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Chinese Physics C 2024年第11期48卷 43-51页

作者： ya-Nan wang ya-di wang Ping wang North China Electric Power Unversity Beijing 102206China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

The paper reports an analytical formula for the production cross section of e^(+)e^(−)annihilation to hadrons in the vicinity of a narrow resonance,particularly in theτ-charm region,while considering initial state *** some approximations in its derivation,comparison between the analytical formula and direct integration of ISR shows good accuracy,indicating that the analytical formula meets current experimental ***,this paper presents a comparison of the cross section between the analytical formula and calculations using the ConExc Monte Carlo *** efficiency of the analytical formula in significantly reducing computing time makes it a favorable choice for the regression procedure to extract the parameters of narrow charmonium resonances in experiments.

关键词： initial state radiation production cross section observed cross section analytic form

Synchrotron infrared spectral regions as signatures for foodborne bacterial typing

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Nuclear Science and Techniques 2019年第2期30卷 109-113页

作者： ya-di wang Xue-Ling Li Jun Hu Jun-Hong Lü division of Physical Biology and CAS Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of Sciences (CAS) University of Chinese Academy of Sciences Shanghai Center for Bioinformation Technology Shanghai Industrial Technology Institute

Fourier-transform infrared(FTIR) spectroscopy has emerged as a viable alternative to biochemical and molecular biology techniques for bacterial typing with advantages such as short analysis time, low cost and laboratorial simplicity. In this study, synchrotron radiationbased FTIR(SR-FTIR) spectroscopy with higher spectral quality was successfully applied to type 16 foodborne pathogenic bacterial strains. Combined with principal component analysis(PCA) and hierarchical cluster analysis(HCA), we found that the specific spectral region1300-1000 cm^(-1), which reflects the information of phosphate compounds and polysaccharides, can be used as the signature region to cluster the strains into groups similar with genetic taxonomic method. These findings demonstrated that FTIR spectra combined with HCA have a great potential in quickly typing bacteria depending on their biochemical signatures.

关键词： Synchrotron radiation FTIR Spectral signature Bacterial typing PCA HCA

discrimination of foodborne pathogenic bacteria using synchrotron FTIR microspectroscopy

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Nuclear Science and Techniques 2017年第4期28卷 38-43页

作者： ya-di wang Xue-Ling Li Zhi-Xiao Liu Xing-Xing Zhang Jun Hu Jun-Hong Lü division of Physical Biology and CAS Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied Physics Chinese Academy of Sciences (CAS)Shanghai 201800 China University of Chinese Academy of Sciences Beijing 100049China Shanghai Center for Bioinformation Technology Shanghai Academy of Science and Technology Shanghai 201203China Center for Clinical and Translational Medicine Shanghai Industrial Technology Institute Shanghai 201203 China

Traditional Fourier transform infrared(FTIR)spectroscopy has been recognized as a valuable method to characterize and classify kinds of *** this study,combined with multivariate statistical analysis,synchrotron radiation-based FTIR(SR-FTIR) microspectroscopy was applied to identify and discriminate ten foodborne bacterial *** results show that the whole spectra(3000-900 cm^(-1)) and three subdivided spectral regions(3000-2800,1800-1500 and 1200-900 cm^(-1),representing lipids,proteins and polysaccharides,respectively) can be used to type *** the whole spectra or the three subdivided spectra are good for discriminating the bacteria at levels of species and subspecies,but the whole spectra should be given preference at the genus *** findings demonstrate that SR-FTIR microspectroscopy is a powerful tool to identify and classify foodborne pathogenic bacteria at the genus,species and subspecies level.

关键词： Synchrotron FTIR microspectroscopy Foodborne pathogens Bacterial discrimination Subdivided spectral regions Multivariate statistical analysis

Synchrotron FTIR spectroscopy reveals molecular changes in Escherichia coli upon Cu^2＋ exposure

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Nuclear Science and Techniques 2016年第3期27卷 45-52页

作者： Xiao-Juan Hu Zhi-Xiao Liu ya-di wang Xue-Ling Li Jun Hu Jun-Hong Lv division of Physical Biology and CAS Key Laboratory of Interfacial Physics and Technology Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Center for Bioinformation Technology Shanghai Academy of Science and TechnologyShanghai 201203China Center for Clinical and Translational Medicine Shanghai Industrial Technology InstituteShanghai 201203China

Copper ions(e.g.,Cu^(2+)) have outstanding antibacterial properties,but the exact mechanism is rather complex and not fully *** this work,synchrotron Fourier transform infrared(FTIR) spectroscopy was used as an analytical tool to investigate the CuCl_2-induced biochemical changes in Escherichia *** spectral measurements indicated that this technique is sensitive enough to detect changes in membrane lipids,nucleic acids,peptidoglycans and proteins of Cu^(2+)-treated ***,for short-time treated cells,the effects on phospholipid composition were clearly shown,while no significant alterations of proteins,nucleic acids and peptidoglycans were *** quantitative nano-mechanics mode atomic force microscopy(AFM)confirmed the changes in the topography and mechanical properties of bacteria upon the Cu^(2+) *** study demonstrated that FTIR spectroscopy combined with AFM can provide more comprehensive evaluation on the biochemical and mechanical responses of bacteria to copper.

关键词： CuCl2 红外光谱大肠杆菌同步原子力显微镜 FTIR光谱分子曝光

New insight of obesity-associated NAFLD: Dysregulated “crosstalk” between multi-organ and the liver?

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Genes & diseases 2023年第3期10卷 799-812页

作者： ya-di wang Liang-Liang Wu Xiao-yan Qi Yuan-Yuan wang Zhe-Zhen Liao Jiang-Hua Liu Xin-Hua Xiao Department of Metabolism and Endocrinology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China Department of Gastrointestinal Surgery The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China

Obesity plays a crucial role in the development of non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanism for the pathogenesis of obesity-associated NAFLD remains largely obscure. Although the “multiple hit” theory provides a more accurate explanation of NAFLD pathogenesis, it still cannot fully explain precisely how obesity causes NAFLD. The liver is the key integrator of the body's energy needs, receiving input from multiple metabolically active organs. Thus, recent studies have advocated the “multiple crosstalk” hypothesis, highlighting that obesity-related hepatic steatosis may be the result of dysregulated “crosstalk” among multiple extra-hepatic organs and the liver in obesity. A wide variety of circulating endocrine hormones work together to orchestrate this “crosstalk”. Of note, with deepening understanding of the endocrine system, the perception of hormones has gradually risen from the narrow sense (i.e. traditional hormones) to the broad sense of hormones as organokines and exosomes. In this review, we focus on the perspective of organic endocrine hormones (organokines) and molecular endocrine hormones (exosomes), summarizing systematically how the two types of new hormones mediate the dialogue between extra-hepatic organs and liver in the pathogenesis of obesity-related NAFLD.

关键词： Exosomes Hormones Non-alcoholic fatty liver disease(NAFLD) Obesity Organolkines

Epithelial membrane protein 1 negatively regulates cell growth and metastasis in colorectal carcinoma

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World Journal of Gastroenterology 2014年第14期20卷 4001-4010页

作者： Guo-Gui Sun ya-di wang Da-Wei Cui Yun-Jie Cheng Wan-Ning Hu Department of Chemoradiotherapy Tangshan People’s Hospital Department of Radiotherapy the Military General Hospital of Beijing PLA Department of Urology Tangshan Workers Hospital Department of Radiotherapy The Fourth Hospital of Hebei Medical University

AIM: To determine the expression and function of epithelial membrane protein 1 (EMP1) in colorectal carcinoma.

关键词： Epithelial membrane protein 1 Colorectal carcinoma Caspase-9 Vascular endothelial growth factor C Prognosis

Bifurcations and Spatiotemporal Patterns in the diffusive Nutrient-Microorganism Model

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Acta Mathematicae Applicatae Sinica 2024年

作者： ya-di wang Hai-long YUAN yan-ling LI School of Arts and Sciences Shaanxi University of Science and Technology School of Mathematics and Statistics Xi'an Jiaotong University School of Mathematics and Information Science Shaanxi Normal University

In this paper, the diffusive nutrient-microorganism model subject to Neumann boundary conditions is considered. The Hopf bifurcations and steady state bifurcations which bifurcate from the positive constant equilibrium of the system are investigated in details. In addition, the formulae to determine the direction of Hopf and steady state bifurcations are derived. Our results show the existence of spatially homogeneous/nonhomogeneous periodic orbits and steady state solutions, which indicates the spatiotemporal dynamics of the system. Some numerical simulations are also presented to support the analytical results.

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Effects on Proliferation and Migration of the Human Colon Carcinoma Cell Line SW620 by Silencing of Hepatocyte Growth Factor Expression

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Clinical oncology and cancer researeh 2010年第5期7卷 277-283页

作者： Yi-tao JIA Lei ZHANG yan LI ya-di wang Wei GUO Lei CAO Zhong-xin LI 3rd Department of Oncology Hebei ProvincialPepeol's Hospital Shijiazhuang 050051 HebeiProvince China. Department of Histology and Embryology Hebei Medical University Shijiazhuang050017 Hebei Province China Department of Radiotherapy Hebei Medical University Fourth Hospital Shijiazhuang050011 Hebei Province China. 2nd Department of Surgery Hebei Medical University Foruth Hospital Shijiazhuang050011 Hebei Province China.

OBJECTIVE Hepatocyte growth factor （HGF） expression is closely related to the progression and poor prognosis of colorectal cancer patients. In this study, we investigated the effects on proliferation and migration of the human colon carcinoma cell line SW620 by silencing HGF expression. METHODS HGF was silenced using specific HGF a/f3 siRNA. The proliferation, migration, cell cycle and ultrastructure of SW620 cells were examined. RESULTS The transfection efficiency was 70%-80%. The expression rate of HGF in the experimental group was significantly lower than that in the negative and blank control groups （P 〈 0.05）. The proliferation inhibition rate in the experimental group at 24, 48, 72 and 96 h after transfection was 14.2%, 50.2%, 39.5% and 23.2%, respectively. The migratory ability of cells in the experimental group was significantly inhibited compared with that in the negative control or blank control groups （58.2% vs. 2.1% or 0%, P 〈 0.05）. CONCLUSION The application of RNA interference to silence the expression of HGF in the colon carcinoma cell line SW620 effectively inhibits the proliferation and migration of tumor cells.

关键词： RNA interference HGF protein human cellular proliferation cell movement colorectal neoplasms.

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局部治疗手段在结直肠癌肝转移治疗中的价值

世界华人消化杂志 2017年第19期25卷 1705-1713页

作者：路娜王雅棣陆军总医院放射治疗科北京市100700

结直肠癌肝转移患者全身治疗是标准治疗,应该作为每一种治疗策略的初始,但局部治疗也发挥着重要价值.手术完全切除肝转移灶仍是目前能治愈结直肠癌和胃肠道神经内分泌肿瘤肝转移的最佳方法 .射频消融主要应用于那些不可切除或术后复发... 详细信息

结直肠癌肝转移患者全身治疗是标准治疗,应该作为每一种治疗策略的初始,但局部治疗也发挥着重要价值.手术完全切除肝转移灶仍是目前能治愈结直肠癌和胃肠道神经内分泌肿瘤肝转移的最佳方法 .射频消融主要应用于那些不可切除或术后复发的局限性病灶,但受转移灶大小、数量和解剖位置的制约.立体定向放射治疗作为一种非手术的局部治疗是安全、有效的.微波消融、冷冻消融、高能聚焦超声刀、经皮穿刺瘤内注射无水乙醇、肝动脉栓塞或肝动脉化疗栓塞、肝动脉灌注化疗等也是重要的局部治疗手段,在患者的综合治疗中发挥重要作用.本文就以上内容作一综述.

关键词：结直肠癌肝转移肝切除术射频消融立体定向放疗

高铁酸钾-Fenton联合氧化法对菲的去除

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环境工程学报 2016年第11期10卷 6536-6540页

作者：王艺霏李亚男王迪王建伟王国英太原理工大学环境科学与工程学院晋中030600

针对焦化废水中多环芳烃(PAHs)难以被有效去除的问题,采用高铁酸钾氧化法与Fenton高级氧化法联用的新技术,选择PAHs中的一种典型有机物菲(PHE)作为研究对象,进行烧杯实验,研究高铁酸钾-Fenton联合氧化法去除菲的最佳反应条件以及反应动... 详细信息

针对焦化废水中多环芳烃(PAHs)难以被有效去除的问题,采用高铁酸钾氧化法与Fenton高级氧化法联用的新技术,选择PAHs中的一种典型有机物菲(PHE)作为研究对象,进行烧杯实验,研究高铁酸钾-Fenton联合氧化法去除菲的最佳反应条件以及反应动力学。结果表明,高铁酸钾-Fenton联合氧化法去除菲的最佳反应条件为:pH=5,K_2FeO_4反应时间t1=5 min,Fenton试剂反应时间t2=15 min,药品投加比例n(PHE)∶n(K_2FeO_4)∶n(H_2O_2)=1∶2∶2,n(H_2O_2)∶n(FeSO_4)=15∶1,结合成本因素,K_2FeO_4投加比例可减少至2∶1(n(PHE)∶n(K_2FeO_4))。菲的去除速率符合一级反应动力学方程,其反应速率常数k=0.161 4。

关键词：高铁酸钾 Fenton 菲多环芳烃焦化废水