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Predictive value of neutrophil-to-lymphocyte ratio in coronary chronic total occlusion patients

Journal of Geriatric Cardiology 2024年第5期21卷 542-549页

作者： Qian LI Yue YU ya-qiong zhou Yi ZHAO Jin WU Yuan-Jing WU Bin DU Pei-Jian WANG Tao ZHENG Department of Cardiovascular Medicine the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Department of Cardiology First Affiliated Hospital of Chengdu Medical CollegeChengduChina Department of Neurology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina

BACKGROUND The neutrophil to lymphocyte ratio(NLR)has been reported as a novel predictor for atherosclerosis and car-diovascular *** study aimed to determine the effects of NLR on long-term clinical outcomes of chronic total occlusion(CTO)*** A total of 670 patients with CTO who met the inclusion criteria were included at the end of the follow-up *** were divided into tertiles according to their baseline NLR levels at admission:low(n=223),intermediate(n=223),and high(n=224).The incidence of major adverse cardiac events(MACEs)during the follow-up period,including all-cause death,nonfatal myocardial infarction(MI),or ischemia-driven revascularization,were compared among the three *** Major adverse cardiac events were observed in 27 patients(12.1%)in the low tertile,40(17.9%)in the intermediate tertile,and 61(27.2%)in the high NLR tertile(P<0.001).Kaplan-Meier analysis demonstrated a significantly higher incidence of MACE,ischemia-driven coronary revascularization,non-fatal MI,and mortality in patients within the high tertile than those in the low and intermediate groups(all P<0.001).Multivariable COX regression analysis showed that the high tertile of baseline NLR level showed a strong association with the risk of MACE(hazard ratio[HR]=2.21;95%confidence interval[CI]:1.21-4.03;P=0.009),ischemia-driven coronary revascularization(HR=3.19;95%CI:1.56-6.52;P=0.001),MI(HR=2.61;95%CI:1.35-5.03;P=0.043)and mortality(HR=3.78;95%CI:1.65-8.77;P=0.001).CONCLUSION Our findings suggest that NLR is an inexpensive and readily available biomarker that can independently pre-dict cardiovascular risk in patients with CTO.

关键词： patients coronary occlusion

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Fabricating functionally graded Fe-Cr-Co permanent magnetic alloys via laser powder bed fusion

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Journal of Iron and Steel Research(International) 2024年第3期31卷 729-737页

作者： ya-zhou He ya-qing Hou Peng Shen Hao Zhang Dong zhou Hang Su Central Iron and Steel Research Institute Co. Ltd.Beijing 100081China Material Digital R&D Center China Iron and Steel Research Institute Group Co.Ltd.Beijing 100081China

Laser powder bed fusion(LPBF)in-situ alloying technology offers the possibility to construct gradient materials with varied structures and *** graded Fe-Cr-Co permanent magnetic alloys were fabricated by LPBF and in-situ alloying mixed powders of Fe,Cr,and Co *** effects of different Fe,Cr and Co contents on the microstructure,magnetic properties and hardness of Fe-Cr-Co alloys prepared by LPBF were *** as-built Fe-Cr-Co alloys present a single body-centered-cubic phase and have a homogeneous distribution of *** mechanical properties and magnetic properties of the compositionally graded sample show a gradient *** the increase in Cr content,the Vickers hardness of the sample increases,and the saturation magnetization of the sample *** optimal magnetic properties in an isotropic state are given as coercivity HcB=21.65 kA/m,remanence Br=0.70 T and energy product(BH)_(max)=5.35 kJ/m^(3),which are comparable to or higher than the reported magnetic properties in an isotropic state prepared by traditional powder *** in-situ alloying technology has the potential to further explore Fe-Cr-Co magnetic materials,such as those consisting of multiple or more constituent elements,and to maximize the compositional flexibility of magnetic materials.

