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Effects of early rehabilitation in improvement of paediatric burnt hands function

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World Journal of Clinical Cases 2021年第32期9卷 9741-9751页

作者： ya-qin zhou Jun-Yi zhou Gao-Xing Luo Jiang-Lin Tan Institute of Burn Research State Key Laboratory of TraumaBurns and Combined InjuriesChongqing Key Laboratory for Disease ProteomicsSouthwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400038China

BACKGROUND Hands are one of the most common burn sites in *** scar contractures in hands after wound healing result in further reductions in their range of motion(ROM),motility,and fine motor *** can improve the function of *** the optimal time of rehabilitation intervention is still ***,this study was designed to investigate the effects of early rehabilitation management of paediatric burnt hands and to compare the efficacy between early and later rehabilitation *** To investigate the effects of early rehabilitation management of paediatric burnt *** A total of 52 children with burnt hands were allocated into the early intervention group(≤1 mo from onset)and a late intervention group(>1 mo from onset)between January 2016 and December *** children received the same rehabilitation programme including skin care,scar massage,passive ROM exercises,active ROM exercises,compression therapy,orthotic devices wearing and game or music *** assessments were performed before and after the rehabilitation *** In the early intervention group,the ROM of the hands was significantly improved after rehabilitation(P=0.001).But in the late group the effect was not significant statistically(P=0.142).In the early group,38.5%of the patients showed significant improvement,while in the late group,69.2%of the patients showed no significant *** time from onset to posttraumatic rehabilitation(P=0.0007)and length of hospital stay(P=0.003)were negatively correlated with the hand function *** length of rehabilitation stay was positively correlated with the hand function improvement(P=0.005).CONCLUSION These findings suggest that early rehabilitation might show better results in terms of ROM.

关键词： Burns Children Rehabilitation Range of motion Hand flexion Hand extension

Aqueous angiopoietin-like levels correlate with optical coherence tomography angiography metrics in diabetic macular edema

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International Journal of Ophthalmology(English edition) 2021年第12期14卷 1888-1894页

作者： Jie yan Wu-Jun Li ya-zhou qin Xuan-Yu Qiu Li qin Jing-Ming Li Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Ophthalmology Yulin Hospital of Traditional Chinese MedicineYulin 719000Shaanxi ProvinceChina

AIM:To quantitatively detect aqueous levels of angiopoietin-like(ANGPTL)3,ANGPTL4,and ANGPTL6 and investigate their correlation with optical coherence tomography angiography(OCTA)findings in patients with diabetic macular edema(DME).METHODS:This cross-sectional study included 23 patients(27 eyes)with type 2 diabetes and 16 control subjects(20 eyes).All patients underwent OCTA imaging and ultra-wide field fundus *** patients were categorized into two groups according to the presence or absence of diabetic retinopathy(DME group,14 patients,16 eyes);and non-diabetic retinopathy(NDR)group,9 patients,11 eyes,*** levels of ANGPTL3,ANGPTL4,and ANGPTL6 were assessed using suspension array technology,and foveal-centered 3×3 mm2 OCTA scans were automatically graded to determine the central,inner,and full vessel density(CVD,IVD,FVD);central,inner,and full perfusion density(CPD,IPD,FPD),foveal avascular zone(FAZ)area,FAZ perimeter,and FAZ circularity index(FAZ-CI)on superficial capillary ***,central subfield thickness(CST),cube volume(CV),and cube average thickness(CAT)were measured in a model of macular cube 512×***:Aqueous ANGPTL3 levels were not significantly different among the three groups(P>0.05).ANGPTL4 levels were significantly higher in the DME group than the control and NDR groups(P<0.0001 and P<0.001),while ANGPTL6 levels were significantly higher in the DME group than the control group(P<0.05).In the whole cohort,the aqueous ANGPTL3 levels correlated negatively with the IVD,FVD,IPD,and FPD,and positively with the CV and *** aqueous ANGPTL4 levels correlated negatively with the CVD,IVD,FVD,CPD,IPD,and FPD,and positively with the FAZ perimeter,CST,CV,and *** aqueous ANGPTL6 levels correlated negatively with the IVD,FVD,IPD,FPD,FAZCI and positively with CST,CV,***:ANGPTL4 and ANGPTL6 may be associated with vascular leakage in DME and may represent good targets for DME *** addition,OCT

