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Catalyst-Free Four-Component Spiropolymerization for the Construction of Spirocopolymers with Tunable Photophysical Properties

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Chinese Journal of Polymer Science 2023年第10期41卷 1525-1532页

作者： Luo-Jie Zhu Gui-Nan Zhu wen-ya yan Peng Sun Jian-Bing Shi Jun-Ge Zhi Bin Tong Zheng-Xu Cai Yu-Ping Dong Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing100081China Key Laboratory of Cluster Science of Ministry of Education School of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing100081China

Spiropolymers have gained a great deal of interest from both academic and industrial fields by virtue of their unique geometric structures and physical ***,we prepared a series of spirocopolymers through the catalyst-free four-component spiropolymerization of diisocyanides,activated alkynes,and two different kinds of monomers with reactive carbonyl *** is found that the polymerization reactivity of monomers,feeding modes,and feed ratios play significant roles in *** with high reactivity and feeding reactive monomers first contribute to improving the molecular weights and yields of the *** constructed copolymers have two different kinds of spiro structures,which is confirmed by the nuclear magnetic *** addition,the spirocopolymers display the unique cluster-triggered emission and aggregation-induced emission properties,and their emission properties can be well-modulated by altering the ratio of *** is highly anticipated that this line of research will enrich the methodology of multi-component spiropolymerization,and provide a new insight into developing spiropolymers with various spiro structures and tunable properties.

关键词： Multi-component spiropolymerization Spirocopolymers Aggregation-induced emissions Clusterization-triggered emissions

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Identification of a Novel Compound Heterozygous Mutation in OTOG in a Chinese Family with Severe Hearing Impairment

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Reproductive and Developmental Medicine 2020年第2期4卷 84-88页

作者： wen-ya yan Fan Xu Bing Li GMU-GIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 511436China Department of Ophthalmology People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021China

Objectives:Hearing loss is a worldwide *** 50%of the patients,hearing loss is caused by genetic problems associated with GJB2,MTRNR1,SLC26A4,and other *** the recent development and cost reduction of whole-exome sequencing,it is possible to filter out the normal genes and find which among the more novel genes contributed to the loss of ***:After prescreening all individuals for GJB2,MTRNR1 and SLC26A4 mutations,whole-exome sequencing was performed in the proband,and the pathogenic variant was confirmed via Sanger ***:The compound-heterozygous variant namely c.8076G>C:p.E2692D and c.6362T>C:p.V2121A in OTOG was identified as a candidate gene of a consanguineous Kazakh ***:This is the first reported case of severe deafness caused by an OTOG compound-heterozygous variant in the world and the first case of deafness caused by an OTOG variant in *** discovery identified the important contribution of OTOG toward deafness and expanded the spectrum of variants responsible for human hearing loss.

关键词： Genetics Hearing Loss OTOG Whole-exome Sequencing

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Research on Networked Rapid Product Development Process

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厦门大学学报（自然科学版） 2002年第S1期41卷 158-159页

作者： NI yan-rong, FAN Fei-ya, JIN Ji-wen, yan Jun-qi (CIM Institute, Department of Mechanical Engineering, Shanghai Jiaotong University, Shanghai 200030, China)

Today the cycle time of the product develop is requ ir ed to be shortened. At the same time the requirement of the customers becomes mo re and more diverse and complex. The capability of the develop unit is limited b ecause of the existence of heterogeneous systems and distributed environments. I n this paper, we bring forward a new approach to solve the problem in product de velopment process. We also settle part key technologies in it. A great deal of information from all kinds of sources in the distributed develop ment process is interweaved. The solution to organize the workflow and manage th e information in the process is called for anxiously. We use a new approach that is asynchronous and synchronous coupling product development approach based on the network. The approach extends the develop process from the time axis. Then t he activities in the process are organized from the asynchronous and synchronous aspects. The state of every activity projects at the ASN (active semantic netwo rk). The ASN includes decision system, intelligent agent, user interface and net work. The ASN decides the types and states of the activities and deals with the couple relationship among them. The knowledge stored in ASN is open to all users through the relative interfaces. Every specialist keeps contact with their user s relying on collaborative platform implements CSCW (computer support collaborat ive work) that integrated product/process design and development. The lack of gl obal communication in product development process can be prevented in the most d egree. The key technologies that exist in the asynchronous and synchronous coupling pro duct develop approach include: integrated development structure, orderly organiz ation of information, transparent management of process, agile transfer of infor mation and rapid prototype. The development process can be completed quickly by these technologies. The technologies involve wide content. In this paper, we dis cuss some key tech

关键词： distributed environment asynchronous and synchro nous coupled active semantic network product development process

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离子交换树脂分离钒渣浸出液中钒与铬

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过程工程学报 2017年第1期17卷 84-91页

作者：阳亚玲颜文斌高峰吉首大学化学化工学院湖南吉首416000 湖南雪天精细化工股份有限公司湖南长沙410015 矿物清洁生产与绿色功能材料开发湖南省重点实验室湖南吉首416000 湖南省2011计划"锰锌钒产业技术"协同创新中心湖南吉首416000

采用5种离子交换树脂分离钒渣浸出液中钒与铬,对比了其吸附选择性、吸附量和吸附速率,考察了pH值、接触时间、温度、初始浓度等因素对钒铬分离的影响.结果表明,SQ-20A树脂对钒具有较强的吸附作用,对铬的吸附作用较弱,在pH=9.0、温度298 ... 详细信息

采用5种离子交换树脂分离钒渣浸出液中钒与铬,对比了其吸附选择性、吸附量和吸附速率,考察了pH值、接触时间、温度、初始浓度等因素对钒铬分离的影响.结果表明,SQ-20A树脂对钒具有较强的吸附作用,对铬的吸附作用较弱,在pH=9.0、温度298 K的条件下,钒铬分离系数达最大值215.23.钒在SQ-20A树脂上的吸附为吸热过程,符合Freundlich和Langmuir方程,反应级数为拟二级,吸附过程的控制步骤为颗粒扩散过程.

关键词：钒渣浸出液钒铬分离离子交换法静态吸附

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Neuroendocrine-Immune Regulating Mechanisms for the Anti-Inflammatory and Analgesic Actions of Acupuncture

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World Journal of Traditional Chinese Medicine 2020年第4期6卷 384-392页

作者： Zhi-Fang Xu Shou-Hai Hong Shen-Jun Wang Xue Zhao yang-yang Liu Sha-Sha Ding Yuan Xu Kuo Zhang Nan-Nan Yu Zhong-Xi Lu Fu-Ming yang Yi-Nan Gong Qin-Qin He Kun Yu Yi-Ping Zhang Bao-Min Dou Lin yao ya-wen yan Tao yang yan-Fang Zhang Bao-Hu Liu Yong-Ming Guo Hsuah-Nee-Connie Wong Yi Guo Research Center of Experimental Acupuncture Science Tianjin University of Traditional Chinese Medicine National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina

Pain and inflammatory diseases are important clinical indications of acupuncture,which have been widely accepted in the international *** studies have been focusing on rapid analgesia of acupuncture through the regulation of nervous system,but few studies on the inflammation regulatory mechanisms in which acupuncture inhibits the peripheral sensitization-induced *** on studies concerning acupoint mechanisms of acupuncture actions and related researches on acupuncture regulating neuroendocrine and immune systems,we put forward the scientific hypothesis that acupuncture regulates neuroendocrine-immune(NEI)network and key response media therein,so as to achieve anti-inflammatory and analgesic effects in target *** have established a platform for acupuncture at ST36 to alleviate inflammatory pain in adjuvant induced arthritic *** on the complex network analysis of multi-dimensional data from multi-time point and multi-site detection of NEI common signaling molecules,we have clarified the regulatory effects of acupuncture on NEI network and corresponding downstream immune *** indicated that monocytes/macrophages are the key targeting cells of acupuncture regulation,and acupuncture may display the anti-inflammatory and analgesic effects by regulating polarization of T cells in lymph nodes and polarization of M1/M2 macrophages in inflamed joints/*** addition,we have spotted a key molecule for acupuncture analgesia,CXCL1,as well as clarified the novel central analgesic mechanism of acupuncture mediated by CXCL1/CXCR2 ***,we have provided novel evidence of the anti-inflammatory and analgesic actions of acupuncture through regulating NEI network and several key substances,highlighting a systemic research paradigm for investigating mechanisms of acupuncture actions.

关键词： Acupuncture anti-inflammation analgesia neuro-endocrine-immune network CXCL1

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医院药剂科中实行安全质量管理的效果研究

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中国卫生产业 2018年第10期15卷 8-9页

作者：杨文艳临沂市兰山区人民医院山东临沂276000

目的探究医院药剂科中实行安全质量管理的效果。方法将2016年1月—2017年10月该院药剂科工作情况进行分析,对照组时间段为2016年1—12月,未实施安全质量管理;2017年1—10月为观察组,实施安全质量管理;对比两组管理效果。结果从管理总满... 详细信息

目的探究医院药剂科中实行安全质量管理的效果。方法将2016年1月—2017年10月该院药剂科工作情况进行分析,对照组时间段为2016年1—12月,未实施安全质量管理;2017年1—10月为观察组,实施安全质量管理;对比两组管理效果。结果从管理总满意度方面分析,观察组为98.50%,明显要比对照组的82.00%高(P<0.05);从药物滥用、药品过期、药品包装破损发生率方面分析,观察组均明显低于对照组(P<0.05)。结论医院药剂科中实行安全质量管理,效果显著,值得推广及使用。

关键词：医院药剂科实行安全质量管理效果

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie Wang Congrui Liu Chao Fang Qiuxia Peng wen Qin Xuebing yan Kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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华蟹甲中1个新的酚苷类化合物

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中草药 2018年第6期49卷 1247-1249页

作者：马雪姣黄雅雯苏艳芳王玮天津市现代药物传递及功能高效化重点实验室天津大学药物科学与技术学院天津300072

目的研究华蟹甲Sinacalia tangutica根茎的化学成分。方法采用大孔树脂、硅胶及反相ODS柱色谱等方法进行分离和纯化,并综合运用~1H-NMR、^(13)C-NMR、DEPT、HSQC、HMBC和HR-ESI-MS等方法鉴定化合物的结构。结果从华蟹甲乙醇提取物正丁... 详细信息

目的研究华蟹甲Sinacalia tangutica根茎的化学成分。方法采用大孔树脂、硅胶及反相ODS柱色谱等方法进行分离和纯化,并综合运用~1H-NMR、^(13)C-NMR、DEPT、HSQC、HMBC和HR-ESI-MS等方法鉴定化合物的结构。结果从华蟹甲乙醇提取物正丁醇萃取部分分离得到1个新的酚苷,鉴定为5-羟基丁香酚-4-O-β-D-木糖基-(1→6)-O-β-D-葡萄糖苷(1)。结论化合物1为新化合物,命名为华蟹甲苷。

关键词：华蟹甲属华蟹甲酚苷华蟹甲苷 5-羟基丁香酚-4-O-β-D-木糖基-(1→6)-O-β-D-葡萄糖苷

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野生大豆GsAP1基因的克隆及功能分析

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大豆科学 2016年第6期35卷 919-927页

作者：郭文雅崔艳梅喻德跃黄方南京农业大学大豆研究所/作物遗传与种质创新国家重点实验室/国家大豆改良中心/农业部大豆生物学与遗传育种实验室(综合性) 江苏南京210095

AP1转录因子在控制花器官的诱导与发育中起着重要的作用,对植物的成花诱导,促进植物提前开花有重要的意义。从野生大豆中分离克隆得到1个AP1-like基因,并命名GsAP1,该基因全长711 bp,包含完整的开放阅读框,编码237个氨基酸。利用实时荧... 详细信息

AP1转录因子在控制花器官的诱导与发育中起着重要的作用,对植物的成花诱导,促进植物提前开花有重要的意义。从野生大豆中分离克隆得到1个AP1-like基因,并命名GsAP1,该基因全长711 bp,包含完整的开放阅读框,编码237个氨基酸。利用实时荧光定量PCR技术对GsAP1在野生大豆不同组织中的表达情况进行了分析,结果显示GsAP1只在花中表达,在四轮不同花器官中的表达显示GsAP1在花萼中表达量比较高,在花瓣中表达量较低,在雄蕊和心皮中不表达。洋葱表皮细胞瞬时表达系统表明GsAP1蛋白定位于细胞核中。酵母转录激活试验显示GsAP1具有明显的转录激活活性。在转基因烟草植株中GsAP1的表达量显著提高,并且使转基因植株的开花期比对照大幅度提前。本文探讨GsAP1在大豆成花中的作用机理,为培育大豆新品种提供了分子资源和理论基础。

关键词：野生大豆花发育 AP1 转录因子功能研究

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大型停车库开发的交通影响分析研究

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现代城市研究 2004年第4期19卷 68-72页

作者：文雅晏克非崔晓天湖南衡山

介绍了大型停车库开发交通影响分析的方法,说明了停车需求预测问题,提出了各出入口进出交通量分担比例以及交通分配模型。最后以某市某大型停车库的交通影响分析研究为例进行了实证说明。

关键词：大型停车库交通分配模型交通规划背景交通量

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