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Cost-effectiveness analysis of different anesthesia strategies for transperineal MRI/US fusion prostate biopsy

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Asian Journal of Andrology 2024年第4期26卷 409-414页

作者： Di Jin Xiao-Qi Kong ya-Juan Zhu Zong-xin chen Xi-Ming Wang Cai-Hua Xu Jin-Xian Pu Jian-Quan Hou Yu-Hua Huang Fu-Hai Ji chen Huang Department of Anesthesiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Radiology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Oncology The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Urology Dushu Lake Hospital Affiliated to Soochow UniversitySuzhou 215000China.

This study aims to conduct a cost-effectiveness analysis of three different anesthesia strategies,namely chatting while under local anesthesia(Chat-LA),total intravenous anesthesia(TIVA),and general anesthesia with laryngeal mask airway(GA-LMA),employed in transperineal magnetic resonance imaging(MRI)/ultrasound(US)fusion prostate biopsy(TP-MUF-PB).A retrospective study was conducted involving 1202 patients who underwent TP-MUF-PB from June 2016 to April 2023 at The First Affiliated Hospital of Soochow University(Suzhou,China).Clinical data and outcomes,including total costs,complications,and quality-adjusted life years(QALYs),were *** sensitivity and subgroup analyses were also ***-LA was found to be the most cost-effective option,outperforming both TIVA and ***,subgroup analyses revealed that in younger patients(under 65 years old)and those with smaller prostate volumes(<40 ml),TIVA emerged as a more cost-effective *** Chat-LA may generally be the most cost-effective and safer anesthesia method for TP-MUF-PB,personalization of anesthesia strategies is crucial,considering specific patient demographics such as age and prostate volume.

关键词： anesthesia strategy cost-effectiveness analysis economic evaluation prostate biopsy prostate cancer

Comparative Analysis of Diagonal and Centrifugal Compressors with Synergy Theory in Compressed Air Energy Storage System

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Journal of Thermal Science 2024年第4期33卷 1325-1339页

作者： ZHANG Yuxin ZUO Zhitao ZHOU xin GUO Wenbin chen Haisheng Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China National Energy Large Scale Physical Energy Storage Technologies R&D Center of Bijie Bijie551700China Nanjing Institute of Future Energy System IETCASNanjing211135China

Energy storage technology is an essential part of the efficient energy *** air energy storage(CAES)is considered to be one of the most promising large-scale physical energy storage *** is favored because of its low-cost,long-life,environmentally friendly and low-carbon *** compressor is the core component of CAES,and the performance is critical to the overall system *** importance is not only reflected in the design point,but also in the continuous efficient operation under variable working *** diagonal compressor is currently the focus of the developing large-scale CAES because of its stronger flow capacity compared with traditional centrifugal *** the diagonal compressor has the higher single stage pressure ratio compared with axial *** this paper,the full three dimensional numerical simulation technologies with synergy theory are used to compare and analyze the internal flow *** performance of the centrifugal and diagonal impellers that are optimized under the same requirements for large-scale CAES has been *** relationship between the internal flow characteristics and performance of the centrifugal and diagonal impellers with the change of mass flow rates and total inlet temperature is given qualitatively and *** the cosine value of the synergy angle is high,the local flow loss is *** smaller proportion of the positive area is the pursuit of *** comparative analysis,it is concluded that the internal flow and performance changes of centrifugal and diagonal impellers are *** results confirm the superiority and feasibility of the off-design performance of the diagonal compressor applied to the developing large-scale CAES.

