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pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging

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Chinese Journal of Polymer Science 2024年第1期42卷 7-13,I0005页

作者： Jing-Yuan Xiang Wen-Long Zhang He-ting Li ya-Ning He Department of Chemical Engineering Key Laboratory of Advanced Materials(MOE)Tsinghua UniversityBejing 100084China

This work reported an AIE fluorescent probe for tumor imaging based on the p H induced self-assembly strategy. The fluorescent probe was composed of an acid-responsive soluble copolymer PEG-b-PAMA-DMMA with a maleic acid amide group and an anionic soluble aggregation-induced emission fluorogen(AIEgen) TPE-2SO_(3)^(-). The polymer could be transformed into a protonated amine-containing polymer after the hydrolysis of maleic acid amide in acidic tumor microenvironment, which would be further self-assembled with TPE-2SO_(3)^(-)to form aggregated nanoparticles. The transition of TPE-2SO_(3)^(-)from dispersed state to aggregated state led to an obvious increase in fluorescence intensity due to its AIE characteristics.

关键词： p H-responsive Self-assembly Fluorescent probe AIE Tumor imaging

Time Parameter Based Low-Energy Data Encryption Method for Mobile Applications

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Computer Modeling in Engineering & Sciences 2024年第9期140卷 2779-2794页

作者： Li-Woei Chen Kun-Lin Tsai Fang-Yie Leu Wen-Cheng Jiang Shih-ting tseng Department of Computer and Information Sciences Chinese Military AcademyKaohsiung830Taiwan Department of Electrical Engineering Tunghai UniversityTaichung407Taiwan Department of Computer Science Tunghai UniversityTaichung407Taiwan

Various mobile devices and applications are now used in daily *** devices require high-speed data processing,low energy consumption,low communication latency,and secure data transmission,especially in 5G and 6G mobile ***-security cryptography guarantees that essential data can be transmitted securely;however,it increases energy consumption and reduces data processing ***,this study proposes a low-energy data encryption(LEDE)algorithm based on the Advanced Encryption Standard(AES)for improving data transmission security and reducing the energy consumption of encryption in Internet-of-Things(IoT)*** the proposed LEDE algorithm,the system time parameter is employed to create a dynamic S-Box to replace the static S-Box of *** indicated that six-round LEDE encryption achieves the same security level as 10-round conventional AES *** reduction in encryption time results in the LEDE algorithm having a 67.4%lower energy consumption and 43.9%shorter encryption time than conventional AES;thus,the proposed LEDE algorithm can improve the performance and the energy consumption of IoT edge devices.

关键词： Mobile application security AES data encryption time parameter mobile device

Morphology and valence state evolution of Cu:Unraveling the impact on nitric oxide electroreduction

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Journal of Energy Chemistry 2024年第4期91卷 276-286页

作者： ting Sun Fengyu Gao ya Wang Honghong Yi Qingjun Yu Shunzheng Zhao Xiaolong Tang School of Energy and Environmental Engineering University of Science and Technology BeijingBeijing 100083China

Ammonia(NH3)serves as a critical component in the fertilizer industry and fume gas ***,the conventional NH3production process,namely the Haber-Bosch process,leads to considerable energy consumption and waste gas *** address this,electrocatalytic nitric oxide reduction reaction(NORR)has emerged as a promising strategy to bridge NH3consumption to NH3production,harnessing renewable electricity for a sustainable ***(Cu)stands out as a prominent electrocatalyst for NO reduction,given its exceptional NH3yield and ***,a crucial aspect that remains insufficiently explored is the effects of morphology and valence states of Cu on the NORR *** this investigation,we synthesized CuO nanowires(CuO-NF)and Cu nanocubes(Cu-NF)as cathodes through an in situ growth ***,CuO-NF exhibited an impressive NH3yield of 0.50±0.02 mg cm^(-2)h^(-1)at-0.6 V *** hydrogen electrode(RHE)with faradaic efficiency of29,68%±1,35%,surpassing that of Cu-NF(0.17±0.01 mg cm^(-2)h^(-1),16.18%±1.40%).Throughout the electroreduction process,secondary cubes were generated on the CuO-NF surface,preserving their nanosheet cluster morphology,sustained by an abundant supply of subsurface oxygen(s-O)even after an extended duration of 10 h,until s-O depletion ***,Cu-NF exhibited inadequate s-O content,leading to rapid crystal collapse within the same *** distinctive current-potential relationship,akin to a volcano-type curve,was attributed to distinct NO hydrogenation *** Tafel analysis revealed the exchange current density(i0)and standard heterogeneous rate constant(k0)for CuO-NF,yielding 3.44×10^(-6)A cm^(-2)and 3.77×10^(-6)cm^(-2)s^(-1)when NORR was driven by *** findings revealed the potential of CuO-NF for NO reduction and provided insights into the intricate interplay between crystal morphology,valence states,and electrochemical performance.

