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The protective effects and underlying mechanisms of dapagliflozin on diabetes-induced testicular dysfunction

Asian Journal of Andrology 2023年第3期25卷 331-338页

作者： Zhi-Chao Luo Zi-Run Jin ya-fei jiang Tian-Jiao Wei ya-Lei Cao Zhe Zhang Rui Wei Hui jiang Department of Urology Peking University Third HospitalBeijing 100191China Department of Endocrinology and Metabolism Peking University Third HospitalBeijing 100191China Department of Reproductive Medicine Center Peking University Third HospitalBeijing 100191China

Male diabetic individuals present a marked impairment in fertility;however,knowledge regarding the pathogenic mechanisms and therapeutic strategies is *** new hypoglycemic drug dapagliflozin has shown certain benefits,such as decreasing the risk of cardiovascular and renal events in patients with *** so,until now,the effects and underlying mechanisms of dapagliflozin on diabetic male infertility have awaited ***,we found that dapagliflozin lowered blood glucose levels,alleviated seminiferous tubule destruction,and increased sperm concentrations and motility in leptin receptor-deficient diabetic db/db ***,the glucagon-like peptide-1 receptor(GLP-1R)antagonist exendin(9-39)had no effect on glucose levels but reversed the protective effects of dapagliflozin on testicular structure and sperm quality in db/db *** also found that dapagliflozin inhibited the testicular apoptotic process by upregulating the expression of the antiapoptotic protein B-cell lymphoma 2(BCL2)and X-linked inhibitor of apoptosis protein(XIAP)and inhibiting oxidative stress by enhancing the antioxidant status,including total antioxidant capacity,total superoxide dismutase(SOD)activity,and glutathione peroxidase(GPx)activity,as well as decreasing the level of 4-hydroxynonenal(4-HNE).Exendin(9-39)administration partially reversed these ***,dapagliflozin upregulated the glucagon-like peptide-1(GLP-1)level in plasma and GLP-1R expression by promoting AKT8 virus oncogene cellular homolog(Akt)phosphorylation in testicular ***(9-39)partially inhibited Akt *** results suggest that dapagliflozin protects against diabetes-induced spermatogenic dysfunction via activation of the GLP-1R/phosphatidylinositol 3-kinase(PI3K)/Akt signaling *** results indicate the potential effects of dapagliflozin against diabetes-induced spermatogenic dysfunction.

关键词： dapagliflozin diabetes glucagon-like peptide-1 receptor male infertility oxidative stress

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Assessing Dual Rh/Ru Cascade Catalysts in One-Pot Homogeneous Synthesis of Ethanol from Syngas and Methanol

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CCS Chemistry 2023年第7期5卷 1549-1560页

作者： Ji-Shu Zhang ya-fei jiang Fanfu Guan Shaoke Zhang Cong-Qiao Xu Shao-Tao Bai Jialin Wen Jun Li Xumu Zhang Department of Chemistry Southern University of Science and TechnologyShenzhen 518055 Guangdong Provincial Key Laboratory of Catalysis Southern University of Science and TechnologyShenzhen 518055 Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055 Department of Chemistry Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of EducationTsinghua UniversityBeijing 100084

The direct conversion of cheap syngas into value-added ethanol at an industrial scale is in high *** we disclose a one-pot homogeneous homologation of methanol to ethanol with syngas via a rhodium/ruthenium bimetallic catalytic *** introducing a catalytic amount of methyl iodide,methanol can be converted to ethanol with high selectivity(>91%ethanol).A syngas ratio of H_(2)/CO=4:1 was found to be *** various phosphine ligands tested,Rh-dppp catalyst gave the highest aldehyde pathway selectivity,thus providing an effective route for the synthesis of ethanol upon coupling with a Ru hydrogenation *** bite angle of the bisphosphine ligands dramatically influences the selectivity of the dual Rh/Ru metallic cascade *** line with the experimental findings,theoretical calculations predicted a rational trend of the selectivity of different bisphosphine ligands via varying bite angle properties.

