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3D printed collagen/silk fibroin scaffolds carrying the secretome of human umbilical mesenchymal stemcells ameliorated neurological dysfunction after spinal cord injury in rats

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Regenerative Biomaterials 2022年第1期9卷 52-66页

作者： Chong chen Hai-Huan Xu Xiao-Yin Liu Yu-Sheng Zhang Lin Zhong You-Wei Wang Lin Xu Pan Wei ya-xing chen Peng Liu chen-Ru Hao Xiao-Li Jia Nan Hu Xiao-yang Wu Xiao-Song Gu Li-Qun chen Xiao-Hong Li Academy of Medical Engineering and Translational Medicine Tianjin University92 Weijin RoadNankai DistrictTianjin 300072China Tianjin Key Laboratory of Neurotrauma Repair Pingjin Hospital Brain CenterCharacteristic Medical Center of People’s Armed Police Forces220 Chenglin RoadDongli DistrictTianjin 300162China Department of Neurosurgery West China Medical SchoolWest China HospitalSichuan UniversityGuoxue Lane 37Wuhou DistrictChengduSichuan 610041China National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan University29 Wangjiang RoadWuhou DistrictChengduSichuan 610064China Department of Hematology The First Affiliated Hospital of Chengdu Medical College278 Baoguang Avenue middle sectionXindu DistrictChengduSichuan 610500China Medical Psychology Section Hubei General Hospital of Armed Police Force475 Minzhu RoadWuchang DistrictWuhanHubei 430071China Department of Neurosurgery The First People’s Hospital of Long Quan yi DistrictYuyang Road Yihe 3 GroupLongquanyi District201 Cheng DuSi Chuan 610000China

Although implantation of biomaterials carrying mesenchymal stem cells(MSCs)is considered as a promising strategy for ameliorating neural function after spinal cord injury(SCI),there are still some challenges including poor cell survival rate,tumorigenicity and ethics *** performance of the secretome derived from MSCs was more stable,and its clinical transformation was more *** antibody array demonstrated that the secretome of MSCs contained 79 proteins among the 174 proteins ***-dimensional(3D)printed collagen/silk fibroin scaffolds carrying MSCs secretome improved hindlimb locomotor function according to the Basso–Beattie–Bresnahan scores,the inclined-grid climbing test and electrophysiological *** with locomotor function recovery,3D printed collagen/silk fibroin scaffolds carrying MSCs secretome could further facilitate nerve fiber regeneration,enhance remyelination and accelerate the establishment of synaptic connections at the injury site compared to 3D printed collagen/silk fibroin scaffolds alone group according to magnetic resonance imaging,diffusion tensor imaging,hematoxylin and eosin staining,Bielschowsky’s silver staining,immunofluorescence staining and transmission electron *** results indicated the implantation of 3D printed collagen/silk fibroin scaffolds carrying MSCs secretome might be a potential treatment for SCI.

关键词： spinal cord injury secretome mesenchymal stem cells 3D printing collagen silk fibroin

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Fixed-Time Anti-Disturbance Average-Tracking for Multi-Agent Systems Without Velocity Measurements

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Journal of Systems Science & Complexity 2024年第3期37卷 985-1002页

作者： LI Yuling LIU chenglin ZHANG ya chen yangyang Key Laboratory of Advanced Process Control for Light Industry(Ministry of Education) Institute of AutomationJiangnan UniversityWuci 214122China School of Automation Southeast UniversityNanjing 210096China

In this paper,the authors tackle a fixed-time average-tracking problem for multi-agent systems which do not require velocity measurements and are affected by external mismatched and matched *** objective requires the considered agents with second-order dynamics to follow the average value of several time-varying reference signals,each of which is acquired by only one *** of all,the average value is estimated by using a novel distributed average estimator in a fixed ***,an original observer is created to provide estimated values in a fixed time for external mismatched and matched disturbances as well as unmeasured velocities of ***,the authors propose a novel fixed-time anti-disturbance average-tracking protocol with the aid of the observer and a sliding mode *** the end,the feasibility of theoretical analysis is illustrated by some simulation experiments.