关键词： NORR Ammonia Synthesis Copper Morphology Valence States Mechanism

The RFI Fast Mitigation Algorithm Based on Block LMS Filter

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Research in Astronomy and Astrophysics 2024年第1期24卷 265-272页

作者： Han Wu Hai-Long Zhang ya-Zhou Zhang Jie Wang Xu Du ting Zhang Xin-Chen Ye Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China

The radio telescope possesses high sensitivity and strong signal collection *** receiving celestial radiation signals,it also captures Radio Frequency Interferences(RFIs)introduced by human ***,as signals originating from sources other than the astronomical targets,significantly impacts the quality of astronomical *** paper presents an RFI fast mitigation algorithm based on block Least Mean Square(LMS)*** enhances the traditional adaptive LMS filter by grouping L adjacent time-sampled points into one block and applying the same filter coefficients for filtering within each *** transformation reduces multiplication calculations and enhances algorithm efficiency by leveraging the time-domain convolution *** algorithm is tested using baseband data from the Parkes 64 m radio telescope's pulsar observations and simulated *** results confirm the algorithm's effectiveness,as the pulsar profile after RFI mitigation closely matches the original pulsar profile.

关键词： methods:data analysis techniques:interferometric (stars:)pulsars:individual(J0437-4715)

Removal of a guide-wire sliding into abdominal cavity via transgastric natural orifice transluminal endoscopic surgery: A case report

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World Journal of Clinical Cases 2024年第3期12卷 596-600页

作者： Shi-Ju Chen Da-ya Zhang yan-ting Lv Fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical University570216 HaikouHainan ProvinceChina Department of Gastroenterology Clinical Medical Center of Hainan ProvinceHaikou 570216Hainan ProvinceChina

BACKGROUND Guidewire slippage into the peritoneal cavity during clinical operations is extremely ***,this paper aims to report a successful case of guidewire removal using transgastric natural orifice transluminal endoscopic surgery(NOTES).The goal is to enhance physicians'understanding of the management plan for this unique scenario and provide a valuable reference for clinical *** SUMMARY A 64-year-old man presented with abdominal distension and was diagnosed with cirrhosis combined with massive *** proceed with treatment,the patient underwent ultrasound-guided peritoneal puncture and underwent catheterization and ***,a 0.035-inch guidewire slipped into the abdominal cavity during the *** a comprehensive evaluation and consultation by a multidisciplinary team,the guidewire was successfully removed using *** This case highlights the potential consideration of transgastric NOTES removal when encountering a foreign body,such as a guidewire,within the abdominal cavity.

关键词： Guidewire Abdominal cavity Natural orifice transluminal endoscopic surgery Cirrhosis Massive ascites Case report

RNF187 governs the maintenance of mouse GC-2 cell development by facilitating histone H3 ubiquitination at K57/80

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Asian Journal of Andrology 2024年第3期26卷 272-281页

作者： Bing-ya Xu Xiang-Ling Yu Wen-Xin Gao ting-ting Gao Hao-Yue Hu Tian-Tian Wu Cong Shen Xiao-yan Huang Bo Zheng Yi-Bo Wu Human Reproductive and Genetic Center Affiliated Hospital of Jiangnan UniversityWuxi 214122China State Key Laboratory of Reproductive Medicine Department of Histology and EmbryologySchool of Basic Medical SciencesNanjing Medical UniversityNanjing 211166China Changzhou Maternal and Child Health Care Hospital Changzhou Medical CenterNanjing Medical UniversityChangzhou 213000China State Key Laboratory of Reproductive Medicine Center for Reproduction and GeneticsSuzhou Municipal HospitalThe Affiliated Suzhou Hospital of Nanjing Medical UniversityGusu SchoolNanjing Medical UniversitySuzhou 215002China

RING finger 187(RNF187),a ubiquitin-ligating(E3)enzyme,plays a crucial role in the proliferation of cancer ***,it remains unclear whether RNF187 exhibits comparable functionality in the development of germline *** investigate thepotential involvement of RNF187 in germ cell development,we conducted interference and overexpression assays using GC-2 cells,a mouse spermatocyte-derived cell *** findings reveal that the interaction between RNF187 and histone H3 increases theviability,proliferation,and migratory capacity of GC-2 ***,we provide evidence demonstrating that RNF187 interactswith H3 and mediates the ubiquitination of H3 at lysine 57(K57)or lysine 80(K80),directly or indirectly resulting in increasedcellular *** is a study to report the role of RNF187 in maintaining the development of GC-2 cells by mediatinghistone H3 ubiquitination,thus highlighting the involvement of the K57 and K80 residues of H3 in the epistatic regulation of *** discoveries provide a new theoretical foundation for further comprehensive investigations into the functionof RNF187 in the reproductive system.