关键词： diabetic retinopathy diabetic macular edema optical coherence tomography angiography angiopoietin-like vascular leakage

Acetylcholinesterase inhibition ameliorates retinal neovascularization and glial activation in oxygen-induced retinopathy

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International Journal of Ophthalmology(English edition) 2020年第9期13卷 1361-1367页

作者： Qiu-Ping Liu Xian Zhang ya-zhou qin Jing-Lin Yi Jing-Ming Li Affiliated Eye Hospital of Nanchang University Nanchang 330006Jiangxi ProvinceChina Department of Ophthalmology First Affiliated Hospital of Xi'an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

AIM:To investigate whether inhibition of acetylcholinesterase(AChE)by donepezil ameliorate aberrant retinal neovascularization(RNV)and abnormal glial activation in oxygen-induced retinopathy(OIR).METHODS:A mouse model of RNV was induced in postnatal day 7(P7)mice by exposure to 75%*** was administrated to P12 mice by intraperitoneal *** and localization of AChE in mouse retinas were determined by *** was evaluated by paraffin sectioning and hematoxylin and eosin(HE)*** of retinal M uller glial cells were examined by immunoblot of glial fibrillary acidic protein(GFAP).rMC-1.a retinal Muller cell line,was used for in vitro *** of hypoxia-induced factor 1α(HIF-1α)and vascular endothelial growth factor(VEGF)were determined by Western-blot analysis,enzyme-linked immunosorbent assay(ELISA)or ***:Aberrant RNV and glial activation was observed after *** note,retinal AChE was mainly expressed by retinal Muller glial cells and markedly increased in OIR *** administration of donepezil significantly reduced RNV and abnormal glial activation in mice with ***,ischemia-induced HIF-1αaccumulation and VEGF upregulation in OIR mouse retinas and cultured rMC-1 were significantly inhibited by donepezil ***:AchE is implicated in RNV with *** of AChE by donepeizl is likely to be a potential therapeutic approach for retinal neovascular diseases.

关键词： acetylcholinesterase oxygen-induced retinopathy neovascularization glosis mice

Comparison of intravitreal aflibercept and dexamethasone implant in the treatment of macular edema associated with diabetic retinopathy or retinal vein occlusion:a Meta-analysis and systematic review

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1511-1519页

作者： Xuan-Yu Qiu Xiao-Fei Hu ya-zhou qin Ji-Xian Ma Qiu-Ping Liu Li qin Jing-Ming Li Department of Ophthalmology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Vitreoretinal Department Affiliated Eye Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

·AIM:To compare the efficacy and safety of intravitreal aflibercept with dexamethasone implant in the treatment of macular edema(ME)associated with diabetic retinopathy(DR)or retinal vein occlusion(RVO).·METHODS:A comprehensive search of studies comparing dexamethasone and aflibercept in patients with ME was conducted at PubMed,Embase,and Cochrane Central Register of Controlled Trials from the beginning of library to April 16,*** the data including bestcorrected visual acuity(BCVA),central retinal thickness(CRT),number of injections and serious adverse events(SAEs)from the final qualified *** 5.3 software was used for Meta-analysis of the included studies.·RESULTS:Totally 7 studies with 369 eyes were *** causes of ME in the final screening study included RVO and *** with the aflibercept treatment group,the BCVA of the dexamethasone implant treatment group showed no significant difference in the follow-up for 3 mo[mean difference(MD):-0.05,95%confidence interval(CI):-0.11,0.02;P=0.17]and 12 mo(MD:-0.01,95%CI:-0.38,0.37;P=0.98),but it was slightly worse than the aflibercept group at 6 mo(MD:0.12.95%CI:0.03,0.21;P=0.008).In terms of CRT reduction,there was no significant difference between the two groups at 3 mo(MD:-28.14,95%CI:-79.95,23.67;P=0.29),6 mo(MD:27.67,95%CI:-84.89,140.24;P=0.63),and 12 mo(MD:-59.00,95%CI:-127.37,9.37;P=0.09).However,dexamethasone implant had fewer injections,but more adverse events such as elevated intraocular pressure(IOP)and cataract.·CONCLUSION:Intravitreal injection of aflibercept and dexamethasone implant can both effectively increase BCVA and reduce *** with aflibercept,dexamethasone implant is not inferior in improving vision and reducing CRT in the initial treatment period(3 mo)and long-term treatment period(12 mo).Besides,it has fewer injections and more likely to cause elevated IOP and cataract.

