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Drug-eluting balloons versus new generation drug-eluting stents for the management of in-stent restenosis: an updated meta-analysis of randomized studies

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Journal of Geriatric Cardiology 2019年第6期16卷 448-457页

作者： Lei GAO ya-bin wang Jing JING Ming ZHANG Yun-Dai CHEN Department of Cardiology Chinese PLA General Hospital

Background New-generation drug-eluting stents (DES) was more effective in the treatment of in-stent restenosis (ISR) compared with the first-generation DES. Drug-eluting balloons (DEB) and new-generation DES had been available strategies in treatment of bare-metal stents/DES ISR (BMS/DES-ISR). Six new randomized trials have recently examined the angiographic outcomes and one-year clinical outcomes of DEB and new generation DES in BMS/DES-ISR. However, the optimal management for BMS/DES-ISR lesions remains controversial. Methods We searched the randomized clinical trials evaluating the angiographic outcomes and one-year clinical outcomes of DEB and new-generation DES in patients with BMS/DES-ISR. The primary endpoints were the angiographic outcomes, including the minimal luminal diameter (MLD), diameter stenosis %(DS%), late lumen loss (LLL), and binary restenosis (BR). Results A total of six randomized clinical trials with 1177 BMS/DES-ISR patients were included in our meta-analysis. For angiographic outcomes, there were significantly less MLD and more DS% with DEB compared to new-generation DES (MLD: MD =?0.18, 95% CI:?0.31– ?0.04, P < 0.001;DS%: MD = 5.68, 95% CI: 1.00–10.37, P < 0.001). Moreover, for one-year clinical outcomes, DEB was associated with a significant increase risk in target lesion revascularization (TLR)(RR = 2.93, 95% CI: 1.50–5.72, P = 0.002). However, DEB was associated with higher risks of major adverse cardiac event, target vessel revascularization, TLR, BR, and more DS% only in DES-ISR group. Conclusions DEB and new-generation DES have the similar clinical efficacy for the treatment of BMS-ISR. However, DES showed more MLD, less DS%, and a decreased risk of TLR for the treatment of DES-ISR.

关键词： Drug-eluting balloons Drug-eluting stents In-stent restenosis Meta-analysis

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Plasticity and melting characteristics of metal Al with Ti-cluster under shock loading

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Chinese Physics B 2021年第7期30卷 200-208页

作者： Dong-Lin Luan ya-bin wang Guo-Meng Li Lei Yuan Jun Chen School of Mechatronic Engineering Beijing Institute of TechnologyBeijing 100081China System Engineering Research Institute Beijing 100094China Beijing Special Vehicle Research Institute Beijing 100072China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China Center for Applied Physics and Technology Peking UniversityBeijing 100871China

Impurity agglomeration has a significant influence on shock response of metal *** this paper,the mechanism of Ti-clusters in metal Al under shock loading is investigated by non-equilibrium molecular dynamics *** results show that the Ti-cluster has obvious effects on the dislocation initiation and melting of bulk ***,the Ti clusters induces the strain concentrate and leads the dislocations to be initiated from the interface of Ti ***,dislocation distribution from the Ti-cluster model results in a formation of a grid-like structure,while the dislocation density is reduced compared with that from the perfect Al ***,the critical shock velocity of dislocation from the Ti-cluster model is lower than from perfect Al ***,it is also found that the temperature near the interface of Ti-cluster is100 K–150 K higher than in the other areas,which means that Ti-cluster interface melts earlier than the bulk area.

关键词： molecular dynamics impurity cluster dislocation shock loading

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Development of an electrochemical immunoassay for detection of gatifloxacin in swine urine

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第2期13卷 118-125页

作者： Jian YI Meng MENG Zhong-qiu LIU Jin-fang ZHI Yuan-yang ZHANG Jing XU ya-bin wang Jin-ting LIU Ri-mo XI School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100China College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai UniversityTianjin 300071China Technical Institute of Physics and Chemistry Chinese Academy of SciencesBeijing 100080China

To detect gatifloxacin （GAT） residue in swine urine, an electrochemical immunoassay was established, An indirect competitive immunoassay was developed, in which the coating antigen is immobilized in an enzyme-linked immunosorbent assay （ELISA） plate and GAT residue from the sample competes with the limited binding sites in added anti-GAT antibody. Horseradish peroxidase （HRP） conjugated to goat anti-rabbit IgG was used as the enzymatic label. A carbon fiber working electrode was constructed and current signals were detected by using hydrogen peroxide as a substrate and hydroquinone as an electrochemical mediator. The electrochemical immunoassay was evaluated by analysis of GAT in buffer or swine urine and an average value of half inhibition concentration （IC50） of 8.9 ng/ml was obtained. Excellent specificity of the antibody was achieved with little cross-reaction with Iomefloxacin （3.0%）, ciprofloxacin （3.0%）, and ofloxacin （1.9%） among commonly used （fluoro）quinolones. In conclusion, the im- munoassay system developed in this research can be used as a rapid, powerful and on-site analytical tool to detect GAT residue in foods and food products.

