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Human amniotic epithelial cell transplantation for the repair of injured brachial plexus nerve: evaluation of nerve viscoelastic properties

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Neural Regeneration Research 2015年第2期10卷 260-265页

作者： Hua Jin Qi yang Feng Ji ya-jie zhang yan Zhao Min Luo Jinan Maternity and Child Care Hospital China-Japan Union Hospital Jilin University Shandong Corps Hospital of Chinese People’s Armed Police Forces

The transplantation of embryonic stem cells can effectively improve the creeping strength of nerves near an injury site in animals. Amniotic epithelial cells have similar biological properties as em-bryonic stem cells; therefore, we hypothesized that transplantation of amniotic epithelial cells can repair peripheral nerve injury and recover the creeping strength of the brachial plexus nerve. In the present study, a brachial plexus injury model was established in rabbits using the C6root avulsion method. A suspension of human amniotic epithelial cells was repeatedly injected over an area 4.0 mm lateral to the cephal and caudal ends of the C6 brachial plexus injury site （1 × 106 cells/mL, 3μL/injection, 25 injections） immediately after the injury. The results showed that the decrease in stress and increase in strain at 7,200 seconds in the injured rabbit C6 brachial plexus nerve were mitigated by the cell transplantation, restoring the viscoelastic stress relaxation and creep properties of the brachial plexus nerve. The forepaw functions were also signiifcantly improved at 26 weeks after injury. These data indicate that transplantation of human amniotic epithelial cells can effec-tively restore the mechanical properties of the brachial plexus nerve after injury in rabbits and that viscoelasticity may be an important index for the evaluation of brachial plexus injury in animals.

关键词： nerve regeneration brachial plexus injury human amniotic epithelial cells forepaw function stress relaxation creep viscoelasticity neural regeneration

Enhanced positive humidity sensitive behavior of p-reduced graphene oxide decorated with n-WS_(2) nanoparticles

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Rare Metals 2021年第7期40卷 1762-1767页

作者： Zai-Hua Duan Qiu-Ni Zhao Cheng-Zhen Li Si Wang ya-Dong Jiang ya-jie zhang Bo-Hao Liu Hui-Ling Tai State Key Laboratory of Electronic Thin Films and Integrated Devices School of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 610054China

Most resistance-type humidity sensors exhibit negative humidity sensitivity,i.e.,their resistance decreases with a corresponding increase in *** is primarily attributed to the dominant role of ionic conduction in adsorbed *** this work,a humidity sensor based on a p-type reduced graphene oxide(p-rGO)with positive humidity sensitivity is ***,its positive humidity sensing response is further enhanced by n-type WS_(2) nanoparticles *** results show that both rGO and r GO/WS_(2) humidity sensors have good linear response in the relative humidity(RH)range of0%-91.5%.The sensitivity of the rGO/WS_(2) humidity sensor is 1.87 times that of rGO humidity sensor,which is mainly attributed to p-n heterojunction between rGO and WS_(2).Besides,the r GO/WS_(2) humidity sensor has small humidity hysteresis(-3%RH)and good *** work demonstrates a humidity sensor based on rGO/WS_(2) composite film and provides a facile route for fabricating humidity sensor with positive humidity sensing properties.

关键词： Reduced graphene oxide WS2 nanoparticles Heterojunction Humidity sensor Humidity sensing mechanism

Inhibition of Girdin enhances chemosensitivity of colorectal cancer cells to oxaliplatin

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World Journal of Gastroenterology 2014年第25期20卷 8229-8236页

作者： ya-jie zhang A-Jian Li Yi Han Lu Yin Mou-Bin Lin Department of General Surgery RuiJin Hospital Affiliated Shanghai Jiaotong University School of Medicine

AIM: To investigate the effect of Girdin knockdown on the chemosensitivity of colorectal cancer cells to oxaliplatin and the possible mechanisms involved.

