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Flexible Graphene Field‑Effect Transistors and Their Application in Flexible Biomedical Sensing

Nano-Micro Letters 2025年第2期17卷 252-313页

作者： Mingyuan Sun Shuai Wang yanbo Liang Chao Wang Yunhong zhang Hong Liu Yu zhang Lin Han Institute of Marine Science and Technology Shandong UniversityQingdao 266237ShandongPeople’s Republic of China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100ShandongPeople’s Republic of China School of Integrated Circuits Shandong UniversityJinan 250100ShandongPeople’s Republic of China Shandong Engineering Research Center of Biomarker and Artificial Intelligence Application Jinan250100ShandongPeople’s Republic of China

Flexible electronics are transforming our lives by making daily activities more *** to this innovation are field-effect transistors(FETs),valued for their efficient signal processing,nanoscale fabrication,low-power consumption,fast response times,and ***,known for its exceptional mechanical properties,high electron mobility,and biocompatibility,is an ideal material for FET channels and *** combination of graphene and FETs has given rise to flexible graphene field-effect transistors(FGFETs),driving significant advances in flexible electronics and sparked a strong interest in flexible biomedical ***,we first provide a brief overview of the basic structure,operating mechanism,and evaluation parameters of FGFETs,and delve into their material selection and patterning *** ability of FGFETs to sense strains and biomolecular charges opens up diverse application *** specifically analyze the latest strategies for integrating FGFETs into wearable and implantable flexible biomedical sensors,focusing on the key aspects of constructing high-quality flexible biomedical ***,we discuss the current challenges and prospects of FGFETs and their applications in biomedical *** review will provide valuable insights and inspiration for ongoing research to improve the quality of FGFETs and broaden their application prospects in flexible biomedical sensing.

关键词： Flexible Graphene Field-effect transistor Wearable Implantable Biosensor

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Zinc-based fiber-shaped rechargeable batteries:Insights into structures,electrodes,and electrolytes

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Nano Research 2025年第1期18卷 278-293页

作者： Xuan zhang Hongcheng zhang Mengxiang Chen Jingqi Lu Evgeny Zhuravlev Jing Jiang Pin Liu Shengyang Dong Du Yuan Guoyin Zhu Lianbo Ma Yizhou zhang Institute of Advanced Materials and Flexible Electronics(IAMFE) School of Chemistry and Materials ScienceNanjing University of Information Science and TechnologyNanjing 210044China School of Materials Science and Engineering Anhui University of TechnologyMaanshan 243002China College of Materials Science and Engineering Changsha University of Science and TechnologyChangsha 410004China

The rapid evolution of flexible wearable electronics has spurred a growing demand for energy storage devices,characterized by low-cost manufacturing processes,high safety standards,exceptional electrochemical performance and robust mechanical *** novel flexible devices,fiber-shaped batteries(FSBs)have emerged as prominent solutions exceptionally suited to future applications,owing to their unique one-dimensional(1D)architecture,remarkable flexibility,potential for miniaturization,adaptability to deformation and compatibility with the conventional textile *** the forefront research on fiber-shaped batteries,zincbased FSBs(ZFSBs)have garnered significant attentions,featured by the promising electrochemical properties of metallic *** enthusiasm is driven by the impressive capacity of Zn(820 mAh·g^(-1))and its low redox potential(Zn/Zn^(2+):-0.76 V *** hydrogen electrode).This review aims to consolidate recent achievements in the structural design,fabrication processes and electrode materials of flexible ***,we highlight three representative structural configurations:parallel type,twisted type and coaxial *** also place special emphasis on electrode modifications and electrolyte ***,we delve into the promising development opportunities and anticipate future challenges associated with ZFSBs,emphasizing their potential roles in powering the next generation of wearable electronics.