关键词： Average-tracking control fixed-time algorithm fixed-time observer mismatched distur-bances multi-agent systems velocity measurements

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Study on concentration distribution and detonation characteristics for non-axisymmetric fuel dispersal

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Defence Technology（防务技术） 2024年第1期31卷 484-495页

作者： Linghui Zeng Zhongqi Wang xing chen Jianping Li State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China College of Environment and Chemical Engineering Sichuan University of Science&EngineeringZigong643000China

The study of non-axisymmetric fuel dispersal and detonation can provide reference for the prevention of industrial cloud explosion accidents and the design of fuel air explosive(FAE).The concentration and detonation fields of 85 kg cylindrical and fan-shaped fuel are investigated by experiments and numerical simulations.A dynamic model of the whole process for fuel dispersal and detonation is *** concentration distribution of fuel is used as the initial condition to calculate the detonation stage,thus solving the initial value problem of detonation *** phase and component changes of fuel cloud at different locations are *** fuel cloud is divided into directions of 0°,90°,135°and 180°.The results show that the maximum cloud radius is 20.94 m in 135°and the minimum is 12.04 m in 0°.The diameter of the detonation fireball is 53.6 m,and the peak temperature is 3455 *** highest peak overpressure is 3.44 MPa in 0°and the lowest is 2.97 MPa in 135°.The proportion of liquid phase in 0°is22.90%,and the fuel loss is 11.8% and 9% higher than that in 135°and cylindrical charge,*** stable propagation distance of blast wave in 135°is 42.50% longer than 0°and 28.37% longer than cylindrical charge.

关键词： Fuel dispersal Concentration distribution Detonation characteristic Fuel loss Numerical simulation

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Topologically protected entanglement switching around exceptional points

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Light(Science & Applications) 2024年第8期13卷 1631-1644页

作者： Zan Tang Tian chen xing Tang Xiangdong Zhang Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081 BeijingChina

The robust operation of quantum entanglement states is crucial for applications in quantum information,computing,and communications^(1–3).However,it has always been a great challenge to complete such a task because of decoherence and ***,we propose theoretically and demonstrate experimentally an effective scheme to realize robust operation of quantum entanglement states by designing quadruple degeneracy exceptional *** encircling the exceptional points on two overlapping Riemann energy surfaces,we have realized a chiral switch for entangled states with high *** to the topological protection conferred by the Riemann surface structure,this switching of chirality exhibits strong robustness against perturbations in the encircling ***,we have experimentally validated such a scheme on a quantum walk *** work opens up a new way for the application of non-Hermitian physics in the field of quantum information.

关键词： exceptional quantum Riemann

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Experimental investigation of spectral evolution in flash radiation by hypervelocity impact on aluminum plates

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Defence Technology（防务技术） 2024年第7期37卷 96-110页

作者： xing chen Yonggang Lu Zhiwen Li Zhonghua Cui Institute of Systems Engineering China Academy of Engineering PhysicsMianyang 621900SichuanChina Chongqing Qianwei Technology Group Co. LtdChongqing 401121China

In this study,a series of hypervelocity impact tests were carried out based on a two-stage light gas gun,and the sequence spectrum and radiation evolution data of the impact products under different impact conditions were *** diameter of the projectile is 3-5 mm,the impact velocity is 3.13-6.58 km/s,and the chamber pressure is 0.56-990 *** spectrum of ejected debris cloud in the 250-310 nm band were obtained using a transient spectral measurement system and a multi-channel radiometer measurement *** test results reveal that the flash radiation intensity increases as a power function with the kinetic energy of the ***,the peak value of the line spectrum decreases as the chamber vacuum degree increases,while the radiation width gradually *** line spectrum in the spectral characterization curve corresponds to the ejected debris clouds splitting phase,which does not produce significant line spectrum during material fragmentation and is dominated by the continuum spectrum produced by blackbody *** will appear one or three characteristic peaks in the flash radiation time curve,the first and second peaks correspond to the penetration phase and the third peak corresponds to the expansion phase of the ejected debris clouds on the time scale,the first and second peaks are more sensitive to the chamber vacuum degree,and when the pressure is higher than 99 Pa,the first and second characteristic peaks will *** radiant heat attenuation of the flash under different impact conditions is significantly different,the attenuation exponent has a power function relationship with the impact velocity and the chamber vacuum degree,while the attenuation exponent has a linear relationship with the diameter of the projectile,the specific expression of the attenuation exponent is obtained by *** findings from this research can serve as a valuable reference for remote diagnostic technologies based on flash radiation characte

关键词： Hypervelocity impact Flash radiation Evolution Spectral characteristics Damage evaluation

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Atorvastatin, etanercept and the nephrogenic cardiac sympathetic remodeling in chronic renal failure rats

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Journal of Geriatric Cardiology 2024年第4期21卷 443-457页

作者： Jing-Yue XU Zheng-Kai XUE ya-Ru ZHANG xing LIU Xue ZHANG Xi yaNG Tong LIU Kang-Yin chen Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of Cardiologythe Second Hospital of Tianjin Medical UniversityTianjinChina

