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Effect of early enteral combined with parenteral nutrition in patients undergoing pancreaticoduodenectomy

World Journal of Gastroenterology 2013年第35期19卷 5889-5896页

作者： Xin-Hua Zhu ya-fu Wu Yu-Dong Qiu Chun-ping Jiang Yi-Tao Ding Department of Hepatobiliary Surgery Affiliated Drum Tower Hospital Medical School of Nanjing University

AIM:To investigate the effect of early enteral nutrition(EEN)combined with parenteral nutritional support in patients undergoing pancreaticoduodenectomy(PD).METHODS:From January 2006,all patients were given EEN combined with parenteral nutrition(PN)(EEN/PN group,n=107),while patients prior to this date were given total parenteral nutrition(TPN)(TPN group,n=67).Venous blood samples were obtained for a nutrition-associated assessment and liver function tests on the day before surgery and 6 d after *** assessment of clinical outcome was based on postoperative ***-up for infectious and noninfectious complications was carried out for 30 d after hospital *** within 30 d afterdischarge was also ***:Compared with the TPN group,a significant decrease in prealbumin(PAB)(P=0.023)was seen in the EEN/PN *** bilirubin(TB),direct bilirubin(DB)and lactate dehydrogenase(LDH)were significantly decreased on day 6 in the EEN/PN group(P=0.006,0.004 and 0.032,respectively).The rate of gradeⅠcomplications,gradeⅡcomplications and the length of postoperative hospital stay in the EEN/PN group were significantly decreased(P=0.036,0.028and 0.021,respectively),and no hospital mortality was observed in our *** with the TPN group(58.2%),the rate of infectious complications in the EEN/PN group(39.3%)was significantly decreased(P=0.042).Eleven cases of delayed gastric emptying were noted in the TPN group,and 6 cases in the EEN/PN *** rate of delayed gastric emptying and hyperglycemia was significantly reduced in the EEN/PN group(P=0.031 and P=0.040,respectively).CONCLUSION:Early enteral combined with PN can greatly improve liver function,reduce infectious complications and delayed gastric emptying,and shorten postoperative hospital stay in patients undergoing PD.

关键词： Enteral nutrition Parenteral nutrition Pancreaticoduodenectomy Complications Metabolism

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A fuzzy Trust Management Mechanism with Dynamic Behavior Monitoring for Wireless Sensor Networks

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China Communications 2024年第5期21卷 177-189页

作者： fu Shiming Zhang ping Shi Xuehong School of Artificial Intelligence Chongqing University of EducationChongqing 400065China School of Communications and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China

Traditional wireless sensor networks(WSNs)are typically deployed in remote and hostile environments for information *** wireless communication methods adopted by sensor nodes may make the network highly vulnerable to various *** encryption and authentication mechanisms cannot prevent attacks launched by internal malicious *** trust-based security mechanism is usually adopted to solve this problem in ***,the behavioral evidence used for trust estimation presents some uncertainties due to the open wireless medium and the inexpensive sensor ***,how to efficiently collect behavioral evidences are rarely *** address these issues,in this paper,we present a trust management mechanism based on fuzzy logic and a cloud ***,a type-II fuzzy logic system is used to preprocess the behavioral evidences and alleviate ***,the cloud model is introduced to estimate the trust values for sensor ***,a dynamic behavior monitoring protocol is proposed to provide a balance between energy conservation and safety *** results demonstrate that our trust management mechanism can effectively protect the network from internal malicious attacks while enhancing the energy efficiency of behavior monitoring.

关键词： behavior monitoring cloud fuzzy trust wireless sensor networks

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Noether＇s Theorem of Nonholonomic Systems in Optimal Control

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Acta Mathematicae Applicatae Sinica 2016年第4期32卷 875-882页

作者： ping-ping CAI Duan SONG Jing-li fu Institute of Mathematical Physics Zhejiang Sci-Tech University Hangzhou 310018 China Eastern Liaodong University Shenyang 118000 China

In this paper, we extend Noether＇s theorem to nonholonomic constraints systems in optimal control. We present a systematic way to calculate conserved quantities along the Pontryagin extremals for optimal control problems with nonholonomic constraints, which are invariant under the parameter groups of infinitesimal transformations that change all （time, state, control） variables. Meanwhile, the Noether equalities corresponding to the conservation laws are given. Then, we obtain a new version of Noether＇s theorem to optimal control systems. An example is given to illustrate the application of these results.