关键词： methanol homologation ethanol rhodium ruthenium syngas

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Breaking the scaling relations for efficient N_(2)-to-NH_(3) conversion by a bowl active site design:Insight from LaRuSi and isostructural electrides

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Chinese Journal of Catalysis 2022年第8期43卷 2183-2192页

作者： ya-fei jiang Jin-Cheng Liu Cong-Qiao Xu Jun Li Hai Xiao Department of Chemistry and Key Laboratory of Organic Optoelectronics&Molecular Engineering of Ministry of Education Tsinghua UniversityBeijing 100084China Department of Chemistry Southern University of Science and TechnologyShenzhen 518055GuangdongChina

The design of optimal heterogeneous catalysts for N_(2)-to-NH_(3) conversion is often dictated by the scaling relations,which result in a volcano curve that poses a limit on the catalytic ***,we reveal a bowl active site that can break the scaling relations,through investigating the catalytic mechanisms of N_(2)-to-NH_(3) conversion on the lanthanide intermetallic electride catalyst LaRuSi by first-principles *** bowl active site,composed of four surface La cations and one subsurface Si atom rich in electrons,plays the key role in enabling efficient *** adaptive electrostatic and orbital interactions,the bowl active site promotes the adsorption and activation of N_(2) that delivers facile cleavage of N-N bond,while destabilizes the adsorptions of ^(*)NH_(x)(x=1,2,3)species,which facilitates the release of the final NH_(3) *** comparison with other electride catalysts isostructural to LaRuSi,we confirm the breaking of scaling relations between the adsorptions of ^(*)NH_(x) species and that of^(*)N on the bowl active ***,this bowl active site presents a design concept that breaks the scaling relations for highly efficient heterogeneous catalysis of N_(2)-to-NH_(3) conversion.

关键词： N_(2)-to-NH_(3)conversion Scaling relations Heterogeneous catalyst design First-principles calculations

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石墨炔负载的双金属单团簇催化剂用于碱性析氢反应

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Chinese Journal of Catalysis 2023年第7期50卷 306-313页

作者：陈斌蒋亚飞肖海李隽清华大学化学系稀土新材料教育部工程研究中心北京100084 南方科技大学化学系广东省催化化学重点实验室广东深圳518055

氢气(H_(2))可以存储可再生能源并应用于燃料电池,其中电化学析氢反应(HER)是可持续制备高纯氢气的方法之一.铂(Pt)是HER最有效的电催化剂之一,但其在碱性介质中存在较高的水解离能垒,限制了Pt电催化剂整体的HER活性,而提高水解离动力... 详细信息

氢气(H_(2))可以存储可再生能源并应用于燃料电池,其中电化学析氢反应(HER)是可持续制备高纯氢气的方法之一.铂(Pt)是HER最有效的电催化剂之一,但其在碱性介质中存在较高的水解离能垒,限制了Pt电催化剂整体的HER活性,而提高水解离动力学可能会增强H吸附,不利于制H_(2),这使得进一步优化Pt基碱性HER电催化剂面临类似Sabatier原则的限制.本文预测,石墨炔(GDY)负载的具有金字塔结构的双金属M1A3(M为后过渡金属,A为前过渡金属)四原子单团簇催化剂(SCCs)是高性能的碱性HER电催化剂.通过第一性原理计算发现,Pt_(1)Ti_(3)/GDYSCC在工作条件下热力学和动力学稳定,能够通过Volmer-Heyrovsky机制提供碱性HER的高催化活性.一方面,Ti金属位点可以协同促进水的解离,降低水解离能垒,并促进水解离形成的H中间体(*H)向邻近的Pt金属位点转移,从而加快了碱性HER过程的Volmer决速步;另一方面,相邻带负电荷的Pt金属位点的d带中心下移,从而有利于H的脱附,提供了更优化的H吸附自由能(ΔG*H).因此,Pt_(1)Ti_(3)/GDY SCC有希望突破Pt基电催化剂类似Sabatier原则的限制.通过筛选M1替代Pt1,获得最佳的ΔG*H和水解离,进一步预测Ir1Ti3/GDY SCC在低*OH覆盖率下是一个更有前景的碱性HER电催化剂.综上,本文提出了一种新型的M1A3/GDYSCCs,它具有作为碱性HER高性能电催化剂的巨大潜力,同时为碱性HER电催化剂的理性设计提供了新见解.

