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Association between coronary artery calcification and cognitive function in a Chinese community-based population

Journal of Geriatric Cardiology 2021年第7期18卷 514-522页

作者： ya-nan ma Wu-Xiang XIE Zhi-Hui HOU Yun-Qiang AN Xin-Shuang REN yan-Jun ma Cheng-Long LI yang-Feng WU Bin LU Department of Radiology Fuwai HospitalPeking Union Medical College&Chinese Academy of Medical SciencesState Key Lab and National Center for Cardiovascular DiseasesBeijingChina Peking University Clinical Research Institute Peking University First HospitalBeijingChina

Background Coronary atherosclerosis and cognitive impairment are both age-related diseases,with similar risk *** artery calcium(CAC),a marker of coronary atherosclerosis,may play a role in early detection of individuals prone to cognitive *** study aimed to investigate the relationship between CAC and cognitive function,and the capability of CAC to identify participants with a high risk of dementia in a Chinese community-based *** A total of 1332 participants,aged 40-80 years and free of dementia from a community located in Beijing were *** participants completed neurocognitive questionnaires and noncontrast CT *** performance tests(including verbal memory,semantic fluency,executive function,and global cognitive function tests),the Cardiovascular Risk Factors,Aging,and Incidence of Dementia(CIDE)risk score,and the CAC score(CACS)were evaluated by questionnaires and CT.A CAIDE score≥10 was considered to indicate a high risk of dementia in *** were divided into three groups according to CACS(0,1-399,≥400).Results After adjusting for risk factors,CACS was significantly associated with verbal memory(r=-0.083,P=0.003)and global cognitive function(r=-0.070,P=0.012).The prevalence of a high risk of dementia in the subgroups of CACS=0,1-399,and≥400 was 4.67%,13.66%,and 24.79%,respectively(Pmarker of subclinical atherosclerosis,was significantly associated with cognitive performance in verbal memory and global cognitive *** had a moderate capability to identify participants with a high risk of dementia,independent of age,education,and other risk factors.

关键词： coronary function cognitive

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Crosstalk between hepatic stellate cells and tumor cells in the development of hepatocellular carcinoma

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Chinese Medical Journal 2021年第21期134卷 2544-2546页

作者： ya-nan ma Shan-Shan Wang Roman Liebe Hui-Guo Ding Department of Gastroenterology and Hepatology Beijing Youan Hospital Affiliated with Capital Medical UniversityBeijing 100069China Department of Molecular Biology Beijing Institute of HepatologyBeijing Youan HospitalCapital Medical UniversityBeijing100069China Department of Gastroenterology Hepatology and Infectious DiseasesUniversity Hospital DusseldorfDusseldorfGermany

Hepatocellular carcinoma(HCC)ranks sixth in population age-standardized incidence(ASI)and fourth in population age-standardized mortality(ASM)globally and is the fourth ASI and the second ASM.

关键词： mortality hepatic carcinoma

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The G-Protein β Subunit AGB1 Promotes Hypocotyl Elongation through Inhibiting Transcription Activation Function of BBX21 in Arabidopsis

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Molecular Plant 2017年第9期10卷 1206-1223页

作者： Dong-bei Xu Institute of Crop Sciences Chinese Academy of Agricultural Sciences (CAAS)/National Key Facility for Crop Gene Resources and Genetic Improvement Key Laboratory of Biology and Genetic Improvement of Crops Ministry of Agriculture Beijing 100081 China Institute of Botany Jiangsu Province and Chinese Academy of Sciences No.1 Qianhu Houcun Zhongshanmen Wai Nanjing Jiangsu Province 210014 PR China [∗]Corresponding author [∗∗]Corresponding author [∗∗∗]Corresponding authorThese authors contributed equally to this article.

