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Epigenetic regulation of the inflammatory response in stroke

Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang Fei yang Zixiao li Qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

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Variation in the Coat Protein Gene of Papaya ringspot Virus Isolates from Multiple Locations of China

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Journal of Integrative Plant Biology 2007年第7期49卷 1062-1069页

作者： Jun-ya Wei De-Bing liu Xiao-ying li Peng Zhou State Key Laboratory for Tropical Crops Biotechnology Institute of Tropical Biology Science China Academy of Tropical Agricultural Science Haikou 571101 China Department of Horticulture South China University of Tropical Agriculture Danzhou 571737 China

The potyvirus Papaya ringspot virus （PRSV） is an important pathogen of papaya that causes severe losses in economic crops for papaya production globally. The coat protein （CP） genes of five PRSV isolates originating from different locations in China were cloned and sequenced. The CP-coding region varied in size from 864-873 nucleotides, encoding proteins of 288-291 amino acids. The five Chinese isolates of PRSV have been characterized as papaya-infecting （PRSV-P）. The CP sequences of the Chinese isolates were compared with those of previously published PRSV isolates originating from different countries at amino acid levels. A number of KE repeat boxes in the N terminus of the PRSV-CP were found in all Chinese isolates. The phylogenetic branching pattern revealed that there was certain extended grouping between geographic locations, and the Asian type probably represents the oldest population of PRSV. The information of CP genes will be useful in designing and developing durable virus resistant-PRSV transgenic papaya in China. Meanwhile broad-spectrum-virus resistant, strongly resistant-PRSV and good safe papaya lines are required.

关键词： coat protein gene Papaya ringspot virus isolates sequence analysis variation.

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Structural Evolution in Flowing Immiscible Blends in the Presence of Rough Particles:Dependence of Shear Rate and Blend Ratio

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Chinese Journal of Polymer Science 2021年第8期39卷 1059-1068,I0008页

作者： Si-ying Xiang ying-Chun yao Miao-Miao Lu ya-Jiang Huang Mi-Qiu Kong Guang-Xian li College of polymer science and engineering State key laboratory of polymer materials engineering of ChinaSichuan UniversityChengdu 670065China

The influence of polystyrene particles with different nanoscale roughnesses on the morphology of polyisobutylene/poly-dimethylsiloxane blends was studied under shear flow by using confocal laser scanning *** was found that the surface roughness of particles strongly affected their diffusion and distribution behaviors,thereby determining the size and spatial arrangement of droplets in the *** roughness effect of particles was found to possess a strong dependence on both the blend ratio and the shear *** result suggested that the particle roughness can serve as a new parameter to control the structure-property correlation in particle-filled polymer blends,especially under slow flow.

关键词： Rough particles Immiscible polymer blends Shear flow

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Rational construction of densely packed Si/MXene composite microspheres enables favorable sodium storage

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Rare Metals 2022年第5期41卷 1626-1636页

作者： Hui-Qi Wang ya-Xin Zhao li Gou li-Yong Wang Mei Wang ying li Sheng-liang Hu School of Energy and Power Engineering North University of ChinaTaiyuan 030051China School of Materials Science and Engineering North University of ChinaTaiyuan 030051China

The fast and reversible sodiation/desodiation of anode materials remains an indelible yet fascinating ***, a class of the densely packed Si/MXene composite microspheres is constructed and prepared, taking advantages of the synergistic effects of the activated Si nanoparticles and conductive flower-like MXene microspheres with ample ion-diffusion pathways. Consequently,the intrinsic MXene nanosheets with intelligently regulated interlayer spacing can accommodate the volume change induced strain during cycling, and the strong interaction between the Si and MXene matrix greatly contributes to the robust structural stability. As expected, the Si/MXene composite architecture exhibits boosted sodium storage performance, in terms of an inspiring reversible capacity of 751 mAh·g^(-1)at 0.1 A·g^(-1), remarkable long-term cycling stability of 376 mAh·g^(-1)at 0.1 A·g^(-1) over 500 cycles, and outstanding rate capability(after one consecutive current density changing from 0.1 to 2.0 A·g^(-1), a large capacity of 275 mAh·g^(-1) is regained after suddenly returning the initial current density back to 0.1 A·g^(-1) and in the subsequent 200 cycles this composite architecture anode still delivers a capacity of 332 mAh·g^(-1)). The kinetics analysis indicates superior pseudocapacitive property, high electronic conductivity, and favorable sodium-ion adsorption and diffusion capability,confirming fast sodium storage performance. Impressively, ex-situ X-ray diffraction and selected area electron diffraction characterizations corroborate the formation of NaSi;as the main sodiation products during the reversible evolutions of cycled proceeding with sodium-ion insertion. This work sheds light on the elaborate design of silicon-based nanostructured anodes towards advanced high-performance sodium-ion batteries.

