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Serotonin receptor 2B induces visceral hyperalgesia in rat model and patients with diarrhea-predominant irritable bowel syndrome

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World Journal of Gastroenterology 2024年第10期30卷 1431-1449页

作者： Zheng-yang Li Yu-Qing Mao Qian Hua Yong-Hong sun Hai-yan wang Xuan-Guang Ye Jing-Xian Hu ya-Jie wang Miao Jiang Department of Gastroenterology Jinshan Hospital of Fudan UniversityShanghai 201508China Department of Gastroenterology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China Department of Gastroenterology Dalian Friendship HospitalDalian 116001Liaoning ProvinceChina Department of Pathology Jinshan Hospital of Fudan UniversityShanghai 201508China

BACKGROUND Serotonin receptor 2B(5-HT2B receptor)plays a critical role in many chronic pain *** possible involvement of the 5-HT2B receptor in the altered gut sensation of irritable bowel syndrome with diarrhea(IBS-D)was investigated in the present *** To investigate the possible involvement of 5-HT2B receptor in the altered gut sensation in rat model and patients with *** Rectosigmoid biopsies were collected from 18 patients with IBS-D and 10 patients with irritable bowel syndrome with constipation who fulfilled the Rome IV criteria and 15 healthy *** expression level of the 5-HT2B receptor in colon tissue was measured using an enzyme-linked immunosorbent assay and correlated with abdominal pain *** IBS-D rat model was induced by intracolonic instillation of acetic acid and wrap *** in visceral sensitivity and 5-HT2B receptor and transient receptor potential vanilloid type 1(TRPV1)expression were examined following 5-HT2B receptor antagonist *** in visceral sensitivity after administration of the TRPV1 antago-INTRODUCTION Irritable bowel syndrome(IBS)is a chronic functional bowel disorder characterized by recurrent abdominal pain with altered bowel habits that affects approximately 15%of the population worldwide[1].IBS significantly impacts the quality of life of *** the pathogenesis of IBS is not completely understood,the role of abnormal visceral sensitivity in IBS has recently emerged[2,3].5-Hydroxytryptamine(5-HT)is known to play a key role in the physiological states of the gastrointestinal *** 5-HT levels in IBS with diarrhea(IBS-D)patients were greater than those in healthy controls[4],suggesting a possible role of 5-HT in the pathogenesis of *** serotonin receptor 2(5-HT2 receptor)family comprises three subtypes:5-HT2A,5-HT2B,and *** 5-HT2 receptors exhibit 46%-50%overall sequence identity,and all of these receptors preferentially bind to Gq/

关键词： Diarrhea-predominant irritable bowel syndrome Serotonin receptor 2B Transient receptor potential vanilloid type-1 Visceral hypersensitivity Abdominal pain

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Design and validation of a variable camber wing structure

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Chinese Journal of Aeronautics 2024年第2期37卷 1-11页

作者： Xiasheng sun Jingfeng XUE Jin ZHOU Zhigang wang Wenjuan wang Mengjie ZHANG Chinese Aeronautical Establishment Beijing 100012China School of Aeronautic Science and Engineering Beihang UniversityBeijing 100191China Aircraft Strength Research Institute of China Xi’an 710065China Graduate School of Chinese Aeronautical Establishment Yangzhou 225002China

Variable camber wing technology is one of the important development trends of green aviation at *** smooth,seamless,continuous and adaptive change of wing camber,the aerodynamic performance is improved in achieving increase in lift and reduction in resistance and *** on the aerodynamic validation model CAE-AVM,Chinese Aeronautical Establishment(CAE)has carried out the design and validation of a variable camber wing,proposed an aerodynamic deformation matrix for the leading and trailing edges of aircraft wings in takeoff,landing and cruise *** structures and driving schemes are compared,and several key technology problems of leading and trailing edge deformation are solved.A full-size leading edge wind tunnel test piece with a span of 2.7 m and a trailing edge ground function test piece are *** deformation and shape maintenance capabilities of the leading edge is verified under real wind load conditions,and the load bearing and deformation capabilities of the trailing edge is verified under simulated follow-on *** results indicate that the leading and trailing edges of the variable camber wing can achieve the required deformation angle and have a certain load-bearing *** study can provide some insights into the application of variable camber wing technology for civil aircraft.

关键词： Variable camber wing Leading edge Trailing edge Structure Measurement and control Test

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Robust Forecasting-Aided State Estimation Considering Uncertainty in Distribution System

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1632-1641页

作者： Dongchen Hou Yonghui sun Linchuang Zhang Sen wang College of Energy and Electrical Engineering Hohai UniversityNanjing 210098China

With the development of the smart grid,the distribution system operation conditions become more complex and ***,due to the influence of observation outliers and uncertain noise statistics,it is more difficult to grasp the dynamic operation characteristics of distribution *** order to address these problems,by using projection statistics and the noise covariance updating technology based on the Sage-Husa noise estimator,for distribution power system with outliers and uncertain noise statistics,a robust adaptive cubature Kalman filter forecasting-aided state estimation method is proposed based on generalized-maximum likelihood type ***,an adaptive strategy,which can enhance the filtering accuracy under normal conditions,is *** the simulation part,the branch parameters and node load parameters of the test system are appropriately modified to simulate the asymmetry of the three-phase branch parameters and the asymmetry of the three-phase ***,through simulation experiments on the improved test system,it is verified that the robust forecasting-aided state estimation method,presented in this paper,can effectively perceive the actual operating state of the distribution network in different simulation scenarios.

