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Selective brain hypothermia-induced neuroprotection against focal cerebral ischemia/reperfusion injury is associated with Fis1 inhibition

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Neural Regeneration Research 2020年第5期15卷 903-911页

作者： ya-Nan Tang Gao-Feng Zhang Huai-Long Chen Xiao-Peng sun wei-wei Qin Fei Shi Li-Xin sun Xiao-Na Xu Ming-Shan Wang Department of Anesthesiology Affiliated Qingdao Municipal Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of Central Laboratory Affiliated Qingdao Municipal Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Selective brain hypothermia is considered an effective treatment for neuronal injury after stroke,and avoids the complications of general ***,the mechanisms by which selective brain hypothermia affects mitochondrial fission remain *** this study,we investigated the effect of selective brain hypothermia on the expression of fission 1 (Fis1) protein,a key factor in the mitochondrial fission system,during focal cerebral ischemia/reperfusion ***-Dawley rats were divided into four *** the sham group,the carotid arteries were exposed *** the other three groups,middle cerebral artery occlusion was performed using the intraluminal filament *** 2 hours of occlusion,the filament was slowly removed to allow blood reperfusion in the ischemia/reperfusion ***,at 4℃ and 37℃,were perfused through the carotid artery in the hypothermia and normothermia groups,respectively,followed by restoration of blood *** function was assessed with the Zea Longa 5-point scoring *** infarct volume was assessed by 2,3,5-triphenyltetrazolium chloride staining,and apoptosis was assessed by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling ***1 and cytosolic cytochrome c levels were assessed by western blot ***1 mRNA expression was assessed by quantitative reverse transcription-polymerase chain *** ultrastructure was evaluated by transmission electron *** with the sham group,apoptosis,Fis1 protein and mRNA expression and cytosolic cytochrome c levels in the cortical ischemic penumbra and cerebral infarct volume were increased after reperfusion in the other three *** changes caused by cerebral ischemia/reperfusion were inhibited in the hypothermia group compared with the normothermia *** findings show that selective brain hypothermia inhibits Fis1 expression and reduces apoptosis,thereby ameliorating focal cerebral ischemia/repe

关键词： apoptosis Fis1 hypothermia ischemia/reperfusion injury mitochondria mitochondrial fission mitochondrial ultrastructure neuroprotection selective brain hypothermia stroke

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Numerical investigation of transcritical liquid film cooling in a methane/oxygen rocket engine

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航空动力学报 2011年第4期26卷 903-916页

作者： yaNG wei sun Bing School of Astronautics Beijing University of Aeronautics and Astronautic Beijing 100191 China

Transcritical film cooling was investigated by numerical study in a methane cooled methane/oxygen rocket *** respective time-averaged Navier-Stokes equations have been solved for the compressible steady three-dimensional(3-D) *** flow field computations were performed using the semi-implicit method for pressure linked equation(SIMPLE) algorithm on several blocks of nonuniform collocated *** calculation was conducted over a pressure range of 202 650.0 Pa to 1.2×107 Pa and a temperature range of 120.0 K to 3 568.0 ***-nine different cases were simulated to calculate the impact of different *** results show that mass flow rate,length,diameter,number and diffused or convergence of film jet channel,injection angle and jet array arrangements have great impact on transcritical film cooling ***,shape of the jet holes and jet and crossflow turbulence also affect the wall temperature *** rows of film arranged in different axial angles and staggered arrangement were proposed as new liquid film *** radial angles have impact on the film cooling effectiveness in two row-jets cooled *** case of in-line and staggered arrangement are almost the same in the region before the second row of jets,but a staggered arrangement has a higher film cooling effectiveness from the second row of jets.

关键词： liquid film cooling numerical study rocket transcritical semi-implicit method for pressure linked equation(SIMPLE) film cooling effectiveness

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内蒙古农牧交错区典型黑土坡耕地土壤侵蚀空间分布特征

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水土保持研究 2025年第1期32卷 13-20页

作者：邹惠杰刘刚舒成博孙波刘亚张琼郭珍中国科学院教育部水土保持与生态环境研究中心黄土高原土壤侵蚀与旱地农业国家重点实验室中国科学院水利部水土保持研究所中国科学院大学西北农林科技大学黄土高原土壤侵蚀与旱地农业国家重点实验室四川华标测检测技术有限公司

[目的]定量了解内蒙古典型黑土区土壤侵蚀速率，探究该区域土壤侵蚀空间分布特征，阐明土壤侵蚀坡面和区域空间分布规律，以期为区域水土流失治理提供参考。[方法]采集内蒙古农牧交错区（海拉尔区、额尔古纳市和牙克石市）典型黑土坡耕... 详细信息

