检索结果-南通市图书馆

Potential metal-related strategies for prevention and treatment of COVID-19

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2022年第4期41卷 1129-1141页

作者： ya-Qiong ni Hui-Hui Zeng Xian-Wen Song Jun Zheng Hui-Qiong Wu Chun-Tai Liu Yi zhang Hunan Provincial Key Laboratory of Micro and Nano Materials Interface Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China Hanshan Normal University Chaozhou 521041China College of Chemistry and Environmental Engineering Shenzhen UniversityShenzhen 518071China Key Laboratory of Materials Processing and Mold(Zhengzhou University) Ministry of EducationZhengzhou 450002China

The coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) has posed severe threats to human health,public safety,and the global *** nutrient elements can directly or indirectly take part in human immune responses,and metal-related drugs have served as antiviral drugs and/or enzyme inhibitors for many years,providing potential solutions to the prevention and treatment of ***-based drugs are currently under a variety of chemical structures and exhibit wide-range bio activities,demonstrating irreplaceable advantages in *** review is an intention to summarize recent progress in the prevention and treatment strategies against COVID-19 from the perspective of metal *** current and potential utilization of metal-based drugs is briefly ***,metallohydrogels that have been shown to present superior antiviral activities are stressed in the paper as potential drugs for the treatment of COVID-19.

关键词： COVID-19 SARS-CoV-2 Metal-related drugs Metal nutrient elements Metallohydrogel

Small extracellular vesicles derived from cerebral endothelial cells with elevated microRNA 27a promote ischemic stroke recovery

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 224-233页

作者： Yi zhang Zhongwu Liu Michael Chopp Michael Millman yanfeng Li Pasquale Cepparulo Amy Kemper Chao Li Li zhang Zheng Gang zhang Department of Neurology Henry Ford HospitalDetroitMIUSA Department of Physics Oakland UniversityRochesterMIUSA Department of Pathology Henry Ford HospitalDetroitMIUSA Division of Pharmacology Department of NeuroscienceReproductive and Dentistry SciencesSchool of MedicineUniversity of Naples“Federico Ⅱ”NaplesItaly

Axonal remodeling is a critical aspect of ischemic brain repair processes and contributes to spontaneous functional *** previous in vitro study demonstrated that exosomes/small extracellular vesicles(sEVs)isolated from cerebral endothelial cells(CEC-sEVs)of ischemic brain promote axonal growth of embryonic cortical neurons and that microRNA 27a(miR-27a)is an elevated miRNA in ischemic *** the present study,we investigated whether normal CEC-sEVs engineered to enrich their levels of miR-27a(27a-sEVs)further enhance axonal growth and improve neurological outcomes after ischemic stroke when compared with treatment with non-engineered CEC-sEVs.27a-sEVs were isolated from the conditioned medium of healthy mouse CECs transfected with a lentiviral miR-27a expression *** EVs isolated from CECs transfected with a scramble vector(Scra-sEVs)were used as a *** male mice were subjected to permanent middle cerebral artery occlusion and then were randomly treated with 27a-sEVs or *** array of behavior assays was used to measure neurological *** with treatment of ischemic stroke with Scra-sEVs,treatment with 27a-sEVs significantly augmented axons and spines in the peri-infarct zone and in the corticospinal tract of the spinal grey matter of the denervated side,and significantly improved neurological *** vitro studies demonstrated that CEC-sEVs carrying reduced miR-27a abolished 27a-sEV-augmented axonal *** analysis revealed that 27a-sEVs systemically administered preferentially localized to the pre-synaptic active zone,while quantitative reverse transcription-polymerase chain reaction and Western Blot analysis showed elevated miR-27a,and reduced axonal inhibitory proteins Semaphorin 6A and Ras Homolog Family Member A in the peri-infarct *** of the Clathrin-dependent endocytosis pathway substantially reduced neuronal internalization of *** data provide evidence that 27a-sEVs have

关键词： axonal remodeling cerebral endothelial cells exosomes miR-27a mitochondria Semaphorin 6A small extracellular vesicles stroke

双轴应变对NbSe_(2)/MoSi_(2)N_(4)肖特基势垒的调控

在线全文

学校读者我要写书评

暂无评论

原子与分子物理学报 2025年第5期42卷 182-188页

作者：张宇哲安梦雅谢泉贵州大学大数据与信息工程学院新型光电子材料与技术研究所贵阳550025

最近一种高质量的二维(Two-dimensional,2D)半导体材料MoSi_(2)N_(4)(MSN)在实验上被成功合成,具有优异的电气和机械性能.尽管最近有大量的研究致力于揭示MSN的材料特性,但到目前为止,对MSN的电接触物理特性的探索还比较少.在这项工作中... 详细信息

最近一种高质量的二维(Two-dimensional,2D)半导体材料MoSi_(2)N_(4)(MSN)在实验上被成功合成,具有优异的电气和机械性能.尽管最近有大量的研究致力于揭示MSN的材料特性,但到目前为止,对MSN的电接触物理特性的探索还比较少.在这项工作中,构建了金属-半导体NbSe_(2)/MSN肖特基结并使用第一性原理密度泛函理论计算研究了该肖特基结的材料特性.发现NbSe_(2)/MSN接触具有超低肖特基势垒高度(Schottky barrier height,SBH),这有利于纳米电子学应用.SBH可以通过施加双轴应变的方式进行有效的调控.当施加拉伸应变时能实现NbSe_(2)/MSN肖特基结由p型肖特基接触转变为p型欧姆接触,而当施加较大的压缩应变时能实现p型肖特基接触和n型肖特基接触之间的转换.我们的研究结果为MSN的2D电触点的物理特性提供了见解,并将为设计基于MSN的2D纳米器件的高性能电触点提供关键的一步.

