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Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-Hao hu Dong-Yi yan Ke-hui Zhang Di Zhang Xi-Mao Cui Xiao-hua Jiang Shun Zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker

Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan hu Yue Li hua Zhang Lian-Lian Wang Wen-Wen Liu Xin yang Ming-Zhao Xiao Hao-Ling Zhang Juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

Molecular mechanism of pancreatic ductal adenocarcinoma:The heterogeneity of cancer-associated fibroblasts and key signaling pathways

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World Journal of Clinical Oncology 2025年第2期16卷 18-28页

作者： Zhong-Yuan hu Ding Ding Yu Song ya-Feng Deng Cheng-Ming Zhang Tao Yu First School of Clinical Medicine Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina College of Acupuncture and Massage Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Graduate School Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Digestive Department I Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 710000Shaanxi ProvinceChina

Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival *** study offers a detailed exploration of epidemiological trends in pancreatic cancer and key molecular drivers,such as mutations in CDKN2A,KRAS,SMAD4,and TP53,along with the influence of cancer-associated fibroblasts(CAFs)on disease *** particular,we focused on the pivotal roles of signaling pathways such as the transforming growth factor-βand Wnt/β-catenin pathways in the development of pancreatic cancer and investigated their application in emerging therapeutic *** study provides new scientific perspectives on pancreatic cancer treatment,especially in the development of precision medicine and targeted therapeutic strategies,and demonstrates the importance of signaling pathway research in the development of effective therapeutic *** studies should explore the subtypes of CAFs and their specific roles in the tumor microenvironment to devise more effective therapeutic methods.

关键词： Pancreatic cancer Fibroblasts Signaling pathways Tumor microenvironment

A facile synthesis of terminal arylacetylenes via Sonogashira coupling reactions catalyzed by MCM-41-supported mercapto palladium(0) complex

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Chinese Chemical Letters 2008年第7期19卷 783-787页

作者： ya Ping Xu Rong hua hu Ming Zhong Cai Department of Chemistry Jiangxi Normal University Nanchang 330022 China Department of Chemistry Jinggangshan University Jian 343009 China

A variety of terminal arylacetylenes have been conveniently synthesized in good to high yields via Sonogashira coupling of aryl iodides with （trimethylsilyl）acetylene catalyzed by MCM-41-supported mercapto palladium（0） complex, followed by desilylation under mild conditions. This polymeric palladium catalyst can be reused many times without any decrease in activity.

关键词： Sonogashira coupling MCM-41-supported catalyst Mercapto palladium(0) complex Terminal arylacetylene Heterogeneouscatalysis

Effects of connection types and elevated temperature on the impact behaviour of restrained beam in portal steel frame

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Defence Technology（防务技术） 2023年第7期25卷 174-191页

作者： Yu-Xu Guo Feng Xi Ying-hua Tan Feng Liu ya-Chao hu School of Civil Engineering Shandong Jianzhu UniversityJinan250101PR China Shandong Provincial Key Laboratory of Civil Engineering Disaster Prevention and Mitigation Shandong University of Science and TechnologyQingdao266590PR China Key Laboratory of Building Structural Retrofitting and Underground Space Engineering Shandong Jianzhu UniversityJinan250101PR China

Based on the background of structural protection and Disaster Reduction Engineering, the dynamic behaviour and failure mechanism of restrained beams in portal steel frames in localised fire are investigated via experimental measurement and numerical simulation techniques. Comprehensive parametric studies are carried out to discuss the influence of end connection types, temperature, impact velocity,impact mass and span-to-depth ratio(SDR) on the dynamic response of the beams. The characteristics of deformation, internal force and energy distribution about the restrained beams and its joints are investigated. A temperature dependent criterion for evaluating the frame joint performance is proposed to measure the degree of performance degradation and impact resistance of the joint. The dynamic displacement amplification factor in different temperature environments are proposed for the different beam end constraint types and SDRs. Results of the experimental and numerical analysis show that the welded connection(WC) of three typical joint types is the strongest, and the extended endplate connection(EEC) is the weakest in terms of the impact resistance performance. With regard to the failure mode of the joint, the failure positions of the WC and the welded-bolted connection are located in the inner web of the column. Meanwhile, the EEC is located in the connection position between the beam and the endplate. Three different internal force stages and two obvious critical temperature boundaries of the restrained beams emerge with the increase in temperature, and they have significant characteristics in terms of deformation trend, internal force transfer and energy distribution. During the impact, a phenomenon known as “compression arch action” develops into “catenary action” with the increase in deflection in the frame beam mechanism.

