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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan yang Zhi-Cheng Zhang Qi Dai Xiao-yan Bao Lin-Jie wu ya-Xin Qin Xin Tan Xiao-yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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多源固废协同制备土壤固化剂及固化机理

森林工程 2025年第1期41卷 195-204页

作者：褚锋吴思吴传山马亚李骏山东高速建设管理集团有限公司济南230000 山东高速济德公路有限公司山东德州253000 山东高速工程检测有限公司济南230002

为实现冶金固废材料的高值化、规模化利用,采用冶金固废材料(高炉矿渣、粉煤灰、电石渣、石膏)协同制备土壤固化剂,通过正交配比优化试验研究不同固废材料对固化土力学性能的影响并获取最优的参数配方。系统研究固废基固化剂(SWC)固化... 详细信息

为实现冶金固废材料的高值化、规模化利用,采用冶金固废材料(高炉矿渣、粉煤灰、电石渣、石膏)协同制备土壤固化剂,通过正交配比优化试验研究不同固废材料对固化土力学性能的影响并获取最优的参数配方。系统研究固废基固化剂(SWC)固化土的力学性能(无侧限抗压强度、劈裂强度、延迟成型)和耐候性能(水稳定性、冻融循环),并与PO 42.5硅酸盐水泥(OPC)进行对比。结果表明,电石渣对固化剂体系起到重要作用,合理的石膏掺量对强度增长有积极作用;固化土的强度随SWC掺量和养护龄期的增加而增大,4%掺量下的固化土7 d无侧限抗压强度大于1 MPa,劈裂强度与OPC固化土基本相当;SWC固化土表现出更久的施工容许延迟时间,拌和后12 h内强度无下降趋势;掺量大于5%时水稳定系数大于90%,同掺量下抗冻系数与水泥相比提高3%~5%,具备良好的水稳定性与抗冻性;X射线衍射(XRD)和扫描电子显微镜(SEM)分析表明,SWC固化土在水化过程中会生成膨胀性水化产物钙矾石(AFt)和硅酸钙(C-S-H),钙矾石晶体对改善固化土的劈裂强度和抵抗开裂变形能力提高作用显著。

关键词：道路工程固化剂力学性能固化土工业固废

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NIR photothermal enhancement to achieve high-efficiency nitrogen reduction to ammonia by polyoxometalates@Fe-polydopamine

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Nano Research 2025年第1期18卷 118-128页

作者： Xiaofei Chen Lixin wu Feng Bai Key Laboratory for Special Functional Materials of Ministry of Education National&Local Joint Engineering Research Center for High-Efficiency Display and Lighting TechnologySchool of Nanoscience and Materials EngineeringHenan UniversityKaifeng 475004China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012China

The development of atmospheric pressure N_(2)reduction to NH_(3)is attracting much attention in green chemistry,yet it is still a challenge to obtain satisfactory activity under mild ***,an efficient near-infrared(NIR)photothermal catalysis reduction of N_(2)constitutes an occurrence is *** or without V-substitute polyoxometalates(POMs)loaded on the surface of Fechelated polydopamine(Fe-PDA)photothermal support through the electrostatic interactions,NIR photothermal catalysts POMs@Fe-PDA are *** induction of“FeV”cofactor facilitates electron transfer between V(V)/V(IV)&Fe(III)/Fe(II)and N_(2),thereby activating N_(2)*** synergy between the catalytic activity of V-POMs and the local NIR photothermal effect of Fe-PDA dramatically enhances N_(2)***,PMo_(10)V_(2)@Fe-PDA exhibits a significantly enhanced NH_(3)production rate of 181.1μmol·LN^(-1)with a turnover frequency of 1006.1 mmol·MN^(-1)·hN^(-1)under 808 nm NIR laser radiation,being the highest values reported at atmospheric *** expect that this work could provide an alternative approach for photothermal catalysis N_(2)reduction under mild conditions.

关键词： polyoxometalate near-infrared photothermal catalysis N_(2)reduction mild condition

Thermodynamic property of ternary compound MgCaSi: A study from ab initio Debye-Grüneisen model

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Chinese Journal of Chemical Engineering 2021年第12期34卷 315-322页

作者： Rui wu ya-Ping Wang Lin Shao wei Wang Bi-Yu Tang School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China Institute of Biological Manufacturing Technology Co.Ltd Guangxi Institute of Industrial TechnologyNanning 530022China