Hypocotyl development in Arabidopsis thaliana is regulated by light and endogenous hormonal cues, mak- ing it an ideal model to study the interplay between light and endogenous growth regulators. BBX21, a B-box （BBX）-Iike zinc-finger transcription factor, integrates light and abscisic acid signals to regulate hypocotyl elongation in Arabidopsis. Heterotrimeric G-proteins are pivotal regulators of plant development. The short hypocotyl phenotype of the G-protein I^-subunit （AGB1） mutant （agbl-2） has been previously identified, but the precise role of AGB1 in hypocotyl elongation remains enigmatic. Here, we show that AGB1 directly interacts with BBX21, and the short hypocotyl phenotype of agbl-2 is partially suppressed in agb1-2bbx21-1 double mutant. BBX21 functions in the downstream of AGB1 and overexpression of BBX21 in agbl-2 causes a more pronounced reduction in hypocotyl length, indicating that AGB1 plays an oppositional role in relation to BBX21 during hypocotyl development. Furthermore, we demonstrate that the C-terminal region of BBX21 is important for both its intracellular localization and its transcriptional activation activity that is inhibited by interaction with AGB1. ChiP assays showed that BBX21 specifically associates with its own promoter and with those of BBX22, HY5, and GA2oxl. which is not altered in agbl-2. These data suggest that the AGB1-BBX21 interaction only affects the transcrip- tional activation activity of BBX21 but has no effect on its DNA binding ability. Taken together, our data demonstrate that AGB1 positively promotes hypocotyl elongation through repressing BBX21 activity.

关键词： Arabidopsis BBX21 G-protein 13 subunit hypocotyl elongation transcriptional activation

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The G-protein β subunit AGB1 promotes hypocotyl elongation through inhibiting transcription activation function of BBX21 in Arabidopsis

The G-protein β subunit AGB1 promotes hypocotyl elongation ...

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第七届长三角植物科学研讨会暨青年学术报告会

作者： Dong-bei Xu ya-nan ma Ming Chen You-zhi ma Institute of Botany Jiangsu Province and Chinese Academy of Sciences

Hypocotyl development in Arabidopsis thaliana is regulated by light and endogenous hormonal cues,making it a good model to study the interplay between light and endogenous growth ***21,a B-box(BBX) like zinc-finger transcription factor,integrates light and abscisic acid(ABA) signaling to regulate hypocotyl elongation in *** G-proteins are pivotal regulators of plant *** short hypocotyl phenotype of the G-protein β subunit(AGB1) mutant(agb1-2) has been previously identified,but the precise role of AGB1 in hypocotyl elongation remained ***,we show that AGB1 directly interacts with BBX21,and the short hypocotyl phenotype of agb1-2 is partially suppressed in agb1-2 bbx21-1 double ***21 is a downstream component of AGB1,and over-expression of BBX21 in the agb1-2 mutant background causes a more pronounced reduction in hypocotyl length,indicating that AGB1 plays an oppositional functional role in relation to BBX21 during hypocotyl ***,we demonstrated that the C-terminal region of BBX21 is important for both its intracellular localization and its transcriptional activation activity,which is inhibited by interaction with *** assays confirmed that BBX21 specifically associates with its own promoter,and those of BBX22,HY5,and GA2 ox1,and this interaction is not altered in agb1 *** data suggest that the AGB1-BBX21 interaction only affects the transcriptional activation activity of BBX21,but has no effect on its ability to bind *** together,our data demonstrate that AGB1 positively promotes hypocotyl elongation through the repression of BBX21 activity.

关键词： Arabidopsis BBX21 G-protein β subunit hypocotyl elongation transcriptional activation

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Biological Characteristics of Persimmon Anthracnose Pathogen Colletotrichum horii and Screening of Inhibitory Fungicides

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Asian Agricultural Research 2018年第10期10卷 71-76页

作者： Xianmei YU Changming HOU Kunpeng ZHANG Jie WANG ya'nan ma Hao ZHAI Miao AN Chengxiang AI Shandong Institute of Pomology Tai'an 271000China Shandong Academy of Agricultural Sciences Ji'nan 250100China

This experiment studied the biological characteristics of Colletotrichum horii causing persimmon anthracnose using the crossing method and blood cell counting plate method,and screened inhibitory fungicides via assessing the effects of 16 common fungicides on the mycelial growth and spore germination. The results showed that the most suitable temperature for mycelial growth of C. horri is 25℃,the most suitable temperature for spore germination is 28℃; the suitable p H for mycelial growth of C. horri is 4. 0-6. 0,the most suitable p H for spore germination is 4. 0; the optimal carbon source is glucose and maltose,and the optimal source of nitrogen is beef extract. Among the 16 common fungicides,33. 5% copper quinolate SC,25% bromothalonil EC and 70% mancozeb WP have the optimal inhibitory effects on the mycelial growth and spore germination of C. horri,and can be used as preferred agent for prevention and control of persimmon anthracnose,followed by70% Polyram WG,400 g/L Flusilazole EC and 50% Thiram WP,which can be used as alternative agents. The results are expected to provide experimental basis for effective control of persimmon anthracnose.