[目的]定量了解内蒙古典型黑土区土壤侵蚀速率，探究该区域土壤侵蚀空间分布特征，阐明土壤侵蚀坡面和区域空间分布规律，以期为区域水土流失治理提供参考。[方法]采集内蒙古农牧交错区（海拉尔区、额尔古纳市和牙克石市）典型黑土坡耕地的土壤样品，利用137Cs示踪技术计算各采样点土壤侵蚀速率，结合小波分析的方法研究土壤侵蚀在坡面的分布特征。[结果]（1） 3个坡面所有采样点137Cs含量均小于背景值（1 984.24 Bq/m2）,表现为所有坡面土壤流失。（2） 3个地区的采样坡面平均侵蚀速率表现为：海拉尔[6 533.37 t/（km2·a）]>额尔古纳[4 174.35 t/（km2·a）]>牙克石[2 765.87 t/（km2·a）]。相同坡面的3个纵向断面的平均侵蚀速率相近，同一断面侵蚀速率的变异程度较高。（3）土壤侵蚀速率沿坡长呈强弱交替的周期性变化，但周期长度并不固定。大部分纵向断面存在周期长度为80～160 m和160～200 m的大小两个周期。部分纵向断面只存在一个周期长度为100～120 m的周期。[结论]该地区土壤侵蚀在坡面尺度表现为全坡面侵蚀且在纵向呈现周期性特征，在区域尺度呈现从东到西逐渐增加趋势。

关键词：土壤侵蚀典型黑土农牧交错带小波分析

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Study on fluid-structure interaction in liquid oxygen feeding pipe systems using finite volume method

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Acta Mechanica Sinica 2011年第5期27卷 706-712页

作者： Xin wei Bing sun Institute of Telecommunication Satellite China Academy of Space Technology100194 Beijing China School of Astronautics Beihang University 100191 Beijing China

The fluid-structure interaction may occur in space launch vehicles,which would lead to bad performance of vehicles,damage equipments on vehicles,or even affect astronauts＇ *** this paper,analysis on dynamic behavior of liquid oxygen （LOX） feeding pipe system in a large scale launch vehicle is performed,with the effect of fluid-structure interaction （FSI） taken into *** pipe system is simplified as a planar FSI model with Poisson coupling and junction *** tests on pipes between the tank and the pump are solved by the finite volume *** show that restrictions weaken the interaction between axial and lateral *** reasonable results regarding frequencies and modes indicate that the FSI affects substantially the dynamic analysis,and thus highlight the usefulness of the proposed *** study would provide a reference to the pipe test,as well as facilitate further studies on oscillation suppression.

关键词： Fluid-structure interaction · Liquid oxygen · Finite volume method

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Neutronic analysis of deuteron-driven spallation target

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Nuclear Science and Techniques 2021年第9期32卷 52-60页

作者： wei-wei Qiu Wu sun Jun Su Sino-French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

Deuteron-driven spallation targets have garnered attention recently because they can provide high-energy neutrons to transmute long-lifetime fission *** this study,the Geant4 toolkit was used to simulate the inter-action between a deuteron beam at 500 MeV and a com-posite target composed of alternating lead-bismuth eutectic(LBE)and *** water was used because it may be employed as a target *** energy spectrum,neu-tron yield,average energy,and total energy of the emitted neutrons were calculated for different thicknesses and thickness ratios between the LBE and *** a constant target thickness,the neutron yield increases with an increasing thickness ratio of LBE to H 2 O,while the aver-age energy of the emitted neutrons decreases with an increasing in the aforementioned thickness *** two aspects support the use of a pure target,either LBE or ***,with an increasing LBE-to-H 2 O thickness ratio,the total energy of the emitted neutrons increases and then *** result supports the addition of water into the LBE *** angular distributions of the emitted neutrons show that the rear of the target is suit-able for loading nuclear waste containing minor actinides and long-lifetime fission products.

关键词： Long-lived nuclear waste product Accelerator-driven sub-critical system Deuteron-induced spallation target Neutron spectrum

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Iterative learning based fault diagnosis for discrete linear uncertain systems

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Journal of Systems Engineering and Electronics 2014年第3期25卷 496-501页

作者： wei Cao Ming sun College of Computer and Control Engineering Qiqihar University

In order to detect and estimate faults in discrete lin-ear time-varying uncertain systems, the discrete iterative learning strategy is applied in fault diagnosis, and a novel fault detection and estimation algorithm is proposed. And the threshold limited technology is adopted in the proposed algorithm. Within the chosen optimal time region, residual signals are used in the proposed algorithm to correct the introduced virtual faults with iterative learning rules, making the virtual faults close to these occurred in practical systems. And the same method is repeated in the rest optimal time regions, thereby reaching the aim of fault diagnosis. The proposed algorithm not only completes fault detection and estimation for discrete linear time-varying uncertain systems, but also improves the reliability of fault detection and decreases the false alarm rate. The final simulation results verify the validity of the proposed algorithm.

关键词： discrete linear uncertain system threshold limited technology iterative learning fault estimation.

