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Impact of body mass index on complications following pancreatectomy:Ten-year experience at National Cancer Center in China

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World Journal of Gastroenterology 2015年第23期21卷 7218-7224页

作者： Ying-Tai Chen Qian Deng Xu Che Jian-wei zhang Yu-Heng Chen Dong-Bin Zhao yan-Tao Tian ya-wei zhang Cheng-Feng Wang Department of Abdominal Surgical Oncology Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical CollegeChina National Cancer Center National Center for Chronic and Non-communicable Disease Control and Prevention Chinese Center for Disease Control and Prevention yale University School of Public Health

AIM: To examine the impact of body mass index(BMI)on outcomes following pancreatic resection in the Chinese ***: A retrospective cohort study using prospectively collected data was conducted at the Cancer Hospital of the Chinese Academy of Medical Sciences, China National Cancer Center. Individuals who underwent pancreatic resection between January2004 and December 2013 were identified and included in the study. Persons were classified as having a normal weight if their BMI was weight/obese if their BMI was ≥ 24 kg/m2 as defined by the International Life Sciences Institute Focal Point in China. A χ 2 test(for categorical variables) or a t test(for continuous variables) was used to examine the differences in patients' characteristics between normal weight and overweight/obese groups. Multiple logistic regression models were used to assess the associationsof postoperative complications, operative difficulty,length of hospital stay, and cost with BMI, adjusting for age, sex, and type of surgery ***: A total of 362 consecutive patients with data available for BMI calculation underwent pancreatic resection for benign or malignant disease from January1, 2004 to December 31, 2013. Of the 362 patients,156 were overweight or obese and 206 were of normal weight. One or more postoperative complications occurred in 35.4% of the patients following pancreatic resection. Among patients who were overweight or obese, 42.9% experienced one or more complications,significantly higher than normal weight(29.6%)individuals(P = 0.0086). Compared with individuals who had normal weight, those with a BMI ≥ 24.0kg/m2 had higher delayed gastric emptying(19.9% vs5.8%, P < 0.0001) and bile leak(7.7% vs 1.9%, P =0.0068). There were no significant differences seen in pancreatic fistula, gastrointestinal hemorrhage, reoperation,readmission, or other complications. BMI did not show a significant association with intraoperative blood loss, operative tim

关键词： Body mass index China Pancreatectomy Pancreatic cancer Postoperative complications

Elderly patients had more severe postoperative complications after pancreatic resection:A retrospective analysis of 727 patients

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World Journal of Gastroenterology 2018年第7期24卷 844-851页

作者： Ying-Tai Chen Fu-Hai Ma Cheng-Feng Wang Dong-Bing Zhao ya-wei zhang yan-Tao Tian Department of Pancreatic and Gastric Surgery National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Surgery Yale School of Medicine

AIM To examine the impact of aging on the short-term outcomes following pancreatic resection(PR) in elderly *** A retrospective cohort study using prospectively collected data was conducted at the China National Cancer Center. Consecutive patients who underwent PR from January 2004 to December 2015 were identifiedand included. ‘Elderly patient' was defined as ones age 65 and above. Comorbidities, clinicopathology, perioperative variables, and postoperative morbidity and mortality were compared between the elderly and young patients. Univariate and multivariate analyses were performed using the Cox proportional hazard model for severe postoperative complications(grades Ⅲb-Ⅴ).RESULTS A total of 454(63.4%) patients were < 65-yearsold and 273(36.6%) patients were ≥ 65-yearsold, respectively. Compared to patients < 65-yearsold, elderly patients had worse American Society of Anesthesiologists scores(P = 0.007) and more comorbidities(62.6% vs 32.4%, P < 0.001). Elderly patients had more severe postoperative complications(16.8% vs 9.0%, P = 0.002) and higher postoperative mortality rates(5.5% vs 0.9%, P < 0.001). In the multivariate Cox proportional hazards model for severe postoperative complications, age ≥ 65 years [hazard ratio(HR) = 1.63; 95% confidence interval(CI): 1.18-6.30], body mass index ≥ 24 kg/m^2(HR = 1.20, 95%CI: 1.07-5.89), pancreaticoduodenectomy(HR = 4.86, 95%CI: 1.20-8.31) and length of operation ≥ 241 min(HR = 2.97; 95%CI: 1.04-6.14) were significant(P = 0.010, P = 0.041, P = 0.017 and P = 0.012, respectively).CONCLUSION We found that aging is an independent risk factor for severe postoperative complications after PR. Our results might contribute to more informed decision-making for elderly patients.

