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Mesenchymal stem cells,extracellular vesicles,and transcranial magnetic stimulation for ferroptosis after spinal cord injury

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Neural Regeneration Research 2023年第9期18卷 1861-1868页

作者： Qi-Feng Song Qian Cui ya-shi wang Li-Xin Zhang Department of Rehabilitation Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Spinal cord injury is characte rized by diffe rent aetiologies,complex pathogenesis,and diverse pathological *** treatments are not ideal,and prognosis is generally *** spinal cord injury,neurons die due to various forms of cell *** them,fe rroptosis causes dysfunction after spinal cord injury,and no existing traditional treatments have been indicated to block its ***,emerging therapies using mesenchymal stem cells,extracellular vesicles,and transcranial magnetic stimulation therapy are promising for reve rsing spinal co rd neuronal ferroptosis after spinal cord ***,no definitive studies have demonstrated the effectiveness of these *** review summarizes the existing research on the mechanisms of ferroptosis;fe rroptosis after spinal cord injury;treatment of spinal cord injury with mesenchymal stem cells,extracellular vesicles,and transc ranial magnetic stimulation;and treatment of ferroptosis using mesenchymal stem cells,extracellular vesicles,and transc ranial magnetic *** ferroptosis can promote the reversal of neurological dysfunction after spinal cord *** addition,mesenchymal stem cells,extracellular vesicles,and transc ranial magnetic stimulation can reve rse adverse outcomes of spinal cord injury and regulate ferroptosis-related fa ***,it can be inferred that mesenchymal stem cells,extracellular vesicles,and transcranial magnetic stimulation have the potential to inhibit fe rroptosis after spinal cord *** review serves as a reference for future research to confirm these conclusions.

关键词： exosomes extracellular vesicles ferroptosis iron overload lipid peroxidation mesenchymal stem cells miRNAs spinal cord injury stem cells transcranial magnetic stimulation

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Protein-protein Interaction Between Domains of PDZ and BAR from PICK1

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Chemical Research in Chinese Universities 2007年第2期23卷 191-195页

作者： XIAO Hong shi ya-wei wang Li-li YUAN Jing-ming Institute of Biotechnology Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education Shanxi University Taiyuan 030006 P. R. China

Two DNA fragments encoding PDZ domain （21-110 residues） and BAR domain （ 150-360 residues） from PICK1 （1-416 residues） were amplified by PCR and then introduced into vectors, pET-32M and pMAL-e2X respectively to generate recombinant plasmids, pE-pdz and pM-bar. Having been separately transferred into the hosts E. coli BL21 and E. coli JM109, these two strains can express fusion proteins： His-tagged PDZ（PDZ domain） and maltose binding protein-BAR（ MBP-BAR domain） respectively, as confirmed by both SDS-PAGE and Wostem blotting. The interaction between these two domains is dose-dependence, as identified by a pull-down test. Moreover, it has been shown from the ELISA analysis that the actual amount of PDZ bound to MBP-BAR-amylose beads reaches （ 16 ± 0. 5）%, as calculated by the molar ratio of PDZ to MBP-BAR. In addition, the interaction between BAR（bait） and PDZ（prey） in vivo was also examined with a yeast two-hybrid system.

关键词： BAR domain PDZ domain PICK1 Protein-protein interaction Pull-down test Yeast two-hybrid

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Critical new insights into the interactions of hexafluoropropylene oxide-dimer acid(GenX or HFPO-DA)with albumin at molecular and cellular levels

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Journal of Environmental Sciences 2025年第3期149卷 88-98页

作者： shi-ya Peng ya-Di yang Rong Tian Naihao Lu Jiangxi Key Laboratory of Green Chemistry College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022China