BACKGROUND Chronic renal failure(CRF) patients are predisposed to arrhythmias, while the detailed mechanisms are unclear. We hypothesized the chronic inflammatory state of CRF patients may lead to cardiac sympathetic remodeling, increasing the incidence of ventricular arrhythmia(VA) and sudden cardiac death. And explored the role of atorvastatin and etanercept in this *** A total of 48 rats were randomly divided into sham operation group(Sham group), CRF group, CRF + atorvastatin group(CRF + statin group), and CRF + etanercept group(CRF + rhTNFR-Fcgroup). Sympathetic nerve remodeling was assessed by immunofluorescence of growth-associated protein 43(GAP-43) and tyrosine hydroxylase positive area fraction. Electrophysiological testing was performed to assess the incidence of VA by assessing the ventricular effective refractory period and ventricular fibrillation threshold. The levels of tumor necrosis factor-alpha(TNF-α) and interleukin-1beta were determined by Western blotting and enzyme-linked immunosorbent *** Echocardiogram showed that compared with the Sham group, left ventricular end-systolic diameter and ventricular weight/body weight ratio were significantly higher in the CRF group. Hematoxylin-eosin and Masson staining indicated that myocardial fibers were broken, disordered, and fibrotic in the CRF group. Western blotting, enzyme-linked immunosorbent assay,immunofluorescence and electrophysiological examination suggested that compared with the Sham group, GAP-43 and TNF-α proteins were significantly upregulated, GAP-43 and tyrosine hydroxylase positive nerve fiber area was increased, and ventricular fibrillation threshold was significantly decreased in the CRF group. The above effects were inhibited in the CRF + statin group and the CRF + *** In CRF rats, TNF-α was upregulated, cardiac sympathetic remodeling was more severe, and the nephrogenic cardiac sympathetic remodeling existed. Atorvastatin and etanercept c

关键词： remodeling cardiac inhibited

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A Novel ISSA–DELM Model for Predicting Rock Mass Permeability

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2825-2848页

作者： chen xing Leihua yao Yingdong Wang School of Engineering and Technology China University of Geosciences(Beijing)Beijing100083China Beijing Engineering Corporation Limited Beijing100024China

In pumped storage projects,the permeability of rock masses is a crucial parameter in engineering design and *** rock mass permeability coefficient(K)is influenced by various geological parameters,and previous studies aimed to establish an accurate relationship between K and geological *** study uses the improved sparrow search algorithm(ISSA)to optimize the parameter settings of the deep extreme learning machine(DELM),constructing a prediction model with flexible parameter selection and high ***,the Spearman method is applied to analyze the correlation between geological parameters.A sample database is built by comprehensively selecting four geological indexes:burial depth,rock quality designation(RQD),fracture density characteristic index(FD),and rock mass integrity designation(RID).Hence,the defects of the sparrow search algorithm(SSA)are enhanced using the improved strategy,and the initial input weights of the DELM are ***,the proposed ISSA–DELM model is employed to predict the permeability coefficient of rock mass in the entire study *** results showed that the predictive performance of the model is superior to that of the DELM and SSA–***,this model successfully provides insights into the distribution characteristics of rock mass permeability at engineering sites.

关键词： ISSA DELM rock mass permeability coefficient geological parameter correlation analysis

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Synthesis and modification of nanowires anchored on electrodes for electrochemical and electrophysical applications

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Nano Research 2024年第10期17卷 8863-8884页

作者： Feiyang Mo Zhitao chen Nian Liu xing Xie School of Civil and Environmental Engineering Georgia Institute of Technology311 Ferst Drive NWAtlantaGA 30332USA School of Chemical and Biomolecular Engineering Georgia Institute of Technology311 Ferst Drive NWAtlantaGA 30332USA

The integration of nanowires onto electrode surfaces marks a significant advancement over traditional electrode materials,conferring upon nanowire-modified electrodes a vast array of applications within electrochemical and electrophysical *** nanowires used for electrode modification can be catalogized into two distinct types:anchored nanowires and free-standing nanowires.A critical advantage of anchored nanowires lies in their enhanced electrical connectivity with the substrate,which reduces electrode resistance and facilitates charge ***,the anchorage of nanowires onto electrodes provides additional mechanical support,bolstering the structural stability of the nanowire ***,we review the development of anchored nanowires designed for applications in energy storage,electrocatalysis,and electric field treatment(EFT)over the past *** focus on the synthesis and modification strategies employed for anchored nanowires,culminating in the evaluation of these fabrication and enhancement *** this analysis,we aim to furnish comprehensive insights into the preparation of anchored nanowires,guiding the selection of appropriate fabrication processes and subsequent functional modifications.