关键词： compressed air energy storage synergy theory diagonal compressor centrifugal compressor comparative analysis

Tensile strength behavior of cement-stabilized dredged sediment reinforced by polypropylene fiber

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 380-392页

作者： Lei LANG Jiangshan LI xin chen Lijun HAN Ping WANG State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicChinese Academy of SciencesWuhan 430071China Hubei Provincial Key Laboratory of Contaminated Sludge and Soil Science and Engineering Wuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

This study evaluated the feasibility of using polypropylene fiber(PF)as reinforcement in improving tensile strength behavior of cement-stabilized dredged sediment(CDS).The effects of cement content,water content,PF content and length on the tensile strength and stress–strain behavioral evolutions were evaluated by conducting splitting tensile strength ***,the micro-mechanisms characterizing the tensile strength behavior inside PF-reinforced CDS(CPFDS)were clarified via analyzing macro failure and microstructure *** results indicate that the highest tensile strengths of 7,28,60,and 90 d CPFDS were reached at PF contents of 0.6%,1.0%,1.0%,and 1.0%,exhibiting values 5.96%,65.16%,34.10%,and 35.83%higher than those of CDS,***,3 mm,PF of showed the best reinforcement *** CPFDS exhibited obvious tensile strain-hardening characteristic,and also had better ductility than *** mix factor(C_(C)^(a)/C_(w)^(b))and time parameter(q_(t0)(t))of CDS,and the reinforcement index(k_(t-PF))of CPFDS were used to establish the tensile strength prediction models of CDS and CPFDS,considering multiple *** PF“bridge effect”and associated cementation-reinforcement coupling actions inside CPFDS were mainly responsible for tensile strength behavior *** key findings contribute to the use of CPFDS as recycled engineering soils.

关键词： dredged sediment chemical stabilization fiber reinforcement splitting tensile strength micro-mechanisms

Aerodynamic/control integrated optimization method for unpowered high-speed vehicle configuration design

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Chinese Journal of Aeronautics 2024年第7期37卷 153-167页

作者： xin PAN Linlin WANG Li LI Lulu JIANG Gang chen State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China Shannxi Key Laboratory for Environment and Control of Flight Vehicle School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an 710049China Beijing Institute of Space Long March Vehicle Beijing 100076China AVIC Xi’an Aeronautics Computing Technique Research Institute Xi’an 710068China

The unpowered high-speed vehicle experiences a significant coupling between the disciplines of aerodynamics and control due to its characteristics of high flight speed and extensive maneuverability within large *** conventional aircraft conceptual design process follows a sequential design approach,and there is an artificial separation between the disciplines of aerodynamics and control,neglecting the coupling effects arising from their *** a result,this design process often requires extensive iterations over long periods when applied to high-speed vehicles,and may not be able to effectively achieve the desired design *** enhance the overall performance and design efficiency of high-speed vehicles,this study integrates the concept of Active Control Technology(ACT)from modern aircraft into the philosophy of aerodynamic/control integrated *** integrated optimization strategies,with differences in coupling granularity,have been ***,these strategies are put into action on a biconical vehicle that operates at Mach *** results reveal that the comprehensive performance of the synthesis optimal model derived from the aerodynamic/control integrated optimization strategy is improved by 31.76%and 28.29%respectively compared to the base model under high-speed conditions,demonstrating the feasibility and effectiveness of the method and optimization strategies ***,in comparison to the single-stage strategy,the multi-stage strategy takes into deeper consideration the impact of control *** a result,the control performance of the synthesis opti-mal model derived from the multi-stage strategy improves by 13.99%,whereas the single-stage strategy only achieves a 5.79%*** method enables a fruitful interaction between aerodynamic configuration design and control system design,leading to enhanced overall performance and design ***,it improves the controllability of high-sp

关键词： Aerodynamic/Control Integrated Optimization MDO High-speed vehicle Shape Optimization Controllability

Experimental study on the size effect on the equation of state of concretes under shock loading

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Defence Technology（防务技术） 2024年第3期33卷 160-167页

作者： Mei Li Jian Cui yanchao Shi Baijian Tang xin chen Key Laboratory of Coast Civil Structural Safety of the Ministry of Education Tianjin UniversityTianjin 300072China School of Civil Engineering Suzhou University of Science and Technology1701 Binhe RoadSuzhou 215011JiangsuChina School of Civil Engineering Tianjin UniversityTianjin 300072China

