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Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice

Zoological Research 2021年第3期42卷 335-338页

作者： Teng-Yu Zhu Huan Qiu Qi-Qi Cao Zi-Lei Duan Feng-Liang Liu Tian-Zhang Song yang Liu ya-qun fang Guang-Ming Wu Yong-Tang Zheng Wen-Jun Ding Ren Lai Lin Jin College of Life Sciences Nanjing Agricultural UniversityNanjingJiangsu 210095China Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China Centre for Cell Lineage and Atlas Bioland LaboratoryGuangzhouGuangdong 510530China Laboratory of Environment and Health University of Chinese Academy of SciencesBeijing 100049China Kunming National High-level Biosafety Research Center for Non-Human Primates Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China

The global outbreak of coronavirus disease 2019(COVID-19),which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),as of 8 May 2021,has surpassed 150700000 infections and 3279000 deaths *** indicates that SARS-CoV-2 RNA can be detected on particulate matter(PM),and COVID-19 cases are correlated with levels of air ***,the mechanisms of PM involvement in the spread of SARS-CoV-2 remain poorly ***,we found that PM exposure increased the expression level of angiotensin-converting enzyme 2(ACE2)and transmembrane serine protease 2(TMPRSS2)in several epithelial cells and increased the adsorption of the SARS-CoV-2 spike *** of PM in a hACE2 mouse model significantly increased the expression of ACE2 and Tmprss2 and viral replication in the ***,PM exacerbated the pulmonary lesions caused by SARS-CoV-2 infection in the hACE2 *** conclusion,our study demonstrated that PM is an epidemiological factor of COVID-19,emphasizing the necessity of wearing anti-PM masks to cope with this global pandemic.

关键词： ACE2 infection involvement

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Foliar-applied zinc promotes cadmium allocation from leaf surfaces to grains in rice

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Journal of Environmental Sciences 2025年第5期151卷 582-593页

作者： ya-Ting Liu Bo-fang yan Xuan Cai Hong-Xiang Zheng Rong-Liang Qiu Ye-Tao Tang School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China Institute of Facility Agriculture Guangdong Academy of Agricultural SciencesGuangzhou 510640China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology Sun Yat-sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Agricultural&Rural Pollution Abatement and Environmental Safety College of Natural Resources and EnvironmentSouth China Agricultural UniversityGuangzhou 510642China

The accumulation of Cd by rice poses significant health *** fertilizationwith Zn can reduce grain Cd contents in rice grown in Cd-contaminated ***,atmospheric deposition on leaves is another vector of Cd contamination,and it remains unclear how Zn application affects the allocation of such *** conducted an experiment where the flag leaves of rice plants were treated with solutions with various Zn concentrations and a constant Cd *** 111Cd stable isotope was used to trace the flux of foliarapplied *** levels of foliar-applied Zn enhanced Cd efflux and grain *** is attributed to limited sequestration of foliar-applied Cd in the leaf cell symplasm and increased Cd desorption from leaf cell walls when a high Zn^(2+)concentration occurs in the *** Zn oxide nanoparticlesmitigated these ***,the expressions of OsLCT1 and OsZIP7 in flag leaves and OsHMA2 and OsZIP7 in the uppermost nodes were upregulated under high-Zn^(2+)treatment,which may facilitate Cd phloem loading and grain *** is advised in using foliar Zn in areas with high atmospheric Cd due to potential grain-contamination risks.

关键词： Atmospheric deposition Isotope labelling Metal interaction Phloem Cell wall

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Double[5]carbohelicene:facile synthesis,chiroptical properties,isomerization study,and lasing application

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Science China Chemistry 2025年第1期68卷 233-240页

作者： Peipei Liu yantong Li Meng-Xiang Wu Hao Kang Xiao-Li Zhao Lin Xu Linlin Liu Xiaodong Li Junfeng fang Zhiwei fang ya Cheng Hai-Bo yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular&Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China School of Physics and Electronic Science Engineering Research Center of Nanophotonics&Advanced InstrumentMinistry of EducationEast China Normal UniversityShanghai 200241China State Key Laboratory of Precision Spectroscopy School of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China Institute of Polymer Optoelectronic Materials&Devices State Key Laboratory of Luminescent Materials&DevicesSouth China University of TechnologyGuangzhou 510640China