关键词： Oxaliplatin Chemosensitivity Girdin Colorectal cancer TOP2B

Compensatory recombination phenomena of neurological functions in central dysphagia patients

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Neural Regeneration Research 2015年第3期10卷 490-497页

作者： Xiao-dong Yuan Li-fu Zhou Shu-juan Wang yan-sheng Zhao Xiao-jie Wang Li-li zhang Shou-hong Wang ya-jie zhang Li Chen Department of Neurology Affiliated Kailuan General Hospital of Hebei United University Department of MRI Room Affiliated Kailuan General Hospital of Hebei United University

We speculate that cortical reactions evoked by swallowing activity may be abnormal in patients with central infarction with dysphagia. The present study aimed to detect functional imaging features of cerebral cortex in central dysphagia patients by using blood oxygen level-depen- dent functional magnetic resonance imaging techniques. The results showed that when normal controls swallowed, primary motor cortex （BA4）, insula （BA13）, premotor cortex （BA6/8）, supramarginal gyrus （BA40）, and anterior cingulate cortex （BA24/32） were activated, and that the size of the activated areas were larger in the left hemisphere compared with the right. In re- current cerebral infarction patients with central dysphagia, BA4, BA13, BA40 aild BA6/8 areas were activated, while the degree of activation in BA24/32 was decreased. Additionally, more areas were activated, including posterior cingulate cortex （BA23/31）, visual association cortex （BA18/19）, primary auditory cortex （BA41） and parahippocampal cortex （BA36）. Somatosen- sory association cortex （BA7） and left cerebellum in patients with recurrent cerebral infarction with central dysphagia were also activated. Experimental findings suggest that the cerebral cortex has obvious hemisphere lateralization in response to swallowing, and patients with recurrent cerebral infarction with central dysphagia show compensatory recombination phenomena of neurological functions. In rehabilitative treatment, using the favorite food of patients can stimu- late swallowing through visual, auditory, and other nerve conduction pathways, thus promoting compensatory recombination of the central cortex functions.

关键词： nerve regeneration blood oxygen level-dependent functional magnetic resonance imag-ing cerebral ischemia dysphagia function restructuring cerebral cortex neural regeneration

Ileal pouch anal anastomosis with modified double-stapled mucosectomy-the experience in China

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World Journal of Gastroenterology 2013年第8期19卷 1299-1305页

作者： ya-jie zhang Yi Han Mou-Bin Lin Yong-Gang He Hao-Bo zhang Lu Yin Liang Huang Department of General Surgery RuiJin Hospital Affiliated Shanghai Jiaotong University School of Medicine Department of Emergency and Trauma Surgery RuiJin Hospital Affiliated Shanghai Jiaotong University School of Medicine

AIM:To investigate the feasibility and long-term functional outcome of ileal pouch-anal anastomosis with modified double-stapled ***:From January 2002 to March 2011,fourtyfive patients underwent ileal pouch anal anastomosis with modified double-stapled mucosectomy technique and the clinical data obtained for these patients were ***:Patients with ulcerative colitis(n = 29) and familial adenomatous polyposis(n = 16) underwent ileal pouch-anal anastomosis with modified doublestapled ***-eight patients underwent one-stage restorative proctocolectomy,ileal pouch anal anastomosis,protective ileostomy and the ileostomy was closed 4-12 mo ***-stage procedures were performed in seventeen urgent patients,proctectomy and ileal pouch anal anastomosis were completed after previous colectomy with *** within the first 30 d of surgery occurred in 10(22.2%) patients,all of them could be treated *** the median follow-up of 65 mo,mild to moderate anastomotic narrowing was occurred in 4 patients,one patient developed persistent anastomotic stricture and need surgical *** percent of patients developed at least 1 episode of *** was no incontinence in our patients,the median functional Oresland score was 6,3 and 2 after 1 year,2.5 years and 5 years *** half patients(44.4%) reported "moderate functioning",37.7% reported "good functioning",whereas in 17.7% of patients "poor functioning" was observed after 1 *** years later,79.2% of patients with good function,16.7% with moderate function,only 4.2% of patients with poor ***:The results of ileal pouch anal anastomosis with modified double-stapled mucosectomy technique are promising,with a low complication rate and good long-term functional results.