Adopting the classical theory of hydrocodes,the constitutive relations of concretes are separated into an equation of state(EoS)which describes the volumetric behavior of concrete material and a strength model which depicts the shear properties of *** experiments on the EoS of concrete is always challenging due to the technical difficulties and equipment limitations,especially for the specimen size effect on the *** some researchers investigate the shock properties of concretes by fly-plate impact tests,the specimens used in their tests are usually in one *** this paper,the fly-plate impact tests on concrete specimens with different sizes are performed to investigate the size effect on the shock properties of concrete *** mechanical background of the size effect on the shock properties are revealed,which is related to the lateral rarefaction effect and the deviatoric stress produced in the *** to the tests results,the modified EoS considering the size effect on the shock properties of concrete are proposed,which the bulk modulus of concrete is unpredicted by up to 20% if size effects are not accounted for.

关键词： Concrete Equation of state Size effect Shock wave Fly-plate impact test

Cascaded four-wave mixing all-optical wavelength converter based on highly nonlinear fiber deposited graphene oxide

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Journal of Materials Science & Technology 2024年第4期171卷 10-15页

作者： Yuanhongliu Gao Xiaoyu chen Tonglei cheng Fang Wang xin yan College of Information Science and Engineering State Key Laboratory of Synthetical Automation for Process IndustriesNortheastern UniversityShenyang 110819China

The all-optical wavelength conversion using cascaded four-wave mixing(FWM)phenomena with graphene oxide(GO)and a highly nonlinear fiber(HNLF)device is demonstrated *** has a strong third-order nonlinear effect and is an excellent nonlinear optical material for nonlinear optical wavelength *** group velocity matching of pump and signal,HNLF,and GO amplification promote the cascaded nonlinear frequency mixing *** the experimental and analytical results,the maximum spacing between signal and pump is 21 nm,and specifically,the order of cascaded FWM light increases from order 1 to order 2 with increasing GO,and the first-order FWM conversion effi-ciency increases to a maximum of−14.5 *** the best of our knowledge,this is the first time that cascaded FWM-based all-optical wavelength conversion in HNLF-GO with wide wavelength selectivity is investigated with combined pump and signal *** findings not only provide an effective method for achieving all-optical wavelength conversion in cascaded FWM but also offer the possibility of fabricating high-performance nonlinear optical devices.

关键词： Four-wave mixing Graphene oxide Highly nonlinear fiber Optical wavelength conversion

Coupling and coordinated evolution characteristics of regional economy-energy-carbon emission multiple systems:A case study of main China's Basin

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Journal of Environmental Sciences 2024年第6期140卷 204-218页

作者： Lu chen xin Li Jingyi Zhao xinyu Kang Lu Liu Minxi Wang Wu chen College of Management Science Chengdu University of TechnologyChengdu 610051China SDU Life Cycle Engineering Department of Green TechnologyUniversity of Southern Denmark5230 OdenseDenmark

Comprehensive analysis of the Economy-Energy-Carbon Emission(EECE)system is beneficial for promoting sustainable social *** study analyzes the system development of major watersheds in China from 2010 to *** research fully considers the system’s internal and external inputs and outputs and proposes an evaluation index system for regional EECE coupling and coordinated ***,using the difference in system weight allocation to improve the coupling and coordination model,the study explores the dynamic system’s coupling and *** results show that(1)The development of the system structure is relatively stable,but the overall development status is not ideal;(2)The downstream of China’s main river basins has obvious economic advantages,while the energy system fluctuates *** efficiency of the carbon emission system will decrease in areas with rapid economic *** coupling and coordination level of the EECE system is better in the yangtze River Basin than in the Yellow River Basin;(3)From the perspective of dynamic coordinated development,the main river basins have been divided into two states since 2012,but it is relatively stable *** dynamic coordination is often at a disadvantage in regions with rapid economic and energy development;(4)The coupling coordination degree of the two river basins has significant positive spatial *** provinces’significant spatial clustering characteristics of the coupling coordination degree are High-High ***-Low type provinces are mainly concentrated *** research process has certain reference significance for the collaborative governance of complex regional systems.

