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Chinese Chemical Letters 2015年第10期26卷 1283-1288页

作者： Jia-Lin Guo Yun-Yong Liu ya-zhong pei The Center for Combinatorial Chemistry and Drug Discovery of Jilin University School of Pharmaceutical Sciences Jilin University Nanjing Gator Medi Tech Company Ltd.

An efficient synthesis of novel 3-（piperidin-4-yl）isoxazolo[4,5-d]pyrimidine scaffold has been designed and deveopled. A series of 5-phenylurea derivatives was synthesized using this method. Their cytotoxic activities against breast cancer cell line BT-474 were evaluated by CCK-8 assay. Most of them showed potent anti-proliferative activities, of which compound 20 and 21 exhibited IC50 s of 1.565 mmol/L and1.311 mmol/L, respectively. Furthermore, compound 20 and 21 also showed potent inhibitory activities against PI3 Kd with IC50 s of 0.286 mmol/L and 0.452 mmol/L, respectively. These results indicate that these 3-（piperidin-4-yl）isoxazolo[4,5-d]pyrimidine derivatives are novel antitumor agents through the inhibition of PI3 Kd.

关键词： Synthesis Isoxazolopyrimidine PI3Kδ inhibitors Cytotoxicity

四波混频Autler-Townes分裂中的探测光影响

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原子与分子物理学报 2025年第3期42卷 110-115页

作者：裴丽娅侯海龙北京化工大学数理学院北京100029

在双Λ-型四波混频系统中,研究了探测光强度对Autler-Townes(AT)分裂效应的影响.随着弱探测光强度增大,由缀饰态共振产生的AT分裂双峰间隔不变,但却逐渐增宽线宽且减弱直至消失;而在强耦合光失谐条件下,不对称地位于单光子共振峰两侧的A... 详细信息

在双Λ-型四波混频系统中,研究了探测光强度对Autler-Townes(AT)分裂效应的影响.随着弱探测光强度增大,由缀饰态共振产生的AT分裂双峰间隔不变,但却逐渐增宽线宽且减弱直至消失;而在强耦合光失谐条件下,不对称地位于单光子共振峰两侧的AT分裂双峰却会逐渐趋于对称分布.详细讨论了探测光场对原子的缀饰影响,提出通过探测光强度可以调控原子两基态之间的有效Raman相干,从而影响AT分裂双峰的特征.

关键词：四波混频原子相干 Autler-Townes分裂缀饰态横向弛豫率

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Synthesis of Novel 3-Aryl Isoindolinone Derivatives

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Chemical Research in Chinese Universities 2013年第3期29卷 487-494页

作者： HU Chen-ming ZHENG Lian-you pei ya-zhong BAI Xu Center for Combinatorial Chemistry and Drug Discovery College of Chemistry and School of Pharmaceutical Sciences Jilin University Changchun 130021 P. R. China

A library of novel 3-aryl isoindolinone derivatives with aromatic amino acid derivative fragments was designed and synthesized. Two synthetic routes were employed to construct 3-aryl isoindolinone ring system for diff... 详细信息

关键词： Molecular library 3-Aryl isoindolinone Aromatic amino acid derivative

Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-Jia Hao Xu-ya Chai pei-Sai Li yang Liu Li-Xia Liu Ying Xu Pan-Pan yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

Brain-inspired Intelligent Robotics:Theoretical Analysis and Systematic Application

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Machine Intelligence Research 2023年第1期20卷 1-18页

作者： Hong Qiao ya-Xiong Wu Shan-Lin zhong pei-Jie Yin Jia-Hao Chen The State Key Laboratory of Management and Control for Complex System Institute of AutomationChineseAcademyof SciencesBeijing100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Chinese Academy of Science Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China School of Mechanical Engineering University of Science and Technology BeijingBeijing 100083China

Traditional joint-link robots have been widely used in production lines because of their high precision for single *** the development of the manufacturing and service industries,the requirement for the comprehensive performance of robotics is *** types of bio-inspired robotics have been investigated to realize human-like motion control and manipulation.A study route from inner mechanisms to external structures is proposed to imitate humans and animals *** this idea,a brain-inspired intelligent robotic system is constructed that contains visual cognition,decision-making,motion control,and musculoskeletal *** paper reviews cutting-edge research in brain-inspired visual cognition,decision-making,motion control,and musculoskeletal *** software systems and a corresponding hardware system are established,aiming at the verification and applications of next-generationbrain-inspired musculoskeletal robots.

关键词： Brain-inspired intelligent robot software and hardware decision making muscle control cognitive intelligence.

The entanglement of deterministic aperiodic quantum walks

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Chinese Physics B 2018年第12期27卷 77-84页

作者： Ting-Ting Liu ya-Yun Hu Jing Zhao Ming zhong pei-Qing Tong Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023China physics Department 104Davey LaboratoryPennsylvania State UniversityUniversity ParkPA 16802USA College of Mathematical and Physical Sciences Anshun UniversityAnshun 561000China Laboratory for Numerical Simulation of Large Scale Complex Systems Nanjing Normal UniversityNanjing 210023China

We study the entanglement between the internal(coin)and the external(position)degrees of freedom in the dynamic and the static deterministic aperiodic quantum walks(QWs).For the dynamic(static)aperiodic QWs,the coin depends on the time(position)and takes two coins C(α)and C(β)arranged in the two classes of generalized Fibonacci(GF)and the Thue–Morse(TM)*** found that for the dynamic QWs,the entanglement of three kinds of the aperiodic QWs are close to the maximal value,which are all much larger than that of the homogeneous ***,the first class of GF(1st GF)QWs can achieve the maximum entangled state,which is similar to that of the dynamic disordered *** the entanglement of 1st GF QWs is greater than that of the TM QWs,being followed closely by the entanglement of the second class of GF(2nd GF)*** the static QWs,the entanglement of three kinds of the aperiodic QWs are also close to the maximal value and 1st GF QWs can achieve the maximum entangled *** entanglement of the TM QWs is between1st GF QWs and 2nd GF ***,the entanglement of the static disordered QWs is less than that of three kinds of the aperiodic *** is different from those of the dynamic *** these results,we can conclude that the dynamic and static 1st GF QWs can also be considered as maximal entanglement generators.