关键词： Pancreatectomy Aged Pancreatic cancer Postoperative complications Mortality

Terahertz spectroscopy and lattice vibrational analysis of pararealgar and orpiment

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Chinese Physics B 2022年第10期31卷 384-388页

作者： ya-wei zhang Guan-Hua Ren Xiao-Qiang Su Tian-Hua Meng Guo-Zhong Zhao Institute of History for the Science and Technology Inner Mongolia Normal UniversityHohhot 010022China School of Yungang Ology Shanxi Datong UniversityDatong 037009China Department of Mathematics and Physics North China Electric Power UniversityBaoding 071003China Institute of Solid State Physics Shanxi Provincial Key Laboratory of Microstructure Electromagnetic Functional MaterialsShanxi Datong UniversityDatong 037009China Department of Physics Capital Normal UniversityBeijing 100048China

Terahertz time-domain spectroscopy(THz-TDS)is an effective nondestructive and noninvasive tool for investigating sulfur-containing *** with Raman spectroscopy and vibrational mode analysis,it is significant for artifact identification and *** this work,the terahertz absorption spectra of pararealgar(As_(4)S_(4))and orpiment(As_(2)S_(3))samples mixed with polytetrafluoroethylene(PTFE)are characterized in a range from 0.2 THz to 2.2 THz,and their distinctive peaks are observed,***,qualitative analysis is also implemented by using Raman spectroscopy as a complementary *** lattice vibrations are simulated by using solid-state density functional theory(ss-DFT),illustrating different characteristic absorption peaks for specific crystalline structures and dynamic *** work provides a reliable database of sulfur-containing pigments for using the THz technology to actually analyze and diagnose cultural relics.

关键词： THz-TDS lattice vibrations solid-state density functional theory(ss-DFT) pararealgar orpiment

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Body mass index does not affect the survival of pancreatic cancer patients

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World Journal of Gastroenterology 2017年第34期23卷 6287-6293页

作者： Qing-long Jiang Cheng-feng Wang yan-tao tian Huang Huang Shui-Sheng zhang Dong-bing Zhao Jie Ma wei Yuan Yue-Min Sun Xu Che Jian-wei zhang Yun-Mian Chu ya-wei zhang Ying-tai Chen Department of Pancreatic and Gastric Surgery National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Surgery Yale School of MedicineYale Cancer Center

AIM to evaluate the association of body mass index(b MI) with the overall survival of pancreatic ductal adenocarcinoma(PDAC) *** A retrospective analysis of PDAC patients diagnosed in the National Cancer Center of China between January 1999 and December 2014 was performed. these patients were categorized into four b MI groups(weight loss during the disease onset and progression. Compared with healthy-weight individuals, newly diagnosed patients who were overweight or obese had more severe weight loss during their disease onset and progression(P weight or obese were associated with positive smoking history(P weight patients. After a median follow-up of 8 mo, the survival analysis showed no association between b MI and the overall survival(P = 0.90, n = 1783). When we stratified the whole cohort by pancreatic cancer stage, no statistically significant association between b MI and overall survival was found for resectable(P = 0.99, n = 217), unresectable locally advanced(P = 0.90, n = 316) and metastatic patients(P = 0.88, n = 1250), respectively. the results did not change when we used the b MI at *** Our results showed no significance of b MI for the overall survival of PDAC pati

关键词： body mass index Pancreatic cancer Overweight Smoking history Survival analysis

Role of gut microbiota in Crohn’s disease pathogenesis:Insights from fecal microbiota transplantation in mouse model

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World Journal of Gastroenterology 2024年第31期30卷 3689-3704页

作者： Qiang Wu Lian-Wen Yuan Li-Chao yang ya-wei zhang Heng-Chang yao Liang-Xin Peng Bao-Jia yao Zhi-Xian Jiang Geriatric Surgery of Department of General Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Inflammatory bowel disease,particularly Crohn’s disease(CD),has been associated with alterations in mesenteric adipose tissue(MAT)and the phenomenon termed“creeping fat”.Histopathological evaluations showed that MAT and intestinal tissues were significantly altered in patients with CD,with these tissues characterized by inflammation and *** To evaluate the complex interplay among MAT,creeping fat,inflammation,and gut microbiota in *** Intestinal tissue and MAT were collected from 12 patients with *** manifestations and protein expression levels were analyzed to determine lesion *** samples were collected from five recently treated CD patients and five control subjects and transplanted into *** intestinal and mesenteric lesions in these mice,as well as their systemic inflammatory status,were assessed and compared in mice transplanted with fecal samples from CD patients and control *** Pathological examination of MAT showed significant differences between CDaffected and unaffected colons,including significant differences in gut microbiota *** microbiota transplantation(FMT)from clinically healthy donors into mice with 2,4,6-trinitrobenzene sulfonic acid(TNBS)-induced CD ameliorated CD symptoms,whereas FMT from CD patients into these mice exacerbated CD ***,FMT influenced intestinal permeability,barrier function,and levels of proinflammatory factors and ***,FMT from CD patients intensified fibrotic changes in the colon tissues of mice with TNBS-induced *** Gut microbiota play a critical role in the histopathology of *** MAT and creeping fat may therefore have potential in the treatment of patients with CD.

关键词： Mesenteric adipose tissue Crohn’s disease Fecal microbiota transplantation Intestinal fibrosis Intestinal barrier

Source analysis of dissolved heavy metals in the Shaying River Basin,China

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Journal of Groundwater Science and Engineering 2023年第4期11卷 408-421页

作者： ya-wei zhang Yun-tao Liu Zi-wen Wang Yu Cao Xiao-ran Tu Di Cao Shuai Yuan Xiao-man Cheng Lian-sheng zhang School of Environmental Studies China University of GeosciencesWuhan 430074China Henan Fifth Geological Exploration Institute Co. Ltd.Zhengzhou 450001China Henan Second Geological Survey Institute Co. Ltd.Zhengzhou 450001China Henan Rock and Mineral Testing Center Zhengzhou 450001China

Over the years,the Shaying River Basin has experienced frequent instances of river *** presence of numerous critical pollutant discharge enterprises and sewage-treatment plants in the vicinity of the Shaying River has transformed it a major tributary with relatively serious pollution challenge within the upper reaches of Huaihe River *** study the sources of manganese(Mn),chromium(Cr),nickel(Ni),arsenic(As),cadmium(Cd)and lead(Pb)in Shaying River water,123 sets of surface water samples were collected from 41 sampling points across the entire basin during three distinct phases from 2019 to 2020,encompassing normal water period,dry season and wet *** primary origins of heavy metals in river water were determined by analyzing the heavy metal contents in urban sewage wastewater,industrial sewage wastewater,groundwater,mine water,and the heavy metal contributions from agricultural non-point source *** analytical findings reveal that Mn primarily originates from shallow groundwater used for agricultural irrigation,While Cr mainly is primarily sourced from urban sewage treatment plant effluents,coal washing wastewater,tannery wastewater,and industrial discharge related to metal processing and *** is mainly contributed by urban sewage treatment plant effluents and industrial wastewater streams associated with machinery manufacturing and metal *** primarily linked to industrial wastewater,particularly from machinery manufacturing and metal processing facilities,while Pb is predominantly associated with urban sewage treatment plant effluents and wastewater generated in Pb processing and recycling *** research provides a crucial foundation for addressing the prevention and control of dissolved heavy metals at their sources in the Shaying River.

关键词： Industrial waste Urban sewage Mine water Agricultural non-point source pollution

Surgical management of duodenal Crohn's disease

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1159-1168页

作者： Li-Chao yang Guo-Tao Wu Qiang Wu Liang-Xin Peng ya-wei zhang Bao-Jia yao Gang-Lei Liu Lian-Wen Yuan Department of Geriatric Surgery The Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of General Surgery The Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of General Surgery The Seventh Affiliated HospitalUniversity of South ChinaChangsha 410119Hunan ProvinceChina

BACKGROUND The case of Crohn's disease involving the duodenum is rare,and its surgical management requires a thorough *** To investigate the surgical management of duodenal Crohn’s *** We systematically reviewed patients diagnosed with duodenal Crohn's disease who underwent surgery in the Department of Geriatrics Surgery of the Second Xiangya Hospital of Central South University from January 1,2004,to August 31,*** general information,surgical procedures,prognosis,and other information of these patients were collected and *** A total of 16 patients were diagnosed with duodenal Crohn’s disease,where 6 cases had primary duodenal Crohn’s disease,and 10 had secondary duodenal Crohn’s *** patients with primary disease,5 underwent duodenal bypass and gastrojejunostomy,and 1 received *** those with a secondary disease,6 underwent closure of duodenal defect and colectomy,3 received duodenal lesion exclusion and right hemicolectomy,and 1 underwent duodenal lesion exclusion and double-lumen *** Crohn's disease involving the duodenum is a rare *** surgical management should be applied for patients with Crohn's disease presenting with different clinical manifestations.

关键词： Duodenum Crohn’s disease Surgical treatment Inflammatory bowel disease

Melting Evaluation of Phase Change Materials Impregnated into Cascaded Metal Foams with Regionalized Enhancement

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Journal of Thermal Science 2025年第1期34卷 223-241页

作者： wei Xinyi zhang Nan zhang Zhaoli CAO Xiaoling YUAN yanping School of Mechanical Engineering Southwest Jiaotong University

Metal foam promotes the heat transfer of phase change materials(PCMs) in the penalty of reducing the energy storage density of the composite *** this work,the effects of constant porosity(0.96,0.94,0.92,or 0.90) and pore density(PPI) of metal foam on heat transfer of composite PCMs are *** rate could be enhanced by employing with low porosity copper ***,aiming to the right bottom phase changing "dead region",a regionalized enhancement strategy of cascaded metal foams is *** dynamic melting performances of all the composite PCMs are comprehensively *** results reveal that the cascaded configuration is beneficial for *** show that the horizontal strategy enhances melting performance:a maximum of 17.98% reduction in total melting time could be reached when the rear part porosity is 90%.The energy storage density rate could be raised by 5.48%.Besides,the vertical strategy performs with a better average temperature uniformity of 0.441 and brings a lower temperature in the heated *** sum up,the regionalized enhancement of copper foam provides better performance in the phase change *** shows significant potential for solar heat storage and thermal protection.

关键词： copper metal foam heat transfer enhancement phase change materials regionalized enhancement

Characterization of a pangolin SARS-CoV-2-related virus isolate that uses the human ACE2 receptor

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Science China(Life Sciences) 2024年第7期67卷 1502-1513页

作者： Luo-Yuan Xia Xue-Feng Wang Xiao-Ming Cui Yi-Ming zhang Zhen-Fei Wang En-Tao Li Chang-Fa Fan Ke Song Yuan-Guo Li Run-Ze Ye Fang-Xu Li Dai-Yun Zhu Jie zhang Zhuang-Zhuang Shi Ming-Zhu zhang Liang-Jing Li Shi-Jing Shen Song Jin ya-wei zhang wei-Guang Fu Lin Zhao Wen-Hao Wang Tie-Cheng Wang You-Chun Wang Jia-Fu Jiang yan-Ling Hu Na Jia Yu-wei Gao Wu-Chun Cao Institute of EcoHealth School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China Changchun Veterinary Research Institute Changchun 130122China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and EpidemiologyBeijing 100071China Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug ControlBeijing 102629China National Institutes for Food and Drug Control Beijing 102629China Life Sciences Institute Guangxi Medical UniversityNanning 530020China College of Life Sciences Shandong Normal UniversityJinan 250014China Research Unit of Discovery and Tracing of Natural Focus Diseases Chinese Academy of Medical SciencesBeijing 100071China

Various SARS-CoV-2-related coronaviruses have been increasingly identified in pangolins,showing a potential threat to *** we report the infectivity and pathogenicity of the SARS-CoV-2-related virus,PCoV-GX/P2V,which was isolated from a Malayan pangolin(Manis javanica).PCoV-GX/P2V could grow in human hepatoma,colorectal adenocarcinoma cells,and human primary nasal epithelial *** replicated more efficiently in cells expressing human angiotensin-converting enzyme 2(hACE2)as SARS-CoV-2 *** intranasal inoculation to the hACE2-transgenic mice,PCoV-GX/P2V not only replicated in nasal turbinate and lungs,but also caused interstitial pneumonia,characterized by infiltration of mixed inflammatory cells and multifocal alveolar *** population immunity established by SARS-CoV-2 infection and vaccination may not protect people from PCoV-GX/P2V *** findings further verify the hACE2 utility of PCoV-GX/P2V by in vivo experiments using authentic viruses and highlight the importance for intensive surveillance to prevent possible cross-species transmission.

关键词： pangolin SARS-CoV-2-related virus infectivity pathogenicity human cell lines human ACE2 receptor hACE2-transgenic mice

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