Double carbohelicenes have attracted considerable attention due to their aesthetic structures,distinctπ-conjugation extension,inherent chirality,and intriguing optical and electronic ***,the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties,isomerization process and lasing application is presented.1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key *** is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM,which were successfully isolated and unambiguously confirmed by Xray *** optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography(HPLC),and 1-PP and 1-MM were characterized by circular ***,it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating,and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated.1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%.Consequently,we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously,which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm^(-2).We believe that our studies,including the facile synthesis methodology,detailed isomerization studies,and lasing application,will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词： double carbohelicene optical resolution organic laser isomerization X-ray diffraction

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Study on the Radiation Synthesis Mechanism and the Electrochemical Property of Polyaniline

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CHINESE JOURNAL OF POLYMER SCIENCE 2025年第2期43卷 328-340页

作者： yan, Shuo Guo, Zi-fang Ge, Zhi-Qing Zhang, Bao-Ying Zhang, ya-Ru Li, Yi-Shao Wang, Mo-Zhen Ge, Xue-Wu Univ Sci & Technol China Dept Polymer Sci & Engn State Key Lab Precis & Intelligent Chem Hefei 230026 Peoples R China Univ Sci & Technol China Sch Nucl Sci & Technol Hefei 230026 Peoples R China

As a highly promising conductive polymer material, the synthesis method, structure regulation, and performance improvement of polyaniline (PANI) are hot research topics. In this work, the radiation-induced polymerization of aniline in HNO3 solution was successfully achieved at room temperature without the use of chemical oxidants. Through the analysis of the radiation chemical reactions of inorganic acids and nitrate salt solutions, the characterization of the intermediate free radicals in the irradiated systems, and the influence of the pH of the solutions on the polymerization activity and product morphologies, the radiation-induced polymerization mechanism of aniline is discussed in detail and proposed. Only at a condition of [HNO3]>[aniline], i.e., pHNO3 generated by radiolysis reactions, and undergoes repeated three steps of monomer free radical recombination, deprotonation, and oxidation reaction of NO3, thus forming a PANI macromolecule. In addition to the polymerization reaction, the aniline units are protonated and oxidized because of the strongly acidity and oxidation of the reaction system under gamma-ray irradiation, which means that the molecular chain structure of the radiation-synthesized PANI can be regulated by pH, nitrate concentration, and irradiation conditions. Radiation-synthesized PANI has a moderate protonation and oxidation state, which can be used for the preparation of PANI supercapacitors with better electrochemical properties than those prepared by chemical oxidation under the same conditions. This work presents a new radiation-synthesis method and polymerization mechanism of PANI, which not only expands the application of radiation technique in the field of polymer synthesis, but also provides a new idea for the structural regulation and electrochemical p

关键词： Aniline Radiation-induced polymerization Polyaniline Electrochemical property

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Insights into microscopic oil occurrence characteristics in shales from the Paleogene Funing Formation in Subei Basin, China

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Petroleum Science 2025年第1期22卷 55-75页

作者： Jun-Jie Wang Peng-Fei Zhang Shuang-fang Lu Zi-Zhi Lin Wen-Biao Li Jun-Jian Zhang Wei-Zheng Gao Neng-Wu Zhou Guo-Hui Chen ya-Jie Yin Han Wu Sanya Offshore Oil & Gas Research Institute of Northeast Petroleum University College of Earth Science and Engineering Shandong University of Science and Technology Key Laboratory of Continental Shale Hydrocarbon Accumulation and Efficient Development Ministry of Education Northeast Petroleum University School of Geoscience China University of Petroleum (East China)

The microscopic occurrence characteristics primarily constrain the enrichment and mobility of shale *** study collected the lacustrine shales from the Palaeogene Funing Formation in the Gaoyou Sag, Subei Basin. Conventional and multistage Rock-Eval, scanning electron microscopy, and nuclear magnetic resonance(NMR) T1-T2were performed to analyze the contents and occurrence characteristics of shale oil. Low-temperature nitrogen adsorption-desorption(LTNA/D) experiments were conducted on the shales before and after extraction. The relationships between shale oil occurrence with organic matter and pore structures were then discussed. Predominantly, the shale oil in the Funing Formation is found within fractures, with secondary occurrences in interparticle pores linked to brittle minerals and sizeable intraparticle pores associated with clay minerals. The selected shales can be categorized into two types based on the nitrogen isotherms. Type A shales are characterized by high contents of felsic and calcareous minerals but low clay minerals, with larger TOC and shale oil values. Conversely, Type B shales are marked by abundant clay minerals but diminished TOC and shale oil contents. The lower BET specific surface area(SSA), larger average pore diameter, and simpler pore surfaces and pore structures lead to the Type A shales being more conducive to shale oil enrichment and mobility. Shale oil content is predominantly governed by the abundance of organic matter, while an overabundance of organic matter typically equates to a reduced ratio of free oil and diminished fluidity. The BET SSA, volumes of pores less than 25 and 100 nm at extracted state all correlate negatively with total and adsorbed oil contents but display no correlation with free oil, while they have positive relationships with capillary-bound ***, pore water is mainly saturated in micropores(<25 nm) and minipores(25-100 nm), as well as adsorbed oil, while free oil, i.e., bound and movable