关键词： Ileal pouch anal anastomosis Stapled mucosectomy Ulcerative colitis Familial adenomatous polyposis Surgical technique

Targeted mutagenesis in Arabidopsis thaliana using CRISPR-Casi2b/C2ci^°°

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Journal of Integrative Plant Biology 2020年第11期62卷 1653-1658页

作者： Fan Wu Xinyu Qiao yafei Zhao Ziyi zhang Yifan Gao Lingfeng Shi Haokun Du Lulu Wang ya-jie zhang Yu zhang Langyu Liu Quan Wang Dejing Kong School of Biological Science and Engineering Hebei University of Science and TechnologyShijiazhuang 050018China College of Life Sciences Capital Normal UniversityBeijing 100048China Lingnan Laboratory of Modern Agriculture Genome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug Shijiazhuang 050018China

Casi2b/C2ci is a newly identified class 2 CRISPR endonuclease that was recently engineered for targeted genome editing in mammals and *** explore the potential applications of the CRISPR-Casi2b system in the dicot Arabidopsis thaliana,we selected BvCasi2b and BhCasi2b v4 for *** successfully used both endonucleases to induce mutations,perform multiplex genome editing,and create large deletions at multiple *** significant mutations were detected at potential off-target *** of the insertion/deletion frequencies and patterns of mutants generated via targeted gene mutagenesis highlighted the potential utility of CRISPRCasi2b systems for genome editing in Arabidopsis.

关键词： rice. CRISPR Arabidopsis

Ultra-broadband and wide-angle reflective terahertz polarization conversion metasurface based on topological optimization

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Chinese Physics B 2024年第10期33卷 287-294页

作者： ya-jie zhang Chao-Long Li Jia-Qi Luan Ming Zhao Ding-Shan Gao Pei-Li Li Faculty of Electrical and Optical Engineering Nanjing University of Posts and CommunicationsNanjing 210023China Wuhan National Laboratory for Optoelectronics and School of Physics Huazhong University of Science and TechnologyWuhan 430074China

Terahertz polarization conversion devices have significant potential applications in various fields such as terahertzimaging and *** this paper,we utilize genetic algorithms to topologically optimize the metasurface unit cellsand design a reflective linear polarization conversion metasurface with ultra-broadband and wide-angle *** partitioning the metallic pattern layer into quadrants,the encoding length is effectively reduced,resulting in a shorteroptimization *** research results indicate that the converter possesses a polarization conversion efficiency ratio higherthan 90%and a relative bandwidth ratio of 125%in a range of 0.231-0.995 ***,it can maintain excellentpolarization conversion properties when the incident angle of terahertz waves is less than 45°and the polarization angle isless than 15°,demonstrating excellent *** insights are provided for the design of terahertz wide-angle ultrawidebandpolarization conversion devices,and the proposed metasurfce has potential applications in terahertz polarizationimaging,spectroscopy and communication fields.

关键词： metasurface polarization conversion topology optimization ultra-broadband

Dynamic behaviors of graphene platelets-reinforced metal foam piezoelectric beams with velocity feedback control

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 63-80页

作者： jie CHEN Xinyue zhang Mingyang FAN School of Mathematics Statistics and Mechanics Beijing University of Technology College of Mechanical & Energy Engineering Beijing University of Technology

Graphene platelets(GPLs)-reinforced metal foam structures enhance the mechanical properties while maintaining the lightweight characteristics of metal foams. Further bonding piezoelectric actuator and sensor layers on the surfaces of GPLs-reinforced metal foam beams enables active vibration control, greatly expanding their applications in the aerospace industry. For the first time, this paper investigates the vibration characteristics and active vibration control of GPLs-reinforced metal foam beams with surfacebonded piezoelectric layers. The constant velocity feedback scheme is used to design the closed-loop controller including piezoelectric actuators and sensors. The effects of the GPLs on the linear and nonlinear free vibrations of the beams are numerically *** Newmark-β method combined with Newton's iteration technique is used to calculate the nonlinear responses of the beams under different load forms including harmonic loads,impact loads, and moving loads. Additionally, special attention is given to the vibration reduction performance of the velocity feedback control on the responses of the beam.

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Direct Asymmetric Mannich Reactions Catalyzed by 4-Long Chain Alkoxyl-L-Proline

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Direct Asymmetric Mannich Reactions Catalyzed by 4-Long Chai...