关键词： electrode modification direct growth etching energy storage electrocatalysis electric field treatment

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Chain Dynamics Heterogeneity in Plasticized Poly(vinyl butyral)(PVB) as Elucidated by Solid-State NMR

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Chinese Journal of Polymer Science 2024年第1期42卷 113-124,I0010页

作者： Jing Lv Xu chen Zi-Shuo Wu ya-Hui Li Wei chen National Synchrotron Radiation Laboratory Anhui Provincial Engineering Laboratory of Advanced Functional Polymer FilmCAS Key Laboratory of Soft Matter ChemistryUniversity of Scienceand Technology of ChinaHefei 230026China

The chain dynamics heterogeneity of the poly(vinyl butyral)(PVB) plasticized by triethylene glycol bis(2-ethylhexa noate)(TEG-EH) was investigated by various solid-state NMR *** plasticized PVB shows two domains in distinct molecular dynamics differences,namely,rigid and soft domains,where the latter is the plasticizer-rich *** time domain low field NMR was first used to investigate the dynamics heterogeneity of the plasticized PVB,and the results show the decreasing activated energy of components in the soft domain of plasticized PVB(E_a=20.2 kJ/mol) as compared with that of the pristine one(E_a=24.3 kJ/mol).Detailed dynamics heterogeneity was obtained by high-field NMR with site-specific *** quadrupole-echo ~2H-NMR was adopted to elucidate the dynamics heterogeneity of the vinyl alcohol(VA) units,where only the hydroxyl group of VA is *** ~1H-^(13)C WISE NMR spectra show that there is not much difference in the mobility of the VB unit in PVB with and without plasticizer,whereas the glass transition temperature differed by approximately 53℃.This is further supported by Torchia's T_1 relaxation *** origin of such an unusual phenomenon is attributed to the critical role of the remaining VA(~22%) in the soft domain,where the VA units locally aggregate through hydrogen ***,the existence of a mobility gradient in the VB unit has been ***,the mobility difference for VB with different stereo-geometry(meso or racemic conformation) is observed for the first *** indicates the importance of modulating the ratio of meso over racemic VB for controlling the macroscopic perfo rmance of PVB.

关键词： Poly(vinyl butyral) Dynamics heterogeneity Plasticizer Solid state NMR

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Analytical solution for the effective elastic properties of rocks with the tilted penny-shaped cracks in the transversely isotropic background

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Petroleum Science 2024年第1期21卷 221-243页

作者： Zheng-Qian Ma xing-yao Yin Zhao-Yun Zong Yuan-Yuan Tan ya-Ming yang National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao266580ShandongChina School of Geosciences China University of Petroleum(East China)Qingdao 266580ShandongChina Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao266200ShandongChina

Seismic prediction of cracks is of great significance in many disciplines,for which the rock physics model is ***,up to now,multitudinous analytical models focus primarily on the cracked rock with the isotropic background,while the explicit model for the cracked rock with the anisotropic background is rarely investigated in spite of such case being often encountered in the ***,we first studied dependences of the crack opening displacement tensors on the crack dip angle in the coordinate systems formed by symmetry planes of the crack and the background anisotropy,respectively,by forty groups of numerical *** on the conclusion from the experiments,the analytical solution was derived for the effective elastic properties of the rock with the inclined penny-shaped cracks in the transversely isotropic ***,we comprehensively analyzed,according to the developed model,effects of the crack dip angle,background anisotropy,filling fluid and crack density on the effective elastic properties of the cracked *** analysis results indicate that the dip angle and background anisotropy can significantly either enhance or weaken the anisotropy degrees of the P-and SH-wave velocities,whereas they have relatively small effects on the SV-wave velocity ***,the filling fluid can increase the stiffness coefficients related to the compressional modulus by reducing crack compliance parameters,while its effects on shear coefficients depend on the crack dip *** increasing crack density reduces velocities of the dry rock,and decreasing rates of the velocities are affected by the crack dip *** comparing with exact numerical results and experimental data,it was demonstrated that the proposed model can achieve high-precision estimations of stiffness ***,the assumption of the weakly anisotropic background results in the consistency between the proposed model and Hudson's published theory for the or

关键词： Effective elastic property Tilted crack Transverse isotropy Analytical solution Crack opening displacement

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