关键词： GC-2 cell histone H3 RNF187 ubiquitination

A possible probe to neutron-skin thickness by fragment parallel momentum distribution in projectile fragmentation reactions

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Nuclear Science and Techniques 2024年第6期35卷 114-119页

作者： Chun-Wang Ma Yi-Jie Duan ya-Fei Guo Chun-Yuan Qiao Yu-ting Wang Jie Pu Kai-Xuan Cheng Hui-Ling Wei College of Physics Henan Normal UniversityXinxiang 453007China Institute of Nuclear Science and Technology Henan Academy of SciencesZhengzhou 450015China

Neutron-skin thickness is a key parameter for a neutron-rich nucleus;however,it is difficult to *** the framework of the Lanzhou Quantum Molecular Dynamics(LQMD)model,a possible probe for the neutron-skin thickness(δ_(np))of neutron-rich ^(48)Ca was studied in the 140A MeV ^(48)Ca+^(9)Be projectile fragmentation reaction based on the parallel momentum distribution(p∥)of the residual fragments.A Fermi-type density distribution was employed to initiate the neutron density distributions in the LQMD simulations.A combined Gaussian function with different width parameters for the left side(Γ_(L))and the right side(Γ_(R))in the distribution was used to describe the p∥of the residual *** neutron-rich sulfur isotopes as examples,Γ_(L) shows a sensitive correlation withδ_(np) of ^(48)Ca,and is proposed as a probe for determining the neutron skin thickness of the projectile nucleus.

关键词： Neutron-skin thickness Projectile fragmentation Parallel momentum distribution Neutron-rich nucleus Quantum molecular dynamics model

Character Sheaves for Classical Graded Lie Algebras

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Acta Mathematica Sinica,English Series 2024年第3期40卷 870-884页

作者： ting XUE School of Mathematics and Statistics University of MelbourneVIC 3010Australia Department of Mathematics and Statistics University of HelsinkiHelsinki 00014Finland

In this note we study character sheaves for graded Lie algebras arising from inner automorphisms of special linear groups and Vinberg’s type Ⅱ classical graded Lie algebras.

关键词： Graded Lie algebras character sheaves Fourier transform nilpotent orbits

Salivary metabolites are promising noninvasive biomarkers of druginduced liver injury

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World Journal of Gastroenterology 2024年第18期30卷 2454-2466页

作者： Si-Miao Yu Hao-Cheng Zheng Si-Ci Wang Wen-ya Rong Ping Li Jing Jing ting-ting He Jia-Hui Li Xia Ding Rui-Lin Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology of Traditional Chinese Medicine The Fifth Medical Center of PLA General HospitalBeijing 100039China The First Clinical Medical College Henan University of Traditional Chinese MedicineZhengzhou 450000Henan ProvinceChina

BACKGROUND Drug-induced liver injury(DILI)is one of the most common adverse events of medication use,and its incidence is ***,early detection of DILI is a crucial challenge due to a lack of biomarkers and noninvasive *** To identify salivary metabolic biomarkers of DILI for the future development of noninvasive diagnostic *** Saliva samples from 31 DILI patients and 35 healthy controls(HCs)were subjected to untargeted metabolomics using ultrahigh-pressure liquid chromatography coupled with tandem mass *** analyses,including partial least squares-discriminant analysis modeling,t tests and weighted metabolite coexpression network analysis(WMCNA),were conducted to identify key differentially expressed metabolites(DEMs)and metabolite *** we utilized least absolute shrinkage and selection operato and random fores analyses for biomarker *** use of each metabolite and metabolite set to detect DILI was evaluated with area under the receiver operating characteristic *** We found 247 differentially expressed salivary metabolites between the DILI group and the HC *** WMCNA,we identified a set of 8 DEMs closely related to liver injury for further prediction ***,the distinct separation of DILI patients and HCs was achieved with five metabolites,namely,12-hydroxydodecanoic acid,3-hydroxydecanoic acid,tetradecanedioic acid,hypoxanthine,and inosine(area under the curve:0.733-1).CONCLUSION Salivary metabolomics revealed previously unreported metabolic alterations and diagnostic biomarkers in the saliva of DILI *** study may provide a potentially feasible and noninvasive diagnostic method for DILI,but further validation is needed.

关键词： Drug-Induced liver injury Salivary Metabolomics Biomarker Weighted metabolite Coexpression network analysis Machine learning Noninvasive Diagnostic method Metabolites