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Improvement and Application of Acute Blood Stasis Rat Model Aligned with the 3Rs (Reduction, Refinement and Replacement) of Humane Animal Experimentation

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Chinese Journal of Integrative Medicine 2020年第4期26卷 292-298页

作者： HUANG Shuai XU Feng WANG Yin-ye shang Ming-ying WANG Chao-qun WANG xuan CAI Shao-qing State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing(100191)China Hubei Engineering Research Center of Viral Vector Wuhan University of BioengineeringWuhan(430415)China Department of Molecular and Cellular Pharmacology School of Pharmaceutical SciencesPeking UniversityBeijing(100191)China Division of Pharmaceutical Analysis School of Pharmaceutical SciencesPeking UniversityBeijing(100191)China

Objective:To establish a novel cardiocentesis method for withdrawing venous blood from the right atrium,and to improve an acute blood stasis rat model using an ice bath and epinephrine hydrochloride(Epi)while considering the 3Rs(reduction,refinement,and replacement)of humane animal ***:An acute blood stasis model was established in male Sprague-Dawley rats by subcutaneous injection(s.c.)Epi(1.2mg/kg)administration at 0h,followed by a 5-min exposure to an ice-bath at 2h and *** administration at *** rats received physiological *** were fasted overnight and treated with Angelicae Sinensis Lateralis Radix(ASLR)and Pheretima the following *** blood was collected using our novel cardiocentesis method and used to test whole blood viscosity(WBV),prothrombin time(PT),activated partial thromboplastin time(APTT),and fibrinogen(FIB)***:The rats survived the novel cardiocentesis technique;WBV value returned to normal while hematological parameters such as hemoglobin level and red blood cell count were restored to>94%of the corresponding values in normal rats following a 14-day ***(1.2 mg/kg,s.c.)combined with a 5-min exposure to the ice bath replicated the acute blood stasis rat model and was associated with the highest WBV *** rats showing acute blood stasis,ASLR treatment[4g/(kg-d)for 8 days]decreased WBV by 9.98%,11.09%,9.34%,9.00%,7.66%,and 7.03%(P<0.05),while Pheretima treatment[2.6g/(kg?d),for 8 days]decreased WBV by 25.49%,25.94%,16.28%,17.76%,11.07%,and 7.89%(P<0.01)at shear rates of 1,3,10,30,100,and 180 s'1,***,Pheretima treatment increased APTT significantly(P<0.01).Conclusions:We presented a stable,reproducible,and improved acute blood stasis rat model,which could be applied to screen drugs for promoting blood circulation and eliminating blood stasis.

关键词： acute blood stasis rat model cardiocentesis whole blood viscosity coagulation parameters Angelicae Sinensis Lateralis Radix Pheretima Chinese medicine syndrome

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铷原子气体自旋噪声谱的测量与改进

物理学报 2018年第8期67卷 185-193页

作者：尚雅轩马健史平钱轩李伟姬扬中国科学院半导体研究所半导体超晶格国家重点实验室北京100083 中国科学院大学材料科学与光电技术学院北京100049 中国科学院大学物理科学学院北京100049 挪威科技大学海事操作与土木工程系挪威奥勒松6025

利用自主设计并制作的基于现场可编程门阵列的实时傅里叶变换采集卡(FFTsDAC),采用线偏振光检测碱金属铷原子气样品中的自旋随机涨落(即自旋噪声谱).详细讨论了背景噪声以及自旋噪声随探测光光强的变化关系,证实了自旋噪声来自于系统中... 详细信息

利用自主设计并制作的基于现场可编程门阵列的实时傅里叶变换采集卡(FFTsDAC),采用线偏振光检测碱金属铷原子气样品中的自旋随机涨落(即自旋噪声谱).详细讨论了背景噪声以及自旋噪声随探测光光强的变化关系,证实了自旋噪声来自于系统中自旋的随机涨落.对比了两种FFTsDAC(8 bit采样的FFTsDACl和12 bit采样的FFTsDAC2)的测量性能,分析了影响实验信噪比的因素.FFTsDAC2具有更高的测量效率和采样深度以及更长的单次采样时间,因而具有更高的信噪比和更好的频率分辨率,与数值模拟的结果一致.

