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Washed microbiota transplantation reduces proton pump inhibitor dependency in nonerosive reflux disease

World Journal of Gastroenterology 2021年第6期27卷 513-522页

作者： ya-mei zheng Xian-Yun Chen Jie-Yi Cai Yu Yuan Wen-Rui Xie Jia-Ting Xu Harry Hua-Xiang Xia Min Zhang Xing-Xiang He Li-Hao Wu Department of Gastroenterology The First Affiliated Hospital of Guangdong Pharmaceutical UniversityResearch Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong ProvinceGuangzhou 510030Guangdong ProvinceChina Department of Science and Education The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510030Guangdong ProvinceChina Department of Epidemiology and Health Statistics Guangdong Pharmaceutical UniversityGuangzhou 510220Guangdong ProvinceChina

BACKGROUND The pathogenesis of gastroesophageal reflux disease(GERD)is closely associated with the intestinal bacteria composition and their *** To investigate whether washed microbiota transplantation(WMT)improves symptoms of nonerosive reflux disease(NERD)with proton pump inhibitor(PPI)*** Patients with recurrent NERD and PPI dependency at the First Affiliated Hospital of Guangdong Pharmaceutical University from 2017 to 2018 were included and divided into a WMT or PPI group treated with PPI with/without *** endpoint was NERD symptom frequency evaluated 1 mo after WMT using reflux disease questionnaire(RDQ)and GERD questionnaire(GERDQ)scores,remission time,PPI dose,and the examination of intestinal mucosal barrier *** In the WMT(n=15)and PPI(n=12)groups,the total remission rate at 1 mo after treatment was 93.3%vs 41.7%.Compared with the PPI group,the WMT group showed better results in GERDQ(P=0.004)and RDQ(P=0.003)and in remission months(8 vs 2,P=0.002).The PPI dose was reduced to some extent for 80%of patients in the WMT group and 33.3%in the PPI *** 24 patients,intestinal mucosal barrier function was examined before treatment,and changes in the degree of damage were observed in 13 of these patients after *** one of the 15 patients had minor side effects,including a mushy stool two or three times a day,which resolved on their own after 1 *** This study is the first to demonstrate that WMT may be safe and effective for relieving NERD symptoms and reducing PPI dependency and recurrence.

关键词： Nonerosive reflux disease Washed microbiota transplantation Proton pump inhibitor dependency Intestinal bacteria Lipopolysaccharide Small intestinal bacterial overgrowth

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中国山水画3D皴法的计算机仿真算法

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系统仿真学报 2009年第5期21卷 1297-1301,1304页

作者：孙美君孙济洲赵亚梅王征天津大学计算机科学与技术学院天津300072

总结中国山水画中披麻皴笔道的形态和分布特征,提出基于素描线的分形造型方法来构建3D山石模型,并基于模型主方向生成"披麻皴基准线"。将风格化信息合成到自定义笔法模型中,运用笔模型和笔法模型完成3D皴法的绘制。结果表明,算法成功实... 详细信息

总结中国山水画中披麻皴笔道的形态和分布特征,提出基于素描线的分形造型方法来构建3D山石模型,并基于模型主方向生成"披麻皴基准线"。将风格化信息合成到自定义笔法模型中,运用笔模型和笔法模型完成3D皴法的绘制。结果表明,算法成功实现了中国山水画仿真中披麻皴效果的3D渲染。

关键词：非真实感绘制 3D皴法仿真分形主方向

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Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng zheng Wang Zhou Ying Mo Biao zheng Miaomiao Han Qin Zhong Wenwen yang Peng Gao Lezhi yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

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Optimizing the key parameter to accelerate the recovery of AMOC under a rapid increase of greenhouse gas forcing

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 39-45页

作者： Haolan Ren Fei zheng Tingwei Cao Qiang Wang International Center for Climate and Environment Science(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina University of Chinese Academy of Sciences BeijingChina College of Oceanography Hohai UniversityNanjingChina CAS Key Laboratory of Ocean Circulation and Waves Institute of OceanologyChinese Academy of Sciences and Pilot National Laboratory for Marine Science and Technology(Qingdao)QingdaoChina

