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FPR1 Antagonist (BOC-MLF) Inhibits Amniotic Epithelial-mesenchymal Transition

Current Medical Science 2024年第1期44卷 187-194页

作者： Xiao-mei HUANG E liao Jun-qun liao ya-ling LIU Yong SHAO Department of Obstetrics and Gynecology The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Maternal and Child Health Hospital of Hubei ProvinceWuhan 430070China Medical Laboratory Science The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Department of Obstetrics Yubei Maternity and Child Healthcare HospitalChongqing 400042China

Objective:Premature rupture of membranes(PROM)is a common pregnancy disorder that is closely associated with structural weakening of fetal membranes.Studies have found that formyl peptide receptor 1(FPR1)activates inflammatory pathways and amniotic epithelial-mesenchymal transition(EMT),stimulates collagen degradation,and leads to membrane weakening and membrane rupture.The purpose of this study was to investigate the anti-inflammatory and EMT inhibitory effects of FPR1 antagonist(BOC-MLF)to provide a basis for clinical prevention of PROM.Methods:The relationship between PROM,FPR1,and EMT was analyzed in human fetal membrane tissue and plasma samples using Western blotting,PCR,Masson staining,and ELISA assays.Lipopolysaccharide(LPS)was used to establish a fetal membrane inflammation model in pregnant rats,and BOC-MLF was used to treat the LPS rat model.We detected interleukin(IL)-6 in blood from the rat hearts to determine whether the inflammatory model was successful and whether the anti-inflammatory treatment was effective.We used electron microscopy to analyze the structure and collagen expression of rat fetal membrane.Results:Western blotting,PCR and Masson staining indicated that the expression of FPR1 was significantly increased,the expression of collagen was decreased,and EMT appeared in PROM.The rat model indicated that LPS caused the collapse of fetal membrane epithelial cells,increased intercellular gaps,and decreased collagen.BOC-MLF promoted an increase in fetal membrane collagen,inhibited EMT,and reduced the weakening of fetal membranes.Conclusion:The expression of FPR1 in the fetal membrane of PROM was significantly increased,and EMT of the amniotic membrane was obvious.BOC-MLF can treat inflammation and inhibit amniotic EMT.

关键词： formyl peptide receptor 1 BOC-MLF epithelial-mesenchymal transition premature rupture of membranes

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Regulation of rhizosphere microenvironment by rice husk ash for reducing the accumulation of cadmium and arsenic in rice

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Journal of Environmental Sciences 2024年第2期136卷 1-10页

作者： Yi Jiang ya Liu Xuantao Yi Peng Zeng Bohan liao Hang Zhou Jiaofeng Gu College of Environmental Science and Engineering Central South University of Forestry and TechnologyChangsha 410004China Hunan Engineering Laboratory for Control of Rice Quality and Safety Changsha 410004China

It is important to reduce Cd and As content in brown rice in contaminated paddy soils.We conducted research on the effects of rice husk ash (RHA) on the Cd and As in the rhizosphere microenvironment (soil,porewater,and iron plaque) and measured the Cd,As,and Si content in rice plants.The main elements in RHA were Si (29.64%) and O (69.17%),which had the maximum adsorption capacity for Cd was 42.49 mg/kg and for As was 18.62 mg/kg.Soil pH and available Si content increased,while soil available Cd and As decreased following application of 0.5%–2%RHA.RHA promote the transformation of Cd to insoluble fraction,while As was transformed from a poorly soluble form to a more active one.RHA reduced Cd content and increased Si content in porewater,and reduced As only at the later rice growth stages.RHA increased the amount of iron plaque,thereby decreasing the Cd content in iron plaque,while increased the As content in it.Cd and inorganic As content in brown rice were decreased,to 0.31 mg/kg and 0.18 mg/kg,respectively.The decrease of Cd in brown rice was due to the decrease of Cd mobility in soil,thereby reducing root accumulation,while the decrease of As in brown rice was affected by the transport from roots to stems.Therefore,RHA can be considered as a safe and efficient in-situ remediation amendment for Cd and As co-contaminated paddy soil.