关键词： Occurrence characteristic Shale oil content Pore structure Low-temperature nitrogen adsorption-desorption Gaoyou Sag

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子宫内膜息肉样病变三维超声图像特征与病理类型及性激素水平相关性分析

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中国超声医学杂志 2025年第1期41卷 93-97页

作者：田亚娜何颍利张晓华方群阜阳市妇女儿童医院超声科阜阳市第二人民医院检验科

目的探究三维超声与子宫内膜息肉(EP)样病变患者病理类型及性激素水平的相关性。方法回顾性选取收治的经病理确诊的EP样病变患者120例，区分患者病理类型，比较二维与三维超声诊断EP样病变的价值；根据病理诊断结果将患者分为良性组... 详细信息

目的探究三维超声与子宫内膜息肉(EP)样病变患者病理类型及性激素水平的相关性。方法回顾性选取收治的经病理确诊的EP样病变患者120例，区分患者病理类型，比较二维与三维超声诊断EP样病变的价值；根据病理诊断结果将患者分为良性组和恶性组，比较两组一般资料、三维超声检查及性激素检查结果，采用Pearson相关系数分析三维超声参数与性激素的关系，应用多因素Logistic回归模型分析EP样病变患者发生癌前病变和癌变的影响因素。结果 120例EP样病变患者中经病理检查确诊为癌前病变(不典型增生)10例、癌变(EP样癌)30例，总发生率为33.33%;三维超声诊断EP样病变的准确度高于二维超声(P10 mm的比例高于良性组，子宫动脉RI低于良性组，血清雌二醇(E2)高于良性组(P10 mm以及高血清E2水平是导致EP样病变患者发生恶性病变的独立危险因素(P10 mm以及E2水平升高是EP样病变患者发生癌前病变和癌变的独立危险因素。

关键词：三维超声子宫内膜息肉样病变病理类型性激素

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主体结构荷载可控的新型组合式防护结构(Ⅱ):影响因素及设计理念

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爆炸与冲击 2025年第1期45卷 16-27页

作者：方秦高矗孔祥振杨亚陆军工程大学爆炸冲击防灾减灾国家重点实验室江苏南京210007 内蒙古财经大学财政税务学院内蒙古呼和浩特010070

为明确泡沫混凝土厚度和强度对组合式防护结构抗爆性能的影响,充分发挥和合理利用泡沫混凝土良好的消波特性,首先通过试验及数值模拟探讨不同泡沫混凝土厚度和强度对组合式防护结构抗爆性能的影响,并分析分层梯度泡沫混凝土在爆炸波作... 详细信息

为明确泡沫混凝土厚度和强度对组合式防护结构抗爆性能的影响,充分发挥和合理利用泡沫混凝土良好的消波特性,首先通过试验及数值模拟探讨不同泡沫混凝土厚度和强度对组合式防护结构抗爆性能的影响,并分析分层梯度泡沫混凝土在爆炸波作用下的消波特性。然后将组合式防护结构与采用中粗砂为分配层的传统成层式结构进行对比分析验证其优越性,在此基础上,总结凝练出组合式防护结构的主体结构荷载可控的设计理念。结果表明,利用泡沫混凝土材料较长的屈服平台和较低的波阻抗,以泡沫混凝土作为能量调控层,通过设计泡沫混凝土强度等级(密度等级)和厚度以及采用多层梯度泡沫混凝土,可使得作用于主体结构上的爆炸荷载峰值恰为泡沫混凝土屈服强度,实现对主体结构上荷载的可控设计,有效解决了中粗砂为分配层的传统成层式结构不易控制作用于主体结构上荷载的问题。研究结果可为抗新型钻地弹的防护设计提供重要参考。

