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FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition

Current Medical Science 2024年第1期44卷 187-194页

作者： Xiao-mei HUANG E LIAO Jun-qun LIAO ya-ling liu Yong SHAO Department of Obstetrics and Gynecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070China Medical Laboratory Science The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Yubei Maternity and Child Healthcare HospitalChongqing 400042China

Objective:Premature rupture of membranes(PROM)is a common pregnancy disorder that is closely associated with structural weakening of fetal *** have found that formyl peptide receptor 1(FPR1)activates inflammatory pathways and amniotic epithelial-mesenchymal transition(EMT),stimulates collagen degradation,and leads to membrane weakening and membrane *** purpose of this study was to investigate the anti-inflammatory and EMT inhibitory effects of FPR1 antagonist(BOC-MLF)to provide a basis for clinical prevention of ***:The relationship between PROM,FPR1,and EMT was analyzed in human fetal membrane tissue and plasma samples using Western blotting,PCR,Masson staining,and ELISA ***(LPS)was used to establish a fetal membrane inflammation model in pregnant rats,and BOC-MLF was used to treat the LPS rat *** detected interleukin(IL)-6 in blood from the rat hearts to determine whether the inflammatory model was successful and whether the anti-inflammatory treatment was *** used electron microscopy to analyze the structure and collagen expression of rat fetal ***:Western blotting,PCR and Masson staining indicated that the expression of FPR1 was significantly increased,the expression of collagen was decreased,and EMT appeared in *** rat model indicated that LPS caused the collapse of fetal membrane epithelial cells,increased intercellular gaps,and decreased ***-MLF promoted an increase in fetal membrane collagen,inhibited EMT,and reduced the weakening of fetal ***:The expression of FPR1 in the fetal membrane of PROM was significantly increased,and EMT of the amniotic membrane was ***-MLF can treat inflammation and inhibit amniotic EMT.

关键词： formyl peptide receptor 1 BOC-MLF epithelial-mesenchymal transition premature rupture of membranes

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Progress toward understanding the contribution of alkali generation in dental biofilms to inhibition of dental caries

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International Journal of Oral Science 2012年第3期4卷 135-140页

作者： ya-ling liu Marcelle Nascimento Robert A Burne Depa rtment of Oral Biology College of Dent stry University of Florida Gainesville USA Department of Restorative Dental Sciences Division of Operative Dentistry College of Dentistry University of Florida Gainesville USA

Alkali production by oral bacteria is believed to have a major impact on oral microbial ecology and to be inibitory to the initiation and progression of dental caries. A substantial body of evidence is beginning to accumulate that indicates the modulation of the alkalinogenic potential of dental biofilms may be a promising strategy for caries control. This brief review highlights recent progress toward understanding molecular genetic and physiologic aspects of important alkali-generating pathways in oral bacteria, and the role of alkali production in the ecology of dental biofilms in health and disease.

关键词： arginine biofilm dental caries microbial ecology urea

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Short-term effects of air pollution on acute myocardial infarctions in Shanghai, China, 2013-2014

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Journal of Geriatric Cardiology 2016年第2期13卷 132-137页

作者： Xiao-Dong WANG Xu-Min ZHANG Shao-Wei ZHUANG Yu LUO Sheng KANG ya-ling liu Department of Cardiology Shanghai East Hospital Tongji University School of Medicine Shanghai China Department of Anesthesiology Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai China