关键词：杂交法血细胞氮源农业牛肉

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不同排放源对华东地区PM_(2.5)影响的数值模拟

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中国环境科学 2018年第5期38卷 1616-1628页

作者：胡亚男马晓燕沙桐高嵩南京信息工程大学气象灾害教育部重点实验室气候与环境变化国际合作联合实验室气象灾害预报预警与评估协同创新中心中国气象局气溶胶与云降水重点开放实验室江苏南京210044 江苏省电力公司电力科学研究院江苏南京210044

使用中尺度气象-化学耦合模式WRF-Chem针对MEIC源清单中五大部门来源(工业源、电力源、民用源、交通源和农业源)对华东地区PM_(2.5)的影响进行了模拟研究,主要得到以下结论:春夏秋季PM_(2.5)约40%~60%来源于工业源,冬季由于采暖供热燃... 详细信息

使用中尺度气象-化学耦合模式WRF-Chem针对MEIC源清单中五大部门来源(工业源、电力源、民用源、交通源和农业源)对华东地区PM_(2.5)的影响进行了模拟研究,主要得到以下结论:春夏秋季PM_(2.5)约40%~60%来源于工业源,冬季由于采暖供热燃用大量散烧煤,导致民用源对PM_(2.5)的贡献最大,在山东、安徽和江苏省等高值区贡献率超过50%;农业源、电力源和交通源对PM_(2.5)影响的季节差异不大,农业源贡献约20%~30%,交通源和火电源贡献约10%.因此冬季需主要控制民用源排放,春夏秋季主要控制工业源排放,其次是农业源排放.一次PM_(2.5)在工业、电力和民用源贡献的PM_(2.5)中所占比例可达50%~60%;NO_3^-和NH_4^+在交通源贡献的PM_(2.5)中总比例可达53%,在农业源中总比例高达93%;由于模式对SO2-4模拟偏低,SO_4^(2-)在工业源和电力源贡献的PM_(2.5)中占比约5%~15%;OC对来自民用源的PM_(2.5)有30%的贡献,BC对来自交通源的PM_(2.5)有15%的贡献;Na+和Cl-对PM_(2.5)的贡献在各大来源中均低于3%.

关键词： PM_(2.5) WRF-Chem MEIC 华东地区

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牛乳源金黄色葡萄球菌EsxA蛋白的表达及免疫原性分析

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生物工程学报 2018年第5期34卷 694-702页

作者：易鸳鸯赵亚南马鹏睿李斌苏艳新疆农业大学动物医学学院新疆乌鲁木齐830052

为分析牛乳源金黄色葡萄球菌(Staphylococcus aureus)EsxA蛋白的免疫原性,构建EsxA-p ET-28a重组表达质粒,重组质粒经诱导表达后进行SDS-PAGE和Western blotting鉴定。用纯化后重组EsxA蛋白免疫小鼠,用间接ELISA检测免疫小鼠血清中的IgG... 详细信息

为分析牛乳源金黄色葡萄球菌(Staphylococcus aureus)EsxA蛋白的免疫原性,构建EsxA-p ET-28a重组表达质粒,重组质粒经诱导表达后进行SDS-PAGE和Western blotting鉴定。用纯化后重组EsxA蛋白免疫小鼠,用间接ELISA检测免疫小鼠血清中的IgG、IgG1和IgG2a水平;免疫小鼠经***菌株攻击后,检测小鼠肝、脾、肾组织荷菌数和免疫保护率,观察***菌株攻击后小鼠肝、脾、肾病理组织学变化。结果表明,成功诱导表达了EsxA重组蛋白,该重组蛋白免疫小鼠后血清抗体效价可达1∶900,与对照相比,重组蛋白免疫后可减少小鼠肝、脾、肾组织的荷菌数,减轻这些脏器的病理损伤,对免疫小鼠保护率达75%。上述结果表明,该重组Esx A蛋白具有良好的免疫原性。