关键词： zinc-based batteries fiber-shape parallel type twisted type coaxial type

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Characteristics of the Main Journal Bearings of an Engine Based on Non-linear Dynamics

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Chinese Journal of Mechanical Engineering 2009年第5期22卷 755-759页

作者： ni Guangjian zhang Junhong CHENG Xiaoming State Key Laboratory of Engine Tianjin University Tianjin 300072 China Tianjin Internal Combustion Engine Research Institute Tianjin 300072 China

Many simple nonlinear main journal bearing models have been studied theoretically, but the connection to existing engineering system has not been equally investigated. The consideration of the characteristics of engine main journal bearings may provide a prediction of the bearing load and lubrication. Due to the strong non-linear features in bearing lubrication procedure, it is difficult to predict those characteristics. A non-linear dynamic model is described for analyzing the characteristics of engine main journal bearings. Components such as crankshaft, main journals and con rods are found by applying the finite element method. Non-linear spring/dampers are introduced to imitate the constraint and supporting functions provided by the main bearing and oil film. The engine gas pressure is imposed as excitation on the model via the engine piston, con rod, etc. The bearing reaction force is calculated over one engine cycle, and meanwhile, the oil film thickness and pressure distribution are obtained based on Reynolds differential equation. It can be found that the maximum bearing reaction force always occurs when the maximum cylinder pressure arises in the cylinder adjacent to that bearing. The simulated minimum oil film thickness, which is 3 μm, demonstrates the reliability of the main journal bearings. This non-linear dynamic analysis may save computing efforts of engine main bearing design and also is of good precision and close connection to actual engine main journal bearing conditions.

关键词： non-linear dynamics engine main journal bearings

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Cyclic Gradient Methods for Unconstrained Optimization

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Journal of the Operations Research Society of China 2024年第3期12卷 809-828页

作者： ya zhang Cong Sun School of Science Beijing University of Posts and TelecommunicationsBeijing100876China

Gradient method is popular for solving large-scale *** this work,the cyclic gradient methods for quadratic function minimization are extended to general smooth unconstrained optimization *** with nonmonotonic line search,we prove its global ***,the proposed algorithms have sublinear convergence rate for general convex functions,and R-linear convergence rate for strongly convex *** experiments show that the proposed methods are effective compared to the state of the arts.

关键词： Gradient method Unconstrained optimization Nonmonotonic line search Global convergence

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The role of leptin in striped hamsters subjected to food restriction and refeeding

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Zoological Research 2014年第4期35卷 262-271页

作者： Zhi-Jun ZHAO Yong-An LIU Jing-ya XING Mao-Lun zhang Xiao-Ying ni Jing CAO College of Life and Environmental Science Wenzhou University Wenzhou 325027 China School of Agricultural Science Liaocheng University Liaocheng 252059 China

Food restriction （FR） and refeeding （Re） have been suggested to impair body mass regulation and thereby making it easier to regain the lost weight and develop over-weight when FR ends. However, it is unclear if this is the case in small mammals showing seasonal forging behaviors. In the present study, energy budget, body fat and serum leptin level were measured in striped hamsters that were exposed to FR-Re. The effects of leptin on food intake, body fat and genes expressions of several hypothalamus neuropeptides were determined. Body mass, fat content and serum leptin level decreased during FR and then increased during Re. Leptin supplement significantly attenuated the increase in food intake during Re, decreased genes expressions of neuropepetide Y （NPY） and agouti-related protein （AgRP） of hypothalamus and leptin of white adipose tissue （WAT）. Hormone-sensitive lipase （HSL） gene expression of WAT increased in leptin-treated hamsters that were fed ad libitum, but decreased in FR-Re hamsters. This indicates that the adaptive regulation of WAT HSL gene expression may be involved in the mobilization of fat storage during Re, which partly contributes to the resistance to FR-Re-induced overweight. Leptin may be involved in the down regulations of hypothalamus orexigenic peptides gene expression and consequently plays a crucial role in controlling food intake when FR ends.