关键词： Cubature Kalman filter distribution power system forecasting-aided state estimation projection statistics

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Path signature-based XAI-enabled network time series classification

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Science China(Information Sciences) 2024年第7期67卷 91-106页

作者： Le sun Yueyuan wang Yongjun REN Feng XIA Department of Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology(CICAEET) Nanjing University of Information Science and Technology School of Computing Technologies Royal Melbourne Institute of Technology

Classifying network time series(NTS) is crucial for automating network administration and ensuring cyberspace security. It enables the detection of anomalies, the identification of network attacks,and the monitoring of performance issues, thereby providing valuable support for network protection and optimization. However, modern communication networks pose challenges for NTS classification *** include handling large-scale and complex NTS data, extracting features from intricate datasets, and addressing explainability requirements. These challenges are particularly pronounced for complex 5G networks. Notably, explainability has become crucial for the widespread deployment of network automation for 5G networks and beyond. To tackle these challenges, we propose a path-signature-based NTS classification model called recurrent signature(Recur Sig). This innovative model is designed to overcome the time-consuming feature selection problem by utilizing deep-learning(DL) techniques. Additionally, it provides a solution for addressing the black-box issue associated with DL models in network automation systems(NAS) by incorporating an explainable classification approach. Extensive experimentation on various public datasets demonstrates that Recur Sig outperforms existing models in accuracy and explainability. The results indicate its potential for application in cyberspace security and automated network management, offering an explainable solution for network protection and optimization.

关键词： network time series classification explainable artificial intelligence path signature automated network management recurrent neural network

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Theoretical model of azimuthal combustion instability subject to non-trivial boundary conditions

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CHINESE JOURNAL OF AERONAUTICS 2024年第9期37卷 113-130页

作者： Qin, Lei wang, Xiaoyu Zhang, Guangyu sun, Xiaofeng Beihang Univ Res Inst Aeroengine Beijing 100191 Peoples R China Beihang Univ Sch Energy & Power Engn Beijing 100191 Peoples R China

The problem of evaluating the sensitivity of non-trivial boundary conditions to the onset of azimuthal combustion instability is a longstanding challenge in the development process of modern gas turbines. The difficulty lies in how to describe three-dimensional in- and outlet boundary conditions in an artificial computational domain. To date, the existing analytical models have still failed to quantitatively explain why the features of the azimuthal combustion instability of a combustor in laboratory environment are quite different from that in a real gas turbine, making the stability control devices developed in laboratory generally lose the effectiveness in practical applications. To overcome this limitation, we provide a novel theoretical framework to directly include the effect of non-trivial boundary conditions on the azimuthal combustion instability. A key step is to take the non-trivial boundary conditions as equivalent distributed sources so as to uniformly describe the physical characteristics of the inner surface in an annular enclosure along with different in- and outlet configurations. Meanwhile, a dispersion relation equation is established by the application of three-dimensional Green's function approach and generalized impedance concept. Results show that the effects of the generalized modal reflection coefficients on azimuthal unstable modes are extremely prominent, and even prompt the transition from stable to unstable mode, thus reasonably explaining why the thermoacoustic instability phenomena in a real gas turbine are difficult to observe in an isolated combustion chamber. Overall, this work provides an effective tool for analysis of the azimuthal combustion instability including various complicated boundary conditions.

关键词： Combustion instability Aeroacoustics Modeling Optimization techniques Control SOUND-TRANSMISSION CALCULATIONS ACTUATOR DISK MODEL RADIATION IMPEDANCES ACOUSTIC RADIATION ACTIVE CONTROL BLADE ROW DUCT STABILITY PROPAGATION TURBOMACHINERY

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Cascade electrolysis and thermocatalysis: a reliable system for upgrading C1 to C4 hydrocarbons

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Rare Metals 2024年第1期43卷 410-412页

作者： Chao-Yue sun Wen Li Hai-Qing wang Institute for Advanced Interdisciplinary Research(iAIR) College of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China

The carbon cycle is important for maintaining a stable climate and carbon balance on Earth. Renewable-electricitydriven upcycling of carbon dioxide (CO_(2)) into value-added multi-carbon molecules is a potentially sus... 详细信息

关键词： cycling hydrocarbons enable

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Inverse aerodynamic design for distributed propulsion wing with expected circulation distribution

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CHINESE JOURNAL OF AERONAUTICS 2024年第9期37卷 206-223页

作者： sun, Pengbo Zhou, Zhou Li, Xu wang, Kelei Northwestern Polytech Univ Sch Aeronaut Xian 710072 Peoples R China

