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Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma

中国药理学与毒理学杂志 2018年第4期32卷 342-343页

作者： Feng ZHI Rong WANG Dan-hi DENG Nai-yuan SHAO Yuan XU Lian XUE ya PENG ya-tian liu Department of Neurosurgery The First People's Hospital of Changzhou Changzhou China Modern Medical Research Center The Third Affiliated Hospital of Soochow UniversityChangzhou 213003 China Department of Radiation Oncology Jiangsu Cancer Ho

OBJECTIVE Glioblastoma multiforme(GBM) is the most malignant primary tumor of the central nervous system and is associated with a very poor *** further improvements in outcomes have been reported since radiotherapy-temozolomide therapy was ***,*** new agents to treat GBM is *** study aimed to evaluate the anti-tumor effect of evodiamine(Evo) on GBM cells,and to determine the underlying mechanisms *** U251,LN229,HEB and PC12 cells were treated with various concentrations of evodiamine for 24 and48 hours,cell viability was measured by MTT *** U251 and LN229 cells were treated with ***(0-10 μmol·L^(-1)) for 24 h,and then stained with Hoechst *** Annexin V-FITC Apoptosis Detection Kit was used to detect apoptosis in the *** oxygen species(ROS) production was detected using dichlorofluorescein diacetate(DCFH-DA) *** changes in mitochondrial *** potential(MMP) were assessed by JC-1 after cells were treated with *** *** levels of p-PI3K,PI3K,p-Akt,Akt,Bax,Bcl-2,p-p38,p38,p-JNK,JNK,p-ERK,ERK,Cytochrome c,Caspase-3,cleaved Caspase-3,PRAP,and cleaved PARP were measured by Western blot *** According to MTT assay results,Evo significantly inhibited the cell proliferation in a time-and dose-dependent *** microscopy and flow cytometry analyses revealed that Evo induced cell apoptosis in a concentration-dependent ***,Evo induced reactive oxygen species(ROS) production and mitochondrial membrane potential(MMP) ***,Evo induced apoptosis in cancer cells by suppressing PI3K/AKT signaling and inducing MAPK ***(p38 and JNK,but not ERK) to regulate apoptotic proteins(Bax,Bcl-2,Cytochrome c,***-3,and PARP).CONCLUSION In summary,Evo inhibits cell proliferation by inducing cellular apoptosis via suppressing PI3K/AKT and activating MAPK in GBM;these results indicate that Evo may be regarded as a ne

关键词：胶质母细胞瘤治疗方法肿瘤临床分析

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Strong-coupling superconductivity with Tc above 70 K in Be-decorated monolayer T-graphene

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Science China(Physics,Mechanics & Astronomy) 2024年第1期67卷 99-105页

作者： liu yang Peng-Fei liu Hao-Dong liu ya-Ping Li Na Jiao Hong-yan Lu Bao-tian Wang Ping Zhang School of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Institute of Applied Physics and Computational Mathematics Beijing 100088China

Using first-principles calculations,we predict a new type of two-dimensional(2D)beryllium(Be)-decorated T-graphene named BeC_(2),where Be atoms are inserted into C–C bonds linking the carbon tetrarings of *** band structure shows that BeC_(2)is metallic,thus,the possible phonon-mediated superconductivity is explored based on the Eliashberg *** calculated electron-phonon coupling(EPC)constantλis up to 4.07,and the corresponding superconducting critical temperature(Tc)is 72.1 K,approaching the liquid nitrogen *** reason for the high Tc is the strong *** it is proved to be an anisotropic single-gap superconductor by analyzing the superconducting gap?kof BeC_(2).The electronic susceptibility calculation shows strong nesting effect in BeC_(2).Since rare 2D superconductors show such a strong EPC constantλwhich originates from the coupling between electrons in C-pzorbital and in-plane vibrations of Be and C atoms,the predicted BeC_(2)provides a new platform for investigating strong EPC 2D superconductor.