关键词： Fe-Cr-Co alloy Laser powder bed fusion In-situ alloying Functional material Magnetic property

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Oxidation behavior of 4774DD1 Ni-based single-crystal superalloy at 980℃ in air

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China Foundry 2024年第2期21卷 116-124页

作者： Yu Fang ya-zhou Li Qiang yang Qun-gong He Xiu-fang Gong Qian Duan Hai-yang Song Fu Wang qiong-yuan Zhang Hong Zeng State Key Laboratory of Long-Life High Temperature Materials Dongfang Turbine Co.Ltd.Deyang 618000SichuanChina State Key Laboratory for Manufacturing System Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China

The oxidation behavior of a novel Ni-based single-crystal 4774DD1 superalloy for industrial gas turbine applications was investigated by the isothermal oxidation at 980℃ and discontinuous oxidation weight gain *** phase constitution and morphology of surface oxides and the characteristics of the crosssection oxide film were analyzed by XRD,SEM and *** show that the oxidation kinetics of the 4774DD1 superalloy follows the cubic law,indicating its weak oxidation resistance at this *** the oxidation time increases,the composition of the oxide film evolves as following:One layer consisting of a bottom Al_(2)O_(3)sublayer and an upper(Al_(2)O_(3)+NiO)mixture sublayer after oxidized for 25 ***,two layers composed of an outermost small NiO discontinuous grain layer and an internal layer for 75 *** internal layer is consisted of the bottom Al_(2)O_(3)sublayer,an intermediate narrow CrTaO_(4)sublayer,and an upper(Al_(2)O_(3)+NiO)mixture *** two layers comprising an outermost relative continuous NiO layer with large grain size and an internal layer as the oxidation time increases to 125 *** internal layer is composed of the upper(Al_(2)O_(3)+NiO)mixture sublayer,an intermediate continuous(CrTaO_(4)+NiWO_(4))mixture sublayer,and a bottom Al_(2)O_(3)***,three layers consisting of an outermost(NiAl2O_(4)+NiCr2O_(4))mixture layer,an intermediate(CrTaO_(4)+NiWO_(4))mixture layer,and a bottom Al_(2)O_(3)layer for 200 h.

关键词： nickel-base single crystal superalloy oxidation kinetics oxide film microstructure mechanism

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A Cross-matching Service for Data Center of Xinjiang Astronomical Observatory

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Research in Astronomy and Astrophysics 2024年第1期24卷 119-127页

作者： Hai-Long Zhang Jie Wang Xin-Chen Ye Wan-qiong Wang Jia Li ya-zhou Zhang Xu Du Han Wu Ting Zhang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Cross-matching is a key technique to achieve fusion of multi-band astronomical catalogs. Due to different equipment such as various astronomical telescopes, the existence of measurement errors, and proper motions of the celestial bodies, the same celestial object will have different positions in different catalogs, making it difficult to integrate multi-band or full-band astronomical data. In this study, we propose an online cross-matching method based on pseudo-spherical indexing techniques and develop a service combining with high performance computing system(Taurus) to improve cross-matching efficiency, which is designed for the Data Center of Xinjiang Astronomical Observatory. Specifically, we use Quad Tree Cube to divide the spherical blocks of the celestial object and map the 2D space composed of R.A. and decl. to 1D space and achieve correspondence between real celestial objects and spherical patches. Finally, we verify the performance of the service using Gaia 3 and PPMXL catalogs. Meanwhile, we send the matching results to VO tools-Topcat and Aladin respectively to get visual results. The experimental results show that the service effectively solves the speed bottleneck problem of crossmatching caused by frequent I/O, and significantly improves the retrieval and matching speed of massive astronomical data.

关键词： virtual observatory tools astronomical databases:miscellaneous catalogs

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METTL5 promotes gastric cancer progression via sphingomyelin metabolism

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1925-1946页

作者： ya-qiong Zhang Jian Li Zhe Qin De-Ming Li Fang-zhou Ye Song-Hua Bei Xiao-Hong Zhang Li Feng Endoscopy Center Minhang Hospital Affiliated to Fudan UniversityShanghai 201100China

BACKGROUND The treatment of gastric cancer(GC)has caused an enormous social burden *** studies have reported that N6-methyladenosine(m6A)is closely related to tumor ***5 is a m6A methyltransferase that plays a pivotal role in maintaining the metabolic stability of ***,its aberrant regulation in GC has not been fully *** To excavate the role of METTL5 in the development of *** METTL5 expression and clinicopathological characteristics were analyzed via The Cancer Genome Atlas dataset and further verified via immunohistochemistry,western blotting and real-time quantitative polymerase chain reaction in tissue microarrays and clinical *** tumor-promoting effect of METTL5 on HGC-27 and AGS cells was explored in vitro by Cell Counting Kit-8 assays,colony formation assays,scratch healing assays,transwell assays and flow *** tumor-promoting role of METTL5 in vivo was evaluated in a xenograft tumor *** EpiQuik m6A RNA Methylation Quantification Kit was used for m6A ***,liquid chromatography-mass spectrometry was used to evaluate the association between METTL5 and sphingomyelin metabolism,which was confirmed by Enzyme-linked immunosorbent assay and rescue *** addition,we investigated whether METTL5 affects the sensitivity of GC cells to cisplatin via colony formation and transwell *** Our research revealed substantial upregulation of METTL5,which suggested a poor prognosis of GC *** METTL5 expression indicated distant lymph node metastasis,advanced cancer stage and pathological *** increased level of METTL5 correlated with a high degree of m6A ***5 markedly promotes the proliferation,migration,and invasion of GC cells in ***5 also promotes the growth of GC in animal ***5 knockdown resulted in significant changes in sphingomyelin metabolism,which implies that METTL5 may impact the development of GC via sphin