关键词： Gatifloxacin Drug residue Antibody Carbon fiber electrode Electrochemical immunoassay

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Cardiotrophin-1 promotes cardiomyocyte differentiation from mouse induced pluripotent stem cells via JAK2/STAT3/Pim-1 signaling pathway

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Journal of Geriatric Cardiology 2015年第6期12卷 591-599页

作者： Tong LIU Ran ZHANG Tao GUO Sai MA Dong HAN Xiu-Juan LI yan JIN Miao-Miao FAN ya-bin wang Yun-Dai CHEN Feng CAO Department of Cardiology Xijing Hospital Fourth Military Medical University Xi 'an Shaanxi China Department of Cardiology Chinese PLA General Hospital Beijing China Research and Development Centre of Tissue Engineering Fourth Military Medical University Xi 'an Shaanxi China

Background The induced pluripotent stem cell （iPSC） has shown great potential in cellular therapy of myocardial infarction （MI）, while its application is hampered by the low efficiency of cardiomyocyte differentiation. The present study was designed to investigate the effects of cardiotrophin-1 （CT-1） on cardiomyocyte differentiation from mouse induced pluripotent stem cells （miPSCs） and the underlying mechanisms involved. Methods The optimal treatment condition for cardiomyocyte differentiation from miPSCs was established with ideal concentration （10 ng/mL） and duration （from day 3 to day 14） of CT-1 administration. Up-regulated expression of cardiac specific genes that accounted for embryonic cardiogenesis was observed by quantitative RT-PCR. Elevated amount of a-myosin heavy chain （ct-MHC） and cardiac troponin I （cTn I） positive cells were detected by immunofluorescence staining and flow cytometry analysis in CT- 1 group. Results Transmission electron microscopic analysis revealed that cells treated with CT- 1 showed better organized sacromeric structure and more mitochondria, which are morphological characteristic of matured cardiomyocytes. Western blot demonstrated that CT-1 promotes cardiomyocyte differentiation from miPSCs partly via JAK2/STAT3/Pim-1 pathway as compared with control group. Conclusions These findings suggested that CT-1 could enhance the cardiomyocyte differentiation as well as the maturation of mouse induced pluripotent stem cell derived cardiomyocytes by regulating JAK2/STAT3/Pim-1 signaling pathway.

关键词： Cardiac differentiation Cardiotrophin-1 Mouse induced pluripotent stem cells Pim-1

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Comparative effects of percutaneous coronary intervention for infarct-related artery only or for both infarct- and non-infarct- related arteries in patients with ST-elevation myocardial infarction and multi-vessel disease

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Chinese Medical Journal 2008年第23期121卷 2384-2387页

作者： HAN ya-ling wang bin wang Xiao-zeng LI Yi wang Shou-li JING Quan-min wang Geng MA Ying-yan LUAN Bo Department of Cardiology Shenyang General Hospital of PLA Shenyang Liaoning 110016 China

Background Rapid recanalization of infarct-related artery （IRA） has become the major target during primary percutaneous coronary intervention （PCI） for patients with ST-elevation myocardial infarction （MI）, but strategy for treatment of non-IRA lesions in this setting remains unclear. This study aimed to compare long-term effects between PCI for IRA only and that for both IRA and non-IRA in ST-elevation MI patients with multi-vessel disease.Methods A total of 242 eligible patients with ST-elevation MI and at least two diseased coronary arteries （luminal narrowing 〉70%） undergoing primary PCI were included. Of them, 149 patients underwent primary PCI for IRA only （group 1）, and 93 received primary PCI for IRA followed by elective PCI for non-IRA 7 to 15 days after acute myocardial infarction （AMI）（group 2）. Drug-eluting stents （DESs） were deployed in more than 90% of the patients. Results The two groups did not differ with respect to baseline clinical and angiographic characteristics. No significant differences were observed in 12-month clinical follow-up results regarding major adverse cardiac events （11.5% vs 15.1%, P 〉0.05） and target lesion revascularization （8.1% vs 7.6%, P 〉0.05） between the two groups. However, patients in group 1 had higher rates of recurrent angina （10.1% vs 2.1%, P 〈0.05） and depressed left ventricular ejection fraction evaluated by echocardiography （0.56±0.22 vs 0.63±0.25, P 〈0.05）. Conclusion With the use of DESs, complete revascularization with elective PCI for non-IRA after primary PCI may exert a beneficial effect on long-term symptomatology and left ventricular function in patients with ST-elevation Mt and multi-vessel disease.