Atlantic Meridional Overturning Circulation(AMOC)plays a central role in long-term climate variations through its heat and freshwater transports,which can collapse under a rapid increase of greenhouse gas forcing in climate *** studies have suggested that the deviation of model parameters is one of the major factors in inducing inaccurate AMOC *** this work,with a low-resolution earth system model,the authors try to explore whether a reasonable adjustment of the key model parameter can help to re-establish the AMOC after its *** a new optimization strategy,the extra freshwater flux(FWF)parameter is determined to be the dominant one affecting the AMOC’s *** traditional ensemble optimal interpolation(EnOI)data assimilation and new machine learning methods are adopted to optimize the FWF parameter in an abrupt 4×CO_(2) forcing experiment to improve the adaptability of model parameters and accelerate the recovery of *** results show that,under an abrupt 4×CO_(2) forcing in millennial simulations,the AMOC will first collapse and then re-establish by the default FWF parameter ***,during the parameter adjustment process,the saltier and colder sea water over the North Atlantic region are the dominant factors in usefully improving the adaptability of the FWF parameter and accelerating the recovery of AMOC,according to their physical relationship with FWF on the interdecadal timescale.

关键词： Recovery of AMOC 4×CO_(2)forcing Key parameter Parameter estimation Data assimilation Machine learning

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The role of axon guidance molecules in the pathogenesis of epilepsy

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Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： zheng Liu Chunhua Pan Hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

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Tunable fabrication of single-crystalline CsPbI_(3) nanobelts and their application as photodetectors

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International Journal of Minerals,Metallurgy and Materials 2021年第6期28卷 1030-1037页

作者： Tao yang ya-peng zheng Kuo-Chih Chou Xin-mei Hou Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China

Lead halide perovskites have received increasing attention recently as a candidate material in various optoelectronic areas because of their high performance as light ***,we report the growth of CsPbI_(3) nanobelts via a solution process.A single-crystalline CsPbI_(3) nanobelt with uniform morphology can be achieved by controlling the amount of PbI_(2).A single-crystalline CsPbI_(3) nanobelt possesses a mean width,length,and thickness of 100 nm,5μm,and 20 nm,*** this work,photodetectors(PDs)based on individual CsPbI_(3) nanobelts are constructed and found to perform well with an external quantum efficiency and responsivity of 2.39×10^(5)% and 770 A/W,*** PDs also show a high detectivity of up to 3.12×10^(12) Jones,which is at par with that of Si *** PDs developed in this work exhibit great promise in various optoelectronic nanodevices.

关键词： photodetector cesium lead triiodide perovskite nanobelt detectivity

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Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin zheng Zi-Yu Ye Jun-Ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

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Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： Jie Wang Wei Wang Xuheng Chen Junfang Bao Qiuyue Hao Heng zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

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Computer Simulation of Microstructure Evolution of 82B Rod at Different Cooling Rates

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Journal of Iron and Steel Research International 2008年第2期15卷 56-59,64页

作者： XU Jin-qiao LIU ya-zheng ZHOU Shu-mei Materials Science and Engineering School University of Science and Technology Beijing Beijing 100083 China

According to thermodynamics and kinetics of phase transformation,a mathematical model of phase transformation was proposed,and the microstructure evolution of an 82B rod at different cooling rates was simulated by using the FEM software Marc/Mentat,based on the measurement of time-temperature transformation（TTT）curves of the 82B *** simulated results were in good agreement with the actual *** the results of computer simulation it was found that the cooling rate of the 82B rod,after laying,should be controlled within 5-8 ℃/*** the microstructure of rod there were over 95% of pearlite volume fraction and a small quantity of dispersive martensite（less than 5%）.

关键词： computer simulation microstructure evolution controlled cooling 82B rod

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Calculation Models of Interlamellar Spacing of Pearlite in High-Speed 82B Rod

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Journal of Iron and Steel Research International 2008年第4期15卷 57-60页

作者： XU Jin-qiao LIU ya-zheng ZHOU Shu-mei School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

With the investigated subject of 82B rod, the interlamellar spacings of pearlite at different isothermal transformation temperatures and different cooling rates during continuous cooling transformation were measured, and the effect of the isothermal transformation temperature and cooling rate on the interlamellar spacing was analyzed quantitatively. Moreover, the relationship models between undercooling and interlamellar spacing were presented by data regression. The experimental results show that the relationship between undercooling and reciprocal interlamellar spacing remains linear when the undercooling is not very large, or else, the interlamellar spacing tends to be constant and the relationship will deviate from linearity.

关键词： interlamellar spacing calculation model high-speed rod 82B

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