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Signature Based on Six Autophagy-related Genes to Predict Prognosis of Head and Neck Squamous Cell Carcinoma

Current Medical Science 2022年第3期42卷 597-605页

作者： Hua ZHANG Liang ZHANG ya-tong fan Tian-ning LI Li-su PENG Kun-peng WANG Jun MA Clinical Laboratory Diagnostics Tianjin Medical University General Hospital Airport SiteTianjin 300308China Department of Health Statistics Public Health School of Tianjin Medical UniversityTianjin 300070China School and Hospital of Stomatology Tianjin Medical UniversityTianjin 300070China Department of Physiology and Pathophysiology Tianjin Medical UniversityTianjin 300070China

Objective The present study aimed to develop an autophagy-related gene prognostic prediction model to provide survival risk prediction for head and neck squamous cell carcinoma(HNSCC)*** The K-mean cluster analysis was performed on HNSCC samples based on the expression values of 210 autophagy-related genes for candidate signature gene *** Cox regression analysis was generated using the potential genes and the risk score was calculated from the prognosis *** risk score was processed as an independent prognostic indicator to construct the nomogram *** immune status including immune cell infiltration ratio and checkpoints of patients with HNSCC in high-and low-risk groups was also *** LASSO Cox regression analysis was performed on the selected autophagy-related *** to the lambda value corresponding to the number of different genes in the LASSO Cox analysis,six genes(GABARAPL2,SAR1A,ST13,GAPDH,FADD and LAMP1)were finally *** risk score based on the genes was generated,which was an independent prognostic marker for *** prognostic prediction model(nomogram)was further optimized by the independent prognostic factors(risk score),which can better predict the prognosis and survival of *** the risk score and prognosis model,eight types of immune cells and six key immune checkpoints(CTLA4,PD1,IDO1,TDO2,LAG3,TIGIT)displayed expression *** This study identified several potential prognostic biomarkers and established an autophagy-related prognostic prediction model for HNSCC,which provides a valuable reference for future clinical research.

关键词： head and neck squamous cell carcinoma autophagy risk score Cox regression nomogram immune cell infiltration ratio

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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui yang Nan Mo Le tong Jianhong Dong Ziwei fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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Effects of carbon content on the microstructure and tensile properties of a low-density steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 391-401页

作者： Yongxuan Shang Mingyu fan Shuyong Jiang Zhongwu Zhang Key Laboratory of Superlight Materials and Surface Technology Ministry of EducationCollege of Materials Science and Chemical EngineeringHarbin Engineering UniversityHarbin 150001China State Key Laboratory of Metal Material for Marine Equipment and Application Iron&Steel Research Institute of Ansteel Group CorporationAnshan 114009China

Carbon can change the phase components of low-density steels and influence the mechanical *** this study,a new method to control the carbon content and avoid the formation ofδ-ferrite by decarburization treatment was *** microstructural changes and mechanical characteristics with carbon content induced by decarburization were systematically ***-Jaoul(C-J)analysis was employed to examine the work hardening characteristics during the tensile *** decarburization by heat treatments,the carbon content within the austenite phase decreased,while Mn and Al were almost unchanged;this made the steel with full austenite transform into the austenite and ferrite dual ***,(Ti,V)C carbides existed in both matrix phase and the mole fraction almost the *** addition,the formation of other carbides *** loss induced a decrease in strength due to the weakening of the carbon solid *** the steel with the single austinite,the deformation mode of austenite was the dislocation planar glide,resulting in the formation of *** the dual-phase steel,the deformation occurred by the dislocation planar glide of austenite first,with the increase in strain,the cross slip of ferrite took place,forming dislocation cells in *** the late stage of deformation,the work hardening of austinite increased rapidly,while that of ferrite increased slightly.

关键词： low-density steels carbon content decarburization strengthening mechanisms work hardening behavior

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Dynamic evolution of Co species and morphological reconstruction on Co-N-C during the nitrate reduction reaction in neutral solution

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Nano Research 2025年第1期18卷 164-172页

作者： Yuanlin Fu Xiaoting yang ya Yu Kang Zhou Xiaoyang Ye Aoxiang Zhang Xiaojiao Hou Bingbing Chen Fuqiang fan Yuhang Li Yu Fu Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China Department of Physical Education Shen Yang Institute of Science and TechnologyShenyang 110167China Sungrow Power Supply Co. Ltd.Hefei 230088China

The electrochemical nitrate reduction reaction(eNO_(3)^(-)RR)is considered an effective approach for converting nitrate-containing wastewater to *** adsorption and activation of NO_(3)^(-)is the critical step for many materials and the high energy barrier inhibits the continuation of the reduction *** Co nanoparticles encapsulated in the carbon layer we prepared spontaneously react with NO_(3)^(-)and the resulting Co^(2+)is then reduced by electroreduction to Co^(0),which circulates *** resulted in overcoming the energy input required for NO_(3)^(-)adsorption and conversion,thereby increasing the catalytic *** the same time,the morphology of the catalyst reconstructed from a dodecahedron to an interwoven nanosheet structure and the increased surface area also gives it better *** obtained Co(OH)_(2)@Co-N-C has an excellent eNO_(3)^(-)RR of 2774.7μg·h^(-1)·cm^(-2)with a Faraday efficiency of 81.4%in neutral *** the same time,the material-modified electrode can run stably for more than 100 *** work provides a new idea for the design of Co-based catalysts for eNO_(3)^(-)RR.