关键词： Rice husk ash(rha) Cadmium Arsenic Silicon Rice Soil

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BMPR-IB gene disruption causes severe limb deformities in pigs

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Zoological Research 2022年第3期43卷 391-403页

作者： Qiang yang Chuan-Min Qiao Wei-Wei Liu Hao-Yun Jiang Qi-Qi Jing ya-ya liao Jun Ren Yu-Yun Xing State Key Laboratory of Pig Genetic Improvement and Production Technology Jiangxi Agricultural UniversityNanchangJiangxi 330045China

In an attempt to generate g.A746G substitution in the BMPR-IB gene,we unexpectedly obtained BMPR-IB homozygous knockout piglets(BMPR-IB^(-/-))and heterogeneous knockout piglets with one copy of the A746G mutation(BMPR-IB-/746G)via CRISPR/Cas9 editing.Polymerase chain reaction(PCR)and sequencing revealed complex genomic rearrangements in the target region.All BMPR-IBdisrupted piglets showed an inability to stand and walk normally.Both BMPR-IB^(-/-)and BMPR-IB-/746G piglets exhibited severe skeletal dysplasia characterized by distorted and truncated forearms(ulna,radius)and disordered carpal,metacarpal,and phalangeal bones in the forelimbs.The piglets displayed more severe deformities in the hindlimbs by visual inspection,including fibular hemimelia,enlarged tarsal bone,and disordered toe joint bones.Limb deformities were more profound in BMPR-IB^(-/-)piglets than in the BMPR-IB-/746G piglets.Proteomic analysis identified 139 differentially expressed proteins(DEPs)in the hindlimb fibula of BMPR-IB-/746G piglets compared to the wild-type(WT)controls.Most DEPs are involved in skeletal or embryonic development and/or the TGF-βpathway and tumor progression.Gene Ontology(GO)and protein domain enrichment analysis suggested alterations in these processes.Of the top 50 DEPs,a large proportion,e.g.,C1QA,MYO1H,SRSF1,P3H1,GJA1,TCOF1,RBM10,SPP2,MMP13,and PHAX,were significantly associated with skeletal development.Our study provides novel findings on the role of BMPR-IB in mammalian limb development.

关键词： BMPR-IB A746G Pigs Limb deformities

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Clinical evolution of antisynthetase syndrome-associated interstitial lung disease after COVID-19 in a man with Klinefelter syndrome:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1144-1149页

作者： Xiang-Xiang Wu Jian Cui Shi-yao Wang Tian-Tian Zhao ya-Fei Yuan Long yang Wei Zuo Wen-Jian liao Department of Respiratory and Critical Care The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina China-Japan Friendship Jiangxi Hospital Nanchang 330006Jiangxi ProvinceChina Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China

BACKGROUND This study presents a case of rapidly developing respiratory failure due to antisynthetase syndrome(AS)following coronavirus disease 2019(COVID-19)in a 33-year-old man diagnosed with Klinefelter syndrome(KS).CASE SUMMARY A 33-year-old man with a diagnosis of KS was admitted to the Department of Pulmonary and Critical Care Medicine of a tertiary hospital in China for fever and shortness of breath 2 wk after the onset of COVID-19.Computed tomography of both lungs revealed diffuse multiple patchy heightened shadows in both lungs,accompanied by signs of partial bronchial inflation.Metagenomic next-generation sequencing of the bronchoalveolar lavage fluid suggested absence of pathogen.A biopsy specimen revealed organizing pneumonia with alveolar septal thickening.Additionally,extensive auto-antibody tests showed strong positivity for anti-SSA,anti-SSB,anti-Jo-1,and anti-Ro-52.Following multidisciplinary discussions,the patient received a final diagnosis of AS,leading to rapidly progressing respiratory failure.CONCLUSION This study underscores the clinical progression of AS-associated interstitial lung disease subsequent to viral infections such as COVID-19 in patients diagnosed with KS.

关键词： Antisynthetase syndrome COVID-19 Klinefelter syndrome Interstitial lung disease Anti-Jo-1 Case report

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Immunomodulatory Function of Pien Tze Huang in T Cell-Mediated Anti-tumor Activity against B16-F10,MC38 and Hep1-6 Tumor Models

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Chinese Journal of Integrative Medicine 2024年第4期30卷 348-358页

作者： FU Yu-bing LIU Chen-feng WANG Jin-jia JI Xiao-lin TANG Rong-han liao Kun-yu CHEN Ling-yue HONG ya-zhen FAN Bin-bin WANG Shi-cong LIU Wen-Hsien State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life ScienceXiamen UniversityXiamenFujian Province(361102)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development ZhangzhouFujian Province(363000)China