关键词： Restrained beam Connection Temperature Impact Failure modes Internal force mechanism

单层Janus Ga_(2)SSe光催化水解性质的第一性原理研究

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原子与分子物理学报 2025年第3期42卷 45-51页

作者：胡新华廖杨芳贵州省贵阳市乌当区第四中学贵阳550018 贵州师范大学物理与电子科学学院贵阳550025

光催化水解制氢为解决能源危机和环境污染问题提供了一种可行的策略.本文通过第一性原理计算,提出了单层Janus Ga_(2)SSe是一种有效的水解光催化剂.结构稳定性分析表明,单层Janus Ga_(2)SSe具有能量和动力学稳定性.电子性质表明,单层Jan... 详细信息

光催化水解制氢为解决能源危机和环境污染问题提供了一种可行的策略.本文通过第一性原理计算,提出了单层Janus Ga_(2)SSe是一种有效的水解光催化剂.结构稳定性分析表明,单层Janus Ga_(2)SSe具有能量和动力学稳定性.电子性质表明,单层Janus Ga_(2)SSe属于间接带隙半导体,有利于降低载流子的复合几率.光催化性能分析表明,单层Janus Ga_(2)SSe的能带边缘位置适合PH=0~14宽范围的光催化水解.此外,单层Janus Ga_(2)SSe具有较高的紫外光和可见光吸收、较大的内建电场、较小的载流子有效质量保证了光生载流子有效分离并快速迁移到反应活性位点参与水的氧化还原反应.研究结果为单层Janus Ga_(2)SSe的合成及其作为水解光催化剂的潜在应用提供了有价值的理论指导.

关键词： Janus材料光催化水解第一性原理

Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye hu Meng-Can Li Zi-Jia Hao Xu-ya Chai Pei-Sai Li yang Liu Li-Xia Liu Ying Xu Pan-Pan yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

Properties of Fe-Mn-Al alloys with different Mn contents using density functional theory

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Rare Metals 2023年第4期42卷 1387-1397页

作者： Xiang Luo Jing Feng ya-hui Liu Ming-Yu hu Xiao-Yu Chong Ye-hua Jiang Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China

The chemical stability,electronic structures,mechanical properties and Debye temperature of Fe-MnAl alloys were investigated using first-principles *** formation enthalpy and cohesive energy are negative for Fe-Mn-Al alloys,showing that they are thermodynamically *** has the lowest formation enthalpy,indicating that FeAl is the most stable alloy in the Fe-Mn-Al *** partial density of states,total density of states and electron density distribution maps were used to analyze the physical properties of the Fe-MnAl alloys.A combination of mainly covalent and metallic bonds exists in these Fe-Mn-Al alloys,resulting in good electronic conductivity,high melting points,and high *** alloys display disparate anisotropy due to the calculated different shapes of the 3D curved surface of the Young's modulus and anisotropic *** has the highest bulk modulus,shear modulus and Yong's modulus of 187.1,119.8 and 296.2 GPa,***,the Debye temperatures and sound velocity of these Fe-Mn-Al compounds were explored.

关键词： Fe-Mn-Al alloys Electronic structures Stability Mechanical properties Debye temperature First-principles calculation

Top-down control on major groups of global marine diazotrophs

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Acta Oceanologica Sinica 2022年第8期41卷 111-119页

作者： hua Wang ya-Wei Luo State Key Laboratory of Marine Environmental Science Xiamen UniversityXiamen 361102China College of Ocean and Earth Sciences Xiamen UniversityXiamen 361102China

Dinitrogen(N_(2))fixed by a group of prokaryotes(diazotrophs)is the dominant process adding bioavailable nitrogen into the *** it has been intensively studied how N_(2) fixation is controlled by resources(bottom-up factors),it is unclear whether the grazing(top-down control)effectively impacts growth and distribution of different diazotroph *** this study,we evaluate this question by conducting log-log regression of diazotroph biomass onto corresponding N_(2) fixation rates in the global *** slope of the regression for Trichodesmium is~0.8,indicating that a small portion of the increase in N_(2) fixation does not accumulate as its *** leads to a conclusion that Trichodesmium is under a substantial top-down control,although bottom-up control still *** also analyze the residuals of the regression in the North Atlantic,concluding that free trichomes of Trichodesmium are subject to stronger top-down control than its *** weak correlation between the biomass and N_(2) fixation of unicellular cyanobacterial diazotrophs indicates that the degree of top-down control on this type of diazotrophs varies *** analyses obtain unrealistic results for diatom-diazotroph assemblages due to complicated nitrogen sources of these *** study reveals the variability of top-down control among different diazotroph groups across time and space,suggesting its importance in improving our understandings of ecology of diazotrophs and predictions of N_(2) fixation in biogeochemical *** of size-specific N_(2) fixation rates and growth rates of different diazotroph groups can be useful to more reliably analyze the top-down control on these key organisms in the global ocean.

关键词： marine diazotrophs nitrogen fixation top-down control bottom-up control Trichodesmium diatom-diazotroph assemblages