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Chinese Chemical Letters 2008年第7期19卷 783-787页

作者： ya ping xu Rong Hua Hu Ming Zhong Cai Department of Chemistry Jiangxi Normal University Nanchang 330022 China Department of Chemistry Jinggangshan University Jian 343009 China

A variety of terminal arylacetylenes have been conveniently synthesized in good to high yields via Sonogashira coupling of aryl iodides with （trimethylsilyl）acetylene catalyzed by MCM-41-supported mercapto palladium（0） complex, followed by desilylation under mild conditions. This polymeric palladium catalyst can be reused many times without any decrease in activity.

关键词： Sonogashira coupling MCM-41-supported catalyst Mercapto palladium(0) complex Terminal arylacetylene Heterogeneouscatalysis

Olfactory ensheathing cells promote nerve regeneration and functional recovery after facial nerve defects

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Neural Regeneration Research 2019年第1期14卷 124-131页

作者： Jian Gu He xu ya-ping xu Huan-Hai Liu Jun-Tian Lang Xiao-ping Chen Wei-Hua xu Yue Deng Jing-ping Fan Department of Otolaryngology Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Department of Otolaryngology Head and Neck Surgery Changzheng Hospital Second Military Medical University Department of Otolaryngology Head and Neck Surgery Gongli Hospital Second Military Medical University

Olfactory ensheathing cells from the olfactory bulb and olfactory mucosa have been tbund to increase axonal sprouting and pathfinding and promote the recovery of vibrissae motor performance in facial nerve transection injured rats. However, it is not yet clear whether olfactory ensheathing cells promote the reparation of facial nerve defects in rats. In this study, a collagen sponge and silicone tube neural conduit was implanted into the 6-mm defect of the buccal branch of the facial nerve in adult rats. Olfactory ensheathing cells isolated from the olfactory bulb of newborn Sprague-Dawley rats were injected into the neural conduits connecting the ends of tile broken nerves, the morphology and function of the regenerated nerves were compared between the rats implanted with olfactory ensheathing cells with the rats injected with saline. Facial paralysis was assessed. Nerve electrography was used to measure facial nerve-induced action potentials. Visual inspection, anatomical microscopy and hematoxylin-eosin staining were used to assess the histomorphology around the trans planted neural conduit and the morphology of the regenerated nerve. Using fluorogold retrograde tracing, toluidine blue staining and lead uranyl acetate staining, we also measured the number of neurons in the anterior exterior lateral f：acial nerve motor nucleus, the number of myelinated nerve fibers, and nerve fiber diameter and myelin sheath thickness, respectively. After surgery, olfactory ensheathing cells de- creased facial paralysis and the latency of the facial nerve-induced action potentials. There were no differences in the general morphology of the regenerating nerves between the rats implanted with olfactory ensheathing cells and the rats injected with saline. Between-group results showed that olfactory ensheathing cell treatment increased the number of regenerated neurons, improved nerve fiber morphology, and increased the number of myelinated nerve fibers, nerve fiber diameter, and myel

关键词： nerve regeneration facial nerve defects olfactory ensheathing cells nerve fibers myelination neurons nerve muscle action potentials facial nerve motor nucleus neural regeneration

Endoscopic papillary balloon intermittent dilatation and endoscopic sphincterotomy for bile duct stones

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World Journal of Gastroenterology 2013年第15期19卷 2425-2432页

作者： Bai-Qing Fu ya-ping xu Li-Sheng Tao Jun yao Chun-Suo Zhou Department of Gastroenterology the People's HospitalAffiliated to Jiangsu University

AIM: To compare the effectiveness and safety of endoscopic papillary balloon intermittent dilatation (EPBID) and endoscopic sphincterotomy (EST) in the treatment of common bile duct stones. METHODS: From March 2011 to May 2012, endoscopic retrograde cholangiopancreatography was performed in 560 patients, 262 with common bile duct stones. A total of 206 patients with common bile duct stones were enrolled in the study and randomized to receive either EPBID with a 10-12 mm dilated balloon or EST (103 patients in each group). For both groups a conventional reticular basket or balloon was used to remove the stones. After the procedure, routine endoscopic nasobiliary drainage was performed. RESULTS: First-time stone removal was successfully performed in 94 patients in the EPBID group (91.3%) and 75 patients in the EST group (72.8%). There was no statistically significant difference in terms of operation time between the two groups. The overall incidence of early complications in the EPBID and EST groups was 2.9% and 13.6%, respectively, with no deaths reported during the course of the study and follow-up. Multiple regression analysis showed that the success rate of stone removal was associated with stone removal method [odds ratio (OR): 5.35; 95%CI: 2.24-12.77; P=0.00], the transverse diameter of the stone (OR: 2.63; 95%CI: 1.19-5.80; P=0.02) and the presence or absence of diverticulum (OR: 2.35; 95%CI: 1.03-5.37; P=0.04). Postoperative pancreatitis was associated with the EST method of stone removal (OR: 5.00; 95%CI: 1.23-20.28; P=0.02) and whether or not pancreatography was performed (OR: 0.10; 95%CI: 0.03-0.35; P=0.00). CONCLUSION: The EPBID group had a higher success rate of stone removal with a lower incidence of pancreatitis compared with the EST group.