关键词： two-dimensional carbon-based superconductor electron-phonon coupling strong coupling high superconducting critical temperature

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Evolution exploration and structure prediction of Keggin-type group IVB metal-oxo clusters

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Chinese Chemical Letters 2024年第5期35卷 487-492页

作者： Run-Han Li tian-Yi Dang Wei Guan Jiang liu ya-Qian Lan Zhong-Min Su School of Chemistry South China Normal UniversityGuangzhou 510006China Institute of Functional Material Chemistry Faculty of ChemistryNortheast Normal UniversityChangchun 130024China Institute of Theoretical Chemistry Jilin UniversityChangchun 130023China

The fascinating chemical structure and broad application prospect of Keggin-type polyoxometalates(POMs)have attracted many chemists to explore and discover *** the traditional Keggin,larger metal atomic radius,higher metal coordinated numbers,lower metal valence states and other features allow the group IVB metal-based Keggin(IVB-Keggin)more space and unknown in terms of structure and ***,density functional theory(DFT)calculations were performed to explore the influences including cores,shells,caps,and terminal ligands,et *** IVB-Keggin,and analyze the possibility of novel structure *** the perspective of multi-layer onion-like clusters,molecular energy level,host-guest interaction energy,surface charge and covalent bond polarity can be further adjusted to achieve the oriented design of functional *** insights are expected to provide theoretical support for experimental synthesis,opening a new perspective to understand the growth of Keggin.

关键词： Keggin Metal-oxo clusters Group IVB Onion pattern DFT

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Plants affect the horizontal transmission of a new densovirus infecting the green peach aphid Myzus persicae by modulating honeydew production

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Insect Science 2024年第1期31卷 236-254页

作者： ya Guo yani Zhao yang yang yahong Zhang Yuying Li Honggang tian Tong-Xian liu Zhaofei Li State Key Laboratory of Crop Stress Biology for Arid Areas Key Laboratory of Northwest Loess Plateau Crop Pest Management of Ministry of AgricultureCollege of Plant ProtectionNorthwest A&F UniversityYanglingChina Institute of Entomology and Institute of Plant Health&Medicine Guizhou UniversityGuiyangChina

In a tritrophic context of plant-insect-entomopathogen,plants play important roles in modulating the interaction of insects and their pathogenic ***,the influence of plants on the transmission of insect viruses has been mainly studied on baculoviruses and some RNA viruses,whereas the impact of plants on other insect viruses is largely ***,we identified a new densovirus infecting the green peach aphid Myzus persicae and tested whether and how host plants influence the transmission of the aphid *** complete single-stranded DNA genome of the virus,*** densovirus 2,is 5727 nt and contains inverted terminal *** and phylogenetic analysis indicated that the virus was distinct from other a few identified aphid *** virus abundance was detected highly in the intestinal tract of aphids,compared with the lower level of it in other tissues including head,embryo,and *** and pepper plants had no obvious effect on the vertical transmission and saliva-mediated horizontal transmission of the ***,the honeydew-mediated horizontal transmission among aphids highly depended on host plants(65%on cabbages versus 17%on peppers).Although the virus concentration in the honeydew produced by aphids between 2 plants was similar,the honeydew production of the infected aphids reared on peppers was dramatically *** together,our results provide evidence that plants influence the horizontal transmission of a new densovirus in an aphid population by modulating honeydew secretion of aphids,suggesting plants may manipulate the spread of an aphid-pathogenic densovirus in nature.

