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Overview of ferroptosis and pyroptosis in acute liver failure

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World Journal of Gastroenterology 2024年第34期30卷 3856-3861页

作者： ya-wen sun Bo-wen Zhao Hai-Fang Li Guang-Xiao Zhang College of Life Sciences Shandong Agricultural UniversityTai’an 271018Shandong ProvinceChina

In this editorial,we comment on the article by Zhou et al published in a recent *** specifically focus on the crucial roles of ferroptosis and pyroptosis in acute liver failure(ALF),a disease with high mortality *** is the result of increased intracellular reactive oxygen species due to iron accumulation,glutathione(GSH)depletion,and decreased GSH peroxidase 4 activity,while pyroptosis is a procedural cell death mediated by gasdermin D which initiates a sustained inflammatory *** this review,we describe the characteristics of ferroptosis and pyroptosis,and discuss the involvement of the two cell death modes in the onset and development of ***,we summarize several interfering methods from the perspective of ferroptosis and pyroptosis for the alleviation of *** observations might provide new targets and a theoretical basis for the treatment of ALF,which are also crucial for improving the prognosis of patients with ALF.

关键词： Acute liver failure Ferroptosis Pyroptosis Glutathione peroxidase 4 Gasdermin D

Identification of LmUAP1 as a 20-hydroxyecdysone response gene in the chitin biosynthesis pathway from the migratory locust, Locusta migratoria

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Insect Science 2018年第2期25卷 211-221页

作者： Xiao-Jian Liu ya-wen sun Da-Qi Li Sheng Li En-Bo Ma[] Jian-Zhen Zhang Research Institute of Applied Biology College of Life Science Shanxi University Taiyuan China Key Laboratory of Insect Developmental and Evolutionary Biology Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

In Locusta migratoria, we found that two chitin biosynthesis genes, UDP N-acetylglucosamine pyrophosphorylase gene LmUAP1 and chitin synthase gene Lm- CHS1, are expressed mainly in the integument and are responsible for cuticle formation. However, whether these genes are regulated by 20-hydroxyecdysone （20E） is still largely unclear. Here, we showed the developmental expression pattern ofLmUAP1, LmCHS1 and the corresponding 20E titer during the last instar nymph stage of locust. RNA interference （RNAi） directed toward a common region of the two isoforms of LmEcR （LmEcRcom） reduced the expression level of LmUAP1, while there was no difference in the expression of LmCHS1. Meantime, injection of 20E in vivo induced the expression of LmUAP1 but not LmCHS1. Further, we found injection-based RNAi of LmEcRcom resulted in 100% mortality. The locusts failed to molt with no apolysis, and maintained in the nymph stage until death. In conclusion, our preliminary results indicated that LmUAP1 in the chitin biosynthesis pathway is a 20E late-response gene and LmEcR plays an essential role in locust growth and development, which could be a good potential target for RNAi-based pest control.

关键词： chitin synthesis Locusta migratoria regulation RNA interference 20-hydroxyecdysone

Protein succinylation,hepatic metabolism,and liver diseases

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World Journal of Hepatology 2024年第3期16卷 344-352页

作者： Shuang Liu Rui Li ya-wen sun Hai Lin Hai-Fang Li College of Animal Science and Veterinary Medicine Shandong Agricultural UniversityTai’an 271018Shandong ProvinceChina College of Life Sciences Shandong Agricultural UniversityTai’an 271018Shandong ProvinceChina

Succinylation is a highly conserved post-translational modication that is processed via enzymatic and non-enzymatic *** exhibits strong effects on protein stability,enzyme activity,and transcriptional *** succinylation is extensively present in the liver,and increasing evidence has demonstrated that succinylation is closely related to hepatic *** instance,histone acetyltransferase 1 promotes liver glycolysis,and the sirtuin 5-induced desuccinylation is involved in the regulation of the hepatic urea cycle and lipid ***,the effects of succinylation on hepatic glucose,amino acid,and lipid metabolism under the action of various enzymes will be discussed in this *** addition,how succinylases regulate the progression of different liver diseases will be reviewed,including the desuccinylation activity of sirtuin 7,which is closely associated with fatty liver disease and hepatitis,and the actions of lysine acetyltransferase 2A and histone acetyltransferase 1 that act as succinyltransferases to regulate the succinylation of target genes that influence the development of hepatocellular *** view of the diversity and significance of protein succinylation,targeting the succinylation pathway may serve as an attractive direction for the treatment of liver diseases.

