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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin Liu Jian Zhang ya.gao Shuyue Li Cui Chang Xiang Liu guofeng ya.g Department of geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-ya.r stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

Chiral universality class of normal-superconducting and exciton condensation transitions on surface of topological insulator

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Frontiers of physics 2015年第3期10卷 65-82页

作者： Dingping Li Baruch Rosenstein B. ya. Shapiro I. Shapiro School of Physics Peking University Beijing 100871 China Collaborative Innovation Center of Quantum Matter Beijing 100084 China Electrophysics Department National Chiao Tung University Hsinchu 30050 Taiwan China physics Department Ariel University Ariel 40700 Israel Physics Department Bar-Ilan University 52900 Ramat-Gan Israel

New two-dimensional systems such as the surfaces of topological insulators （TIs） and graphene offer the possibility of experimentally investigating situations considered exotic just a decade ago. These situations include the quantum phase transition of the chiral type in electronic systems with a relativistic spectrum. Phonon-mediated （conventional） pairing in the Dirac semimetal appearing on the surface of a TI causes a transition into a chiral superconducting state, and exciton condensation in these gapless systems has long been envisioned in the physics of narrow-band semiconductors. Starting from the microscopic Dirac Hamiltonian with local attraction or repulsion, the Bardeen- Cooper-Schrieffer type of gaussian approximation is developed in the framework of functional integrals. It is shown that owing to an ultrarelativistic dispersion relation, there is a quantum critical point governing the zero-temperature transition to a superconducting state or the exciton condensed state. Quantum transitions having critical exponents differ greatly from conventional ones and belong to the chiral universality class. We discuss the application of these results to recent experiments in which surface superconductivity was found in TIs and estimate the feasibility of phonon pairing.

关键词： topological insulator Weyl semimetal superconductivity quantum criticality

The Iwasava decomposition and intermediate subgroups of the Steinberg groups over the field of fractions of a principal ideal ring

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Science China Mathematics 2009年第2期52卷 318-322页

作者： MOISEENKOVA T. V. NUZHIN ya. N. Institute of Fundamental Development Siberian Federal University St. Kirenskogo 26Krasnoyarsk 660074Russia

Abstract The Iwasava decomposition is proved for the Steinberg groups of types 2 A 2l?1, 2 D l , 2 E 6, 3 D 4 over the field of fractions of a principal ideal ring. By using this decomposition, it is described that su... 详细信息

关键词： principal ideal ring Steinberg group intermediate subgroups 20g25

Medium effects in ΛK~＋ pair production by 2.83 geV protons on nuclei

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Chinese Physics C 2017年第12期41卷 88-105页

作者： E. ya. Paryev M. Hartmann Yu. T. Kiselev Institute for Nuclear Research Russian Academy of Sciences Moscow 117312 Russia Institute for Theoretical and Experimental Physics Moscow 117218 Russia Institut für Kernphysik and Jülich Centre for Hadron Physics Forschungszentrum Jiilich D-52425 Jiilich Germany

We study ΛK~＋ pair production in the interaction of protons of 2.83 geV kinetic energy with C, Cu,Ag, and Au target nuclei in the framework of the nuclear spectral function approach for incoherent primary proton–nucleon and secondary pion–nucleon production processes, and processes associated with the creation of intermediate Σ~0K~＋ pairs. The approach accounts for the initial proton and final Λ hyperon absorption, final K~＋ meson distortion in nuclei, target nucleon binding, and Fermi motion, as well as nuclear mean-field potential effects on these *** calculate the Λ momentum dependence of the absolute ΛK~＋ yield from the target nuclei considered, in the kinematical conditions of the ANKE experiment, performed at COSY, within the different scenarios for the Λ-nucleus effective scalar potential. We show that the above observable is appreciably sensitive to this potential in the low-momentum region. Therefore, direct comparison of the results of our calculations with the data from the ANKE-at-COSY experiment can help to determine the above potential at finite momenta. We also demonstrate that the two-step pion–nucleon production channels dominate in the low-momentum ΛK~＋ production in the chosen kinematics and, therefore, they have to be taken into account in the analysis of these data.

关键词： proton-nucleus reactions medium effects hyperon nuclear potential

Dynamic evolution of Co species and morphological reconstruction on Co-N-C during the nitrate reduction reaction in neutral solution

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Nano Research 2025年第1期18卷 164-172页

作者： Yuanlin Fu Xiaoting ya.g ya.Yu Kang Zhou Xiaoya.g Ye Aoxiang Zhang Xiaojiao Hou Bingbing Chen Fuqiang Fan Yuhang Li Yu Fu Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China Department of Physical Education Shen Yang Institute of Science and TechnologyShenyang 110167China Sungrow Power Supply Co. Ltd.Hefei 230088China

The electrochemical nitrate reduction reaction(eNO_(3)^(-)RR)is considered an effective approach for converting nitrate-containing wastewater to *** adsorption and activation of NO_(3)^(-)is the critical step for many materials and the high energy barrier inhibits the continuation of the reduction *** Co nanoparticles encapsulated in the carbon layer we prepared spontaneously react with NO_(3)^(-)and the resulting Co^(2+)is then reduced by electroreduction to Co^(0),which circulates *** resulted in overcoming the energy input required for NO_(3)^(-)adsorption and conversion,thereby increasing the catalytic *** the same time,the morphology of the catalyst reconstructed from a dodecahedron to an interwoven nanosheet structure and the increased surface area also gives it better *** obtained Co(OH)_(2)@Co-N-C has an excellent eNO_(3)^(-)RR of 2774.7μg·h^(-1)·cm^(-2)with a Faraday efficiency of 81.4%in neutral *** the same time,the material-modified electrode can run stably for more than 100 *** work provides a new idea for the design of Co-based catalysts for eNO_(3)^(-)RR.

