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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 64-70页

作者： Guo-Fu xu Department of Physics Shandong University

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era, building accurate intermediate-scale nonadiabatic holonomic quantum computers is clearly necessary. Given that measurements are the sole means of extracting information, they play an indispensable role in nonadiabatic holonomic quantum computers. Accordingly, developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great importance. However, while much attention has been given to the research on nonadiabatic holonomic gates, the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely lacking. In this study, we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum computers. The reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic gates. Given these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

APACHE Ⅱ评分与PEWS评分对急性呼吸窘迫综合征患儿预后的预测价值探究

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中国医学前沿杂志（电子版） 2018年第6期10卷 161-164页

作者：何亚妮曾苹徐娟成都市妇女儿童中心医院中深度镇静室成都610091

目的探讨急性生理与慢性健康状况评分系统Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分与儿童早期预警评分(pediatric early warning score,PEWS)评分对急性呼吸窘迫综合征患儿预后的预测价值。方法选择2016年1... 详细信息

目的探讨急性生理与慢性健康状况评分系统Ⅱ(acute physiology and chronic health evaluationⅡ,APACHEⅡ)评分与儿童早期预警评分(pediatric early warning score,PEWS)评分对急性呼吸窘迫综合征患儿预后的预测价值。方法选择2016年1月至2018年1月本院收治的急性呼吸窘迫综合征患儿131例为研究对象。所有患儿入院后均采取积极对症治疗,包括治疗创伤、控制感染、呼吸支持、维持电解质平衡等。将患儿入院且诊断为急性呼吸窘迫综合征作为研究起点,患儿痊愈出院或死亡作为终点。根据预后情况将入选患儿分为存活组和死亡组。采用APACHEⅡ评分和PEWS评分评价急性呼吸窘迫综合征患儿预后。结果存活组患儿入院后第3天APACHEⅡ评分低于第1天,死亡组患儿入院后第3天APACHEⅡ评分高于第1天,均具有显著差异(P_均<0.05);存活组患儿入院后第1天和第3天APACHEⅡ评分均显著低于同期死亡组(P_均<0.05)。存活组患儿入院后第3天PEWS评分低于第1天,死亡组患儿入院后3天PEWS评分高于第1天,均具有显著差异(P_均<0.05);存活组患儿入院后第1天和第3天PEWS评分均低于同期死亡组(P_均<0.05)。入院后第1天,APACHEⅡ评分变量的ROC曲线下面积为0.830,PEWS评分变量的ROC曲线下面积为0.796;入院后第3天,APACHEⅡ评分变量的ROC曲线下面积为0.932,PEWS评分变量的ROC曲线下面积为0.893。结论 APACHEⅡ评分与PEWS评分对急性呼吸窘迫综合征患儿预后均具有一定预测价值,值得临床借鉴。

关键词：急性生理与慢性健康状况评分系统 Ⅱ 儿童早期预警评分急性呼吸窘迫综合征预后

覆膜与非覆膜胆道金属支架治疗胆道恶性梗阻的临床疗效分析

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中国内镜杂志 2016年第8期22卷 61-65页

作者：陶立生许亚平姚俊邱彩玉江苏省镇江市第一人民医院消化科江苏镇江212007

目的比较覆膜与非覆膜金属支架治疗胆道恶性梗阻的临床疗效。方法回顾性分析2003年5月-2014年5月123例胆道恶性梗阻患者临床资料,评价预后主要以死亡为研究终点。随访时间截止2015年3月,统计学分析比较患者生存期及治疗前后各实验室指... 详细信息

目的比较覆膜与非覆膜金属支架治疗胆道恶性梗阻的临床疗效。方法回顾性分析2003年5月-2014年5月123例胆道恶性梗阻患者临床资料,评价预后主要以死亡为研究终点。随访时间截止2015年3月,统计学分析比较患者生存期及治疗前后各实验室指标的改变,并且统计分析支架通畅时间,并评价其疗效。结果内镜下覆膜与非覆膜支架均能明显降低胆红素、转氨酶、碱性磷酸酶(ALP)等胆系酶谱,且两组下降程度差异无统计学意义(P>0.05),两组在术后胆管炎发生率及累积生存率方面差异无统计学意义(P>0.05)。术后1年生存率与肿瘤种类相关(r=-1.55,P<0.05)。结论内镜下覆膜与非覆膜支架治疗胆总管中下段恶性肿瘤相比,具有同样的退黄及缓解肝功能效果,两者在支架开放时间上差异无统计学意义,术后累计生存率方面差异无统计学意义。

关键词：胆道覆膜金属支架胆道非覆膜金属支架胆道恶性梗阻

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塞来昔布对大鼠重症急性胰腺炎的治疗作用

世界华人消化杂志 2009年第31期17卷 3197-3202页

作者：薛翠华高振军李秋萍许亚平周春锁姚俊付白清江苏大学附属人民医院消化科江苏省镇江市212002 江苏省连云港市第一人民医院消化科江苏省连云港市222002

目的:探讨塞来昔布对大鼠重症急性胰腺炎(severe acute pancreatitis,SAP)治疗效果及机制.方法:SD大鼠共135只,其中75只随机平均分为SAP组,低剂量及高剂量塞来昔布组,观察其生存率;60只SD大鼠随机平均分为对照组(假手术组),SAP组,低剂... 详细信息