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Obesity paradox in patients with community-acquired pneumonia:Have you fully considered the confounding factors?

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World Journal of Clinical Cases 2025年第9期13卷 53-55页

作者： Jin-Ke sun Hui Tian Department of Pulmonary and Critical Care Medicine Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250000Shandong ProvinceChina Department of Critical Care Medicine Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina

There exists a notion that there is an obesity paradox in the prognosis of community-acquired *** other words,obese individuals with communityacquired pneumonia have a better *** study by Wang et al supports this claim,but we believe that the obesity paradox should not be proposed hastily as it is influenced by numerous subjective and objective confounding factors.

关键词： Community-acquired pneumonia Mortality Body mass index Overweight Obesity paradox

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Corneal endothelial cells and acoustic cavitation in phacoemulsification

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World Journal of Clinical Cases 2023年第8期11卷 1712-1718页

作者： Kai Chen Wen-ya Xu Si-Si sun Hong-wei Zhou Department of Ophthalmology Lianshui County People's HospitalHuai’an 223400Jiangsu ProvinceChina Department of Ophthalmology Huai’an 82 HospitalHuai'an 223001Jiangsu ProvinceChina Department of Industrial Engineering Tsinghua UniversityBeijing 100084China

Postoperative complications of phacoemulsification,such as corneal edema caused by human corneal endothelial cell(CEC)injury,are still a matter of *** several factors are known to cause CEC damage,the influence of ultrasound on the formation of free radicals during surgery should be *** in aqueous humor induces cavitation and promotes the formation of hydroxyl radicals or reactive oxygen species(ROS).ROS-induced apoptosis and autophagy in phacoemulsification have been suggested to significantly promote CEC *** cannot regenerate after injury,and measures must be taken to prevent the loss of CEC after phacoemulsification or other CEC *** can reduce the oxidative stress injury of CEC during *** from rabbit eye studies shows that ascorbic acid infusion during operation or local application of ascorbic acid during phacoemulsification has a protective effect by scavenging free radicals or reducing oxidative *** in experiments and clinical practice,hydrogen dissolved in the irrigating solution can also prevent CEC damage during phacoemulsification ***(AST)can inhibit oxidative damage,thereby protecting different cells from most pathological conditions,such as myocardial cells,luteinized granulosa cells of the ovary,umbilical vascular endothelial cells,and human retina pigment epithelium cell line(ARPE-19).However,existing research has not focused on the application of AST to prevent oxidative stress during phacoemulsification,and the related mechanisms need to be *** Rho related helical coil kinase inhibitor Y-27632 can inhibit CEC apoptosis after *** experiments are required to confirm whether its effect is realized through improving the ROS clearance ability of CEC.

关键词： Cataract Phacoemulsification Corneal endothelial cells Ultrasound Acoustic cavitation Oxidative stress Antioxidant

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Adaptive Maneuvering Frequency Method of Current Statistical Model

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IEEE/CAA Journal of Automatica Sinica 2017年第1期4卷 154-160页

作者： wei sun Yongjian yang Department of Applied Science Xijing University Aeronautics and Astronautics Engineering College Air Force Engineering University

Current statistical model(CSM) has a good performance in maneuvering target tracking. However, the fixed maneuvering frequency will deteriorate the tracking results, such as a serious dynamic delay, a slowly converging speedy and a limited precision when using Kalman filter(KF) algorithm. In this study, a new current statistical model and a new Kalman filter are proposed to improve the performance of maneuvering target tracking. The new model which employs innovation dominated subjection function to adaptively adjust maneuvering frequency has a better performance in step maneuvering target tracking, while a fluctuant phenomenon appears. As far as this problem is concerned, a new adaptive fading Kalman filter is proposed as well. In the new Kalman filter, the prediction values are amended in time by setting judgment and amendment rules,so that tracking precision and fluctuant phenomenon of the new current statistical model are improved. The results of simulation indicate the effectiveness of the new algorithm and the practical guiding significance.

关键词： Current statistical model(CSM) maneuvering target tracking adaptive fading Kalman filter(AFKF)

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Modeling and Finite-Time Tracking Control for Mobile Manipulators with Affine and Holonomic Constraints

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Journal of Systems Science & Complexity 2016年第3期29卷 589-601页

作者： sun wei WU Yuqiang School of Mathematics Science Liaocheng University Institute of Automation Qufu Normal University

This paper focuses on the problem of modeling and finite-time tracking control for mobile manipulators with affine and holonomic constraints. A reduced dynamic model is obtained by appropriately processing anne and holonomic constraints, respectively. Then finite-time tracking controllers are designed to ensure that output tracking errors of closed-loop system converge to zero in finite time while the constraint force remains bounded. Finally, detailed simulation results are provided to confirm the effectiveness of the control strategy.

关键词： Affine constraints finite-time tracking holonomic constraints mobile manipulators

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