关键词： multi-vessel disease percutaneous coronary intervention revascularization ST-elevation myocardial infarction

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A high maintenance dose of clopidogrel improves short-term clinical outcomes in patients with acute coronary syndrome undergoing drug-eluting stent implantation

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Chinese Medical Journal 2009年第7期122卷 793-797页

作者： HAN ya-ling wang bin LI Yi XU Kai wang Shou-li JING Quan-min wang Zu-lu wang Dong-mei MA Ying-yan wang Geng Department of Cardiology Shenyang Northern HospitalShenyang Liaoning 110016 China

Background Recurrent ischemic events occurred even during routine use of 75 mg clopidogrel in addition to aspirin, that indicated a potentially insufficient maintenance dosage of clopidogrel. The aim of the present study was to evaluate the short-term efficacy and safety of a 150 mg maintenance dose of clopidogrel following a 600 mg loading dose in patients with an acute coronary syndrome （ACS） undergoing drug eluting stent （DES） implantation. Methods Between November 2005 and November 2006, a total of 813 consecutive ACS patients undergoing DES implantation were enrolled. A 600 mg loading dose was administered before percutaneous coronary intervention （PCI） and patients were randomized to receive clopidogrel 75 mg or 150 mg for 30 days in addition to 300 mg aspirin daily. Primary end points were the composite of cardiac death, non-fatal myocardial infarction （MI） and urgent target vessel revascularization （UTVR）. Secondary end points included stent thrombosis （ST）, major and minor bleeding events at 30 days. Results At a follow-up period of 30 days, 4 （1.0%） patients in the 150 mg group and 9 （2.2%） patients in the 75 mg group （P 〉0.05） reached the primary end points. There was no significant difference in the incidences of MI （0.5% vs 1.2%, P〉0.05）, UTVR （0.7% vs 2.0%, P 〉0.05）, and cardiac death （0.2% vs 0.2%, P 〉0.05） between the two groups. The incidence of ST （0 vs 1.5%, P 〈0.05） was significantly lower in the 150 mg group than that in the 75 mg group. There were no significant differences between both groups regarding the risk of major （0.2% vs 0, P 〉0.05） or minor （0.5% vs 0.2%, P 〉0.05） bleedings. Conclusion A high clopidogrel maintenance dose of 150 mg daily following a 600 mg loading dose for the first month after PCI procedure reduces the risk of ST and appears to be safe in patients with ACS undergoing DES implantation.

关键词： angioplasty, transluminal, percutaneous coronary clopidogrel maintenance dose

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Effect of Nb-V microalloying on the hot deformation behavior of medium Mn steels

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 360-368页

作者： Yumeng wang Qinyi Guo bin Hu Haiwen Luo School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The influence of Nb-V microalloying on the hot deformation behavior and microstructures of medium Mn steel(MMS)was investigated by uniaxial hot compression *** establishing the constitutive equations for simulating the measured flow curves,we successfully constructed deformation activation energy(Q)maps and processing maps for identifying the region of flow *** concluded the following consequences of Nb-V alloying for MMS.(i)The critical strain increases and the increment diminishes with the increasing deformation temperature,suggesting that NbC precipitates more efficiently retard dynamic recrystallization(DRX)in MMS compared with solute Nb.(ii)The deformation activation energy of MMS is significantly increased and even higher than that of some reported high Mn steels,suggesting that its ability to retard DRX is greater than that of the high Mn content.(iii)The hot workability of MMS is improved by narrowing the hot processing window for the unstable flow stress,in which fine recrystallized and coarse unrecrystallized grains are present.

关键词： medium manganese steel niobium-vanadium microalloying flow behavior dynamic recrystallization hot workability

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Decreased expression of ApoF associates with poor prognosis in human hepatocellular carcinoma

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Gastroenterology Report 2019年第5期7卷 354-360,I0002页