关键词： Body mass Food restriction Hypothalarnus neuropeptides Leptin Striped hamster

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Effect of Al content on the reaction between Fe-10Mn-xAl(x=0.035wt%,0.5wt%,1wt%,and 2wt%)steel and CaO-SiO_(2)-Al_(2)O_(3)-MgO slag

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International Journal of Minerals,Metallurgy and Materials 2022年第2期29卷 256-262页

作者： Huixiang Yu Dexin yang Jiaming zhang Guangyuan Qiu ni zhang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The effect of Al content(0.035 wt%,0.5 wt%,1 wt%,and 2 wt%)on the composition change of steel and slag as well as inclusion transformation of high manganese steel after it has equilibrated with Ca O-Si O_(2)-Al_(2)O_(3)-Mg O slag was studied using the method of slag/steel *** experimental results showed that as the initial content of Al increased from 0.035 wt%to 2 wt%,Al gradually replaced Mn to react with Si O_(2)in slag to avoid the loss of Mn due to the reaction;this process caused both Al_(2)O_(3)in slag and Si in steel to increase while Si O_(2)and Mn O in slag to *** addition,the type of inclusions also evolved as the initial Al content *** evolution route of inclusions was Mn O→Mn O-Al_(2)O_(3)-Mg O→Mg O→Mn O-Ca O-Al_(2)O_(3)-Mg O and Mn O-Ca O-Mg *** shape of inclusions evolved from spherical to irregular,became faceted,and finally transformed to *** average size of inclusions presented a trend that was increasing first and then *** transformation mechanism of inclusions was *** the initial content of Al increased,Mg and Ca were reduced from top slag into molten steel in sequence,which consequently caused the transformation of inclusions.

关键词： medium/high manganese steel Al content steel composition slag composition non-metallic inclusion slag/steel reaction

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生物反馈助力电刺激对慢性非特异性腰痛患者下肢步行功能的改善

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中国组织工程研究 2025年第3期29卷 547-553页

作者：郑翔张明兴黄雅单莎瑞广东药科大学附属第一医院广东省广州市510080

背景:国内外关于慢性非特异性腰痛生物反馈疗法和三维步态功能分析的相关研究已开展很多,但是对二者结合的研究少有报道。目的:利用三维步态分析采集步态参数数据,研究生物反馈助力电刺激对慢性非特异性腰痛患者步行能力的改变效果。方... 详细信息

背景:国内外关于慢性非特异性腰痛生物反馈疗法和三维步态功能分析的相关研究已开展很多,但是对二者结合的研究少有报道。目的:利用三维步态分析采集步态参数数据,研究生物反馈助力电刺激对慢性非特异性腰痛患者步行能力的改变效果。方法:选择2021年6月至2022年9月在广东药科大学附属第一医院收治的60例慢性非特异性腰痛患者,男34例,女26例,年龄32-58岁。采用随机数字表法将60例患者分为对照组(n=30)与试验组(n=30),两组患者均接受腰部动态干扰电的常规治疗(20 min/次,1次/d,每周5次,持续治疗20次),对照组患者在常规治疗的基础上进行仰卧搭桥和俯卧搭桥的悬吊核心肌群训练(每周5次,持续治疗20次),试验组在对照组治疗的基础上进行生物反馈助力电刺激治疗(20 min/次,1次/d,每周5次,持续治疗20次)。比较分析两组患者治疗前后的腰痛评分、肌电信号平均值和步态参数。结果与结论:①两组患者治疗结束后的数字类比表评分、日本骨科协会(JOA)评分、Oswestry功能障碍指数均较治疗前明显改善(P<0.05),试验组治疗结束后的数字类比表评分、JOA评分、Oswestry功能障碍指数均优于对照组(P<0.05);②两组患者治疗结束后的腹直肌、臀大肌、竖脊肌表面肌电平均值均高于治疗前(P<0.05),试验组治疗结束后的腹直肌、臀大肌、竖脊肌表面肌电平均值均高于对照组(P<0.05);③两组患者治疗结束后的步宽、步速、步频、健患侧步长比值、健患侧支撑相比值、患健侧摆动相比值、健患侧髋关节及膝关节矢状面活动度和健患侧足偏角均优于治疗前(P<0.05),试验组治疗结束后的上述指标均优于对照组(P<0.05);④结果表明,生物反馈助力电刺激能明显缓解慢性非特异性腰痛,改善了患者下肢步行功能。

关键词：三维步态生物反馈助力电刺激慢性非特异性腰痛步行功能核心稳定训练

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DOXORUBICIN-LOADED BORON-RICH POLYMER NANOPARTICLES FOR ORTHOTOPICALLY IMPLANTED LIVER TUMOR TREATMENT

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Chinese Journal of Polymer Science 2013年第5期31卷 778-786页