关键词： Gastric cancer METTL5 Sphingomyelin metabolism Cisplatin

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Stability of the Phase Separation State for Compressible Navier-Stokes/Allen-Cahn System

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 45-74页

作者： ya-zhou Chen Hakho Hong Xiao-ding Shi Department of Mathematics College of Mathematics and PhysicsBeijing University of Chemical TechnologyBeijing100029China Institute of Mathematics State Academy of SciencesPyongyangKorea

This paper is concerned with the large time behavior of the Cauchy problem for Navier-Stokes/AllenCahn system describing the interface motion of immiscible two-phase flow in 3-D. The existence and uniqueness of global solutions and the stability of the phase separation state are proved under the small initial perturbations. Moreover, the optimal time decay rates are obtained for higher-order spatial derivatives of density,velocity and phase. Our results imply that if the immiscible two-phase flow is initially located near the phase separation state, then under small perturbation conditions, the solution exists globally and decays algebraically to the complete separation state of the two-phase flow, that is, there will be no interface fracture, vacuum, shock wave, mass concentration at any time, and the interface thickness tends to zero as the time t → +∞.

关键词： Navier-Stokes/Allen-Cahn system existence uniqueness large time behavior decay rate

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Advanced Machine Learning Methods for Prediction of Blast-Induced Flyrock Using Hybrid SVR Methods

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1595-1617页

作者： Ji zhou Yijun Lu qiong Tian Haichuan Liu Mahdi Hasanipanah Jiandong Huang College of Civil and Environmental Engineering Hunan University of Science and EngineeringYongzhou425006China Hunan Provincial Key Laboratory of Intelligent Protection and Utilization Technology in Masonry Artifacts Hunan University of Science and EngineeringYongzhou425006China School of Civil Engineering Guangzhou UniversityGuangzhou510006China Institute of Research and Development Duy Tan UniversityDa Nang550000Vietnam School of Engineering&Technology Duy Tan UniversityDa Nang550000Vietnam

Blasting in surface mines aims to fragment rock masses to a proper ***,flyrock is an undesirable effect of blasting that can result in human *** this study,support vector regression(SVR)is combined with four algorithms:gravitational search algorithm(GSA),biogeography-based optimization(BBO),ant colony optimization(ACO),and whale optimization algorithm(WOA)for predicting flyrock in two surface mines in ***,three other methods,including artificial neural network(ANN),kernel extreme learning machine(KELM),and general regression neural network(GRNN),are employed,and their performances are compared to those of four hybrid SVR *** modeling,the measured and predicted flyrock values are validated with some performance indices,such as root mean squared error(RMSE).The results revealed that the SVR-WOA model has the most optimal accuracy,with an RMSE of 7.218,while the RMSEs of the KELM,GRNN,SVR-GSA,ANN,SVR-BBO,and SVR-ACO models are 10.668,10.867,15.305,15.661,16.239,and 18.228,***,combining WOA and SVR can be a valuable tool for accurately predicting flyrock distance in surface mines.