关键词： MoSi_(2)N_(4) NbSe_(2) 肖特基结欧姆接触

维普期刊数据库博看期刊

Deciphering the role of ultra-low-loaded rhodium in niFe-MIL-53 for superior oxygen evolution reaction

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： Jinzhi Jia Jinhua zhang Kailu Guo Lanyue zhang Gening Du Hao You Junfeng Huang Mudong Tu Hua Li Yong Peng Wei Dou Cailing Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,niFe-MIL-53 modified with ultra-low rhodium（Rh@niFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of niFe-MIL-53 and the in-situ formed Rh@niFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between niFeOOH and niFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the niFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@niFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： niFe-MIL-53 Rh Electrochemical reconstruction Catalytic mechanism Oxygen evolution reaction

Linear-grating hybridized electromagnetic-triboelectric nanogenerator for sustainably powering portable electronics

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2016年第4期9卷 974-984页

作者： Kewei zhang ya yang Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 100083 China

Utilizing a nanogenerator to scavenge mechanical energy from our living environment is an effective method to solve the power source issue of portable electronics. We report a linear-grating hybridized electromagnetic-triboelectric nanogenerator for scavenging the mechanical energy generated from sliding motions to sustainably power certain portable electronics. The hybridized nano- generator consists of a slider and a stator in the structural design, and possesses a 66-segment triboelectric nanogenerator （TENG） and a 9-segment electromagnetic generator （EMG） in the functional design. At a sliding acceleration of 20 m/s2 the hybridized nanogenerator can deliver maximum powers of 102.8 mW for the TENG at a loading resistance of 0.4 Mr2 and 103.3 mW for the EMG at a loading resistance of 6 kf2. With an optimal hybridized combination of the TENG with a transformer and the EMG with a power management circuit, a 10 mF capacitor can be easily charged to 2.8 V in 20 s. A packaged hybridized nanogenerator with a light weight of 140 g and small dimensions of 12 cm× 4 cm× 1.6 cm excels in scavenging low-frequency sliding energy to sustainably power portable electronics.

关键词： energy harvesting hybridized nanogenerator conjunction operation sliding motion self-powered electronics

Fully Distributed Economic Dispatch for Cyber-physical Power System with Time Delays and Channel Noises

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1472-1481页

作者： Yuhang zhang Ming ni Yonghui Sun College of Energy and Electrical Engineering Hohai UniversityNanjing 210098China NARI Group Corporation(State Grid Electric Power Research Institute) Nanjing 211106China NARI Technology Co. Ltd.Nanjing 211106China State Key Laboratory of Smart Grid Protection and Control Nanjing 211106China

Economic dispatch problem(EDP)is a fundamental optimization problem in power system operation,which aims at minimizing the total generation *** fact,the power grid is becoming a cyber-physical power system(CPPS).Therefore,the quality of communication is a key *** this paper,considering two important factors,i.e.,time delays and channel noises,a fully distributed consensus based algorithm is proposed for solving *** critical maximum allowable upper bounds of heterogeneous communication delays and self-delays are *** should be pointed out that the proposed algorithm can be robust against the time-varying delays and channel noises considering generator *** addition,even with time-varying delays and channel noises,the power balance of supply and demand is not broken during the *** simulation studies are presented to validate the correctness and superiority of the developed results.

关键词： Distributed economic dispatch consensus-based algorithm cyber-physical power system time delay channel noises

Autophagy-targeting modulation to promote peripheral nerve regeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： yan Chen Hongxia Deng Nannan zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

The dopaminergic system and Alzheimer's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan zhang Yuan Liang Yixue Gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

Influences of different forces on the bubble entrainment into a stationary Gaussian vortex

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2013年第11期56卷 2162-2169页

作者： zhang AMan ni BaoYu College of Shipbuilding Engineering Harbin Engineering University

Simulations of bubble entrainment into a stationary Gaussian vortex are performed by using the combined particle tracking method(PTM)and boundary element method(BEM).Before the bubble is captured by the vortex core,oscillation and migration of the quasi-spherical nucleus are solved by using improved RP equation and the momentum theorem in the Lagrangian reference frame simultaneously,and the trajectory of the nucleus presents a kind of reduced helix *** captured by the vortex core,the bubble grows immediately and moves and deforms along the vortex core *** non-spherical evolution and deformation of the bubble is simulated by adopting a mixed Eulerian-Lagrangian *** output of quasi-spherical stage is taken as the input of non-spherical stage,and all the behaviors of the entrained bubble can be simulated such as inception,motion,deformation and *** results agree well with published experimental *** this basis,the influences of various factors such as viscosity,surface tension,buoyancy are studied *** the results from this paper would provide some insight into the control on vortex bubble entrainment.

关键词： bubble entrainment gaussian vortex trajectory split