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Chinese Chemical Letters 2014年第8期25卷 1198-1202页

作者： Xiao-Lan Li Dong-ling Meng Jiao Zhao ya-ling yang Technology Centre of China Tobacco Guangxi Industrial Co. Ltd. College of Life Science and Technology Kunming University of Science and Technology

This study aimed to establish a rapid analytical method to determine antioxidants in essence. A simple,efficient and practical, vortex-assisted, cloud-point extraction（VACPE） procedure is proposed for extracting and pre-concentrating four different of synthetic phenolic antioxidants（SPAs）, propyl gallate（PG）, tert-butylhydroquinone（TBHQ）, butylated hydroxyanisole（BHA）, butylated hydroxytoluene（BHT） in essence prior to high performance liquid chromatography（HPLC） analysis. The non-ionic surfactant, fatty alcohol polyoxyethylene ether-9（AEO-9）, was used as extractant and vortex-mixing was utilized to reduce extraction time and improve extraction efficiency. The effective parameters of the extraction process, such as volume of extraction solvent, pH, vortex-mixing time, equilibration temperature and time, were optimized. Under the optimum conditions, the linear range of PG, TBHQ,BHA and BHT was 8.0–800 ng/mL. All correlation coefficients of the calibration curves were higher than0.996 and relative standard deviations（RSD, n = 5） were 2.36%–5.46%. The proposed method was successfully applied to the extraction and determination of antioxidants in essence samples with satisfactory relative recoveries of 89.4%–103.5%. The results confirmed the SPAs of essence could be effectively monitored by this method and also established good reference criteria for essence.

关键词： Vortex-assisted cloud-point extraction AEO-9 Antioxidant High performance liquid chromatography Essence

Synthesis and characterization of A1 doped δ-laminar crystal sodium silicate

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Chinese Chemical Letters 2009年第4期20卷 462-464页

作者： Xue Jing yang ya ling yang Wei Zhen Mou Sheng Liu Jun Hong Chai Faculty of Life Science and Technology Kunming University of Science and Technology Kunming 650224 China Kunming Fruit Business and Economics Co. Ltd. Kunming 650106 China

An modified laminar crystal sodium silicate （A1-SKS-6） was synthesized by spray drying and high temperature crystallization using sodium silicate as silicon source, A1 atom as inorganic source and hexadecyltrimethy ammonium bromide （CTMAB） as the structure template. The hydrothermal stability of product was at least 1 h. The synthesized material was characterized by XRD and SEM. The results indicated that shape and intensity of XRD diffraction peak at 20 took changes, but raw material 8 phase crystal form kept unchanged, and assured high Ca^2＋ and Mg^2＋ binding capacity of the products. The Ca^2＋ and Mg^2＋ binding capacity of product is up to 380 mg Ca/g and 410mg Mg/g respectively. It was found that the hole of product became smaller and appeared rod structure based on SEM. The hydrothermal stability was increased due to the pillaring of AI atom.

关键词： A1 doping δ-Laminar crystal sodium silicate Detergent builder Stability

Autoimmune encephalitis after surgery for appendiceal cancer:A case report

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World Journal of Clinical Cases 2023年第11期11卷 2576-2581页

作者： yan-Hui Mao Lu Li Li-Ming Wen Jia-Min Qin ya-ling yang Li Wang Fan-Rong Wang Yi-Zhou Zhao Department of Gastroenterology Sichuan Mianyang 404 HospitalMianyang 621000Sichuan ProvinceChina Department of Pathology Sichuan Mianyang 404 HospitalMianyang 621000Sichuan ProvinceChina Department of Medical Imaging Sichuan Mianyang 404 HospitalMianyang 621000Sichuan ProvinceChina

BACKGROUND Primary cancer of the appendix is rare and often difficult to diagnose preoperatively due to the lack of specific clinical symptoms. Autoimmune encephalitis(AIE) is the most common cause of non-infectious encephalitis. The etiologies of AIE include tumors(paraneoplastic), infections(parainfections), or recessive infections. The tumors that have been reported to cause AIE include thymomas, ovarian teratomas, lung cancers, and breast cancers. However, there are no reports of AIE occurring after surgery for appendiceal cancer. This report describes the diagnosis and treatment of a patient with an appendiceal cancer and postoperative *** SUMMARY We report the case of a 47-year-old man who was transferred to our hospital due to a recurrent low intestinal obstruction. Abdominal enhanced computed tomography was used to consider the possibility of a terminal ileal tumor with serous infiltration and lymph node metastasis. A right hemi-colectomy was performed under general anesthesia with an ileo-transcolon anastomosis and laparoscopic exploration. The postoperative pathologic evaluation revealed a high-grade goblet cell carcinoma of the appendix, accompanied by mesangial and abdominal lymph node metastases, and neural tube and vascular infiltration. The operation was completed without complication. The patient developed restlessness on postoperative day 4, and gradually developed a disturbance of consciousness on postoperative day 6. He was transferred to West China Hospital of Sichuan University and diagnosed with *** Albeit rare, the occurrence of neurologic and psychiatric symptoms in patients with an appendiceal cancer postoperatively suggests the possibility of AIE.

关键词： Appendiceal cancer Goblet cell carcinoma Repeated ileus Postoperative Autoimmune encephalitis Case report

语义知识神经表征的fMRI研究:通道特异性或类别特异性?