关键词： Endoscopic papillary balloon dilatation Endoscopic retrograde cholangiopancreatography Endoscopic sphincterotomy Common bile duct stones Success rate

FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation

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World Journal of Gastroenterology 2014年第39期20卷 14430-14441页

作者： Jun yao Chun-Suo Zhou Xiong Ma Bai-Qing Fu Li-Sheng Tao Miao Chen ya-ping xu Department of Gastroenterology the People’s Hospital Affiliated to Jiangsu University Department of Gastroenterology Renji Hospital Shanghai Jiao Tong University School of Medicine Department of Pathology the Zhenjiang First People’s Hospital

AIM: To examine the effect of farnesoid X receptor (FXR) activation by GW4064 on endotoxin-induced hepatic inflammation in nonalcoholic fatty liver disease (NAFLD) and the underlying mechanism.

关键词： Farnesoid X receptor Nonalcoholic fatty liver disease GW4064 Nonalcoholic fatty liver disease activity score Lipopolysaccharide-induced hepatic inflammation Macrophage activation

The 2002 AJCC TNM classification is a better predictor of primary small cell esophageal carcinoma outcome than the VALSG staging system

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Chinese Journal of Cancer 2013年第6期32卷 342-352页

作者： Sheng-Ye Wang Wei-Ming Mao Xiang-Hui Du ya-ping xu Su-Zhan Zhang Department of Radiation Oncology Zhejiang Cancer Hospital Department of Oncology Τhe Second Affiliated Hospital Zhejiang University

Small cell carcinoma of the esophagus (SCCE) is a rare and aggressive malignant tumor with a poor prognosis. The optimal disease staging system and treatment approaches have not yet been defined. This study aimed to evaluate the prediction of different staging systems for prognosis and treatment options of SCCE. We retrospectively accessed the clinicopathologic characteristics, treatment strategy, and prognosis of 76 patients diagnosed with primary SCCE between 2001 and 2011. The 1-, 2-, 3-, and 5-year overall survival rates were 58%, 31%, 19%, and 13%, respectively. Univariate analysis showed that the 2002 American Joint Committee on Cancer (AJCC) tumor-node-metastasis (TNM) classification (P=0.002), Veterans Administration Lung Study Group (VALSG) stage (P=0.001), predisposing factors (P<0.001), T category (P=0.023), and M category (P<0.001) were prognostic factors for overall survival. Multivariate analysis showed that the 2002 AJCC TNM stage (P<0.001) was the only independent prognostic factor for survival. The value of the area under the receiver operator characteristic (ROC) curve (AUC) of the 2002 AJCC TNM staging system was larger than that of VALSG staging system with regard to predicting overall survival (0.774 vs. 0.620). None of the single treatment regimens showed any benefit for survival by Cox regression analysis. Thus, the 2002 AJCC TMN staging system improved the prediction of SCCE prognosis; however, the optimal treatment regimen for SCCE remains unclear.

关键词：系统预测 TNM 食管癌细胞原发性治疗方案分类病理特征

Ginsenoside Rg1 promotes sleep in rats by modulating the noradrenergic system in the locus coeruleus and serotonergic system in the dorsal raphe nucleus

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Ginsenoside Rg1 promotes sleep in rats by modulating the nor...

Protective effect of heme oxygenase-1 on Wistar rats with heart failure through the inhibition of inflammation and amelioration of intestinal micro- circulation

第九届中国药理学会补益药药理专业委员会学术研讨会

作者： ya-ping xu Xiang-Yu Cui Yu-Tong Liu Su-Ying Cui Yong-He Zhang Department of Pharmacology School of Basic Medical SciencePeking University

Panax ginseng Mayer has been used as tranquilizer to improve sleep disorder,but its active component is not *** study investigated the effects of the most abundant constituents of ***—protopanaxatriol ginsenoside Rg1...

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Journal of Geriatric Cardiology 2015年第4期12卷 353-365页

作者： Li ZHANG Zhuo-Kun GAN Li-Na HAN Hao WANG Jie BAI Guo-Juan TAN Xiao-Xia LI ya-ping xu Yu ZHOU Mei-Liang GONG Mo-Si LIN Xiao-yang HAN Department of Cardiology Internal Medicine Nanlou Branch of Chinese PLA General Hospital Beijing China VIP Cardiovascular Department Navy General Hospital Beijing China Department of Clinical Laboratory Nanlou Branch of Chinese PLA General Hospital Beijing China Department of Ultrasonography Nanlou Branch of Chinese PLA General Hospital Beijing China School of Chemical Biology and Pharmaceutical Sciences Capital Medical University Beijing China Department of Pharmacy Out-patient Clinic of Aerospace City General Armament Hospital Beijing China