关键词： Protein succinylation Hepatic metabolism Fatty liver Hepatitis Hepatocellular carcinoma

Brain Genomics Hub: A Web-based Database to Explore the Spatiotemporal Expression of the Genes through Human Brain Development

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Brain Genomics Hub: A Web-based Database to Explore the Spat...

Clinicopathological characteristics and surgical outcomes of sarcomatoid hepatocellular carcinoma

2018中国遗传学会第十次全国会员代表大会暨学术讨论会

作者： Xue Lin Ming ya Wang wen ya sun Jian Li Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical University Institute of Life Sciences Southeast University

Motivation: Many brain diseases are evident to be associated with neurodevelopmental abnormalities and some of which can be treated as transnosological manner. This implicates a common molecular basis through the brain development among these brain diseases. Gene expression analysis of human brain has been used to find the genes that are associated with diseases. However the analysis is restricted within individuals or certain brain areas. Therefore, it would be valuable to have a reference of the spatio-temporal gene expression of normal human brain through development to provide potential candidate genes that are responsible for brain diseases. Results: We developed an online tool, Brain Genomics Hub, a freely accessible database that archives and disseminates the spatio-temporal expression of the genes in human brain development. The expression data are retrieved mainly from the Gene Expression Omnibus（ GSE25219）. The database offers searching functions for quick queries with gene symbols, brain regions, development time points, or diseases of interest. And the query results can also be downloaded in a number of ways. Currently, the database contains data of 16 regions comprising the cerebellar cortex, thalamus, striatum, amygdala, hippocampus and 11 areas of the neocortex. It also covers data of fifteen periods ranging from embryonic development to late adulthood. The database is continuously updated by a dedicated team of curators.

关键词： database brain diseases brain development gene expression

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World Journal of Gastroenterology 2020年第29期26卷 4327-4342页

作者： Jian-Ping Wang Zhi-Gang yao ya-wen sun Xi-Han Liu Feng-Kai sun Cun-Hu Lin Fu-Xin Ren Bei-Bei Lv Shuai-Jun Zhang yang Wang Fan-Ying Meng Shun-Zhen Zheng Wei Gong Jun Liu Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial HospitalCheeloo College of MedicineShandong UniversityJinan 250021Shandong ProvinceChina Department of Liver Transplantation and Hepatobiliary Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Pathology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Cancer Prevention and Control Research Office of Shandong Province Shandong Cancer Hospital and InstituteShandong First Medical University and Shandong Academy of Medical SciencesJinan 250117Shandong ProvinceChina Cheeloo College of Medicine Shandong UniversityJinan 250012Shandong ProvinceChina Department of Gastroenterology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Shandong Medical Imaging Research Institute Shandong UniversityJinan 250021Shandong ProvinceChina Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the sixth most common type of cancer and the fourth leading cause of cancer-related death *** HCC,which contains poorly differentiated carcinomatous and sarcomatous components,is a rare histological subtype of HCC that differs from conventional *** is highly aggressive and has a poor *** clinicopathological characteristics,surgical outcomes and underlying mechanisms of its highly aggressive nature have not been fully *** To examine the clinicopathological characteristics and surgical outcomes of sarcomatoid HCC and explore the histogenesis of sarcomatoid *** In total,196 patients[41 sarcomatoid HCC and 155 high-grade(Edmondson-Steiner grade III or IV)HCC]who underwent surgical resection between 2007 and 2017 were retrospectively *** characteristics and surgical outcomes of sarcomatoid HCC were compared with those of patients with high-grade *** histological composition of invasive and metastatic sarcomatoid HCCs was *** Sarcomatoid HCC was more frequently diagnosed at an advanced stage with a larger tumor and higher rates of nonspecific symptom,adjacent organ invasion and lymph node metastasis than high-grade HCC(all P20 ng/mL;36.6%vs 78.7%,P<0.001).The sarcomatoid group had a significantly shorter median recurrence-free survival(5.6 mo vs 16.4 mo,log-rank P<0.0001)and overall survival(10.5 mo vs 48.1 mo,log-rank P<0.0001)than the high-grade *** controlling for confounding factors,the sarcomatoid subtype was identified as an independent predictor of poor *** analyses indicated that invasive and metastatic lesions were mainly composed of carcinomatous *** Sarcomatoid HCC was associated with a more advanced s