Background Although particulate matter, with diameters 〈 2.5 μm （PM2.5） and 〈 10 μm （PM10）, and other pollutants have been associated with cardiovascular morbidity and mortality, the effect of pollutants on acute myocardial infarctions （AMIs） has rarely been investigated in Asia, especially in Shanghai, China. Methods Between 1 November 2013 and 27 April 2014, 972 patients from the Pudong District, Shanghai City, were assessed by the Emergency Medical Service. A case-crossover design was used to analyze exposure to air pollution and the AMI risk. Exposures to PM2.5, PM10, nitrogen dioxide （NO2）, sulphurdioxide （SO2）, and carbon monoxide （CO） were based on the mean urban background levels. The associations among AMI admissions, the included pollutants, temperature, and relative humidity were analyzed using correlation and logistic regression. Results The urban background levels of PM2.5, PM10 and CO were associated with an increased risk of AMI, unlike NO2 and SO2 levels. The OR （95% CI） for AMI were 1.16 （1.03-1.29）, 1.05 （1.01-1.16）, 0.82 （0.75-1.02）, 0.87 （0.63-1.95）, and 1.08 （1.02-1.21） for PM2.5, PM10, NO2, SO2, and CO, respectively. Increases in the air quality index （AQI） were associated with more AMI occurrences. There was no correlation between fluctuations in temperature and relative humidity with AMI hospital admissions. Conclusions Short-term exposure to moderate-serious pollution levels is associated with increased risk of AMI. Increased PM2.5, PM10 and CO levels are related to increased AMI admissions.

关键词： Air pollution Myocardial infarction Particulate matter

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Role of the ultra-wide-field imaging system in the diagnosis of pigmented paravenous chorioretinal atrophy

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International Journal of Ophthalmology(English edition) 2022年第11期15卷 1878-1880页

作者： ya-ling liu ya-Rou Hu Miao-Hong Chen Zhen Yu Guo-Ming Zhang Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina Department of ophthalmology the Second Clinical Medical College of Jinan UniversityGuangzhou 510632Guangdong ProvinceChina

Dear Editor,P igmented paravenous chorioretinal atrophy(PPCRA), which was first described by Hewiston-Brown in 1937, is a rare pigmentary retinopathy affecting the retina and choroid;most patients mainly manifest symm... 详细信息

关键词： atrophy diagnosis venous

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Differences in Immune Responses between Children and Adults with COVID-19

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Current Medical Science 2021年第1期41卷 58-61页

作者： Yin YUAN Qiu-peng WANG Dan SUN Zu-bo WU Hua PENG Xin-wen liu ya-ling liu Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Neurology Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China

Over 85590000 individuals have been infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Although there have been an increasing number of reports on coronavirus disease 2019(COVID-19),it is unclear why infected children show milder symptoms than adults.A retrospective case study was performed at two designated hospitals for ***(56 children and 63 adults)with confirmed SARS-CoV-2 infection and mild pneumonia were randomly enrolled in this *** median age of the children was 7.0 years,and 51.79%of them were *** median age of the adults was 57 years,and 47.62%were *** most common symptoms were fever,cough,sputum and *** were no significant differences in symptoms between children and adult *** terms of immunological indices on admission,adult patients displayed typical leukopenia and markedly higher levels of IL-2,IL-4,and IL-6 than child *** elevation of IL-2,IL-4 and IL-6 in adults induced more extensive lung *** effective and non-aggressive immune response successfully resisted SARS-CoV-2 invasion and maintained mild symptoms in child *** correlation of higher IL-2,IL-4,and IL-6 with the lung injury might be evidence that preventing excessive cytokine production can avoid further lung damage in these patients.

关键词： COVID-19 child adult immune response

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Microstructure and mechanical properties of Al-10Si alloy modified with Al-5Ti

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China Foundry 2018年第6期15卷 405-410页

作者： ya-ling liu Chang-jun Wu Hao Tu Xiao-wang Lu Jian-hua Wang Xu-ping Su Jiangsu Key Laboratory of Material Surface Science and Technology School of Materials Science and Engineering Changzhou University National Experimental Teaching Demonstration Center of Materials Science and Engineering Changzhou University Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering Changzhou University

The microstructure, fracture morphology and mechanical properties of Al-10 Si alloy modified with Al-5 Ti were analyzed and tested by optical microscopy, scanning electron microscopy, and universal electronic testing machine. Compared with unmodified Al-10 Si alloy, the area fraction of α-Al phase in Al-10 Si alloy modified at 740 °C increased first and then decreased with the increase of added amounts of Al-5 Ti, and reached the maximum when the added amount of Al-5 Ti was 0.5 wt.%. When the modification temperature increased from 700 to 740 °C with Al-5 Ti being fixed at 0.5 wt.%, α-Al dendrites were refined obviously and the area fraction remarkably increased. Compared with unmodified Al-10 Si alloy, the ultimate tensile strength and elongation of the alloy modified at 740 °C with 0.5 wt.% Al-5 Ti increased by 9% and 49%, respectively. The fracture surface of modified alloy predominantly exhibited ductile fracture.