关键词： aphids densovirus host plants MpDV2 Myzus persicae transmission

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Recent progress in side chain engineering of Y-series non-fullerene molecule and polymer acceptors

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Science China Chemistry 2024年第3期67卷 788-805页

作者： Li tian Chunchen liu Fei Huang School of Materials Science and Engineering Henan University of TechnologyZhengzhou 450001China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

Organic solar cells(OSCs) have drawn considerable attention in the last decade due to the great potential of light weight,flexibility, and low-cost solution processing. Particularly, Y-series non-fullerene acceptors(NFAs) including small molecular acceptors(SMAs) and polymerized small molecular acceptors(PSMAs) have become research hot spots due to their excellent power conversion efficiency. Side chain engineering is crucial to adjust the solubility and crystallinity of NFAs, which will significantly affect the morphology of active layers and the efficiency of OSCs. However, the understanding of side chain engineering on NFAs is still limited and lacks a systematic review. This review aims to provide a brief summary of the recent developments in side chain engineering of NFAs, with a special focus on the design and application of Y-series SMAs and PSMAs for high-efficiency non-fullerene organic solar cells(NF-OSCs). In addition, the review also points out challenges and provides useful guidance regarding side chain regulation for Y-series NFAs.

关键词： organic solar cell Y-series non-fullerene acceptors side chain engineering

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SnS_(2) nanosheets decorated SnO_(2) hollow multishelled nanostructures for enhanced sensing of triethylamine gas

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Rare Metals 2024年第5期43卷 2339-2348页

作者： Wen-Di liu ya Xiong Ao Shen Xin-Zhen Wang Xiao Chang Wen-Bo Lu Jian tian School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China College of Physics Qingdao UniversityQingdao 266071China Zernike Institute for Advanced Materials University of Groningen9747 AG GroningenThe Netherlands

Highly sensitive,fast and low-temperature detection of triethylamine(TEA)gas based on SnO_(2) is attractive yet remains ***,SnS_(2) nanosheets(NSs)/SnO_(2) hollow multishelled structures(HoMSs)-based sensors are designed by the synthesis of SnO_(2) HoMSs,followed by in situ sulfuration with *** varying the thioacetamide levels,Sn S_(2)/SnO_(2) heterostructures with different SnS_(2) contents were obtained and their TEA gas sensing performances were investigated.

关键词： SnS attractive sheets

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Model-driven path planning for robotic plasma cutting of branch pipe with single Y-groove based on pipe-rotating scheme

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Advances in Manufacturing 2024年第1期12卷 94-107页

作者： yan liu Qiu Tang Xin-Cheng tian School of Control Science and Engineering Shandong UniversityJinan250061People’s Republic of China Engineering Research Center of Intelligent Unmanned System Ministry of EducationJinan250061People’s Republic of China School of Mechanical and Electronic Engineering Shandong Jianzhu UniversityJinan250101People’s Republic of China

The automatic cutting of intersecting pipes is a challenging task in *** improved automation and accuracy,this paper proposes a model-driven path planning approach for the robotic plasma cutting of a branch pipe with a single ***,it summarizes the intersection forms and introduces a dual-pipe intersection *** on this model,the moving three-plane structure(a description unit of the geometric characteristics of the intersecting curve)is constructed,and a geometric model of the branch pipe with a single Y-groove is ***,a novel mathematical model for plasma radius and taper compensation is ***,the compensation model and groove model are integrated by establishing movable ***,to prevent collisions between the plasma torch and workpiece,the torch height is planned and a branch pipe-rotating scheme is *** the established models and moving frames,the planned path description of cutting robot is provided in this novel *** accuracy of the proposed method is verified by simulations and robotic cutting experiments.

关键词： Automatic groove cutting of intersecting pipes Model-driven robot path planning Plasma beam radius and taper compensation

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Fixed-Time Anti-Disturbance Average-Tracking for Multi-Agent Systems Without Velocity Measurements

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Journal of Systems Science & Complexity 2024年第3期37卷 985-1002页

作者： LI Yuling liu Chenglin ZHANG ya CHEN yangyang Key Laboratory of Advanced Process Control for Light Industry(Ministry of Education) Institute of AutomationJiangnan UniversityWuci 214122China School of Automation Southeast UniversityNanjing 210096China