关键词： Sarcomatoid hepatocellular carcinoma Histological composition Liver resection Overall survival Recurrence-free survival

Curcumin in gastric cancer treatment:A commentary on mechanistic insights and future directions

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 265-267页

作者： Xin-Yue Wei wen-Bo Cao Sai-Jun Mo Zhi-yan sun Department of Pathophysiology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina School of Basic Medical Science Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Basic Science of Oncology School of Basic Medical SciencesZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Special Service No.988 Hospital of the Joint Service Support Force of PLAZhengzhou 450042Henan ProvinceChina

The study by yang et al presents a comprehensive investigation into the thera-peutic potential of curcumin for gastric cancer(GC).Using network pharma-cology,the researchers identified 48 curcumin-related genes,31 of which overlap with GC *** genes,including ESR1,EGFR,CYP3A4,MAPK14,CYP1A2,and CYP2B6,are linked to poor survival in GC *** docking con-firmed strong binding affinity of curcumin to these *** vitro experiments demonstrated that curcumin effectively inhibits the growth and proliferation of BGC-823,suggesting its therapeutic potential in GC through multiple targets and pathways.

关键词： Curcumin Gastric cancer Network pharmacology Mechanism of action In vitro experiments

“沟通理性”与全球化时代的法律哲学——凡·豪埃克《作为沟通的法律》述要

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法制与社会发展 2006年第1期12卷 152-160页

作者：徐亚文孙国东武汉大学法学院湖北武汉430072

20世纪60年代以来,西方社会的变迁为法理学提供了新的课题。豪埃克教授以哈贝马斯的沟通行为理论为指导,提出一种沟通视角的法理学。他认为,法律在本质上是基于沟通:立法者与国民间的沟通,法庭与诉讼当事人间的沟通,立法者与法官间的沟... 详细信息

20世纪60年代以来,西方社会的变迁为法理学提供了新的课题。豪埃克教授以哈贝马斯的沟通行为理论为指导,提出一种沟通视角的法理学。他认为,法律在本质上是基于沟通:立法者与国民间的沟通,法庭与诉讼当事人间的沟通,立法者与法官间的沟通等。这种沟通现在被认为是法律合法化的来源:法律人之间的理性对话是“正确”地解释和适用法律的最终保证。

关键词：法律沟通行为合法化

Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： ya-Xin Xu Xiao-Xuan Niu wen-Chang Jia Jing wen Xue-Lin Cheng yan Han Ming-Hui Peng Jing Zhou yao Liu sun-Fang Jiang Xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

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长白山天然次生林的主要类型及其经营对策

吉林林业科技 2000年第6期29卷 51-54页

作者：温雅稚孙淑莲吉林省林业勘察设计研究院吉林长春130021

长白山天然次生林可分为以柞树、杨桦、水曲柳和胡桃楸为主的 3种类型。其经营的主要措施是在保护的基础上 ,引进针叶树种。本文还对次生林的改造及抚育提出了建议。

关键词：长白山天然次生林类型经营改造抚育