关键词： Flyrock induced by blasting optimization algorithms SVR GRNN

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Integrated interconnected porous and lamellar structures realized fast ion/electron conductivity in high-performance lithium-sulfur batteries

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Chinese Chemical Letters 2024年第6期35卷 161-167页

作者： ya Song Mingxia zhou Zhu Chen Huali Nie Jiao-Jing Shao Guangmin zhou School of Materials and Metallurgy Guizhou UniversityGuiyang 550025China Medical College of Guizhou University Guiyang 550025China College of Biological Science and Medical Engineering Donghua UniversityShanghai 201620China Shenzhen Geim Graphene Center Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China

The practical application of high-energy-density lithium-sulfur(Li-S)batteries have been highly praised for energy storage devices,while are largely hindered by the“shuttling effect”.Herein,core-shell carbon spheres composed of interlinked porous core and lamellar shell were designed to restrain the polysulfide *** microporous structure with pore size of around 1 nm effectively trap lithium ***,the interconnected porous core shortens the ion transfer distance and the lamellar carbon shell endows the carbon spheres with fast electron conduction,finally facilitating polysulfide conversion ***,the Li-S batteries with the carbon spheres as the interlayer show high discharge specific capacity of 1002 m Ah/g at 2 C with 574 m Ah/g remaining after 600 cycles,and high areal capacity of 5.48 m Ah/cm^(2) with sulfur loading of 4.67 mg/cm^(2) at 0.1 *** corresponding pouch cells also exhibit stable cycling stability with an initial discharge specific capacity of 1082 m Ah/g at 0.1 C.

关键词： Interlayer Shuttle effect Strong adsorption Porous carbon spheres Lithium-sulfur batteries

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In-situ SEM characterization of fracture mechanism of TiB/Ti-2Al-6Sn titanium matrix composites after electroshocking treatment

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Rare Metals 2024年第6期43卷 2805-2818页

作者： ya-ya Wu Jian zhou Guo-Lei Han yan Wen zhou Wang Li-Qiang Wang Wei-Jie Lv Le-Chun Xie Lin Hua Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan 430070China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

In this article,in-situ scanning electron microscope characterization of the tensile properties of TiB/Ti-2Al-6Sn titanium matrix composite(TMC)was conducted before and after electroshocking treatment(EST).After EST,the tensile strength increased by 113.2 *** effect of EST on the tensile strength and fracture behavior of TiB was investigated using in-situ characterization of the fracture morphology and crack propagation path of the matrix and *** EST,TiB fracture introduced cracks that extended into the matrix,resulting in material *** EST,the refined TiB improved the bearing capacity of the matrix,thereby improving TMC ***,after EST,the cracks were introduced into the matrix,and resulting the fracture of matrix *** an increase in the external load,cracks in the matrix were observed to propagate to TiB,and the refined TiB was fractured,detached,and pulled out,resulting in the formation of *** the propagation path of the main crack after EST showed that the deflection angle of the main crack *** micro structure of the fracture surface indicated that the fracture of the matrix was plastic,whereas that of TiB was *** EST,the size and area of the dimples increased,confirming the increase in *** results revealed that the comprehensive mechanical properties of TiB/Ti-2Al-6Sn improved after ***,EST is an efficient method for tailoring the micro structures and mechanical properties of TMCs.

关键词： TiB/Ti-2Al-6Sn In-situ microstructure characterization Tensile properties Reinforcement Electroshocking treatment(EST)

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Simulation and Analysis of Cascading Faults in Integrated Heat and Electricity Systems Considering Degradation Characteristics

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Energy Engineering 2024年第3期121卷 581-601页

作者： Hang Cui Hongbo Ren qiong Wu Hang Lv Qifen Li Weisheng zhou College of Energy and Mechanical Engineering Shanghai University of Electric PowerShanghai200090China Shanghai Non-Carbon Energy Conversion and Utilization Institute Shanghai200240China College of Policy Sciences Ritsumeikan UniversityKyoto603-8577Japan

Cascading faults have been identified as the primary cause of multiple power outages in recent *** the emergence of integrated energy systems(IES),the conventional approach to analyzing power grid cascading faults is no longer appropriate.A cascading fault analysis method considering multi-energy coupling characteristics is of vital *** this study,an innovative analysis method for cascading faults in integrated heat and electricity systems(IHES)is *** considers the degradation characteristics of transmission and energy supply com-ponents in the system to address the impact of component aging on cascading ***,degradation models for the current carrying capacity of transmission lines,the water carrying capacity and insulation performance of thermal pipelines,as well as the performance of energy supply equipment during aging,are ***,a simulation process for cascading faults in the IHES is *** utilizes an overload-dominated development model to predict the propagation path of cascading faults while also considering network islanding,electric-heating rescheduling,and load *** propagation of cascading faults is reflected in the form of fault ***,the results of cascading faults under different aging levels are analyzed through numerical examples,thereby verifying the effectiveness and rationality of the proposed model and method.

关键词： Cascading fault degradation characteristics integrated heat and electricity system multi-energy flow

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