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Application of exosome-derived noncoding RNAs in bone regeneration:Opportunities and challenges

World Journal of Stem Cells 2022年第7期14卷 473-489页

作者： Yuan-Zhong Ren Shan-Shan Ding ya-ping jiang Hui Wen Tao Li Department of Emergency Trauma Surgery Luoyang Central Hospital Affiliated to Zhengzhou UniversityLuoyang 471000Henan ProvinceChina Department of Geriatrics Luoyang Central Hospital Affiliated to Zhengzhou UniversityLuoyang 471000Henan ProvinceChina Department of Oral Implantology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Joint Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

With advances in the fields of regenerative medicine,cell-free therapy has received increased *** have a variety of endogenous properties that provide stability for molecular transport across biological barriers to cells,as a form of cell-to-cell communication that regulates function and *** addition,exosomes are an important component of paracrine signaling in stemcell-based therapy and can be used as a stand-alone therapy or as a drug delivery *** remarkable potential of exosomes has paved the pathway for cell-free treatment in bone *** are enriched in distinct noncoding RNAs(ncRNAs),including microRNAs,long ncRNAs and circular *** ncRNAs have multiple *** expression of ncRNA in exosomes is associated with the regenerative potential and development of various diseases,such as femoral head osteonecrosis,myocardial infarction,and *** there is increasing evidence that exosome-derived ncRNAs(exoncRNAs)have the potential for bone regeneration,the detailed mechanisms are not fully ***,we review the biogenesis of exo-ncRNA and the effects of ncRNAs on angiogenesis and osteoblast-and osteoclast-related pathways in different ***,there are still many unsolved problems and challenges in the clinical application of ncRNA;for instance,production,storage,targeted delivery and therapeutic potency *** in exo-ncRNA methods and design will promote the development of therapeutics,revolutionizing the present landscape.

关键词： Exosomes Non-coding RNA Bone Osteogenesis Angiogenesis Osteoclasts

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Efficacy and safety of Cimicifuga foetida extract on menopausal syndrome in Chinese women

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Chinese Medical Journal 2013年第11期126卷 2034-2038页

作者： ZHENG Ting-ping SUN Ai-jun XUE Wei WANG ya-ping jiang Ying ZHANG Ying LANG Jing-he Department of Obstetrics and Gynecology Peking Union MedicalCollege Hospital Chinese Academy of Medical Sciences & PekingUnion Medical College Beijing 100730 China

Background It is now recognized that Cimicifuga foetida extract is effective in alleviating menopausal symptoms. But the durations reported were usually short. This paper compares the clinical effects of different regimens of three-month course on climacteric symptoms in Chinese women, so as to evaluate the efficacy and safety of Cimicifuga foefida extract. Methods This was a prospective, randomized trial. Ninety-six early menopausal women were recruited and randomly assigned into 3 groups to take different kinds of medicine for 3 months; participants were given Cimicifuga foefida extract daily in group A （n=32）, given estradiol valerate and progesterone capsule cycle sequentially in group B （n=32）, and given estradiol valerate and medroxyprogesterone acetate cycle sequentially in group C （n=32）. The questionnaires of Kupperman menopause index, Menopause-Specific Quality of Life, and Hospital Anxiety and Depression Scale were finished before and after the treatment. The status of vaginal bleeding and breast tenderness was recorded every day. Results Eighty-nine participants （89/96, 92.7%） completed the treatment. Kupperman menopause index decreased after taking the medicine for 3 months in each group （with all P〈0.001）, but the score after the treatment was higher in group A than in the other 2 groups. Except for the score of sexual domain in group A （P=0.103）, the scores of all domains of the Menopause-Specific Quality of Life decreased significantly after the treatment in all groups （with all P〈-0.01）. Score of anxity decreased significantly in group A （P=0.0l 5） and B （P=0.003）. Incidence of breast tenderness was 12.9% （4/31） in groupA, 36.7% （11/30） in group B, and 14.3% （4/28） in group C. Incidence of vaginal bleeding was 6.5% （2/31）in group A, 26.7% （8/30） in group B, and 82.1% （23/28）in group C. Conclusions Cimicifuga foeticla extract is effective and safe in the treatment of menopausal syndrome. It is worth extending its use in the treatment of climacteric c