A key characteristic to be elucidated,to address the harmful health risks of environmental perfluorinated alkyl substances(PFAS),is their binding modes to serum albumin,the most abundant protein in *** oxide-dimer acid(GenX or HFPO-DA)is a new industrial replacement for the widespread linear long-chain ***,the detailed interaction of new-generation short-chain PFAS with albumin is still ***,the binding characteristics of bovine serum albumin(BSA)to GenX were explored at the molecular and cellular *** found that this branched short-chain GenX could bind to BSA with affinity lower than that of legacy linear long-chain perfluorooctanoic acid(PFOA).Site marker competitive study and molecular docking simulation revealed that GenX interacted with subdomain IIIA to form BSA-GenX *** with its weaker affinity to albumin protein,the cytotoxicity of branched short-chain GenX was less susceptible to BSA binding compared with that of the linear long-chain *** contrast to the significant effects of strong BSA-PFOA interaction,the weak affinity of BSA-GenX binding did not influence the structure of protein and the cytotoxicity of *** detailed characterization and direct comparisons of serum albumin interaction with new generation short-chain GenX will provide a better understanding for the toxicological properties of this new alternative.

关键词： GenX Protein binding Albumin Cytotoxicity Risk assessment

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Delicate synthesis of quasi-inverse opal structural Na_(3)V_(2)(PO_(4))_(3)/N-C and Na4MnV(PO_(4))_(3)/N-C as cathode for high-rate sodium-ion batteries

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Rare Metals 2022年第5期41卷 1637-1646页

作者： Xin-Ran Qi Yuan Liu Lin-Lin Ma Bao-Xiu Hou Hong-Wei Zhang Xiao-Hui Li ya-shi wang Yi-Qing Hui Ruo-Xun wang Chong-yang Bai Hao Liu Jian-Jun Song Xiao-Xian Zhao Department of Chemistry College of ScienceHebei Agricultural UniversityBaoding 071001China College of Physics Qingdao UniversityQingdao 266071China Centre for Clean Energy Technology School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneySydney NSW 2007Australia

Poor conductivity and sluggish Na^(+) diffusion kinetic are two major drawbacks for practical application of sodium super-ionic conductor(NASICON) in sodium-ion batteries. In this work, we report a simple approach to synthesize quasi-inverse opal structural NASICON/N-doped carbon for the first time by a delicate one-pot solution-freeze drying-calcination process, aiming at fostering the overall electrochemical performance. Especially, the quasi-inverse opal structural Na_(3)V_(2)(PO_(4))_(3)/N-C(Q-NVP/N-C) displayed continuous pores, which provides interconnected channels for electrolyte permeation and abundant contacting interfaces between electrolyte and materials, resulting in faster kinetics of redox reaction and higher proportion of capacitive *** a cathode material for sodium-ion batteries, the Q-NVP/N-C exhibits high specific capacity of 115 mAh·g^(-1) at 1C, still 61 mAh·g^(-1) at ultra-high current density of 100C,and a specific capacity of 89.7mAh·g^(-1) after 2000 cycles at *** work displays the general validity of preparation method for not only Q-NVP/N-C,but also Na_(3)V_(2)(PO_(4))_(3),which provides a prospect for delicate synthesis of NASICON materials with excellent electrochemical performance.

关键词： Sodium battery Structural regulation Inverse opal structure Sodium super-ionic conductor(NASICON) Na_(3)V_(2)(PO_(4))_(3)

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Detection and Recognition of Spray Code Numbers on Can Surfaces Based on OCR

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Computers, Materials & Continua 2025年第1期82卷 1109-1128页

作者： Hailong wang Junchao shi School of Computer Science Zhongyuan University of TechnologyZhengzhou450007China

A two-stage algorithm based on deep learning for the detection and recognition of can bottom spray codes and numbers is proposed to address the problems of small character areas and fast production line speeds in can bottom spray code number *** the coding number detection stage,Differentiable Binarization Network is used as the backbone network,combined with the Attention and Dilation Convolutions Path Aggregation Network feature fusion structure to enhance the model detection *** terms of text recognition,using the Scene Visual Text Recognition coding number recognition network for end-to-end training can alleviate the problem of coding recognition errors caused by image color distortion due to variations in lighting and background *** addition,model pruning and quantization are used to reduce the number ofmodel parameters to meet deployment requirements in resource-constrained environments.A comparative experiment was conducted using the dataset of tank bottom spray code numbers collected on-site,and a transfer experiment was conducted using the dataset of packaging box production *** experimental results show that the algorithm proposed in this study can effectively locate the coding of cans at different positions on the roller conveyor,and can accurately identify the coding numbers at high production line *** Hmean value of the coding number detection is 97.32%,and the accuracy of the coding number recognition is 98.21%.This verifies that the algorithm proposed in this paper has high accuracy in coding number detection and recognition.