关键词： Al-10Si modification microstructure mechanical properties

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Early Intratracheal Administration of Corticosteroid and Pulmonary Surfactant for Preventing Bronchopulmonary Dysplasia in Preterm Infants with Neonatal Respiratory Distress Syndrome: A Meta-analysis

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Current Medical Science 2019年第3期39卷 493-499页

作者： yan-yan ZHONG Jin-chun LI ya-ling liu Xiao-bo ZHAO Musa MALE Dong-kui SONG yan BAI Department of Pediatrics Huazhong University of Science and Technology Hospital Wuhan 430074China Neonatal Intensive Care Unit Hubei Maternity and Children's Hospital Wuhan 430070China Department of Pediatrics Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430022 China Department of Urology Tongji Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhan 430030 China

There is uncertain result with regard to the use of inhalation or instillation steroids to prevent bronchopulmonary dysplasia in preterm infants. This meta-analysis was designed to evaluate the efficacy and safety of early airway administration (within 2 days after birth) of corticosteroids and pulmonary surfactant (PS) for preventing bronchopulmonary dysplasia (BPD) in premature infants with neonatal respiratory distress syndrome (NRDS). The related studies were retrieved in PubMed, EMBASE, the Cochrane Library, Clinical Trial, CNKI, Wanfang and VIP Database from inception to August 2018. Two reviewers independently screened the studies to ensure that all patients with diagnosis of NRDS were enrolled to studies within 1 day after birth, assessed the quality of included studies by GRADEpro system and extracted the data for review. The meta-analysis was performed by RevMan 5.2 software. A subgroup analysis about inhaled corticosteroid (ICS) delivery method was made between ICS inhalation subgroup [inhalation of ICS by nebulizer or metered dose inhaler (MDI)] and ICS intratracheal instillation subgroup (PS used as a vehicle). Eight randomized controlled trials were enrolled in the meta-analysis, 5 trials of which stated the randomized method, grouping and blinded method, and the follow-up procedures were reported. GRADEpro system showed high quality of 4 trials (5 articles), and the rest 4 trials had moderate quality. Meta-analysis showed that the incidence of BPD was decreased in ICS group, the relative risk (RR) was 0.56 (95% CI: 0.42-0.76), and similar trends were found in ICS inhalation subgroup and ICS intratracheal instillation subgroup, with the corresponding RR being 0.58 (95% CI: 0.41-0.82) and 0.47 (95% CI: 0.24-0.95) respectively. ICS could also significantly reduce the mortality risk as compared with placebo control group (RR: 0.67;95% CI: 0.45-0.99), with RR of ICS inhalation subgroup and ICS intratracheal instillation subgroup being 0.81 (95% CI: 0.34-1.

关键词： corticosteroid pulmonary surfactant preterm infants bronchopulmonary dysplasia neonatal respiratory distress syndrome meta-analysis

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Boosting solar hydrogen production via electrostatic interaction mediated ***-TiO_(2−x)biohybrid system

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Nano Research 2024年第6期17卷 5390-5398页

作者： Xingxing Lv Weicheng Huang ya Gao Rui Chen Xiaowei Chen Danqing liu ling Weng Liangcan He Shaoqin liu School of Material Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150040China School of Medicine and Health and Key Laboratory of Micro-systems and Micro-structures Manufacturing of Ministry of EducationHarbin Institute of TechnologyHarbin 150001China Department of Physics School of ScienceJimei UniversityXiamen 361021China Zhengzhou Research Institute Harbin Institute of TechnologyZhengzhou 450046China