作者： ya-bin wang Bo-Xuan Zhou Yun-Biao Ling Zhi-Yong Xiong Rui-Xi Li Yue-Si Zhong Ming-Xing Xu Yi Lu Hao Liang Gui-Hua Chen Zhi-Cheng yao Mei-Hai Deng Department of Liver Transplantation Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary Surgery Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of General Surgery The Lingnan Hospital of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Hepatocellular carcinoma(HCC)is frequently associated withmetabolism *** evidence has demonstrated the crucial role of lipidmetabolismin HCC *** function of apolipoprotein F(ApoF),a lipid transfer inhibitor protein,in HCC is incompletely *** aimed to evaluate the functional role of ApoF in HCC in this ***:We used quantitative reverse-transcription polymerase chain reaction(qRT-PCR)to detect ApoF mRNA expression in HCC tissues and hepatoma cell lines(SMMC-7721,HepG2,and Huh7).Immunohistochemistry was performed to detect the expression of ApoF in HCC *** associations between ApoF expression and clinicopathological features as well as HCC prognosis were *** effect of ApoF on cellular proliferation and growth of SMMC-7721 and Huh7 cells was examined in vitro and in ***:ApoF expression was significantly down-regulated at both mRNA and protein levels in HCC tissues as compared with adjacent *** SMMC-7721 and Huh7 HCC cells,ApoF overexpression inhibited cell proliferation and *** a xenograft nude mouse model,ApoF overexpression effectively controlled HCC ***–Meier analysis results showed that the recurrence-free survival rate of HCC patients with low ApoF expression was significantly lower than that of other HCC *** ApoF expression was associated with several clinicopathological features such as liver cirrhosis,Barcelona Clinic Liver Cancer stage and tumor-node-metastasis ***:ApoF expression was down-regulated in HCC,which was associated with low recurrence-free survival *** may serve as a tumor suppressor in HCC and be a potential application for the treatment of this disease.

关键词： hepatocellular carcinoma biomarkers apolipoprotein F prognosis

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Fabricating multifunctional polymeric nanofilm capable of resisting corrosion and activating copper surface by electrochemical and hydrolysis-condensation approach

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Transactions of Nonferrous Metals Society of China 2016年第11期26卷 2947-2959页

作者：王亚斌黄玉东亓玉台哈尔滨工业大学化工与化学学院哈尔滨150001 中国科学院青海盐湖研究所西宁810008

A multifunctional polymeric nanofilm of triazinedithiolsilane monosodium salt, which can resist corrosion and activatecopper surface concurrently, was prepared by galvanostatic technique and the following hydrolysis-condensation *** tests were carried out to evaluate the resistant ability of nanofilm. The changes of functional groups atop thenanofilms were monitored with Fourier transform infrared spectroscopy （FT-IR） and contact angles （CA） simultaneously. Thechemical composition and the morphology of the polymeric nanofilm were investigated by X-ray photoelectron spectroscopy （XPS）and scanning electron microscope （SEM）, respectively. The results reveal that the preferentially developed disulfide units protect thecopper during the whole preparation process, and the subsequently hydrolyzed nanofilms without/with heating shape into newinterface phases bearing the multifunctionality. This multifunctional interface （the polymeric nanofilm on copper surface） opens upthe possibilities for other OH-containing reagents to be anchored onto copper surface in demanding researches or industrialapplications.

关键词： copper triazinedithiolsilane galvanostatic technique multifunctional polymeric nanofilm functionalized interface

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The Simulation of Grinding Wheels and Ground Surface Roughness Based on Virtual Reality Technology

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厦门大学学报（自然科学版） 2002年第S1期41卷 29-页

作者： GONG ya-dong, wang bin, wang Wan-Shan (School of Mechanical Engineering & Automation, Northeastern University, Shenyang 110004, China)

The paper describes the feasibility and method of the application of virtual reality technology to grinding process, and introduces the modeling method of object entity in the environment of virtual reality. The simulation process of grinding wheels and ground surface roughness is discussed, and the computation program system of numerical simulation is compiled with Visual C++ programming language. At the same time, the three-dimensional simulation models of grinding wheels and ground surface roughness are made with OpenGL tool. The choice of grinding wheels, the forecast of ground surface quality and some simulation results can be realized by interactively inputting grinding parameters. The paper applies virtual reality technology to grinding process,makes the model of virtual grinding wheel and simulates the grinding process. The roughness of ground surface is showed in three-dimensional images, and therefore the grinding technology is studied. Computer simulation can not only be used as a shortcut to analyze and research the grinding process, but also increase the research scope and content. The virtual reality technology used in the paper is an advanced visualized simulation with interaction. The surface roughness Ra on simulated ground workpiece can be calculated by the arithmetic average of contour warp absolute value in sampling length of simulated ground workpiece. The parameters of virtual wheel and simulated grinding process can be changed by interaction input, so the simulated results in the desired grinding condition are gained. The effect of each parameter to ground surface can be analyzed by comparing the grinding results in different condition.

关键词： virtual reality simulation ground surface roughness

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