Objective To investigate the anti-tumor effects of Pien Tze Huang(PZH)in mouse models of B16–F10 melanoma,MC38 colorectal cancer,Hep1-6 hepatocellular carcinoma and chemically induced hepatocellular carcinoma model.Methods Various tumor models,including B16–F10,MC38 and Hep1-6 tumor hypodermic inoculation models,B16–F10 and Hep1-6 pulmonary metastasis models,Hep1-6 orthotopic implantation model,and chemically induced hepatocellular carcinoma model,were utilized to evaluate the anti-tumor function of PZH.Tumor growth was assessed by measuring tumor size and weight of solid tumors isolated from C57BL/6 mice.For cell proliferation and death of tumor cells in vitro,as well as T cell activation markers,cytokine production and immune checkpoints analysis,single-cell suspensions were prepared from mouse spleen,lymph nodes,and tumors after PZH treatment.Results PZH demonstrated significant therapeutic efficacy in inhibiting tumor growth(P0.05).Nevertheless,PZH exhibited a remarkable ability to enhance T cell activation and the production of interferon gamma,tumor necrosis factor alpha,and interleukin 2 in CD4^(+)T cells in vitro(P<0.01 or P<0.05).Importantly,PZH substantially inhibited T cell exhaustion and boosted cytokine production by tumor-infiltrating CD8^(+)T cells(P<0.01 or P<0.05).Conclusion This study has confirmed a novel immunomodulatory function of PZH in T cell-mediated anti-tumor immunity,indicating that PZH holds promise as a potential therapeutic agent for cancer treatment.

关键词： Pien Tze Huang metastasis anti-tumor immunity T cell activation T cell exhaustion immune checkpoints Chinese medicine

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Entanglement quantification via weak measurements assisted by deep learning

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Photonics Research 2024年第4期12卷 712-719页

作者： MU yaNG ya XIAO ZE-yaN HAO YU-WEI liao JIA-HE CAO KAI SUN EN-HUI WANG ZHENG-HAO LIU YUTAKA SHIKANO JIN-SHI XU CHUAN-FENG LI GUANG-CAN GUO CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China College of Physics and Optoelectronic Engineering Ocean University of ChinaQingdao 266100China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China Electric Power Research Institute State Grid Anhui Electric Power Co.Ltd.Hefei 230601China Institute of Systems and Information Engineering University of TsukubaIbaraki 305-8573Japan Center for Artificial Intelligence Research University of TsukubaIbaraki 305-8577Japan Graduate School of Science and Technology Gunma UniversityGunma 371-8510Japan Institute for Quantum Studies Chapman UniversityOrangeCalifornia 92866USA JST PRESTO Saitama 332-0012Japan

Entanglement has been recognized as being crucial when implementing various quantum information tasks.Nevertheless, quantifying entanglement for an unknown quantum state requires nonphysical operations or post-processing measurement data. For example, evaluation methods via quantum state tomography require vast amounts of measurement data and likely estimation.

关键词： estimation quantum angle

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Towards sustainable adversarial training with successive perturbation generation

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Frontiers of Information Technology & Electronic Engineering 2024年第4期25卷 527-539页

作者： Wei LIN Lichuan liao College of Computer Science and Mathematics Fujian University of TechnologyFuzhou 350118China College of Economics and Management Xi’an University of TechnologyXi’an 710048China Fujian Provincial Key Laboratory of Big Data Mining and Applications Fujian University of TechnologyFuzhou 350118China

Adversarial training with online-generated adversarial examples has achieved promising performance in defending adversarial attacks and improving robustness of convolutional neural network models.However,most existing adversarial training methods are dedicated to finding strong adversarial examples for forcing the model to learn the adversarial data distribution,which inevitably imposes a large computational overhead and results in a decrease in the generalization performance on clean data.In this paper,we show that progressively enhancing the adversarial strength of adversarial examples across training epochs can effectively improve the model robustness,and appropriate model shifting can preserve the generalization performance of models in conjunction with negligible computational cost.To this end,we propose a successive perturbation generation scheme for adversarial training(SPGAT),which progressively strengthens the adversarial examples by adding the perturbations on adversarial examples transferred from the previous epoch and shifts models across the epochs to improve the efficiency of adversarial training.The proposed SPGAT is both efficient and effective;e.g.,the computation time of our method is 900 min as against the 4100 min duration observed in the case of standard adversarial training,and the performance boost is more than 7%and 3%in terms of adversarial accuracy and clean accuracy,respectively.We extensively evaluate the SPGAT on various datasets,including small-scale MNIST,middle-scale CIFAR-10,and large-scale CIFAR-100.The experimental results show that our method is more efficient while performing favorably against state-of-the-art methods.