关键词： nonholonommic system symmetry conservation law Noether's theorem optimal control

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Kidney fibrosis:from mechanisms to therapeutic medicines

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1664-1683页

作者： Rongshuang Huang ping fu Liang Ma Kidney Research Institute Division of NephrologyWest China HospitalSichuan UniversityChengdu 610041China

Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney fibrosis, characterized by excessiveextracellular matrix deposition leading to scarring, is a hallmark manifestation in different progressive CKD;However, at present noantifibrotic therapies against CKD exist. Kidney fibrosis is identified by tubule atrophy, interstitial chronic inflammation andfibrogenesis, glomerulosclerosis, and vascular rarefaction. Fibrotic niche, where organ fibrosis initiates, is a complex interplaybetween injured parenchyma (like tubular cells) and multiple non-parenchymal cell lineages (immune and mesenchymal cells)located spatially within scarring areas. Although the mechanisms of kidney fibrosis are complicated due to the kinds of cellsinvolved, with the help of single-cell technology, many key questions have been explored, such as what kind of renal tubules areprofibrotic, where myofibroblasts originate, which immune cells are involved, and how cells communicate with each other. Inaddition, genetics and epigenetics are deeper mechanisms that regulate kidney fibrosis. And the reversible nature of epigeneticchanges including DNA methylation, RNA interference, and chromatin remodeling, gives an opportunity to stop or reverse kidneyfibrosis by therapeutic strategies. More marketed (e.g., RAS blockage, SGLT2 inhibitors) have been developed to delay CKDprogression in recent years. furthermore, a better understanding of renal fibrosis is also favored to discover biomarkers of fibroticinjury. In the review, we update recent advances in the mechanism of renal fibrosis and summarize novel biomarkers andantifibrotic treatment for CKD.

关键词： Kidney therapeutic inflammation

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Fluorescence Nanobiosensor for Simultaneous Detection of Multiple Veterinary Drugs in Chicken Samples

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Journal of Analysis and Testing 2022年第2期6卷 77-88页

作者： ya-ping Peng ya-Wen He ya-Fang Shen Ao-Ming Liang Xi-Bin Zhang Yuan-Jie Liu Jian-Han Lin Jian-ping Wang yan-Bin Li Ying-Chun fu College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China Quality Control for Feed and Products of Livestock and Poultry Key Laboratory of Sichuan Province New Hope Liuhe Co.Ltd.Chengdu 610023China Weifang Heshengyuan Food Co. Ltd.Weifang 262100China College of Information and Electrical Engineering China Agricultural UniversityBeijing 100083China Department of Biological and Agricultural Engineering University of ArkansasFayettevilleAR 72701USA

Some veterinary drug residues in food products and environment have been widely regarded as severe threats to human *** and simultaneous detection methods are crucial to monitor and control veterinary drug ***,we propose a fluorescence biosensor utilizing immunomagnetic beads(IMBs)and quantum dots(QDs)for the rapid and simultaneous detection of 1-adamantylamine(ADA),enrofloxacin(ENR)and tilmicosin(TIL)in raw chicken meat.A pretreatment method using sodium phosphotungstate–magnesium as extraction reagent was developed to simultaneously extract ADA,ENR and TIL from chicken meat with minor interference in background or *** adding the IMBs modified with three types of antibodies and the QD-antigens modified with three types of BSA-antigens to sample,IMBs competitively conjugated to target antigens in a sample or *** magnetic separation,the residual QD-antigens were adopted to collect signals using fluorescence *** QDs with well separated emission peaks,the detection of one type of targets was minorly interfered by the *** the optimum conditions,the biosensor exhibited the limit of detection of 0.96,3.32,and 3.17 ng/mL for ADA,ENR and TIL in chicken samples,respectively,as well as good *** to the way of direct collection of signals in extracts,the tedious and complicated multiple magnetic separation and signal amplification procedures in conventional methods were avoided,thus the procedures were significantly simplified,and the reduction of the operation time of 30 min for sample pretreatment and 40 min for detection part was *** biosensor might be promising in the rapid,in-field and sensitive screening of multiple veterinary drugs to ensure agriculture and food safety.

关键词： Simultaneous detection Veterinary drugs Magnetic separation Quantum dots Poultry

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Application of intraoperative ultrasound in liver surgery

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 501-502页

作者： ya-Wei Xu Hong fu Department of Hepatobiliary Surgery Shaoxing People’s HospitalShaoxing Hospital of Zhejiang UniversityShaoxing 312000China

With the development of color Doppler and laparoscopic ultrasound, now intraoperative ultrasound(IOUS) plays an important role in liver surgery. Compared to percutaneous ultrasound(US), IOUS is conducted directly on the liver surface, with no blind spots or dead ends, thus improves the detection, localization and characterization of lesions without influencing factors, such as obesity.