Hydrogen is garnering growing attention as a green energy source with zero carbon ***,most hydrogen production technologies still rely on the consumption of fossil fuels and are therefore *** has driven the search for more environmentally friendly methods of hydrogen *** this work,we present an innovative approach to enhance hydrogen generation via electrostatic interaction in the Escherichia coli and defective titanium dioxide(TiO_(2−x))*** method involves narrowing the forbidden bandwidth of TiO2 while introducing defect bands into its conduction band to facilitate visible light absorption and efficient charge *** biohybrid system,consisting of *** and TiO_(2−x),demonstrates a remarkable capability to produce 1.25 mmol of hydrogen within a 3-h timeframe under visible light *** accomplishment signifies a 3.31-fold rise in hydrogen production in comparison to ***,signifying a substantial enhancement in hydrogen production ***,we delve into the alterations in biological metabolites associated with hydrogen production and the changes in electron transfer in different biohybrid *** provides valuable insights into the understanding of the intrinsic mechanisms that drive the *** work introduces a novel and promising avenue for achieving this exciting goal.

关键词： Escherichia coli TiO_(2−x)nanoparticles biohybrid system hydrogen production

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The identification of AMZ2 as a candidate causative gene in a severe teratozoospermia patient characterized by vacuolated spermatozoa

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Asian Journal of Andrology 2024年第1期26卷 107-111页

作者： liu liu Jing yang Wen-Jing Zhang Yi-ling Zhou Gui-Jun Zhao ya Huang Shu-yan Tang Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases Shanghai 200011China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development Department of Computational BiologySchool of Life SciencesFudan UniversityShanghai 200436China Shanghai Towako Hospital Shanghai 200131China Shanghai Institute of Medical Genetics Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China

Teratozoospermia with cephalic defects is one of the most severe types of sperm defects known to *** several monogenic factors are linked to cephalic abnormalities,such as globozoospermia and macrozoospermia,the genetic cause of vacuolated spermatozoa remains inadequately ***,we analyzed whole-exome sequencing(WES)data for an individual from a consanguineous family with severely vacuolated *** analysis revealed a novel homozygous c.520A>G(***174Ala)variant in the archaelysin family metallopeptidase 2(AMZ2),a gene that encodes a zinc metalloprotease previously shown to be highly expressed in the testes and *** algorithms predicted this variant to be a damaging *** with an autosomal recessive mode of inheritance,this variant was inherited from heterozygous parental *** investigate the potential pathogenicity of the identified variant,we compared the AMZ2 expression in sperm cells from the patient with the AMZ2 variant and from a healthy *** analysis revealed that the homozygous missense variant in AMZ2 abolished AMZ2 expression in the *** findings reveal a candidate causative gene for vacuolated spermatozoa.

关键词： AMZ2 male infertility sperm quality teratozoospermia

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Numerical study on the effective thermal conductivity and thermal tortuosity of porous media with different morphologies

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Science China(Technological Sciences) 2024年第6期67卷 1685-1694页

作者： DU Shen LI Dong LI Meng-Jie HE ya-ling Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an710049China

Effective thermal conductivity and thermal tortuosity are crucial parameters for evaluating the effectiveness of heat conduction within porous *** direct pore-scale numerical simulation method is applied to investigate the heat conduction processes inside porous structures with different *** thermal conduction performances of idealized porous structures are directly compared with real foams across a wide range of *** foam structures are reconstructed using X-ray computed tomography and image processing techniques,while Kelvin and Weaire-Phelan structures are generated through periodic unit cell *** detailed temperature fields inside the porous structures are determined by solving the heat conduction equation at the pore *** results present that the equivalent thermal conductivity of Kelvin and Weaire-Phelan structures is similar to and greater than that of the real foam structure with the same strut *** thermal tortuosity of real foam structure is relatively larger and the heat conduction path becomes straighter by adopting the anisotropic *** thermal tortuosity of the fluid channels for Kelvin,Weaire-Phelan,and real foam structures is close to *** thermal conductivity of porous structures with heat transfer fluid increases as the thermal conductivity ratio of fluid to solid becomes larger.A small porosity of porous media leads to a larger equivalent thermal conductivity due to the dominant contribution of porous skeleton in the heat conduction *** derived from parallel and series models,as well as the Maxwell-Eucken models,provide decent predictions of effective thermal conductivity,with an average error of less than 8%in the entire range of thermal conductivity ratio.

关键词： volumetric solar receiver porous morphology direct pore-scale simulation equivalent thermal conductivity thermal tortuosity empirical correlation

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