关键词： electrochemical nitrate reduction reaction Co-based catalyst dynamic evolution of Co species morphological reconstruction

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Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun Tang fan fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

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Tackling the microlensing wave effects of strong lensing gravitational waves with TAAH

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 257-258页

作者： Zuhui fan South-Western Institute for Astronomy Research Yunnan University

The rapid development of gravitational wave（GW） observations since their first detection in 2015 [1] has opened a completely new window for exploring the Universe. Consequently, astronomical research has entered the multimessenger era, allowing us to use different tracers to view the cosmos from various perspectives. Among others, the appealing application of gravitational wave events from compact binary mergers is that they can act as standard sirens to determine absolute cosmic distances entirely independent of standard candles. This approach is one of the most promising means to solve the current H0tension problem.

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Bandgap characteristics analysis and graded design of a novel metamaterial for flexural wave suppression

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 1-24页

作者： fan yaNG Zhaoyang MA Xingming GUO Shanghai Key Laboratory of Mechanics in Energy Engineering Shanghai Institute of Applied Mathematics and Mechanics School of Mechanics and Engineering ScienceShanghai University Shanghai Institute of Aircraft Mechanics and Control

A novel elastic metamaterial is proposed with the aim of achieving lowfrequency broad bandgaps and bandgap regulation. The band structure of the proposed metamaterial is calculated based on the Floquet-Bloch theorem, and the boundary modes of each bandgap are analyzed to understand the effects of each component of the unit cell on the bandgap formation. It is found that the metamaterials with a low elastic modulus of ligaments can generate flexural wave bandgaps below 300 Hz. Multi-frequency vibrations can be suppressed through the selective manipulation of bandgaps. The dual-graded design of metamaterials that can significantly improve the bandgap width is proposed based on parametric studies. A new way that can regulate the bandgap is revealed by studying the graded elastic modulus in the substrate. The results demonstrate that the nonlinear gradient of the elastic modulus in the substrate offers better bandgap performance. Based on these analyses, the proposed elastic metamaterials can pave the way for multi-frequency vibration control, low-frequency bandgap broadening, and bandgap tuning.

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Dynamic behaviors of graphene platelets-reinforced metal foam piezoelectric beams with velocity feedback control

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 63-80页

作者： Jie CHEN Xinyue ZHANG Mingyang fan School of Mathematics Statistics and Mechanics Beijing University of Technology College of Mechanical & Energy Engineering Beijing University of Technology

Graphene platelets(GPLs)-reinforced metal foam structures enhance the mechanical properties while maintaining the lightweight characteristics of metal foams. Further bonding piezoelectric actuator and sensor layers on the surfaces of GPLs-reinforced metal foam beams enables active vibration control, greatly expanding their applications in the aerospace industry. For the first time, this paper investigates the vibration characteristics and active vibration control of GPLs-reinforced metal foam beams with surfacebonded piezoelectric layers. The constant velocity feedback scheme is used to design the closed-loop controller including piezoelectric actuators and sensors. The effects of the GPLs on the linear and nonlinear free vibrations of the beams are numerically *** Newmark-β method combined with Newton's iteration technique is used to calculate the nonlinear responses of the beams under different load forms including harmonic loads,impact loads, and moving loads. Additionally, special attention is given to the vibration reduction performance of the velocity feedback control on the responses of the beam.

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Toward the Design of High-performance Supercapacitors by Prussian Blue, its Analogues and their Derivatives

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Energy & Environmental Materials 2020年第3期3卷 323-345页

作者： Yueqiang Lin Longhai Zhang ya Xiong tong Wei Zhuangjun fan State Key Laboratory of Heavy Oil Processing College of Materials Science and EngineeringChina University of PetroleumQingdao 266580China College of Materials Science and Chemical Engineering Harbin Engineering UniversityHarbin 150001China

Supercapacitors(SCs)with high power output have attracted increasing attention as efficient and environmentally friendly energy storage *** blue and its analogues(PB/PBAs)are simple coordination polymers with tunable chemical compositions and open *** blue can act as electrode materials in its pristine form and has also been utilized to derive various metallic nanostructures for electrochemical applications due to their simple fabrication process,non-toxic characteristics,and low ***,we firstly describe the charge storage mechanisms of SCs briefly followed by an introduction of the fabrication methods of PB/PBAs and their ***,a comprehensive review on recent studies of the use of PB/PBAs and their derivatives as the electrode materials for SCs are given with a focus on strategies to improve their electrochemical ***,we discuss critical challenges in this research area and propose some general ideas for future research.

关键词： derivatives hybrids prussian blue and its analogues supercapacitors

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-fan yang Zhi-Cheng Zhang Qi Dai Xiao-yan Bao Lin-Jie Wu ya-Xin Qin Xin Tan Xiao-yan Sun Xu-fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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