作者： Lu-zhong zhang ya-jun zhang 武伟蒋锡群 Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering College of Chemistry & Chemical Engineering Jiangsu Provincial Laboratory for Nanotechnology Nanjing University Jiangsu Key Laboratory of Neuroregeneration Nantong University

The in vivo behaviors of doxorubicin （DOX）-loaded dextran-poly（3-acrylamidophenylboronic acid）（Dextran- PAPBA） nanoparticles （NPs） were studied. The DOX-loaded NPs had a narrowly distributed diameter of ca. 74 nm and mainly accumulated in liver of tumor-bearing mice after intravenous injection as demonstrated by in vivo real-time near infrared fluorescent imaging. The DOX contents in various tissues were quantified and consisted well with the results of fluorescent imaging. The biodistribution pattern of DOX-loaded NPs encourages us to investigate their liver tumor treatment by using an orthotopically implanted liver tumor model, revealing that the DOX-loaded NPs formulation had better antitumor effect than free DOX.

关键词： Dextran-PAPBA nanoparticles DOX Drug delivery Antitumor.

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Multi-verse optimizer based parameters decision with considering tool life in dry hobbing process

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Advances in Manufacturing 2021年第2期9卷 216-234页

作者： Heng-Xin ni Chun-Ping yan Shen-Fu ni Huan Shu Yu zhang State Key Laboratory of Mechanical Transmission Chongqing UniversityChongqing 400030People’s Republic of China Hefei Meiya Photoelectric Technology Co.Ltd Hefei 230088People’s Republic of China

Dry hobbing has received extensive attention for its environmentally friendly processing *** to the absence of lubricants,hobbing process is highly dependent on process parameters combination since using unreasonable parameters tends to affect the machining ***,the consideration of tool life is frequently ignored in gear ***,to settle the above issues,a multiobjective parameters decision approach considering tool life is ***,detailed quantitative analysis between process parameters and hobbing performance,i.e.,machining time,production cost and tool life is ***,a multi-objective parameters decision-making model is constructed in search for optimum cutting parameters(cutting velocity v,axial feed rate f_(a))and hob parameters(hob diameter d_(0),threads z_(0)).Thirdly,a novel algorithm named multi-objective multi-verse optimizer(MOMVO)is utilized to solve the presented model.A case study is exhibited to show the feasibility and reliability of the proposed *** results reveal that(i)a balance can be achieved among machining time,production cost and tool life via appropriate process parameters determination;(ii)optimizing cutting parameters and hob parameters simultaneously contributes to optimal objectives;(iii)considering tool life provides usage precautions support and process parameters guidance for practical machining.

关键词： Process parameters Decision-making Tool life Dry hobbing Multi-objective multi-verse optimizer(MOMVO)

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Animal models of Alzheimer’s disease: Applications, evaluation, and perspectives

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Zoological Research 2022年第6期43卷 1026-1040页

作者： Zhi-ya Chen yan zhang State Key Laboratory of Membrane Biology College of Life SciencesPeking UniversityBeijing 100871China

Although great advances in elucidating the molecular basis and pathogenesis of Alzheimer’s disease(AD)have been made and multifarious novel therapeutic approaches have been developed,AD remains an incurable *** shows that AD neuropathology occurs decades before clinical *** is divided into three stages:preclinical stage,mild cognitive impairment(MCI),and AD *** the natural world,some animals,such as non-human primates(NHPs)and canines,can develop spontaneous AD-like ***,most animals do not develop *** the development of transgenic techniques,both invertebrate and vertebrate animals have been employed to uncover the mechanisms of AD and study treatment *** AD research focuses on early-onset familial AD(FAD)because FAD is associated with specific genetic ***,there are no well-established late-onset sporadic AD(SAD)animal models because SAD is not directly linked to any genetic mutation,and multiple environmental factors are ***,the widely used animal models are not able to sufficiently recapitulate the pathological events that occur in the MCI or preclinical *** review summarizes the common models used to study AD,from yeast to NHP models,and discusses the different applications,evaluation methods,and challenges related to AD animal models,as well as prospects for the evolution of future studies.

关键词： Alzheimer’s disease Animal models Neuroinflammation Amyloid-β Tau protein

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