In this paper,the authors tackle a fixed-time average-tracking problem for multi-agent systems which do not require velocity measurements and are affected by external mismatched and matched *** objective requires the considered agents with second-order dynamics to follow the average value of several time-varying reference signals,each of which is acquired by only one *** of all,the average value is estimated by using a novel distributed average estimator in a fixed ***,an original observer is created to provide estimated values in a fixed time for external mismatched and matched disturbances as well as unmeasured velocities of ***,the authors propose a novel fixed-time anti-disturbance average-tracking protocol with the aid of the observer and a sliding mode *** the end,the feasibility of theoretical analysis is illustrated by some simulation experiments.

关键词： Average-tracking control fixed-time algorithm fixed-time observer mismatched distur-bances multi-agent systems velocity measurements

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Off-Grid Compressed Channel Estimation with Parallel Interference Cancellation for Millimeter Wave Massive MIMO

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China Communications 2024年第3期21卷 51-65页

作者： liu Jinru tian Yongqing liu Danpu Zhang Zhilong Beijing Laboratory of Advanced Information Network Beijing Key Laboratory of Network System Architecture and ConvergenceBeijing University of Posts and TelecommunicationsBeijing100876China

Millimeter wave(mmWave)massive multiple-input multiple-output(MIMO)plays an important role in the fifth-generation(5G)mobile communications and beyond wireless communication systems owing to its potential of high ***,channel estimation has become very challenging due to the use of massive MIMO antenna ***,the mmWave channel has strong sparsity in the spatial angle domain,and the compressed sensing technology can be used to convert the original channel matrix into the sparse matrix of discrete angle *** the high-dimensional channel matrix estimation is transformed into a sparse recovery problem with greatly reduced computational ***,the path angle in the actual scene appears randomly and is unlikely to be completely located on the quantization angle grid,thus leading to the problem of power ***,multiple paths with the random distribution of angles will bring about serious interpath interference and further deteriorate the performance of channel *** address these off-grid issues,we propose a parallel interference cancellation assisted multi-grid matching pursuit(PIC-MGMP)algorithm in this *** proposed algorithm consists of three stages,including coarse estimation,refined estimation,and inter-path cyclic iterative inter-ference *** specifically,the angular resolution can be improved by locally refining the grid to reduce power leakage,while the inter-path interference is eliminated by parallel interference cancellation(PIC),and the two together improve the estimation *** results show that compared with the traditional orthogonal matching pursuit(OMP)algorithm,the normalized mean square error(NMSE)of the proposed algorithm decreases by over 14dB in the case of 2 paths.

关键词： channel estimation compressed sensing inter-path interference millimeter wave massive MIMO off-grid parallel interference cancellation

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A thermodynamics-based three-scale constitutive model for partially saturated granular materials

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第5期16卷 1813-1831页

作者： Jianqiu tian Enlong liu Yuancheng Guo State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China School of Geoscience and Technology Southwest Petroleum UniversityChengdu610500China College of Civil Engineering Zhengzhou UniversityZhengzhou450001China

A three-scale constitutive model for unsaturated granular materials based on thermodynamic theory is *** three-scale yield locus,derived from the explicit yield criterion for solid matrix,is developed from a series of discrete interparticle contact *** three-scale yield locus is sensitive to porosity changes;therefore,it is reinterpreted as a corresponding constitutive model without phenomenological ***,a water retention curve is proposed based on special pore morphology and experimental *** features of the partially saturated granular materials are well captured by the *** wetting and isotropic compression,volumetric compaction occurs,and the degree of saturation ***,the higher the matric suction,the greater the strength,and the smaller the volumetric *** with the phenomenological Barcelona basic model,the proposed three-scale constitutive model has fewer parameters;virtually all parameters have clear physical meanings.

关键词： Unsaturated granular material Unsaturated porous material Geomaterials Multi-scale constitutive model Water retention curve Plasticity

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