关键词：自旋噪声谱背景噪声法拉第旋转实时傅里叶变换采集卡

Transition-Metal-Free Catalyzed Dehydrative Coupling of Quinoline and Isoquinoline N-Oxides with Propargylic Alcohols

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Chinese Journal of Chemistry 2022年第1期40卷 71-78页

作者： Zhao-Nan Cai Xiang-xuan Feng Yuecheng Zhang Cong-Cong Lu ya-Ping Han Jiquan Zhao School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300130China

A novel,green,and transition-metal-free protocol for the facile modification of quinoline and isoquinoline derivatives is introduced,starting from readily available and environmentally benign quinoline and isoquinoline N-oxides with propargylic alcohols in the presence of Na_(2)S_(2)O_(8) or K_(2)S_(2)O_(8) at 100℃.The one-pot transformation features the advantages of good functional group compatibility,short reaction time,operational simplicity,and highly efficient reaction *** protocol,which produces water as the only byproduct,provides efficient and atom-economical access to a class of fascinating quinoline and isoquinoline products in satisfactory *** method is effective on the gram scale,thus highlighting the inherent practicality of this methodology.

关键词： Synthetic methods Alcohols Nitrogen heterocycles Transition-metal-free Solvent-free

Erratum to: Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2022年第2期23卷 171-172页

作者： xuan LIU Xueqing ZHOU Xuwei shang Li WANG Yi LI Hong YUAN Fuqiang HU College of Pharmaceutical Science Zhejiang UniversityHangzhou 310058China

The original version of this article(Liu et al.,2020)unfortunately contained some ***.7c and 7d in p.229 were *** upper left and bottom left pictures in Fig.7c were accidentally duplicated with the pictures at the sam... 详细信息

关键词： treatment picture

Clinical potentials of ginseng polysaccharide for treating gestational diabetes mellitus

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World Journal of Clinical Cases 2021年第19期9卷 4959-4968页

作者： xuan-Yin Zhao Fang Zhang Wei Pan Yi-Fang yang Xiao-ya Jiang First Affiliated Hospital Guizhou University of Traditional Chinese MedicineGuiyang 550002Guizhou ProvinceChina Maternal and Child Health Hospital of Guiyang Guiyang 550002Guizhou ProvinceChina

Gestational diabetes mellitus(GDM)is the most common glucose metabolism complication or cause of potential impaired glucose tolerance that can occur either before or during pregnancy and *** prevalence of GDM and its related complications in young women is increasing,and this condition may cause serious outcomes and health hazards to the ***,traditional oral hypoglycaemic drugs have potential safety hazards;therefore,it is urgent to develop new,safe,effective,and easily administered agents and *** polysaccharide(GPS),which is isolated from Panax(P.)ginseng ***,exhibits notably promising biological activities and effects;specifically,it has been shown to lower blood glucose with mild,safe,and nontoxic characteristics,and it can also improve human bodily ***,we hypothesise that GPS might be used as an additional therapy and candidate agent for treating *** review innovatively summarizes the available reports and evidence from basic studies to analyze the potential for and feasibility of using GPS as a new therapeutic agent for treating ***,for the first time,this review provides a rationale for the use of *** summarized results show that GPS may be developed as a novel antidiabetic drug and a remedy for use in preventing and treating GDM,with great application prospects.

关键词： Ginseng polysaccharide Gestational diabetes mellitus Biological activities Anti-diabetes Review

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Cu-Fe合金凝固过程中结构变化研究

原子与分子物理学报 2025年第6期42卷 183-192页

作者：王旭锋张真豪高绪锋金雅璇张寒雨李运刚华北理工大学冶金与能源学院唐山063210

采用分子动力学模拟方法研究了Cu_(100-X)Fe_(X)(X=1%、3%、5%)合金在冷却速率为2×10^(10)K/s条件下合金凝固过程.研究表明,Fe含量为1%时,随着合金温度的降低Fe原子始终保持均匀分布的状态,未出现Fe原子聚集现象,晶体结构是以FCC为主... 详细信息

采用分子动力学模拟方法研究了Cu_(100-X)Fe_(X)(X=1%、3%、5%)合金在冷却速率为2×10^(10)K/s条件下合金凝固过程.研究表明,Fe含量为1%时,随着合金温度的降低Fe原子始终保持均匀分布的状态,未出现Fe原子聚集现象,晶体结构是以FCC为主的Cu基体,Fe原子以固溶形式存在于基体中.Fe含量为3%时,随着合金温度的降低Fe原子有聚集趋势,但BCC晶体结构占比较小,晶体结构仍是以FCC为主的Cu基体.Fe含量为5%,随着合金温度的降低Fe原子发生明显聚集,最终形成以FCC、HCP晶体类型为主镶嵌Fe原子的Cu基体.研究了Fe团簇的形成过程,结果表明,Fe团簇的形成、长大是一个连续的过程,该过程受形核生长机制控制,不同阶段形成Fe团簇的大小和数量受Fe-Fe原子相互作用力、Fe原子的扩散能力以及Fe团簇与Cu基体间的界面能三个因素共同影响.