关键词： Cimicifuga foetida extract menopause Kupperman menopause index menopause-specific quality of life vaginal bleeding breast tenderness

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财政转移支付与西部资源诅咒认知

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西北师大学报（社会科学版） 2017年第5期54卷 52-59页

作者：周亚平陈文江兰州大学哲学社会学院甘肃兰州730000

中国西部资源丰富但经济发展却相对落后,中国东部资源稀缺但经济发展相对迅速。在西部遭受某种"资源诅咒"的前提下,西部民众如何看待"东部经济发展"和"西部资源开发"的关系?研究使用"西部社会经济发展变迁调查"数据,旨在探讨宏观的财政... 详细信息

中国西部资源丰富但经济发展却相对落后,中国东部资源稀缺但经济发展相对迅速。在西部遭受某种"资源诅咒"的前提下,西部民众如何看待"东部经济发展"和"西部资源开发"的关系?研究使用"西部社会经济发展变迁调查"数据,旨在探讨宏观的财政制度影响下,西部民众对这种资源诅咒的社会认知,即财政转移支付及实施的透明度能否影响西部民众所持有的东部经济发展是以牺牲西部资源为代价的这一认知。数据分析结果显示,财政转移支付越高的省份,民众越不认同"东部经济发展"会导致"西部资源流失";财政透明度越高的省份,民众更认同"东部经济发展"会导致"西部资源流失"。这表明在信息对称的情形下,西部民众对东部发展优先的东部主义持消极态度,但财政转移支付在某种程度上能缓解这种消极态度。

关键词：资源诅咒财政转移支付财政透明度社会认知

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真菌性角膜炎的治疗进展

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国际眼科杂志 2015年第9期15卷 1542-1545页

作者：姜亚萍陈轶卉同济大学附属第十人民医院眼科中国上海市200072

真菌性角膜炎(fungal keratitis,FK)是一种由致病真菌引起的、致盲率极高的感染性角膜病,随着现代医学的发展,早期患者或者对药物敏感的真菌感染患者,药物或手术治愈率较前有了明显的提高,但是晚期患者及对药物不敏感的致病真菌感染患者... 详细信息

真菌性角膜炎(fungal keratitis,FK)是一种由致病真菌引起的、致盲率极高的感染性角膜病,随着现代医学的发展,早期患者或者对药物敏感的真菌感染患者,药物或手术治愈率较前有了明显的提高,但是晚期患者及对药物不敏感的致病真菌感染患者,药物难以控制、溃疡迁延不愈、病情进展恶化,目前仍旧是临床上角膜盲的主要病因之一。在文中我们将就真菌性角膜炎药物及手术治疗的近5a国内外的研究进展作一综述。

关键词：角膜炎真菌性药物手术

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Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan ping Yu Emily Choi Michael Qjiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

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炔诺酮片国际药典标准的制定

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中国药学杂志 2017年第2期52卷 147-151页

作者：孙春艳赵亚萍张立姜红湖北省食品药品监督检验研究院武汉430075

目的制定炔诺酮片的国际药典质量标准。方法参照国内外已有的炔诺酮及炔诺酮片的质量标准和文献,按照国际药典标准的制定要求,选择合适的方法并进行验证。结果薄层鉴别系统适用性试验中炔诺酮和炔雌醇可有效分离;有关物质检测色谱条件... 详细信息

目的制定炔诺酮片的国际药典质量标准。方法参照国内外已有的炔诺酮及炔诺酮片的质量标准和文献,按照国际药典标准的制定要求,选择合适的方法并进行验证。结果薄层鉴别系统适用性试验中炔诺酮和炔雌醇可有效分离;有关物质检测色谱条件可有效分离9种已知杂质和其他未知杂质,液质联用试验证明主峰相对保留时间1.1倍处的杂质为炔雌醇;炔诺酮片在含0.09%的SDS的0.1 mol·L^(-1)的盐酸中30 min均能溶出90%以上,溶出曲线达到平台;按照含量测定的色谱条件实验,炔诺酮在0.746~29.840μg·m L^(-1)内与峰面积呈良好线性关系(r=0.999 9),炔诺酮和炔雌醇的分离度大于4.0。结论制定的质量标准简便、准确,充分考虑了方法的可行性、试剂可及性,可有效控制产品质量。