关键词：泡沫混凝土组合式防护结构可控设计爆炸波消波

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Analysis on Dissociation of Pyramidal I Dislocation in Magnesium by Generalized-Stacking-Fault Energy

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Acta Metallurgica Sinica(English Letters) 2015年第7期28卷 876-882页

作者： qun Zu ya-fang Guo Xiao-Zhi Tang Institute of Engineering Mechanics Beijing Jiaotong University

The generalized-stacking-fault energies are calculated to illustrate the dissociation of〈c＋a〉dislocation on pyramidal I plane in *** c surfaces of {1011} plane and its adjacent planes {3034} and {3032} are presented using Liu embedded-atom-method potential method,and one possible dissociation path of 1/3{1123} dislocation on {1011} plane with minimum energy is ***,another two reasonable dissociation paths of 1/3{1123} dislocation successively on {3034} and {3032} planes are also ***,based on molecular dynamics simulations of magnesium single crystals under c-axis compression,the possible slip path is further examined and discussed.

关键词： Generalized-stacking-fault energies (GSFEs) Molecular dynamics (MD) 〈c + a〉 slip Dissociation Magnesium

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What is the role of nonalcoholic fatty liver disease in pulmonary carcinoma development?

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World Journal of Gastroenterology 2025年第5期31卷 7-12页

作者： Qin Pan Qing-yang Xu Lang-Hua Zhang ya-fang He Shanghai Institute of Pediatric Research Shanghai Key Laboratory of Pediatric Gastroenterology and NutritionXinhua HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200092China Department of Gastroenterology Xinhua HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200092China School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of Gastroenterology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina School of Medical Technology Shanghai University of Medicine and Health SciencesShanghai 201318China Department of Pediatric Respiratory Xinhua HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200092China

This article summarizes the epidemiological characteristics and clinical manifest-ations of nonalcoholic fatty liver disease(NAFLD).The incidence of NAFLD has been increased dramatically and become the leading cause of chronic liver disease *** addition to its adverse outcomes of liver fibrosis,cirrhosis,and hepatocellular carcinoma,and related complications,NAFLD has recently been found to be associated with the high-risk extrahepatic carcinomas,such as various types of lung cancer(i.e.,lung adenocarcinoma,squamous cell carcinoma,and small cell lung cancer).The presence of hepatic steatosis also predisposes lung cancer to liver metastasis,but has better response to immune checkpoint *** other factors(i.e.,gender,smoking,etc.)are associated with NAFLD and lung cancer remains *** also comment on the reciprocal rela-tionships between NAFLD and components of metabolic *** meta-bolic syndrome components are suggested to facilitate lung cancer development via activating insulin/insulin-like growth factor *** addition,suppressed anti-tumor immunity and accelerated tumor progression could be attributed to the cell-specific metabolic reprogramming in condition of high-fat diet and related *** findings may reveal the role of NAFLD in pulmonary carcinoma and help develop new treatment strategies for this disease.

关键词： Nonalcoholic fatty liver disease Lung Cancer Adenocarcinoma Metabolic syndrome Component

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数字体育赋能大学生体质健康发展研究

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湖北开放职业学院学报 2025年第2期38卷 151-153页

作者：房亚群万辉艳江苏食品药品职业技术学院基础教学部江苏淮安223003

在数字技术与学校体育深度融合的趋势下,以学生体质健康促进政策为导向,利用体质健康测试大数据、云计算等媒介手段,探讨大学生体质健康促进实施路径的新方向。依托数字体育的生态拓展能力,以学生发展为导向,通过践行“数字+体育”的健... 详细信息

在数字技术与学校体育深度融合的趋势下,以学生体质健康促进政策为导向,利用体质健康测试大数据、云计算等媒介手段,探讨大学生体质健康促进实施路径的新方向。依托数字体育的生态拓展能力,以学生发展为导向,通过践行“数字+体育”的健康第一理念,发挥数字素养教育效能,来论证数字化体质健康测试、体育场馆服务转型、高校体育云赛事发展、数字技术与课程教学深度融合等路径的现实价值。通过闭环式大学生体质健康数字化促进方案,激发大学生参加体育锻炼活动的内部动机,为高校大学生体质健康促进新模式的构建与革新提供理论借鉴与思考。

关键词：数字体育大学生体质健康

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