关键词： Cu-Fe合金快速凝固晶体结构 Fe团簇

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Ziyin Huatan Recipe, a Chinese herbal compound, inhibits migration and invasion of gastric cancer by upregulating RUNX3 expression

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Journal of Integrative Medicine 2022年第4期20卷 355-364页

作者： shang-jin Song xuan Liu Qing Ji Da-zhi Sun Li-juan Xiu Jing-yu Xu Xiao-qiang Yue Department of Traditional Chinese Medicine Changzheng HospitalNaval Medical UniversityShanghai 200003China Strategic Support Force Xingcheng Special Duty Sanatorium Xingcheng 125100Liaoning ProvinceChina Cancer Institute Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China

Objectives: Ziyin Huatan Recipe(ZYHT), a traditional Chinese medicine comprised of Lilii Bulbus, Pinelliae Rhizoma, and Hedyotis Diffusa, has shown promise in treating gastric cancer(GC). However, its potential mechanism has not yet been clearly addressed. This study aimed to predict targets and molecular mechanisms of ZYHT in treating GC by network pharmacology analysis and to explore the role of ZYHT in GC both in vitro and in ***: Targets and molecular mechanisms of ZYHT were predicted via network pharmacology analysis. The effects of ZYHT on the expression of metastasis-associated targets were further validated by Western blot and quantitative real-time polymerase chain reaction. To explore the specific molecular mechanisms of the effects of ZYHT on migration and invasion, the runt-related transcription factor 3(RUNX3) gene was knocked out by clustered regularly interspaced short palindromic repeats/Cas9, and lentiviral vectors were transfected into SGC-7901 cells. Then lung metastasis model of GC in nude mice was established to explore the anti-metastasis effect of ZYHT. Western blot and immunohistochemistry were used to explore the impact of ZYHT on the expression of metastasis-related proteins with or without RUNX3 ***: The network pharmacology analysis showed that ZYHT might inhibit focal adhesion, migration,invasion and metastasis of GC. ZYHT inhibited the proliferation, migration and invasion of GC cells in vitro via regulating the expression of metastasis-associated targets. Knocking out RUNX3 almost completely reversed the cell phenotypes(migration and invasion) and protein expression levels elicited by *** vivo studies showed that ZYHT inhibited the metastasis of GC cells to the lung and prolonged the survival time of the nude mice. Knocking out RUNX3 partly reversed the metastasis of GC cells to the lung and the protein expression levels elicited by ***: ZYHT can effectively inhibit the invasion and migration of GC in

关键词： Ziyin Huatan Recipe Gastric cancer Traditional Chinese medicine Metastasis Runt-related transcription factor 3

Effect of Froude similitude deviation on curved channel simulations: A case study in the Middle yangtze River

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Water Science and Engineering 2023年第3期16卷 289-294页

作者： Xiao-ting yang Qian-qian shang Hui Xu Guo-bin Li ya-jun Gao Qi-lin yang Tibet Agricultural and Animal Husbandry University Linzhi 860001China State Key Laboratory of Hydrology–Water Resources and Hydraulic Engineering Nanjing 210029China River and Harbor Engineering Department Nanjing Hydraulic Research InstituteNanjing 210029China

Froude similitude and friction similitude are the two crucial similarity conditions that are often used in physical-scale modeling of ***,models often deviate from Froude similitude when dealing with real-world *** study developed several fixed-bed river models with various curvatures to determine the effect of Froude similitude deviation on curved channel *** were constructed according to the characteristics of the Middle yangtze *** in longitudinal slope,transverse slope,and main stream line location were measured by varying Froude similitude *** deviations of longitudinal slope and velocity were negligible because friction similitude was accounted *** transverse slope varied significantly with the Froude similitude deviation,and the main stream line varied with the curvature and Froude similitude *** were derived to estimate the slope *** analyses helped to clarify the feasibility of the method of Froude similitude deviation for curved channels.

关键词： Fixed-bed river model Froude similitude deviation Flow movement Water surface slope Middle yangtze river

Quality Guaranteed for Export and Import Commodities

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China's Foreign Trade 1997年第7期 13-14页

作者： shang xuan

Our commodity inspection departments have been focusing their efforts on upgrading their testing and inspection to ensure the high quality of import and export commodities. Thus they have achieved progress and breakthroughs in all aspects of their work and safeguarded China’s rights and interests and its foreign trade reputation. According to statistics, some 1.888 million batches of import and export commodities were inspected in 1996, worth us$91.82 billion——19.95 percent and 16.20 percent increase respectively over the previous year. Of these, export commodities accounted for 1.

关键词： over Quality Guaranteed for Export and Import Commodities US