关键词： Can coding recognition differentiable binarization network scene visual text recognition model pruning and quantification transport model

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Bifurcations and Spatiotemporal Patterns in the Diffusive Nutrient-Microor ganism Model

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Acta Mathematicae Applicatae Sinica 2025年第1期41卷 162-178页

作者： ya-di wang Hai-long YUAN yan-ling LI School of Arts and Sciences Shaanxi University of Science and TechnologyXi'an 710021China School of Mathematics and Statistics Xi'an Jiaotong UniversityXi'an 710049China School of Mathematics and Information Science Shaanxi Normal UniversityXi'an 710062China

In this paper,the diffusive nutrient-microorganism model subject to Neumann boundary conditions is *** Hopf bifurcations and steady state bifurcations which bifurcate from the positive constant equilibrium of the system are investigated in *** addition,the formulae to determine the direction of Hopf and steady state bifurcations are *** results show the existence of spatially homogeneous/nonhomogeneous periodic orbits and steady state solutions,which indicates the spatiotemporal dynamics of the *** numerical simulations are also presented to support the analytical results.

关键词： nutrient-microorganism model Hopf bifurcation steady state bifurcation simulations

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Ecological security pattern construction using landscape ecological quality:A case study of yanchi County,northern China

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Journal of Arid Land 2025年第1期17卷 19-42页

作者： LI Junhao wang ya shi Gui PEI Xiaodong ZHANG Cong ZHOU Lihua yaNG Guojing Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China Institutes of Science and Development Chinese Academy of SciencesBeijing 100190China

Ecological security patterns are paramount to the advancement of an ecological civilization in China,aiming to enhance the stability and service functions of ecosystems to achieve sustainable regional ***,current regional ecological protection efforts have not been effectively integrated into the regional development planning of ecological security *** study systematically assessed the effectiveness of ecological protection projects in yanchi County,Ningxia Hui Autonomous Region,China,through the evaluation of landscape ecological *** on the evaluation results of landscape ecological quality,this study used morphological pattern analysis(MSPA),minimum cumulative resistance(MCR)model,and gravity model together to construct the ecological security pattern of yanchi *** findings revealed that from 1990 to 2020,with the implementation of ecological protection projects started from 2000,the landscape stability of yanchi County first decreased and then increased,and the intensity of landscape disturbance first intensified but then decreased,indicating an improvement in the landscape ecological quality and a significant enhancement of the ecological environment in yanchi *** ecological security pattern of yanchi County consisted of 10 ecological sources,10 ecological source points,23 ecological corridors,and 27 ecological *** ecological security pattern of yanchi County exhibited distinct spatial variations,with stronger ecological security observed in the southern part than in northern part of the *** ecological sources were denser in the southern part than in the northern part of the county,and accordingly,the length of ecological corridors was shorter and denser in the southern than that in the northern part of the *** on the spatial distribution of landscape ecological quality and the characteristics of ecological security pattern of yanchi County in 2020,we suggested yanchi County to build four zon

关键词： landscape ecological quality landscape stability landscape disturbance ecological network ecological source ecological corridor farming-pastoral area

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Engineering strategies of biomaterial-assisted exosomes for skin wound repair:Latest advances and challenges

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Chinese Chemical Letters 2025年第1期36卷 99-109页

作者： yang Xu Le Ma yang wang Chunmeng shi Institute of Rocket Force Medicine State Key Laboratory of Trauma and Chemical PoisoningThird Military Medical University(Army Medical University)Chongqing 400038China