目的:探讨塞来昔布对大鼠重症急性胰腺炎(severe acute pancreatitis,SAP)治疗效果及机制.方法:SD大鼠共135只,其中75只随机平均分为SAP组,低剂量及高剂量塞来昔布组,观察其生存率;60只SD大鼠随机平均分为对照组(假手术组),SAP组,低剂量及高剂量塞来昔布组.胆胰管内注射牛磺胆酸钠溶液造模,ELISA法检测大鼠血清TNF-α、IL-1β及IL-6的表达;RT-PCR检测胰腺组织COX-2mRNA的表达;HE染色、胰腺组织半定量积分评价胰腺病理学改变.结果:塞来昔布可降低大鼠SAP的病理损害积分,高剂量组在造模后的24h可显著减低组织水肿(2.28±0.30vs2.73±0.22,P<0.05);在12和24h均可显著降低腺泡坏死(2.03±0.15vs2.48±0.24,2.09±0.10vs2.65±0.25,均P<0.05)及炎性细胞浸润(1.80±0.22vs2.51±0.17,1.57±0.26vs2.20±0.22,均P<0.05).造模后COX-2mRNA表达及TNF-α、IL-1β及IL-6产生增加,塞来昔布治疗组上述检测指标明显低于SAP组(均P<0.05),且随塞来昔布剂量的增加其抑制作用逐渐增强.塞来昔布高剂量治疗组可显著提高大鼠SAP的生存率(16%vs52%,P<0.05).结论:塞来昔布可能通过抑制TNF-α、IL-1β及IL-6的表达,改善胰腺局部病理改变及预后.

关键词：重症急性胰腺炎细胞因子炎症环氧合酶-2 塞来昔布

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi xu Junqiu Jia Rui Mao Xiang Cao Yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： Quan Shi Yun-Hao xu Ming-Hui Chen Peng Zhao Wen-Bo Deng Ji Xiong Kai Guo ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry Jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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花魔芋中三种功能性成分联产分离工艺

天然产物研究与开发 2017年第7期29卷 1224-1229页

作者：周秀秀丁亚平徐乐乐胡中立靳素荣武汉理工大学化学化工与生命科学学院化学系武汉430070 武汉大学生命科学学院武汉430072

采用超声辅助联产工艺法对魔芋活性成分的提取及分离进行了研究。用正交优化试验考察了提取神经酰胺与生物碱的影响因素,确定了最佳提取工艺条件:提取温度60℃、乙醇浓度70%、提取时间20 min、料液比1∶40。在此条件下得到魔芋中神经酰... 详细信息

采用超声辅助联产工艺法对魔芋活性成分的提取及分离进行了研究。用正交优化试验考察了提取神经酰胺与生物碱的影响因素,确定了最佳提取工艺条件:提取温度60℃、乙醇浓度70%、提取时间20 min、料液比1∶40。在此条件下得到魔芋中神经酰胺提取量为1.57 mg/g,生物碱提取量为0.41 mg/g。采用柱层析、重结晶等技术纯化后神经酰胺和生物碱的纯度分别为80.77%和71.68%;采用乙醇沉淀法从魔芋残渣中提取KGM类化合物,提取量为0.51 g/g,纯化后的纯度为93.86%。进一步对神经酰胺的保湿性能进行研究,结果显示其保湿效果强于橄榄油和甘油。本研究对提高魔芋的综合利用、降低生产成本、增加附加经济值以及提高经济效益具有重要意义。

关键词：魔芋联产工艺神经酰胺生物碱葡甘聚糖

[Determination of eight phthalate metabolites in urine of pregnant women and evaluation of neonatal birth outcomes based on solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 60-67页

作者： Zi-Hao Wang Meng-Fei xu Bei-Ni Li ping Wu Wei Wu Hubei University of Chinese Medicine Wuhan 430065 China.

Phthalates (PAEs) are endocrine-disrupting chemicals that are widely present in everyday life and enter the human body through various pathways. The release of PAEs into the environment through pathways that include leaching, evaporation, abrasion, and the use of personal care products exposes humans to PAEs via ingestion, inhalation, and dermal absorption. Pregnant women, as a particularly vulnerable population, risk adverse newborn growth and development when exposed to PAEs. While the concentrations of PAEs in urine reflect recent exposure levels in humans, urinary levels of phthalate metabolites (mPAEs) are commonly used as biomarkers of internal exposure owing to the relatively short biological half-lives of PAEs (<24 h). In this study, we developed a solid-phase extraction-high performance liquid chromatography-tandem mass spectrometry (SPE-HPLC-MS/MS) method for simultaneously detecting eight mPAEs in the urine of pregnant women. Urine samples were enzymatically hydrolyzed with -glucosidase and then purified using the Bond Elut Plexa SPE column, with subsequent elution, concentration, and redissolved performed prior to HPLC-MS/MS. Separation was achieved using an Agilent Eclipse Plus C18 column (100 mm×3 mm, 3.5 μm), with gradient elution performed using 0.1% acetic acid aqueous solution and 0.1% acetic acid acetonitrile as mobile phases. Multiple reaction monitoring (MRM) mode was used for detection, with quantification performed using the internal-standard method. Good linearities were obtained in the range of 0.1-200 ng/mL for the eight mPAEs, with limits of detection (LODs) and quantification (LOQs) of 0.015-0.048 and 0.050-0.160 ng/mL, respectively. The eight mPAEs exhibited recoveries of 80.2%-99.7% at three spiked levels (1, 10, and 50 ng/mL). This method was subsequently used to analyze the eight mPAEs levels in urine samples of 497 pregnant women from the Ezhou Maternity and Child Health Care Hospital. The participants exhibited widespread exposure t

关键词： birth outcomes high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) phthalate metabolites (mPAEs) urine samples of pregnant women