关键词： Adversarial training Adversarial attack Stochastic weight average Machine learning Model generalization

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Effects of microenvironment and biological behavior on the paracrine function of stem cells

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Genes & Diseases 2024年第1期11卷 135-147页

作者： Zhixin Xue Yunjun liao Ye Li The Department of Plastic and Cosmetic Surgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Mesenchymal stem cells(MSCs),the most well-studied cell type in the field of stem cell therapy,have multi-lineage differentiation and self-renewal potential.MsC-based thera-pies have been used to treat diverse diseases because of their ability to potently repair tissue and locally restore function.An increasing body of evidence demonstrates that paracrine func-tion is central to the effects of MsC-based therapy.Growth factors,cytokines,chemokines,extracellular matrix components,and extracellular vehicles all contribute to the beneficial ef-fects of MSCs on tissue regeneration and repair.The paracrine substances secreted by MSCs change depending on the tissue microenvironment and biological behavior.In this review,we discuss the bioactive substances secreted by MsCs depending on the microenvironment and biological behavior and their regulatory mechanisms,which explain their potential to treat human diseases,to provide new ideas for further research and clinical cell-free therapy.

关键词： Bioactive behavior Mesenchymal stem cells Microenvironment Paracrine Secretome

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An indicator model for assessing community resilience to the COVID-19 pandemic and its validation: A case study in Hong Kong

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Journal of Safety Science and Resilience 2024年第2期5卷 222-234页

作者： Nan liao Muhammad Nawaz Departnent of Geography Faculty Art and Social SciencesSingapore 65166666Singapore

The COVID-19 outbreak had a significant negative impact on the world,and the fifth wave of COVID-19 in Hong Kong brought a considerable shock to Chinese society.There is a growing call for more resilient cities.However,empirical evidence and validation of modeling studies of resilience indicators for urban community responses to the COVID-19 pandemic still need to be provided.In this study,a resilience assessment indicator model comprising 4 subsystems,7 indicators,and 12 variables was developed to assess the resilience of Hong Kong communities in response to COVID-19(i.e.,Resilience Index).Furthermore,this study utilized regression models such as geographically weighted regression(GWR)and multiscale GWR(MGWR)to validate the resilience model proposed in this study at the model and variable levels.In the regression model,the Resilience Index and the individual variables in the resilience model are explanatory variables,and the outcomes of the COVID-19 pandemic(confirmed cases,confirmation rate,discharged cases,discharge rate)are dependent variables.The results showed that:(i)the resilience of Hong Kong communities to the COvID-19 pandemic was not strong in general and showed some clustered spatial distribution characteristics;(i)the validation results at the model level showed that the Resilience Index did not explain the consequences of the COvID-19 pandemic to a high degree;(ii)the validation results at the variable level showed that the MGWR model was the best at identifying the relationships between explanatory variables and the dependent variable;and(iv)compared with the model-level assessment results,the variable-level assessment explained the consequences of the COvID-19 pandemic better than the model level assessment results.The above analysis and the spatial distribution maps of the resilience variables can provide empirically based and targeted insights for policymakers.

关键词： Resilience Community resilience CoVID-19pandemic Resilience assessment indicator model Resilience model validation MGWR

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Organic Brønsted Acid-Catalyzed Stereoselective Cationic RAFT Polymerization:The Effect of RAFT Agents

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Chinese Journal of Polymer Science 2024年第6期42卷 711-717页

作者： Zheng-Yi Zhang Zan yang Yun liao Sai-Hu liao Key Laboratory of Molecule Synthesis and Function Discovery(Fujian Province University) College of ChemistryFuzhou UniversityFuzhou350108China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China Beijing National Laboratory for Molecular Sciences Beijing100190China

The tacticity of vinyl polymers is a key factor affecting the properties of materials.Recently,organic Brønsted acids have been demonstrated as effective catalysts for the development of highly stereoselective cationic reversible addition-fragmentation chain transfer(RAFT)polymerizations of vinyl ethers,in which the use of RAFT agents could allow the control the molecular weight and tacticity of polymer products simultaneously.However,the effect of RAFT agents on the tacticity-regulation remains elusive and lacks of investigation.In this study,we synthesized four types of RAFT agents and evaluated their influence in the stereoselective cationic polymerization of isobutyl vinyl ether in the presence of PADI as a Brønsted acid catalyst,which unveils that the Z group of RAFT agents could not only affect the polydispersity of the products,but also exert a profound effect on the stereoselectivity.After extensive screening of the RAFT agents,high stereoregularity(isotacticity,90%m)was obtained when using dithiocarbonate ester-type RAFT agents with a benzyloxy Z group.

关键词： Bronsted acid catalysis Stereoselective cationic polymerization RAFT polymerization Chain transfer agents Tacticity

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