关键词： surgery liver intraoperative

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Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization

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Chinese Journal of Polymer Science 2024年第5期42卷 570-578,I0005页

作者： Xiao-Fei Sun Xu Zhang Shu-ping Song ya-Qun yao yan Zhang Cheng-Liang Wang Jing-Jiang Sun Qing-fu Wang Key Laboratory of Rubber-plastics Ministry of EducationSchool of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao266042China Qingdao Research Academy of Environmental Science Qingdao266012China

L-glutamic acid(LA)is a bio-based,non-toxic,environmentally friendly material derived from *** present study reports the application of Passerini three-component polymerization(P-3CP)for the straightforward preparation of LA-based light-responsive polyesters(PLTDs)under mild *** with molar masses up to 8500 g/mol and high yields exceeding 90%are *** chemical structures and light-responsive self-immolative behavior of PLTDs are comprehensively characterized by employing ultraviolet-visible(UV-Vis)spectroscopy,size exclusion chromatography(SEC),nuclear magnetic resonance(NMR)spectroscopy,and liquid chromatography mass spectrometry(LC-MS).Meanwhile,monodisperse PLTD-based doxorubicin-loaded nanoparticles(PLTD-DOX-NP)(size=193 nm,PDI=0.018)are formulated by nanoprecipitation *** light-induced depolymerization,the PLTD-DOX-NP undergoes rapid decomposition,resulting in a burst release of 80%cargo within 13 ***,according to biological toxicity tests,the PLTD-NP possesses adequate biosafety,both before and after ***,the incorporation of P-3CP with biorenewable LA-based monomer adheres to the principles of green chemistry,significantly simplifying the synthetic pathway of light-responsive polymers.

关键词： L-glutamic acid Passerini three-component polymerization Light-responsive Polyester Nanoparticles

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Arbitrary-oriented target detection in large scene sar images

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Defence Technology（防务技术） 2020年第4期16卷 933-946页

作者： Zi-shuo Han Chun-ping Wang Qiang fu Shijiazhuang Campus Army Engineering UniversityShijiazhuang050003China

Target detection in the field of synthetic aperture radar(SAR) has attracted considerable attention of researchers in national defense technology worldwide,owing to its unique advantages like high resolution and large scene image acquisition capabilities of ***,due to strong speckle noise and low signal-to-noise ratio,it is difficult to extract representative features of target from SAR images,which greatly inhibits the effectiveness of traditional *** order to address the above problems,a framework called contextual rotation region-based convolutional neural network(RCNN) with multilayer fusion is proposed in this ***,aimed to enable RCNN to perform target detection in large scene SAR images efficiently,maximum sliding strategy is applied to crop the large scene image into a series of sub-images before *** of using the highest-layer output for proposal generation and target detection,fusion feature maps with high resolution and rich semantic information are constructed by multilayer fusion ***,we put forwards rotation anchors to predict the minimum circumscribed rectangle of targets to reduce redundant detection ***,shadow areas serve as contextual features to provide extraneous information for the detector identify and locate targets *** results on the simulated large scene SAR image dataset show that the proposed method achieves a satisfactory performance in large scene SAR target detection.

关键词： Target detection Convolutional neural network Multilayer fusion Context information Synthetic aperture radar

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Note on the Lax Pair of a Coupled Hybrid System

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Chinese Physics Letters 2012年第1期29卷 5-7页

作者： LIU ping fu Pei-Kai Department of Electronic Engineering University of Electronic Science and Technology of China Zhongshan InstituteZhongshan 528402 Academic Affairs Division Zhongshan PolytechnicZhongshan 528404

The hybrid lattice,known as a discrete Korteweg-de Vries(KdV)equation,is found to be a discrete modified Korteweg-de Vries(mKdV)*** coupled hybrid lattice,which is pointed out to be a discrete coupled KdV system,is also found to be a discrete form of a coupled mKdV *** lax pairs for the single and coupled discrete hybrid systems are proposed as a different study from previous ones.

关键词： equation. lattice coupled

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The multiwavelength emission from the gamma-ray binary LS I + 61 303

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Research in Astronomy and Astrophysics 2011年第4期11卷 445-456页

作者： Jian-fu Zhang ya Zhu Li Zhang Department of Physics and Electronic Science Tongren University Tongren 554300 China Department of Physics Yunnan University Kunming 650091 China

This paper presents a hadronic dominated jet model to investigate multi- wavelength emission from the microquasar LS I ＋61 303. In this scenario, we take into account evolutions of the primary particles and secondary e± pairs; these pairs are produced by the collisional interactions of the accelerated protons with the cold jet protons and the stellar wind ions. In this model, the non-thermal photons are produced by πο decay emission, synchrotron and inverse Compton scattering processes from the primary electrons and secondary pairs, and relativistic bremsstrahlung emission from the secondary leptonic pairs. Based on this model framework, we show that the spectral energy distributions can be produced by the primary and secondary particles via interactions with the cold matter, and magnetic and stellar radiation fields. We also consider the attenuation of angular dependence γ-γ due to the effects of the stel- lar target photon fields. The resulting model can approximately reproduce the recent quasi-simultaneous observational data points and the non-simultaneous multi-band observations.

关键词： radiation mechanism non-thermal -- gamma rays general -- X-ray binaries -- stars: individual: LS I + 61 303

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