The treatment of skin wounds,especially chronic wounds,remains a critical clinical challenge and places a heavy burden on patients and healthcare *** recent years,the engineering strategy of using biomaterial-assisted exosomes has emerged as a powerful tool for skin *** to treatments such as debridement and regular dressing changes,the design of biomaterial-assisted exosomes not only maintains the bioactivity of exosomes at the wound site but also provides an appropriate microenvironment for the repair of complex tissues,thereby accelerating wound *** review systematically introduces the general characteristics of exosomes and their functions in skin wound healing,highlights recent advances in classification of natural exosomes and engineering methods which enriching their functions in intercellular ***,various emerging and innovative approaches based on biomaterials delivery of exosomes are comprehensively *** review seeks to bring an in-depth understanding of bioactive dressings based on exosomes therapeutic strategies,aiming to facilitate new clinical application value.

关键词： Exosomes Biomaterials Hydrogel Delivery system Wound healing

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Selenium deficiency exacerbates ROS/ER stress mediated pyroptosis and ferroptosis induced by bisphenol A in chickens thymus

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Journal of Environmental Sciences 2025年第2期148卷 13-26页

作者： Kun wang Xu shi Hongjin Lin Tong Xu shiwen Xu College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Harbin 150030China

Bisphenol A(BPA)is an industrial pollutant that can cause immune *** acts as an antioxidant,as selenium deficiency often accompanies oxidative stress,resulting in organ *** study is the first to demonstrate that BPA and/or selenium deficiency induce pyroptosis and ferroptosis-mediated thymic injury in chicken and chicken lymphoma cell(MDCC-MSB-1)via oxidative stress-induced endoplasmic reticulum(ER)*** established a broiler chicken model of BPA and/or selenium deficiency exposure and collected thymus samples as research subjects after 42 *** results demonstrated that BPA or selenium deficiency led to a decrease in antioxidant enzyme activities(T-AOC,CAT,and GSH-Px),accumulation of peroxides(H2O2 and MDA),significant upregulation of ER stress-relatedmarkers(GRP78,IER 1,PERK,EIF-2α,ATF4,and CHOP),a significant increase in iron ion levels,significant upregulation of pyroptosis-related gene(NLRP3,ASC,Caspase1,GSDMD,IL-18 and IL-1β),significantly increase ferroptosis-related genes(TFRC,COX2)and downregulate GPX4,HO-1,FTH,*** vitro experiments conducted in MDCC-MSB-1 cells confirmed the results,demonstrating that the addition of antioxidant(NAC),ER stress inhibitor(TUDCA)and pyroptosis inhibitor(Vx765)alleviated oxidative stress,endoplasmic reticulum stress,pyroptosis,and ***,this study concludes that the combined effects of oxidative stress and ER stress mediate pyroptosis and ferroptosis in chicken thymus induced by BPA exposure and selenium deficiency.

关键词： Bisphenol A Selenium deficiency ROS/ER stress Pyroptosis Ferroptosis Thymic injury

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Effect of pyrite content on chalcopyrite flotation under different regrinding conditions

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 49-57页

作者： Zejun wang Qing shi Guofan Zhang Yuxuan Zhu Binbin Li School of Minerals Processing and Bioengineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Clean and Efficient Utilization of Strategic Calcium-containing Mineral Resources Central South UniversityChangsha 410083China

This study aimed to investigate the effect of varying pyrite(Py)content on copper(Cu)in the presence of different regrinding conditions,which were altered using different types of grinding media:iron,ceramic balls,and their mixture,followed by flotation in the cleaner *** flotation performance of rough Cu concentrate can be improved by changing the regrinding conditions based on the Py *** electron microscopy,X-ray spectrometry,ethylenediaminetetraacetic acid disodium salt extraction,and X-ray photoelectron spectroscopy studies illustrated that when the Py content was high,the use of iron media in regrinding promoted the generation of hydrophilic Fe OOH on the surface of Py and improved the Cu *** ceramic medium with a low Py content prevented excessive Fe OOH from covering the surface of chalcopyrite(Cpy).Electrochemical studies further showed that the galvanic corrosion current of Cpy-Py increased with the addition of Py and became stronger with the participation of iron media.

关键词： chalcopyrite regrinding media pyrite galvanic corrosion flotation

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