Distributed Propulsion Wing (DPW) technology offers significant advantages in terms of flight energy savings, but the strong aerodynamic coupling between the propulsive internal flow and aerodynamic external flow brings significant design challenges. As the primary DPW profile design is of great significance, this paper proposes a hybrid method to solve the inverse problem mainly based on the formula relationship between the required aerodynamic loads and the profile shape, which is more direct and instructive compared with traditional parametric iterative methods. The aerodynamic characteristics are described by the circulation distribution in the Fourier series form, then the mean camber line of the profile is solved through the re-derived airfoil theory considering disk's influence. Further CFD correction methods are also proposed. To validate the effectiveness and feasibility of the proposed hybrid inverse method, several DPW profile design tests are then conducted. Finally, the relationship between 2D and realistic 3D unit shape is also researched. The results show that the proposed inverse design method has great accuracy and convergence speed in the design tests, and shows good robustness against changes of the design parameters. The 2D profile shape and the actual 3D shape of DPW unit can establish an aerodynamicpropulsion equivalent relationship based on the same internal mass fluxes. (c) 2024 Production and hosting by Elsevier Ltd. on behalf of Chinese Society of Aeronautics and Astronautics. This is an open access article under the CC BY-NC-ND license (http://***/ licenses/by-nc-nd/4.0/).

关键词： Inverse problem Aerodynamic load Fourier series Flux FLOW SIMULATION SHAPE DESIGN HYBRID OPTIMIZATION

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A Distortion Self-Calibration Method for Binocular High Dynamic Light Adjusting and Imaging System Based on Digital Micromirror Device

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 2036-2038页

作者： Pei Wu yanjie wang Honghai sun Zhuoman Wen University of Chinese Academy of Sciences Beijing 100049and NIO Inc.Shanghai 200000China Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China

Dear Editor,In order to realize the pixel level light adjusting control of the binocular high dynamic light adjusting and imaging system, this letter proposed a novel self-calibration method. By analyzing the optical design of the system, the causes of the distortion are given and a distortion model is established. Then, a quick and accurate self-calibration method is designed. The experiments indicate that the method can calibrate the two image sensors of the system at the same time,the average pixel deviation of the calibrated system is less than 0.5pixels and the maximum deviation is less than 1 pixel.

关键词： Dynamic system deviation

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Asymmetric two-dimensional diffraction grating via a vortex field in an inverted-Ytype atomic system

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Communications in Theoretical Physics 2024年第5期76卷 77-85页

作者： Duo Zhang Ke wang Kunpeng Zhao Mei wang Zhaoyu sun School of Electrical and Electronic Engineering Wuhan Polytechnic UniversityWuhan 430023China

We propose a theoretical scheme to realize a two-dimensional(2D)diffraction grating in a four-level inverted-Y-type atomic system coupled by a standing-wave(SW)field and a Laguerre-Gaussian(LG)vortex *** to asymmetric spatial modulation of the LG vortex field,the incident probe field can be lopsidedly diffracted into four domains and an asymmetric 2D electromagnetically induced grating is *** adjusting the detunings of the probe field and the LG vortex field,the intensities of the LG vortex field and the coherent SW field,as well as the interaction length,the diffraction properties and efficiency,can be effectively *** addition,the effect of the azimuthal parameter on the Fraunhofer diffraction of the probe field is also *** asymmetric 2D diffraction grating scheme may provide a versatile platform for designing quantum devices that require asymmetric light transmission.

关键词： asymmetric diffraction grating standing-wave field Laguerre-Gaussian vortex field diffraction property

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Gelation mechanisms of gel polymer electrolytes for zinc-based batteries

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Chinese Chemical Letters 2024年第5期35卷 97-116页

作者： Mengjun sun Zhi wang Jvhui Jiang Xiaobing wang Chuang Yu Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals Key Laboratory of Green Chemical Media and ReactionsMinistry of EducationSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang 453007China Key Laboratory for Yellow River and Huaihe River Water Environment and Pollution Control Ministry of EducationHenan Key Laboratory for Environmental Pollution ControlSchool of EnvironmentHenan Normal UniversityXinxiang 453007China State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074China

Zinc-based batteries(ZBs)have been deemed as a potential substitute for lithium-ion batteries due to its unique advantages of abundant resources,low cost and acceptable energy *** great progress in designing electrode materials has been made,the development of high-performance ZBs still remain challenges,such as the dendrite growth of zinc anode,hydrogen evolution reaction,limited electrochemical stability window,water evaporation and liquid *** polymer electrolytes(GPEs),including hydrous GPEs with low content of active water and anhydrous GPEs without the presence of water,are proposed to avoid these ***,employing GPEs is conductive to fabricate flexible devices owing to the good mechanical *** date,most of researches focus on discovering new GPEs and exploring its application on flexible or wearable *** reviews also have outlined the polymer matrixes and advances of GPEs in various battery *** this,herein,we seek to summarize the gelation mechanisms of GPEs,involving physical gel of polymer,chemical crosslinking of polymer and chemical polymerization of ***,the preparation methods are also *** addition,not only the features and central conundrum of GPEs are analyzed but also the corresponding strategies are discussed,contributing to design GPEs with ideal properties for high-performance ZBs.

关键词： Gelation mechanisms Gel polymer electrolytes Zinc-based batteries Gelation methods

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