation but the weakest chromium *** chemical composition of the middle slag was the closest to that of the original *** the bottom steel slag,in addition to magnesium,certain depositions of other elements were *** matrix phases in the aged slag were dicalcium silicate and merwinite,and the chromium was mainly wrapped in these matrix phases in the form of oxides,spinels,or *** the combined effects of carbonation and oxidation,the leaching characteristics of the chromium in the aged slag varied greatly depending on the *** bottom slag had the strongest chromium leachability,and the hexavalent chromium had long-term continuous leachability.

关键词： Argon oxygen decarburization slag Aging Chromium Leaching Mineral phase

The multiwavelength emission from the gamma-ray binary LS I + 61 303

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Research in Astronomy and Astrophysics 2011年第4期11卷 445-456页

作者： Jian-Fu Zhang ya.zhu Li Zhang Department of Physics and Electronic Science Tongren University Tongren 554300 China Department of Physics Yunnan University Kunming 650091 China

This paper presents a hadronic dominated jet model to investigate multi- wavelength emission from the microquasar LS I ＋61 303. In this scenario, we take into account evolutions of the primary particles and secondary e± pairs; these pairs are produced by the collisional interactions of the accelerated protons with the cold jet protons and the stellar wind ions. In this model, the non-thermal photons are produced by πο decay emission, synchrotron and inverse Compton scattering processes from the primary electrons and secondary pairs, and relativistic bremsstrahlung emission from the secondary leptonic pairs. Based on this model framework, we show that the spectral energy distributions can be produced by the primary and secondary particles via interactions with the cold matter, and magnetic and stellar radiation fields. We also consider the attenuation of angular dependence γ-γ due to the effects of the stel- lar target photon fields. The resulting model can approximately reproduce the recent quasi-simultaneous observational data points and the non-simultaneous multi-band observations.

关键词： radiation mechanism non-thermal -- gamma rays general -- X-ray binaries -- stars: individual: LS I + 61 303

Performance analysis and optimization model based on dynamics equation for heterogeneous wireless networks

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The Journal of China Universities of Posts and Telecommunications 2015年第3期22卷 49-55页

作者： zhu Xiaorong Zhao ya.nan Wang Yong Wireless Communication Key Lab of Jiangsu Province Nanjing University of Posts and Telecommunications National Mobile Communications Research Laboratory Southeast University Patent Information Service Institution of Jiangsu Province

In this paper, we propose a model based on dynamics equation for performance analysis and optimization for heterogeneous wireless networks （HWNs）. First, the channel occupation state with time of HWNs is modelled by dynamics equation, in which users＇ mobility as an important factor affecting system performance is considered. Then the steady state probability distribution of channel occupation is derived. Based on the results, the expression of the throughput of HWNs is deduced, which includes a factor p which is the ratio of service arrival rate accessing one of the networks to the total service arrival rate in the overlapping area. And this paper proposes to maximize the throughput of the HWNs by optimizing the factor p to efficiently utilize the resources. Simulation results show that the proposed optimization method can effectively improve the throughput and in the meanwhile decrease the blocking probability of the whole system.

关键词： heterogeneous wireless networks dynamics equation handoff rate performance analysis

Interdecadal Variations of Winter Temperatures in East China During the Past 100 Years and Related Atmospheric Circulation

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Atmospheric and Oceanic Science Letters 2013年第5期6卷 290-294页

作者： zhu ya.Li Nansen-zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of Sciences Climate Change Research Center Chinese Academy of Sciences

The winter temperature changes in East China during the past 100 years are investigated by using the Twentieth Century Version 2(20th-v2)*** typical warm(P1,1911–30;P4,1991–2010)and cold(P2,1938–57;P3,1961–80)periods are identified for the East China winter temperature *** of160-station observational data,NCAR sea level pressure(SLP)data,and NCEP/NCAR Reanalysis shows that the20th-v2 Reanalysis can successfully depict the major features of the warming from P3 to P4,which is part of the global warming *** cooling from P1 to P2is a regional phenomenon under global ***,both changes are consistent with the phase change of the Arctic Oscillation(AO),while the second change is also accompanied by the phase change of Antarctic Oscillation(AAO)from negative to *** sources of the interdecadal shifts of the AO and winter temperature in East China require further research.

关键词： East China winter temperature global warming decadal change