关键词：牛乳源金黄色葡萄球菌 EsxA蛋白原核表达免疫原性

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肥胖男性精浆锌-α2糖蛋白与精液质量的相关性

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中华男科学杂志 2018年第3期24卷 216-220页

作者：齐亚楠马婧韩瑞钰马静王树松河北医科大学研究生学院河北石家庄050017 河北省计划生育科学技术研究院/国家卫计委计划生育与优生重点实验室河北石家庄050071

目的:探讨肥胖男性精浆锌-α2糖蛋白(ZAG)与精液质量的关系。方法:130例在生殖中心就诊的男性特发性不育患者为研究对象,采用ELISA方法检测精浆ZAG蛋白含量,比较不同精浆ZAG水平下精液质量情况,分析ZAG、精浆锌与精液质量的相关性以及... 详细信息

目的:探讨肥胖男性精浆锌-α2糖蛋白(ZAG)与精液质量的关系。方法:130例在生殖中心就诊的男性特发性不育患者为研究对象,采用ELISA方法检测精浆ZAG蛋白含量,比较不同精浆ZAG水平下精液质量情况,分析ZAG、精浆锌与精液质量的相关性以及肥胖对精浆锌、ZAG和精液质量的影响。结果:130例研究对象精浆ZAG含量为(111.29±26.50)μg/ml,以精浆ZAG进行三分位分组,3组间精子浓度和精子总数差异有统计学意义(P<0.05)。相关性分析发现,精浆ZAG与体质指数(BMI)、腰围(WC)、精子浓度和精子总数呈显著负相关(P<0.01);精浆锌与BMI、腰围呈正相关(P<0.05),与精液量和精子前向运动百分率呈负相关(P<0.05),而血清ZAG与精浆锌、ZAG和精液质量无相关性。以WC和BMI分组发现,肥胖男性精浆ZAG和精子前向运动百分率显著降低,精浆锌含量显著增高,差异有统计学意义(P<0.05)。结论:肥胖可能引起精浆中锌和ZAG代谢紊乱,精浆微环境发生改变从而影响精液质量。

关键词：精浆锌锌-α2 糖蛋白精液质量肥胖

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Regulation of Jasmonate-Mediated Artemisinin Biosynthesis by an AaORA-AaDAB Complex in Artemisia annua

Regulation of Jasmonate-Mediated Artemisinin Biosynthesis by...

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第十届上海市植物生物学青年学术研讨会

作者： ya-nan ma Ling Li Xue-qing Fu Pu Shi Qian Shen Xiao-long Hao Yue-Li Tang Qian He Li-hui Xie Ting-xiang yan Ming-hui Chen Qi-fang Pang Xiao-fen Sun Ke-xuan Tang Plant Biotechnology Research Center Fudan-SJTU-Nottingham Plant Biotechnology R&D Center School of Agriculture and Biology Shanghai Jiao Tong University

Artemisia annua produces a valuable medicinal component,artemisinin,a sesquiterpene lactone widely used in malaria *** jasmonate(JA)is well-known to induce the expression of all the crucial enzymes in artemisinin

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我国短缺药品供应保障政策研究

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卫生经济研究 2017年第8期34卷 57-60页

作者：盛亚楠李勇马爱霞赵梦蕊胡安琪中国药科大学国际医药商学院江苏南京211198

基于实地调研,分析我国短缺药品现状,发现我国现行的短缺药品供应保障政策存在薄弱环节:药品短缺处于常态,且集中分布在国家基本药物目录和低价药品目录,短缺药品多为临床必需和不可替代的药品,主要用于治疗心血管疾病、血液和造血器官... 详细信息

基于实地调研,分析我国短缺药品现状,发现我国现行的短缺药品供应保障政策存在薄弱环节:药品短缺处于常态,且集中分布在国家基本药物目录和低价药品目录,短缺药品多为临床必需和不可替代的药品,主要用于治疗心血管疾病、血液和造血器官疾病、神经系统疾病以及肿瘤,尚未建立重特大疾病药品短缺应急机制;药品短缺大多超过6个月,且多为省级和区域性短缺,缺乏短缺药品省级联合协调和保障机制。对此,应引起政府部门的重视。

关键词：短缺药品保障机制药品供应

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