关键词： Silicon MXene Composite microspheres Sodium-ion batteries Flower-like anode Efficient sodiumion storage

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Effect of family caregiver nursing education on patients with rheumatoid arthritis and its impact factors:A randomized controlled trial

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World Journal of Clinical Cases 2021年第28期9卷 8413-8424页

作者： Jing li ying Zhang ya-Juan Kang Nan Ma Department of Immunology and Rheumatology The Third Hospital of Hebei Medical UniversityShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Rheumatoid arthritis(RA)is a common autoimmune *** education for family caregivers is considered a workable and effective intervention,but the validity of this intervention in RA has not been *** To explore whether family caregiver nursing education(FCNE)works on patients with RA and the factors that influence *** In this randomized controlled study,a sample of 158 pairs was included in the study with 80 in the intervention group and 78 in the control *** data of patients and caregivers was *** FCNE intervention was admi-nistered to caregivers,and inflammation level indicators,disease activity indicators and mood disorder indicators of patients were followed up and *** Baseline characteristics of the intervention and the control groups had no significant *** were significantly reduced in the intervention group compared to the control *** intervention group showed significant differences in stratification of relationship,education duration and *** The effect of FCNE on RA is multifaceted,weakening inflammation level,alleviating disease activity and relieving mood *** between caregiver and patient,caregiver’s education level and patient’s age may act as impact factors of FCNE.

关键词： Nursing education Family nursing Rheumatoid arthritis Family caregivers Depression Anxiety

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Analysis on the spatial pattern and evolution of China's petroleum trade under the dual effect of international oil price and “Belt and Road” Framework

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Petroleum Science 2023年第6期20卷 3945-3953页

作者： Shuang-ying Wang ya-yao Hua Bao-Ju li Ping Wei Peng Gao Business School Qingdao University of TechnologyQingdao266555ShandongChina Changdao Comprehensive Test Area Economic Development Bureau Yantai265800ShandongChina

“Belt and Road” is the important origin of oil import in China. Based on social network analysis and stochastic frontier gravity model, this paper studied the characteristic evolution and influence factor of oil import network between China and “Belt and Road” countries. Then by constructing a stochastic frontier gravity model including the crude oil future price and oil importing price, it found that the international crude oil future price, the oil importing price, the political situation, the trade agreements have the effects on the China's oil import from “Belt and Road” region. It provided suggestions for improving the spatial pattern of China's petroleum trade.

关键词： "Belt and Road" Oil import network Stochastic frontier gravity model International oil futures price

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Sandwich-structured nanocomposites of N-doped graphene and nearly monodisperse Fe304 nanoparticles as high-performance li-ion battery anodes

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Nano Research 2017年第9期10卷 2923-2933页

作者： Wen Qi Xuan li Hui li Weikang Wu Pei li ying Wu Chunjiang Kuang Shaoxiong Zhou Xiaolin li Beijing Key Laboratory of Energy Nanomaterials Advance Technology & Materials Co. Ltd. China Iron & Steel Research Institute Group Beijing 10008 I China School of Materials Science and Engineering Tianjin University Tianjin 300072 China Key Laboratory for liquid-Solid Structural Evolution and Processing of Materials Ministry of Education Shandong University Jinan250061 China Department of Stationary Energy Storage Pacific Northwest National Laboratory Richland Washington 99354 USA

Iron oxides have attracted considerable interest as abundant materials for high-capacity li-ion battery anodes. However, their fast capacity fading owing to poorly controlled reversibility of the conversion reactions greatly hinders their application. Here, a sandwich-structured nanocomposite of N-doped graphene and nearly monodisperse Fe3O4 nanoparticles were developed as high-performance li-ion battery anode. N-doped graphene serves as a conducting framework for the self-assembled structure and controls Fe3O4 nucleation through the interaction of N dopants, surfactant molecules, and iron precursors. Fe3O4 nanoparticles were well dispersed with a uniform diameter of ~15 nm. The unique sandwich structure enables good electron conductivity and li-ion accessibility and accommodates a large volume change. Hence, it delivers good cycling reversibility and rate performance with a capacity of ~1,227 mA·h·g–1 and 96.8% capacity retention over 1,000 cycles at a current density of 3 A·g–1. Our work provides an ideal structure design for conversion anodes or other electrode materials requiring a large volume change.

关键词： N-doped graphene iron oxides self-assembly li-ion battery density functional theory

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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin li Xiaolei Chu Qi li Ruihua li Qingwen li Kai-Yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

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口服苯肼致小鼠慢性贫血模型的建立

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现代生物医学进展 2017年第6期17卷 1029-1032页

作者：侯亚颖李瑶瑶吴凡韩琳琳郁多男扬州大学非编码RNA研究中心江苏省中西医结合老年病防治重点实验室江苏扬州225001

目的:应用苯肼建立小鼠急性溶血性贫血的方法已经成熟,但用苯肼建立慢性溶血性贫血模型尚未见报道。本研究试图应用苯肼口服法建立慢性溶血性贫血动物模型并探索最适建模的苯肼浓度。方法:42只C57BL/6小鼠随机分为6组通过口服不同浓度... 详细信息

目的:应用苯肼建立小鼠急性溶血性贫血的方法已经成熟,但用苯肼建立慢性溶血性贫血模型尚未见报道。本研究试图应用苯肼口服法建立慢性溶血性贫血动物模型并探索最适建模的苯肼浓度。方法:42只C57BL/6小鼠随机分为6组通过口服不同浓度的苯肼溶液,于口服后的第0,1,2,3,4,5,6周目内眦采集小鼠外周血检测,记录相关指标变化比较各组之间的差异,筛选出最佳慢性溶血效果的给药浓度。结果:口服苯肼溶液浓度在250 mg/L以下时C57BL/6小鼠没有出现明显的贫血状态,当浓度调至250mg/L-350mg/L时可使C57BL/6小鼠在5-7周内出现溶血性贫血症状,各组小鼠的皮肤和粘膜颜色苍白,外周血红细胞数量、血红蛋白含量、红细胞压积降低网织红细胞比例增高。但是当浓度达到350 mg/L时小鼠贫血情况过重且达不到慢性贫血的要求。当浓度为300 mg/L时小鼠各项血液指标平稳下降。结论:本实验建立了一种新的小鼠慢性贫血模型,且通过实验发现小鼠口服苯肼致慢性贫血的最佳浓度为300mg/L。据我们所知,这是首次使用苯肼建立慢性贫血的动物模型,此模型对研究人类慢性贫血具有重要价值。

关键词：慢性溶血性贫血苯肼动物模型

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Crystallization,Mechanical,Thermal and Rheological Properties of Polypropylene Composites Reinforced by Magnesium Oxysulfate Whisker

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Chinese Journal of Polymer Science 2017年第5期35卷 659-671页

作者： li Dang Xue-ying Nai Xin liu Dong-hai Zhu ya-ping Dong 李武 Key Laboratory of Salt Lake Resources Chemistry Qinghai Institute of Salt LakesChinese Academy of Sciences Key Laboratory of Comprehensive and Highly Efficient Utilization of Salt Lake Resources Qinghai Institute of Salt Lakes Chinese Academy of Sciences University of Chinese Academy of Sciences

Polypropylene （PP） composites containing magnesium oxysulfate whisker （MOSw） or lauric acid （LA） modified MOSw （LAMOSw） were prepared via melt mixing in a torque rheometer. The heterogeneous nucleating effect of LAMOSw was clearly observed in polarized light microscopy （PLM） pictures with the presence of an abundance of small spherulites. MOSw exhibited no nucleation effect and formed a few spherulites with large size. Compared with PP/MOSw composites, PP/LAMOSw exhibited better impact strength, tensile strength and nominal strain at break, ascribing to three possible reasons：（i） more β-crystal PP formed, （ii） better dispersity of LAMOSw in PP matrix and （iii） the plasticizing effect of LA. The results of dynamic mechanical thermal analysis （DMTA） indicated that brittleness of the PP matrix at low temperature was improved by the addition of LAMOSw, while the interracial interactions between MOSw and PP matrix were actually weakened by LA, as evidenced by the higher tan8 values over the entire range of test temperatures. In terms of the rheological properties of the composites, both the η＊ and G＇ at low frequencies increase with the addition of MOSw or LAMOSw, indicating that the PP matrix was transformed from liquid-like to solid-like. However, a network of whiskers did not form because no plateau was found in the G＇ at low frequencies. With low filler content, LAMOSw produced a stronger solid-like behavior than MOSw mainly due to the better dispersion of the LAMOSw in PP matrix. However, for highly-filled composites, the η＊ of PP/LAMOSw at low frequencies was smaller than that of PP/MOSw composite, since the particle- particle contact effect played a major role.

关键词： PP/MOSw composites Crystallization Thermal properties Mechanical properties Rheological properties

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