关键词： Meta-analysis macular edema dexamethasone aflibercept best-corrected visual acuity central retinal thickness

土体各向异性边界面模型隐式算法在ABAQUS软件中的实现

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岩土力学 2012年第1期33卷 307-313页

作者：钦亚洲孙钧同济大学岩土及地下工程教育部重点实验室上海200092 杭州丰强土建工程研究院杭州310006

基于Wheeler土体各向异性旋转硬化法则,结合边界面理论,构造一个能够反映土体初始各向异性及加载后应力诱发各向异性的边界面本构模型,并借助ABAQUS软件提供的UMAT子程序接口,采用隐式积分算法——图形返回算法实现。通过对正常固结状态... 详细信息

基于Wheeler土体各向异性旋转硬化法则,结合边界面理论,构造一个能够反映土体初始各向异性及加载后应力诱发各向异性的边界面本构模型,并借助ABAQUS软件提供的UMAT子程序接口,采用隐式积分算法——图形返回算法实现。通过对正常固结状态下(OCR=1)高岭土试样三轴不排水剪切试验进行模拟,并将模拟结果与ABAQUS自带的修正剑桥模型模拟结果进行了比较分析,表明本模型的模拟结果能够反映土体在偏压加载过程中产生的各向异性现象。在此基础上,采用本模型对中等超固结(OCR=4)高岭土试样三轴不排水剪切试验进行模拟,并再次与ABAQUS自带的修正剑桥模型模拟结果进行比较,表明本模型能够较好地反映中等超固结土在小应变情况下的非线性特性。相比于经典弹塑性模型,如修正剑桥模型,本模型的模拟结果更符合中等超固结土的变形特性。

关键词：土体各向异性边界面模型图形返回算法 ABAQUS软件 UMAT接口

Comparative study between swept-source and spectraldomain OCTA for imaging of choroidal neovascularization in age-related macular degeneration

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International Journal of Ophthalmology(English edition) 2024年第11期17卷 2067-2073页

作者： Ji-Xian Ma Zhuo-Yi Zhang Rong Di Jia-Jie yang Si-Wen Tian ya-zhou qin Wan-Hu Zhang Jian-qin Lei Qiu-Ping Liu Jing-Ming Li Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Affiliated Eye Hospital of Nanchang University Nanchang 330006Jiangxi ProvinceChina Department of Ophthalmology First Affiliated Hospital of Nanhua UniversityHengyang 421005Hunan ProvinceChina

AIM:To compare the dif ferences of choroidal neovascularization(CNV)measurements between sweptsource and spectral-domain optical coherence tomography angiography(SS-OCTA and SD-OCTA)in neovascular agerelated macular degeneration(nAMD)and the imaging reliability of the two ***:Prospective comparative ***-OCTA and SD-OCTA were used to scan the same eye with the modes of 3×3 and 6×6 mm2 centered on the *** qualified images were chosen and the border of CNV was manually delineated by two graders *** area of CNV(ACNV),vascular perfusion density(PD),and vessel length density(VLD)within the delineation were calculated using Image *** differences of CNV measurements between the two OCTA devices were compared using Bland-Altman *** agreement between the two graders on the measurements of each device was compared using the intraclass correlation coefficient(ICC).RESULTS:A total of 18 patients(22 eyes)with nAMD were *** measurements of ACNV,PD,and VLD were 7.247±4.586 and 4.901±3.741 mm^(2),43.202±9.636 and 34.904±10.489,6.339±1.228 and 5.908±1.741 mm^(-1) for SS-OCTA and SD-OCTA,*** differences between the two devices were 2.346±3.030 mm^(2)(Z=-3.782,P<0.0001),8.298±14.160(Z=-2.419,P=0.016),and 0.431±2.114 mm^(-1)(Z=-0.828,P=0.408)for ACNV,PD and VLD,*** ICC between two graders were 0.893(P<0.001),0.902(P<0.001),0.885(P<0.001)for ACNV,PD,VLD in SS-OCTA,and 0.971(P<0.001),0.976(P<0.001),0.973(P<0.001)in SD-OCTA,***:Both OCTA devices have high imaging *** with SD-OCTA,SS-OCTA has a larger ACNV measurements,but doesn’t show better resolution of internal vessels of CNV and well signal strength.