关键词： electrochemical nitrate reduction reaction Co-based catalyst dynamic evolution of Co species morphological reconstruction

g-C_(3)N_(4)负载双金属Rh@Ru催化氨硼烷析氢反应机理研究

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原子与分子物理学报 2025年第5期42卷 17-21页

作者：郭雅琼武警警官学院成都610213

本文采用密度泛函理论,研究了双金属Rh@Ru在g-C_(3)N_(4)上不同负载位点,确定了稳定的催化剂构型,并详细研究了该催化剂催化氨硼烷析氢的反应机理.通过比较氨硼烷析氢反应三条路径所需活化能,发现路径Ⅲ控制步骤活化能较低,而路径Ⅰ、... 详细信息

本文采用密度泛函理论,研究了双金属Rh@Ru在g-C_(3)N_(4)上不同负载位点,确定了稳定的催化剂构型,并详细研究了该催化剂催化氨硼烷析氢的反应机理.通过比较氨硼烷析氢反应三条路径所需活化能,发现路径Ⅲ控制步骤活化能较低,而路径Ⅰ、Ⅱ所需活化能较高,反应路径Ⅲ更容易进行,Ⅰ为最优析氢路径.从微观角度揭示双贵金属Rh@Ru负载g-C_(3)N_(4)催化氨硼烷析氢的三条机理,希望为氨硼烷析氢催化剂的优化和设计提供理论信息.

关键词：双金属催化剂 g-C_(3)N_(4) NH_(3)BH_(3) 密度泛函理论反应机理

The Effect of Super Volcanic Eruptions on Ozone Depletion in a Chemistry–Climate Model

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Advances in Atmospheric Sciences 2019年第8期36卷 823-836页

作者： Luya.g XU Ke WEI Xue WU S. P. SMYSHLya.V Wen CHEN V. ya. gALIN Center for Monsoon System Research Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Middle Atmosphere and global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100190China Russian State Hydrometeorological University Malookhtinskii pr.98St.Petersburg 195196Russia Institute of Numerical Mathematics Russian Academy of Sciencesul.Gubkina 8Moscow 11999Russia

With the gradual yet unequivocal phasing out of ozone depleting substances(ODSs), the environmental crisis caused by the discovery of an ozone hole over the Antarctic has lessened in severity and a promising recovery of the ozone layer is predicted in this century. However, strong volcanic activity can also cause ozone depletion that might be severe enough to threaten the existence of life on Earth. In this study, a transport model and a coupled chemistry–climate model were used to simulate the impacts of super volcanoes on ozone depletion. The volcanic eruptions in the experiments were the 1991 Mount Pinatubo eruption and a 100 × Pinatubo size eruption. The results show that the percentage of global mean total column ozone depletion in the 2050 RCP8.5 100 × Pinatubo scenario is approximately 6% compared to two years before the eruption and 6.4% in tropics. An identical simulation, 100 × Pinatubo eruption only with natural source ODSs, produces an ozone depletion of 2.5% compared to two years before the eruption, and with 4.4% loss in the tropics. Based on the model results,the reduced ODSs and stratospheric cooling lighten the ozone depletion after super volcanic eruption.

关键词： stratospheric ozone volcanic eruptions stratospheric aerosols chemistry–climate model

Results of Thirty Years of Research on Corals and Reefs of Vietnam

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Open Journal of Marine Science 2016年第2期6卷 283-292页

作者： Yuri ya. Latypov A.V. Zhirmunsky Institute of Marine Biology Far East Branch Russian Academy of Sciences Vladivostok Russia

The author traced the history of the thirty years of study of the Vietnamese reefs since the second half of the 20th century up to the present time. This paper describes the types of reefs, taxonomic composition and structure of Scleractinian reef ecosystems. It is shown that due to a high level of diverse knowledge revealed, high species richness of coral fauna of Vietnam (376 species of 80 genera) is a single point of origin coral fauna Indo-Pacific. Analysis of knowledge of Vietnamese corals and reefs revealed the extent of their positive or negative status under anthropogenic influence or under the level of wilderness protection, experiment on artificial cultivation of corals and the re-establishment of a coral community.

关键词： Scleractinia Coral Communities Species Richness Vietnam

The Bivalve Mollusc <i>Abra ovata</i>: Role in Succession of Soft Bottom Communities on Newly Flooded Area of the Caspian Sea

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American Journal of Climate Change 2015年第3期4卷 239-247页

作者： Yuri ya. Latypov A.V. Zhirmunsky Institute of Marine Biology Far East Branch Russian Academy of Sciences Vladivostok Russia

The succession of an Abra ovata community that had formed at the flooded area in Sulaksky Bay (the Caspian Sea) since the mid-1980s was investigated. The resident species Abra ovata and Cerastoderma glaucum, the pioneer settlers, were found remaining dominant in the community structure and driving the course of its succession, despite some decrease in settlement density and in the rate of occurrence. It was the tolerance of the Sulaksky pioneer settlers for later colonists (macrophytes, mytilids, crustaceans and other organisms) that determined the development of the first succession stage. The next succession stage in Abra ovata communities of Sulaksky Bay does not quite agree with the pattern typical of solid substrates. On the one hand, the community development supports the tolerance model: the pioneer Abra, in spite of being dominant through all the succession stages, does not oppose the settling of other multiple colonists;on the other hand, it agrees with a facilitation model where the abundance of the original settlers, the grazing species, provokes appearance of sturgeon.

关键词： Caspian Sea Flooded Area Succession Bottom Community Bivalve Mollusc Abra ovata