关键词：炔诺酮片国际药典薄层色谱法液质联用高效液相色谱法

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Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： Song jiang Congwen Zhu Ning jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

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除草剂扑草净和阿特拉津对海草与大型藻类的毒性比较

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水生生物学报 2017年第4期41卷 930-934页

作者：高亚平蒋增杰杜美荣房景辉姜娓娓方建光中国科学院海洋研究所青岛266071 中国水产科学研究院黄海水产研究所农业部可持续发展重点开放实验室青岛266071 中国科学院大学北京100049

陆地径流等可引起海域中除草剂浓度升高,从而威胁海洋大型植物——海草和大型藻类的生长。以叶绿素荧光为主要指标测定除草剂阿特拉津和扑草净的低、中、高(1、5和25μg/L)浓度对4种常见海草:大叶藻(Zostera marina L.)、丛生大叶藻(***... 详细信息

陆地径流等可引起海域中除草剂浓度升高,从而威胁海洋大型植物——海草和大型藻类的生长。以叶绿素荧光为主要指标测定除草剂阿特拉津和扑草净的低、中、高(1、5和25μg/L)浓度对4种常见海草:大叶藻(Zostera marina L.)、丛生大叶藻(*** M.)、矮大叶藻(*** Aschers.&Graebn.)、红须根虾形藻(Phyllospadix iwatensis M.)和2种常见大型藻类:孔石莼Ulva lactuca L.和海索面Nemalion helminthoides的光合抑制。结果显示,低浓度1μg/L的扑草净和5μg/L的阿特拉津即对矮大叶藻、孔石莼和海索面产生了显著的光合抑制,抑制率约而7.54%—12.97%;大叶藻、丛生大叶藻和红须根虾形藻的扑草净和阿特拉津的显著作用浓度为5μg/L,在相同浓度下,扑草净的光合抑制较阿特拉津更强,同时,矮大叶藻及两种大型藻类较其他3种海草成体对除草剂作用更为敏感。

关键词：扑草净阿特拉津海草大型藻类叶绿素荧光毒性作用

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Toward understanding the role of genomic repeat elements in neurodegenerative diseases

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Neural Regeneration Research 2025年第3期20卷 646-659页

作者： Zhengyu An Aidi jiang Jingqi Chen Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence Fudan UniversityShanghaiChina Zhangjiang Fudan International Innovation Center ShanghaiChina

Neurodegenerative diseases cause great medical and economic burdens for both patients and society;however, the complex molecular mechanisms thereof are not yet well understood. With the development of high-coverage sequencing technology, researchers have started to notice that genomic repeat regions, previously neglected in search of disease culprits, are active contributors to multiple neurodegenerative diseases. In this review, we describe the association between repeat element variants and multiple degenerative diseases through genome-wide association studies and targeted sequencing. We discuss the identification of disease-relevant repeat element variants, further powered by the advancement of long-read sequencing technologies and their related tools, and summarize recent findings in the molecular mechanisms of repeat element variants in brain degeneration, such as those causing transcriptional silencing or RNA-mediated gain of toxic function. Furthermore, we describe how in silico predictions using innovative computational models, such as deep learning language models, could enhance and accelerate our understanding of the functional impact of repeat element variants. Finally, we discuss future directions to advance current findings for a better understanding of neurodegenerative diseases and the clinical applications of genomic repeat elements.

关键词： Alzheimer's disease ataxia deep learning long-read sequencing neurodegeneration neurodegenerative diseases Parkinson's disease repeat element structural variant

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C反应蛋白与缺血性卒中

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国外医学（脑血管疾病分册） 2005年第7期13卷 533-536页

作者：汪春娟姜亚平华中科技大学同济医学院附属同济医院神经内科武汉430030

C反应蛋白(CRP)是一种急相蛋白,是机体潜在炎症的征兆,在机体天然免疫过程中发挥着重要作用。近年来的研究表明炎症与缺血性卒中有关。文章就CRP与缺血性卒中发病和预后之间的关系做了综述。

关键词： C反应蛋白缺血性卒中 C反应蛋白(CRP) 急相蛋白天然免疫炎症机体

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