关键词： neovascular age-related macular degeneration swept-source spectral-domain optical coherence tomography angiography

各向异性弹黏塑性模型在ABAQUS中的研发

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岩土力学 2012年第4期33卷 1240-1246页

作者：钦亚洲李宁许建聪同济大学岩土及地下工程教育部重点实验室上海200092 同济大学地下建筑与工程系上海200092

通过将Perzyna过应力理论与临界状态理论相结合,并引入Wheeler旋转硬化法则,提出一个能描述土体初始各向异性及应力诱发各向异性的三维弹黏塑性本构模型。模型考虑流变发生的下限,在三维应力空间,模型存在形状相似的静屈服面及动态加载... 详细信息

通过将Perzyna过应力理论与临界状态理论相结合,并引入Wheeler旋转硬化法则,提出一个能描述土体初始各向异性及应力诱发各向异性的三维弹黏塑性本构模型。模型考虑流变发生的下限,在三维应力空间,模型存在形状相似的静屈服面及动态加载面。采用缩放形式的幂函数。本构模型数值算法采用回映算法,借助ABAQUS软件UMAT子程序接口实现。并通过对三轴不排水蠕变试验的模拟,确定合适的积分步长。此后,分别对三轴不排水蠕变试验及常应变率三轴不排水剪切试验进行了模拟。模拟中通过设置不同参数值,可将模型退化为各向同性模型,并对这两种模拟结果进行了比较。模拟结果表明:(1)对于三轴不排水蠕变,在低剪应力水平下,各向同性模型和各向异性模型模拟的结果相差不大,而在高剪应力水平下,各向异性模型模拟结果更接近试验结果;(2)对于常应变率加载试验的模拟,模型合理反映了土体不排水强度随着加载速率的增大而增大现象。

关键词：各向异性弹黏塑性模型回映算法 ABAQUS软件 UMAT子程序

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降雨诱发浅层滑坡稳定性的计算模型研究

岩土力学 2012年第5期33卷 1485-1490页

作者：李宁许建聪钦亚洲同济大学岩土及地下工程教育部重点实验室上海200092 同济大学地下建筑与工程系上海200092

我国是一个滑坡灾害频发的国家,众多事实表明:降雨是影响边坡稳定性,导致边坡失稳的最主要和最普遍的环境因素,是浅层滑坡的触发因素。为了更好地对降雨诱发浅层滑坡进行研究,采用非饱和土VG模型与改进的Green-Ampt入渗模型对Mein-Larso... 详细信息

我国是一个滑坡灾害频发的国家,众多事实表明:降雨是影响边坡稳定性,导致边坡失稳的最主要和最普遍的环境因素,是浅层滑坡的触发因素。为了更好地对降雨诱发浅层滑坡进行研究,采用非饱和土VG模型与改进的Green-Ampt入渗模型对Mein-Larson降雨入渗模型进行改进,并结合无限边坡提出了一个降雨诱发浅层滑坡的简化计算模型。与以往提出的简化计算模型相比,该模型既考虑了坡面倾斜的影响,又考虑了非饱和土的特性,并可用于两种降雨形式下的边坡浅层稳定性估算,具有更广的应用范围。通过与有限元得到的结果进行比较可得:在不同降雨条件下,该计算模型得到的各项结果与数值解是接近的,安全系数计算结果是偏于安全的,因此,可将该计算模型用于降雨诱发浅层滑坡的近似估算;该计算模型公式简单,便于计算,计算效率较高。

关键词：降雨入渗模型无限边坡非饱和土浅层滑坡

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong qin zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia