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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen Yuan Ping Wang bin liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

Protein arginine methyltransferase-6 regulates heterogeneous nuclear ribonucleoprotein-F expression and is a potential target for the treatment of neuropathic pain

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Neural Regeneration Research 2025年第9期20卷 2682-2696页

作者： Xiaoyu Zhang Yuqi liu Fangxia Xu Chengcheng Zhou Kaimei Lu bin Fang Lijuan Wang Lina Huang Zifeng Xu Department of Anesthesiology International Peace Maternity and Child Health HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Anesthesiology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Embryo Original Diseases ShanghaiChina

Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal ***,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this *** this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic *** results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer *** addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain ***,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 ***,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was ***,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ***,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 *** findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.

关键词： dorsal root ganglion heterogeneous nuclear ribonucleoprotein F neuropathic pain protein arginine methyltransferase-6 sensory neurons

Physical Layer Security Scheme With AoI-Awareness for Industrial IoT Based on Covert Communications

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 276-278页

作者： yaping Li Zhi-Xin liu Jia-Wei Su ya-Zhou Yuan the Key Laboratory of Industrial Computer Control Engineering of Hebei Province Yanshan University

Dear Editor,Industrial Internet of things(IIoT) is a typical application of cyberphysical system(CPS). In the IIoT, wireless communication is an inevitable trend to replace the deployment-limited wired transmission for cases with large-scale and mobile devices. However, wireless communication gives rise to critical issues related to physical security, such as malicious detections and attacks [1].

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双膦酸盐预防中国妇女绝经后骨质疏松骨折的系统评价及药物经济学分析

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中国医院药学杂志 2017年第8期37卷 740-745页

作者：邹雅敏张斌刘丹杨浩杰西安交通大学医院陕西西安710049 西安市红会医院陕西西安710054 西安市第五医院陕西西安710082

目的:评估3种双膦酸盐预防中国妇女绝经后骨质疏松骨折的有效性、安全性和经济性。方法:计算机检索国内外常用文献数据库中使用阿仑膦酸、利塞膦酸、唑来膦酸预防中国妇女绝经后骨质疏松骨折的随机对照试验(RCT),提取资料后进行Meta分析... 详细信息

目的:评估3种双膦酸盐预防中国妇女绝经后骨质疏松骨折的有效性、安全性和经济性。方法:计算机检索国内外常用文献数据库中使用阿仑膦酸、利塞膦酸、唑来膦酸预防中国妇女绝经后骨质疏松骨折的随机对照试验(RCT),提取资料后进行Meta分析,并建立决策树模型进行成本-效果分析。结果:Meta分析结果显示,与单用钙剂/维生素D_3方案相比,联用双膦酸盐能显著减少中国妇女绝经后骨质疏松的椎体骨折[RR0.50,95%CI(0.33,0.74)]和非椎体骨折[RR0.36,95%CI(0.20,0.65)]的风险,差异有统计学意义(P<0.01)。亚组分析显示,唑来膦酸能显著减少中国妇女绝经后骨质疏松椎体骨折[RR0.44,95%CI(0.25,0.77)]风险,阿仑膦酸和利塞膦酸亦表现出减少绝经后骨质疏松非椎体骨折的风险的优势[RR0.16,95%CI(0.04,0.72)和RR0.28,95%CI(0.10,0.80)]。安全性方面,加用双膦酸盐期间不良事件的发生率与对照组比较差异无统计学意义。成本-效果分析显示,联用双膦酸盐较单用钙剂和维生素D_3方案经济性更优,阿仑膦酸联合钙剂/维生素D3方案为经济性最优方案。结论:联用双膦酸盐(尤其是阿仑膦酸)较单用钙剂/维生素D_3方案能显著地减少中国妇女绝经后骨质疏松骨折的风险,安全性较好,经济性更优。

关键词：双膦酸盐绝经期妇女骨质疏松系统评价药物经济学决策树模型

Early identification of stroke through deep learning with multi-modal human speech and movement data

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Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang bin Zhang Haobang Liang Bei Hu Longlong Ren yanjuan liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li Xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong bin Zhang Baiyun liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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红外线镜反射式自动仿形装置的研究与设计

绿洲农业科学与工程 2016年第4期2卷 18-24页

作者：王涛李亚雄胡斌刘洋李斌新疆农垦科学院机械装备研究所新疆石河子832000 石河子大学机械电气工程学院新疆石河子832000

本文研究基于红外线测高技术的玉米雄穗高度识别与定位方法，获取玉米雄穗的位置信息，为玉米抽雄机械提供自动仿形的理论依据。利用红外线技术识别玉米雄穗，通过信号反馈得到雄穗有效高度，通过数据处理，由主控板处理器对传感器的信... 详细信息

本文研究基于红外线测高技术的玉米雄穗高度识别与定位方法，获取玉米雄穗的位置信息，为玉米抽雄机械提供自动仿形的理论依据。利用红外线技术识别玉米雄穗，通过信号反馈得到雄穗有效高度，通过数据处理，由主控板处理器对传感器的信号读取并通过脉宽调制输出信号，最后控制电动推杆和升降液压缸对雄穗高度自动仿形，进而有效指导抽雄作业。田间试验结果表明，使用红外线镜反射式传感器的方法能够从采集到的信号中有效地提取出玉米雄穗的高度，能够为抽雄机的自动化提供理论指导的依据。

关键词：制种玉米机械抽雄自动仿形试验研究

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钱塘江富阳段鱼类资源现状

淡水渔业 2017年第3期47卷 45-51页

作者：郝雅宾刘金殿郭爱环张爱菊倪蒙浙江省淡水水产研究所农业部淡水渔业健康养殖重点实验室浙江省淡水水产遗传育种重点实验室中国水产科学研究院东海水产研究所浙江研究中心浙江湖州313001

2014年11月—2015年12月对钱塘江富阳江段3个断面鱼类资源进行了逐月采样调查,对该水域鱼类种类组成、优势种、群落多样性指数和捕捞量进行分析。结果显示:共采集鱼类48种,隶属8目13科37属,其中鲤科鱼类种类最多,占总种类数的64.58%,优... 详细信息

2014年11月—2015年12月对钱塘江富阳江段3个断面鱼类资源进行了逐月采样调查,对该水域鱼类种类组成、优势种、群落多样性指数和捕捞量进行分析。结果显示:共采集鱼类48种,隶属8目13科37属,其中鲤科鱼类种类最多,占总种类数的64.58%,优势种为鲢、鲤、鲫和光泽黄颡鱼。各月中,4月份捕获的鱼类种数最多,占总种数的52.08%;9月份鱼类捕获量最高,占总渔获量的17.85%。Margalef丰富度指数4月份较高,2月份较低;Shannon-Wiener多样性指数和Pielou均匀度指数在7月份较高,9月份较低,而Simpson多样性指数与之相反。富阳段鱼类捕捞强度较大,渔获物中小个体鱼类占主要部分。与历史记录比较,富阳江段鱼类群落组成已经发生了显著变化,除本地种光泽黄颡鱼外,增殖放流鱼种已成为了优势或重要种群。

关键词：鱼类资源优势种富阳段

多管并联SiC MOSFET驱动电路串扰抑制方法

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电力电子技术 2017年第9期51卷 57-59页

作者：柴艳鹏李亚斌刘永飞安国亮保定四方三伊电气有限公司河北保定071023 华北电力大学电力工程系河北保定071003

为解决大功率高频串联谐振逆变器中多管并联碳化硅(SiC)金属-氧化物半导体场效应晶体管(MOSFET)驱动电路存在的串扰问题,分析了驱动电路串扰问题产生的机理和常用驱动串扰抑制方法,优化了驱动电路结构和器件参数,设计了一种具有串扰抑... 详细信息

为解决大功率高频串联谐振逆变器中多管并联碳化硅(SiC)金属-氧化物半导体场效应晶体管(MOSFET)驱动电路存在的串扰问题,分析了驱动电路串扰问题产生的机理和常用驱动串扰抑制方法,优化了驱动电路结构和器件参数,设计了一种具有串扰抑制作用的多管并联SiC MOSFET驱动电路。搭建了一台SiC MOSFET高频H桥串联谐振逆变电源样机,对驱动电路进行了相关测试,验证了所设计的驱动电路可有效抑制串扰。

关键词：晶体管多管并联驱动电路串扰抑制