The thermodynamic properties of Mg Ca Si and its mother phase Ca2 Si are comparatively investigated from ab initio calculations and quasi-harmonic Debye-Grüneisen model. At 0 K, Mg Ca Si is more thermodynamically stable. Under high temperature, the advantage of higher thermodynamically stability of Mg Ca Si is reduced, originating from the less negative entropy contribution because the thermodynamic entropy of Mg Ca Si increases more slowly with temperature and the entropy values are slightly *** increasing temperature, the anti-softening ability for Mg Ca Si is slightly smaller due to the slightly faster decrease trend of bulk modulus than that of Ca2 Si, although the bulk modulus of Mg Ca Si is higher in the whole temperature range considered. The thermal expansion behaviors of both Mg Ca Si and Ca_(2)Si exhibit similar increase trend, although thermal expansion coefficient of MgCaSi is slightly lower and the increases is slightly slower at lower temperature. The isochoric heat capacity CVand isobaric heat capacity CPof MgCaSi and Ca_(2)Si rise nonlinearly with temperature, and both CVare close to the Dulong–Petit limit at high temperature due to the negligibly small electronic contribution. The Debye temperature of both phases decrease with increasing temperature, and the downtrend for Mg Ca Si is slightly ***, MgCaSi possess slightly higher Debye temperature, implying the stronger chemical bonds and higher thermal conductivity than the mother phase Ca_(2)Si. The Grüneisen parameter of MgCaSi and Ca_(2)Si increase slightly with temperature, the values of MgCaSi are slightly larger. The investigation of electronic structures shows that with substitution of partial Ca by Mg in Ca_(2)Si, the stronger MgASi,MgACa and SiASi covalent bonds are formed, and plays a very significant role for the structural stability and mechanical properties.

关键词： MgCaSi alloys Density functional theory Thermodynamic properties Structural stabilities Quasi-harmonic Debye-Grüneisen model

Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： Yingli Gu Kijung Sung Chengbiao wu Department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”to date,yields over 33,000 *** fundamental biology to potential therapeutic applications,BDNF has clearly garnered extensive and significant attention in the field of neurobiology research.

关键词： Huntington homeostasis therapeutic

Chain Dynamics Heterogeneity in Plasticized Poly(vinyl butyral)(PVB) as Elucidated by Solid-State NMR

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Chinese Journal of Polymer Science 2024年第1期42卷 113-124,I0010页

作者： Jing Lv Xu Chen Zi-Shuo wu ya-Hui Li wei Chen National Synchrotron Radiation Laboratory Anhui Provincial Engineering Laboratory of Advanced Functional Polymer FilmCAS Key Laboratory of Soft Matter ChemistryUniversity of Scienceand Technology of ChinaHefei 230026China

The chain dynamics heterogeneity of the poly(vinyl butyral)(PVB) plasticized by triethylene glycol bis(2-ethylhexa noate)(TEG-EH) was investigated by various solid-state NMR *** plasticized PVB shows two domains in distinct molecular dynamics differences,namely,rigid and soft domains,where the latter is the plasticizer-rich *** time domain low field NMR was first used to investigate the dynamics heterogeneity of the plasticized PVB,and the results show the decreasing activated energy of components in the soft domain of plasticized PVB(E_a=20.2 kJ/mol) as compared with that of the pristine one(E_a=24.3 kJ/mol).Detailed dynamics heterogeneity was obtained by high-field NMR with site-specific *** quadrupole-echo ~2H-NMR was adopted to elucidate the dynamics heterogeneity of the vinyl alcohol(VA) units,where only the hydroxyl group of VA is *** ~1H-^(13)C WISE NMR spectra show that there is not much difference in the mobility of the VB unit in PVB with and without plasticizer,whereas the glass transition temperature differed by approximately 53℃.This is further supported by Torchia's T_1 relaxation *** origin of such an unusual phenomenon is attributed to the critical role of the remaining VA(~22%) in the soft domain,where the VA units locally aggregate through hydrogen ***,the existence of a mobility gradient in the VB unit has been ***,the mobility difference for VB with different stereo-geometry(meso or racemic conformation) is observed for the first *** indicates the importance of modulating the ratio of meso over racemic VB for controlling the macroscopic perfo rmance of PVB.

关键词： Poly(vinyl butyral) Dynamics heterogeneity Plasticizer Solid state NMR

西罗莫司洗脱支架和金属裸支架治疗冠心病的远期安全比较研究

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中国实用内科杂志 2010年第11期30卷 1004-1006页

作者：何继强高阅春张晓玲罗亚玮吴长燕李宇张维东陈方首都医科大学附属北京安贞医院北京市心肺血管疾病研究所北京100029

目的比较西罗莫司药物洗脱支架和金属裸支架治疗冠心病患者的远期安全性。方法选择北京安贞医院2000年1月至2004年8月置入金属裸支架的冠心病患者505例,与2004年1月至2005年1月置入西罗莫司洗脱支架的984例冠心病患者进行历史性对照分析... 详细信息