关键词： System structure Efficiency measure Coupling mechanism Dynamic coordination

Paradigm for Determining the Optimal Ultradeep and Superthick Saline Aquifer for High-TDS Mine Water Geological Storage

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 771-785页

作者： LI xin chen Ge XU Zhimin LIU Qi chen Tianci SUN yajun School of Resources and Geosciences China University of Mining and TechnologyXuzhouJiangsu 221116China National Professional Central Laboratory of Basic Research on Mine Water Disaster Prevention and Control Technology XuzhouJiangsu 221116China

Saline aquifers are the most popular waste and CO_(2)injection and storage reservoirs *** project proposes that several optimal injection positions should be investigated as hydraulic pressure-focused positions,in order to relieve the high demands of pump *** comprehensive indices(F_(i))representing the injectivity of different burial depths were obtained by using information entropy,based on the mercury injection experimental data of 13 rock *** results demonstrated that the burial depths of No.4,No.1 and No.2 in the Liujiagou Formation were the most suitable positions for hydraulic focused injection,which means the upper 30 m thickness could be regarded as the hydraulic focused range in the saline aquifer with an average thickness of 400 *** addition,some laboratory experiments and in situ tests were carried out for the purpose of certifying and analyzing results,including SEM,XRD,brittleness index and *** results suggested that the rock samples at the No.4,No.1 and No.2 burial depth ranges have loose microstructure,weak cementation,as well as dual pores and *** lithology is mainly quartz and feldspar,but the clay mineral content is high(10%-25%),which is positive for *** lithology is suitable for hydraulic fracturing to form extended cracks and micro-fissures during high-TDS(total dissolved solids)mine water injection,because of the high brittleness ***,a theoretical and technical framework for high-TDS mine water injection was established,based on operating pilot *** theoretical defects and drawbacks learned from the field practices were summarized and solutions *** research in this study could provide guidance and a paradigm for the inexpensive treatment of high-TDS mine water by injection and storage.

关键词： ultradeep Liujiagou Formation high-TDS mine water optimal hydraulic injection positions information entropy reservoir spatial characteristics

Paclitaxel-lipid prodrug liposomes for improved drug delivery and breast carcinoma therapy

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Chinese Chemical Letters 2024年第2期35卷 335-340页

作者： xin Wu xinmei chen xinyu Wang Haisheng He Jianming chen Wei Wu Key Laboratory of Smart Drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Department of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350122China Shanghai Wei Er Lab Shanghai 201707China Shanghai Skin Disease Hospital Tongji University School of MedicineShanghai 200443China

Paclitaxel(PTX)is widely applied for the treatment of unresectable and metastasis breast carcinoma as well as other cancers,whereas its efficacy is always impeded by poor *** are one kind of the most successful drug carriers which are capable of solubilizing PTX and improving patients’tolerance owing to excellent biocompatibility and ***,poor compatibility between PTX and liposomes compromises the stability,drug loading and anti-tumor capacity of liposomal *** address this issue,three lipids with various chain lengths,namely,myristic acid(MA,14C),palmitic acid(PA,16C)and stearic acid(SA,18C),were conjugated to PTX via ester bonds and the synthesized prodrugs with high lipophilicity were further formulated into liposomes,*** liposomes show high stability and drug loadings,as well as sustained drug *** chain lengths of lipids are negatively correlated with drug release and enzymatic conversion rates,which further impact the pharmacokinetics,tumor accumulation,and anti-tumor efficacy of liposomal *** rapid nor slow drug release facilitates high tumor accumulation as well as anti-tumor efficacy of *** all liposomes,PTX-PA-loaded liposomes show the longest circulation and highest tumor accumulation of PTX and exert the most potent anti-tumor capacities in vivo,owing to its moderate drug release and enzymatic conversion *** its superior safety,PTX-PA liposomes hold potential for further clinical translation.

关键词： Paclitaxel Lipids Prodrugs Liposomes Drug release Chemotherapy