关键词： quantum walks quantum entanglement aperiodic entanglement production

Study on 6-DOF active vibration-isolation system of the ultra-precision turning lathe based on GA-BP-PID control for dynamic loads

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Advances in Manufacturing 2024年第1期12卷 33-60页

作者： Bo Wang zhong Jiang pei-Da Hu Department of Precision Instrument Tsinghua UniversityBeijing100084People’s Republic of China Institute of Machinery Manufacturing Technology China Academy of Engineering PhysicsMianyang621900SichuanPeople’s Republic of China

The vibration disturbance from an external environment affects the machining accuracy of ultra-precision machining *** active vibration-isolation systems(AVIS)have been developed based on static *** a vibration-isolation load changes dynamically during ultra-precision turning lathe machining,the system parameters change,and the efficiency of the active vibration-isolation system based on the traditional control strategy *** solve this problem,this paper proposes a vibration-isolation control strategy based on a genetic algorithm-back propagation neural network-PID control(GA-BP-PID),which can automatically adjust the control parameters according to the machining ***-isolation simulations and experiments based on passive vibration isolation,a PID algorithm,and the GA-BP-PID algorithm under dynamic load machining conditions were *** experimental results demonstrated that the active vibration-isolation control strategy designed in this study could effectively attenuate vibration disturbances in the external environment under dynamic load *** design is reasonable and feasible.

关键词： Ultra-precision diamond turning lathe Active vibration isolation Six degrees of freedom Dynamic load Genetic algorithm-back propagation neural network-PID(GA-BP-PID)control

The single-sample network module biomarkers(sNMB)method reveals the pre-deterioration stage of disease progression

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Journal of Molecular Cell Biology 2022年第8期14卷 17-28页

作者： Jiayuan zhong Huisheng Liu pei Chen School of Mathematics and Big Data Foshan UniversityFoshan 528000China School of Mathematics South China University of TechnologyGuangzhou 510640China Pazhou Lab Guangzhou 510330China School of Life Sciences and Technology Tongji UniversityShanghai 200092China

The progression of complex diseases generally involves a pre-deterioration stage that occurs during the transition from a healthy state to disease deterioration,at which a drastic and qualitative shift *** development of an effective approach is urgently needed to identify such a pre-deterioration stage or critical state just before disease deterioration,which allows the timely implementation of appropriate measures to prevent a catastrophic ***,identifying the pre-deterioration stage is a challenging task in clinical medicine,especially when only a single sample is available for most patients,which is responsible for the failure of most statistical *** this study,a novel computational method,called single-sample network module biomarkers(sNMB),is presented to predict the pre-deterioration stage or critical point using only a single ***,the proposed single-sample index effectively quantifies the disturbance caused by a single sample against a group of given reference *** method successfully detected the early warning signal of the critical transitions when applied to both a numerical simulation and four real datasets,including acute lung injury,stomach adenocarcinoma,esophageal carcinoma,and rectum *** addition,it provides signaling biomarkers for further practical application,which helps to discover prognostic indicators and reveal the underlying molecular mechanisms of disease progression.

关键词： critical point pre-deterioration stage critical transition dynamic network biomarker(DNB) single-sample network module biomarkers(sNMB)

Estimation of velocity potential of water waves using a Luenberger-like observer

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Science China(Information Sciences) 2020年第12期63卷 139-152页

作者： yang YU Hai-Long pei Cheng-zhong XU Key Laboratory of Autonomous Systems and Networked Control Ministry of EducationSouth China University of Technology Unmanned Aerial Vehicle Systems Engineering Technology Research Center of Guangzhou South China University of Technology LAGEPP University Claude Bernard-Lyon 1

We propose a Luenberger-like observer for a water wave system. The water wave dynamics are assumed to be governed by the linearized water wave equation(LWWE). Our proposed observer estimates the velocity potential of water waves by measuring only the surface wave elevation. The information of the water-wave velocity field is then extracted from the gradient of the velocity potential. It is shown that the estimation error of the observer converges exponentially to zero as time tends to infinity. Furthermore,we numerically solve the LWWE and observer equation by the finite difference method. The efficiency of our proposed numerical scheme and the performance of the observer are validated by numerical simulation results.

关键词： linearized water wave equation LWWE Luenberger-like observer numerical simulations

The Number of Rooted Essential Maps on Surfaces

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Acta Mathematica Sinica,English Series 2008年第8期24卷 1303-1312页

作者： Wen zhong LIU yan pei LIU Department of Mathematics Nanjing University of Aeronautics and AstronauticsNanjing 210016 P. R. China Department of Mathematics Beijing Jiaotong University Beijing 100044 P. R. China

In this paper, general functional equations of rooted essential maps on surfaces （orientable and nonorientable） are deduced and their formal solutions are presented. Further, three explicit for- mulae for counting e... 详细信息

关键词： essential map enufunction Euler formula Langrangian inversion