关键词：碱性析氢反应水解离动力学单团簇催化 Pt1Ti3/Graphdiyne

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ARTMAP与模糊逻辑结合的字符智能识别方法

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红外与毫米波学报 1998年第5期17卷 363-368页

作者：徐立亚戚飞虎蒋隽林纯青上海交通大学计算机科学与工程系

研究了将ＡＲＴＭＡＰ神经网络与模糊规则相结合的字符识别方法．ＡＲＴＭＡＰ用于对字符的学习、训练，而模糊规则和ＡＲＴＭＡＰ共同用于对字符的智能识别．实验证明这种将模糊技术与神经网络相结合的混合系统具有较高的识别率和较快... 详细信息

研究了将ＡＲＴＭＡＰ神经网络与模糊规则相结合的字符识别方法．ＡＲＴＭＡＰ用于对字符的学习、训练，而模糊规则和ＡＲＴＭＡＰ共同用于对字符的智能识别．实验证明这种将模糊技术与神经网络相结合的混合系统具有较高的识别率和较快的识别速度，采用ＡＲＴＭＡＰ神经网络只需要较少的网络训练时间．

关键词：神经网络 ARTMAP 模糊规则字符识别

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半制备-高效液相色谱法测定食品中的V_D

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食品科技 2011年第1期36卷 246-249页

作者：崔亚娟姜菲菲唐华澄李东北京市营养源研究所分析检测中心北京100069

建立了食品中VD含量测定的方法,样品经皂化、石油醚萃取后,正相半制备HPLC净化,反相HPLC定量分析,内标法定量。方法的平均回收率为94.4%,RSD为4.58%;精密度RSD为0.56%;两个样品重现性RSD为1.95%和2.52%。采用该方法分析了奶粉、AD钙奶... 详细信息

建立了食品中VD含量测定的方法,样品经皂化、石油醚萃取后,正相半制备HPLC净化,反相HPLC定量分析,内标法定量。方法的平均回收率为94.4%,RSD为4.58%;精密度RSD为0.56%;两个样品重现性RSD为1.95%和2.52%。采用该方法分析了奶粉、AD钙奶、豆奶粉、蛋白粉、强化饼干等5种食品中VD含量,该法可用于食品中VD含量的测定。

关键词：半制备-高效液相色谱法内标法 VD 食品

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Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： Song jiang Congwen Zhu Ning jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

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Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien Wu Jiwen jiang fei Long Liyuan Han Qifeng Han Yi‑Bing Cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

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A Classification Method for Web Information Extraction

A Classification Method for Web Information Extraction

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The First Conference on Web Information System and Applications

作者： LI Xiang-yang , ZHANG ya-fei , LU Jian-jiang, XU Bao-wen Institute of Communications Engineering, People''s Liberation Army University of Science and Technology, Nanjing 210007, jiangsu, China Department of Computer Science and Engineering, Southeast University, Nanjing 210096, jiangsu, China

＜正＞ Web information extraction is viewed as a classification process and a competing classification method is presented to extract Web information directly through classifica-tioa Web fragments are represented with three general features and the similarities between fragments are then defined on the bases of these features. Through competitions of fragments for different slots in information templates, the method classifies fragments into slot classes and filters out noise information . Far less annotated samples are needed as compared with rule-based methods and therefore it has a strong portability. Experiments show that the method has good performance and is superior to DOM-based method in information extraction.

关键词： information extraction competing classification feature extraction wrapper induction

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Constraints on holographic QCD phase transitions from PTA observations

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 71-78页

作者： Song He Li Li Sai Wang Shao-jiang Wang Center for Theoretical Physics and College of Physics Jilin University School of Physical Science and Technology Ningbo University Max Planck Institute for Gravitational Physics (Albert Einstein Institute) CAS Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of Sciences (UCAS) School of Physical Sciences University of Chinese Academy of Sciences (UCAS) Theoretical Physics Division Institute of High Energy Physics Chinese Academy of Sciences

The underlying physics of QCD phase transition in the early Universe remains largely unknown due to its strong-coupling nature during the quark-gluon plasma/hadron gas transition, yet a holographic model has been proposed to quantitatively fit the lattice QCD data while with its duration of the first-order phase transition(FoPT) left undetermined. At specific baryon chemical potential, the first-order QCD phase transition agrees with the observational constraint of baryon asymmetry. It, therefore, provides a scenario for phase transition gravitational waves(GWs) within the standard model of particle physics. If these background GWs could contribute dominantly to the recently claimed common-spectrum red noise from pulsar timing array(PTA) observations, the duration of this FoPT can be well constrained, and the associated primordial black holes are still allowed by current observations.

关键词： pulsar timing array QCD phase transition gravitational waves primordial black holes

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