Background Myocardial infarction （MI） has likely contributed to the increased prevalence of heart failure （HF）. As a result of re- duced cardiac function, splanchnic blood flow decreases, causing ischemia in villi and damage to the intestinal barrier. The induction of heme oxygenase-1 （HO-1） could prevent, or lessen the effects of stress and inflammation. Thus, the effect and mechanism thereof of HO-1 on the intestines of rats with HF was investigated. Methods Male Wistar rats with heart failure through ligation of the left coronary artery were identified with an left ventricular ejection fraction of 〈 45% through echocardiography and then divided into various experimental groups based on the type of peritoneal injection they received [MI： saline; MI ＋ Cobalt protoporphyrin （CoPP）： CoPP solution; and MI ＋ Tin mesoporphyrin IX dichloride （SnMP）： SnMP solution]. The control group was comprised of rats without coronary ligation. Echocardiogra- phy was performed before ligation for a baseline and eight weeks after ligation in order to evaluate the cardiac function of the rats. The bac- terial translocation （BT） incidence, mesenteric microcirculation, amount of endotoxins in the vein serum, ileum levels of HO- 1, carbon oxide （CO）, nitric oxide （NO）, intedeuldn （IL）-10, turnour necrosis factor-et （TNF-ct）, and the ileum morphology were determined eight weeks after the operation. Results The rats receiving MI ＋ CoPP injections exhibited a recovery in cardiac function, an amelioration of mesenteric microcirculation and change in morphology, a lower BT incidence, a reduction in serum and ileac NO and TNF-ct levels, and an elevation in ileac HO-1, CO, and interleukin-10 （[L-10） levels compared to the MI group （P 〈 0.05）. The rats that received the MI ＋ SnMP injections exhibited results inverse to the MI （P 〈 0.05） group. Conclusions HO-1 exerted a protective effect on the intestines of rats with HF by inhibiting the inflammation and amelioration of microcirculation through t

关键词： Carbon monoxide Heart failure Heme oxygenase-1 Intestine

内镜下柱状气囊扩张术与内镜下柱状气囊扩张术联合乳头括约肌小切开治疗胆总管大结石的比较研究

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中国内镜杂志 2017年第6期23卷 82-86页

作者：陶立生许亚平姚俊江苏省镇江市第一人民医院消化科江苏镇江212007

目的比较内镜下柱状气囊扩张术(EPBD)与EPBD联合十二指肠乳头括约肌小切开术(SEST)治疗胆总管大结石的有效性和安全性。方法 2014年1月-2015年12月该院78例胆总管大结石患者,随机分为EPBD组和EPBD+SEST组,比较两组取石成功率、术后24 h... 详细信息

目的比较内镜下柱状气囊扩张术(EPBD)与EPBD联合十二指肠乳头括约肌小切开术(SEST)治疗胆总管大结石的有效性和安全性。方法 2014年1月-2015年12月该院78例胆总管大结石患者,随机分为EPBD组和EPBD+SEST组,比较两组取石成功率、术后24 h血淀粉酶、术前术后总胆红素(TBL)、转氨酶、碱性磷酸酶(ALP)、内镜逆行胰胆管造影术(ERCP)次数及术后胰腺炎等并发症。结果两组一次性取石成功率、ERCP取石次数、操作时间及1周后肝酶谱下降水平差异无统计学意义。两组术后并发症如术后高淀粉酶血症、术后胰腺炎和术后出血等并发症差异无统计学意义。结论 EPBD与EPBD+SEST治疗胆总管大结石具有相似的临床效果,其并发症无明显差异,值得临床广泛应用。

关键词：内镜逆行胰胆管造影术 EPBD 十二指肠乳头括约肌小切开术

Rivastigmine inhibits voltage-activated potassium currents in rat hippocampal pyramidal neurons

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Rivastigmine inhibits voltage-activated potassium currents i...

2002全国青年药理学英文学术会议

作者： PAN ya-ping, xu Xiang-Hua, WANG Xiao-Liang(Department of Pharmacology, Institute of Materia Medica, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100050, China)

AIM: Rivastigmine is a new acetylcholinesterase (ACHE) inhibitor following tacrine and donepezil. It displays specificity for central ACHE. Potassium channels in the brain has been found in close relationship with learning and memory. While no research about the action of rivastigmine on central potassium currents has been reported up to date. In the present study, we examined the effects of rivastigmine on two main voltage-activated outward potassium currents including transient outward potassium current (I) and delayed rectifier potassium current (I) in rat hippocampal neurons. METHODS: Hippocampal

关键词： rivastigmine hippocampus pyramidal neurons potassium currents patch clamp technique

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通用航空产业园的发展及空间布局研究

建材世界 2017年第3期38卷 118-122页

作者：危娅蕾中国航空规划设计研究总院有限公司北京100120

由通航产业发展现状及社会效应入手,研究分析了通航产业园的设计模式及空间布局规划的多种可能,就今后通航产业园是否会在我国特定的政策背景与经济环境下衍生出新形态及空间规划模式提出了思考。

关键词：通用航空通航产业园发展现状布局