目的比较西罗莫司药物洗脱支架和金属裸支架治疗冠心病患者的远期安全性。方法选择北京安贞医院2000年1月至2004年8月置入金属裸支架的冠心病患者505例,与2004年1月至2005年1月置入西罗莫司洗脱支架的984例冠心病患者进行历史性对照分析,比较两组患者支架术后随访2年的死亡、支架内血栓、非致死性心肌梗死发生率。结果两组患者在合并吸烟、高血压、高血脂、糖尿病所占比例及冠状动脉病变支数方面差异均无统计学意义。西罗莫司洗脱支架组患者平均年龄较大、分叉病变比例高、置入支架平均直径小且平均支架长度较长。临床随访2年,两组患者生存率、支架内血栓、非致死性心肌梗死及死亡/非致死性心肌梗死发生率方面差异均无统计学意义(分别为99.3%、1.3%、1.1%、1.8%和98.3%、1.7%、1.7%、3.5%,P>0.05)。结论西罗莫司洗脱支架和金属裸支架在冠心病患者中应用的远期安全性相似。

关键词：冠状动脉疾病西罗莫司洗脱支架金属裸支架

Interference of human's ankle to the channel characteristics of near surface wuSN

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The Journal of China Universities of Posts and Telecommunications 2014年第1期21卷 36-42页

作者： LI Li wu wei CHEN Jian-ya LIU Yun-jie State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications Beijing Key Laboratory of Network System Architecture and Convergence Beijing University of Posts and Telecommunications

Because of its potential applications in agriculture, environment monitoring and so on, wireless underground sensor network（wuSN） has been researched more and more extensively in recent years. The main and most important difference of wuSN to terrestrial wireless sensor network（WSN） is the channel characteristics, which determines the design methodology of it. In this paper, the propagation character of electromagnetic（EM） wave in the near surface wuSN is analyzed, as well as the path loss model of it is given. In addition, the influence of human＇s ankle to the channel characteristics of near surface wuSN is investigated by electromagnetic theory analysis, simulation and experiment. A novel path loss model of near surface wuSN which takes the interference of human＇s ankle into consideration is proposed. It is verified that the existing of human above the wuSN system may cause additional attenuation to the signal of near surface wuSN which propagates as lateral wave along the ground. Moreover, the relation of the attenuation and operating frequency is deduced, which gives a reference to extend the frequency band applied in wuSN.

关键词： wuSN lateral wave human tissue path loss model EM wave attenuation

STUDY OF VORTEX CHARACTERISTICS OF THE FLOW AROUND A HORIZONTAL CIRCULAR CYLINDER AT VARIOUS GAP-RATIOS IN THE CROSS-FLOW

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Journal of Hydrodynamics 2006年第3期18卷 334-340页

作者： QI E-rong LI Guo-ya LI wei wu Jian ZHANG Xin State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University Wuhan430072 China China Three Gorges Project Corporation Yichang 443002 China Central South Building Design Institute Wuhan 430071 China

In the gap-ratio range of 0.0≤G≤7.0, a particle image velocimetry PIV is applied to conduct a systematic experimental research of the flow around a horizontal circular cylinder in the cross-flow of shallow water. The velocity distribution of transient flow field at various gap-ratios is obtained. Based on these data, the phenomena and rules of the vortex and its course of generation, development and evolvement at various gap-ratios are analyzed, and it is found that there are similar unshedding vortex structures at G = 0.0 and G = 7.0, and others are structures of shedding vortex. The figures of typical vortex movements are given. Based on this, the differences between the transient flow field and the time-averaged flow field and the characteristics of the vortex structures are analyzed. In addition when the Strouhal number keeps constant （about 0.2） concerning vortex shedding have been discussed. The findings of this paper are of guiding significance for engineering issues with similar flowing features.

关键词： PIV flow around a circular cylinder vortex structure Strouhal number

Preparation and electrochemical properties of carbon-coated LiFePO_4 hollow nanofibers

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International Journal of Minerals,Metallurgy and Materials 2016年第4期23卷 474-480页

作者： Bin-bin wei yan-bo wu Fang-yuan Yu ya-nan Zhou College of Environmental and Chemical Engineering Dalian Jiaotong University

Carbon-coated LiFePO_4 hollow nanofibers as cathode materials for Li-ion batteries were obtained by coaxial electrospinning. X-ray diffraction, scanning electron microscopy, transmission electron microscopy, Brunauer–Emmett–Teller specific surface area analysis, galvanostatic charge–discharge, and electrochemical impedance spectroscopy（EIS） were employed to investigate the crystalline structure, morphology, and electrochemical performance of the as-prepared hollow nanofibers. The results indicate that the carbon-coated LiFePO_4 hollow nanofibers have good long-term cycling performance and good rate capability： at a current density of 0.2C（1.0C = 170 mA ·g^-1） in the voltage range of 2.5–4.2 V, the cathode materials achieve an initial discharge specific capacity of 153.16 mA h·g^-1 with a first charge–discharge coulombic efficiency of more than 97%, as well as a high capacity retention of 99% after 10 cycles; moreover, the materials can retain a specific capacity of 135.68 mA h·g^-1, even at 2C.

关键词： electrospinning lithium-ion batteries carbon coatings phosphates nanofibers electrochemical properties