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心理学报 2005年第2期37卷 159-166页

作者：金花刘鹤龄杨娅玲莫雷华南师范大学体育系长庚纪念医院磁振中心美国南加州大学心理系 usa90089 华南师范大学心理应用研究中心广州510631

在同一实验中同时考虑类别与通道二个因素,并采用典型的语义提取任务应用功能磁共振成像技术探讨了语义知识的神经基础,结果发现不同类型的语义知识的脑激活模式(含左梭形回的激活)无论在范围还是强度上存在很大的相似性;而且,在严格的... 详细信息

在同一实验中同时考虑类别与通道二个因素,并采用典型的语义提取任务应用功能磁共振成像技术探讨了语义知识的神经基础,结果发现不同类型的语义知识的脑激活模式(含左梭形回的激活)无论在范围还是强度上存在很大的相似性;而且,在严格的统计阈值下,不存在通道或是类别特异性激活的脑区。结果提示语义知识的神经表征分布于整个大脑皮层;在提取物体语义知识时都会同时激活该物体的视觉表象。另外,研究观察到的语义提取过程中BA9区的激活进一步证实并扩展了关于“汉语和表音文字在皮层组织上存在重要差异的观点”。

关键词：语义知识功能性磁共振成像神经表征

Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie yang Ganggang Zhang Chen Wang yanlian yang ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-Jia Hao Xu-ya Chai Pei-Sai Li yang Liu Li-Xia Liu Ying Xu Pan-Pan yang ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

病原DNA识别及其诱导天然免疫调节机制研究进展

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生物化学与生物物理进展 2011年第12期38卷 1099-1105页

作者：邢雅玲郑洋王凯陈晓娟陈忠斌军事医学科学院放射与辐射医学研究所北京100850

机体天然免疫系统拥有一系列可以探测和抵制微生物侵袭的机制.目前,关于病原RNA的细胞内识别机制有了较为深入的研究和相关报道,但细胞内病原DNA的识别和相应的天然免疫应答机制仍未完全被揭示.阐明上述机制有助于了解和治疗一系列微生... 详细信息

机体天然免疫系统拥有一系列可以探测和抵制微生物侵袭的机制.目前,关于病原RNA的细胞内识别机制有了较为深入的研究和相关报道,但细胞内病原DNA的识别和相应的天然免疫应答机制仍未完全被揭示.阐明上述机制有助于了解和治疗一系列微生物感染相关的疾病,包括病毒和细菌感染类疾病、病毒相关的肿瘤、自身免疫性疾病等.近年来,细胞内多个充当"DNA传感器"的分子和干扰素调节分子被认为在细胞质DNA诱导宿主天然免疫反应过程中起着关键性调节作用.综述了对细胞内病原DNA的主要识别分子、信号通路以及相关的天然免疫调控机制.

关键词：病原DNA DNA传感器天然免疫干扰素

Progress of research in the application of ultrasound technology for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2823-2837页

作者： Qiuquan Cai Lianghui Meng Meina Quan ling Wang Jing Ren Chenguang Zheng Jiajia yang Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Innovation Center for Neurological Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory Tianjin UniversityTianjinChina Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin UniversityTianjinChina

Alzheimer’s disease is a common neurodegenerative disorder defined by decreased reasoning abilities,memory loss,and cognitive *** presence of the blood-brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer’s *** use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent *** a safe and feasible therapeutic and drug-delivery method,ultrasound has shown promise in improving cognitive *** article provides a summary of the application of ultrasound technology for treating Alzheimer’s disease over the past 5 years,including standalone ultrasound treatment,ultrasound combined with microbubbles or drug therapy,and magnetic resonance imaging-guided focused ultrasound *** is placed on the benefits of introducing these treatment methods and their potential *** found that several ultrasound methods can open the blood-brain barrier and effectively alleviate amyloid-βplaque *** believe that ultrasound is an effective therapy for Alzheimer’s disease,and this review provides a theoretical basis for future ultrasound treatment methods.

关键词： Alzheimer’s disease blood-brain barrier drugs magnetic resonance imaging-guided focused ultrasound microbubbles scanning ultrasound ultrasound ultrasound stimulation

南秦岭中生代东河群碎屑锆石U-Pb年龄及其地质意义

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岩石矿物学杂志 2018年第2期37卷 211-229页

作者：杨涛张亚峰杨玲易鹏飞何元方仵桐陕西省地质调查中心陕西西安710068

南秦岭微陆块是秦岭造山带的重要构造单元,为了探讨南秦岭中生代断陷盆地的物质来源,本文选取凤太地区下白垩统东河群田家坝组复成分砾岩、周家湾组凝灰质砂岩为研究对象,对其中的碎屑锆石进行了LA-ICP-MS锆石U-Pb同位素测年,获得2组各4... 详细信息

南秦岭微陆块是秦岭造山带的重要构造单元,为了探讨南秦岭中生代断陷盆地的物质来源,本文选取凤太地区下白垩统东河群田家坝组复成分砾岩、周家湾组凝灰质砂岩为研究对象,对其中的碎屑锆石进行了LA-ICP-MS锆石U-Pb同位素测年,获得2组各40个有效年龄。结果明显可以分为5个年龄峰,范围分别是:2 595~2 771 Ma、1 215~1 916 Ma、749~1 142 Ma、424~576 Ma、218~306 Ma,分别对应Kenor、Columbia、Rodinia、Gondwana、Pangaea等5次超大陆事件。通过对测年数据进行分析,结合区域地质资料,认为北秦岭增生造山带和华北板块为南秦岭中生代盆地提供了大部分的物源,扬子板块次之,北祁连造山带和西秦岭北缘构造带也有一定的贡献。

关键词：碎屑锆石测年东河群早白垩世中生代盆地南秦岭

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin Liu Jian Zhang ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein