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Knockdown of HE4 suppresses tumor growth and invasiveness in lung adenocarcinoma through regulation of EGFR signaling

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Oncology Research 2024年第6期32卷 1119-1128页

作者： YUE zhang WENYU yaNG XIAOWANG HAN YUE QIAO HAITAO WANG TING CHEN TIANYING LI WEN-BIN ou Department of Biopharmaceutics College of Life Sciences and MedicineZhejiang Provincial Key Laboratory of Silkworm Bioreactor and BiomedicineZhejiang Sci-Tech UniversityHangzhou310018China Department of Thoracic Surgery Zhejiang Provincial People’s HospitalHangzhou310014China

It has been shown that the high expression of human epididymis protein 4(HE4)in most lung cancers is related to the poor prognosis of patients,but the mechanism of pathological transformation of HE4 in lung cancer is still *** current study is expected to clarify the function and mechanism of HE4 in the occurrence and metastasis of lung adenocarcinoma(LUAD).Immunoblotting evaluated HE4 expression in lung cancer cell lines and biopsies,and through analysis of The Cancer Genome Atlas(TCGA)*** HE4 overexpression was demonstrated in LUAD,but not in lung squamous cell carcinoma(LUSC),indicating that HE4 can serve as a biomarker to distinguish between LUAD and ***4 knockdown significantly inhibited cell growth,colony formation,wound healing,and invasion,and blocked the G1-phase of the cell cycle in LUAD cell lines through inactivation of the EGFR signaling downstream including PI3K/AKT/mTOR and RAF/MAPK *** first-line EGFR inhibitor gefitinib and HE4 shRNA had no synergistic inhibitory effect on the growth of lung adenocarcinoma cells,while the third-line EGFR inhibitor osimertinib showed additive anti-proliferative ***,we provided evidence that HE4 regulated EGFR expression by transcription regulation and protein interaction in *** findings suggest that HE4 positively modulates the EGFR signaling pathway to promote growth and invasiveness in LUAD and highlight that targeting HE4 could be a novel strategy for LUAD treatment.

关键词： Lung adenocarcinoma Human epididymis protein 4 Epidermal growth factor receptor Biomarker Targeted therapies

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Comprehensive genomic analysis of early and late-onset hepatocellular carcinoma

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Genes & Diseases 2024年第4期11卷 77-81页

作者： Jialin yang Chao Chen Song Wang yaru zhang Jiaohui Pang yajun Wang Qiuxiang ou Hao Jiang Juying Liu Department of Radiation Oncology Sichuan Cancer Hospital&InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610041China Jinling Hospital Department of OncologyNanjing Medical UniversityNanjingJiangsu 210002China Geneseeq Research Institute Nanjing Geneseeq Technology Inc.NanjingJiangsu 210000China Department of Oncology Haian Hospital of Traditional Chinese MedicineHaianJiangsu 226600China Interventional Therapy Department Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsu 210009China

Hepatocellular carcinoma(HCC)is the major histologic type of primary liver cancer,accounting for approximately 75%of liver cancer cases.'Despite many advancements in its treatment,the prognosis and drug response of HCC patients are ***,there is an unmet clinical need to explore genomic aberrations underlying early-and lateonset HcC,which might facilitate drug discovery and provide personalized biomarker-driven treatment options for these patients.

关键词： patients prognosis cancer

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Predicting the prognosis of hepatic arterial infusion chemotherapy in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2380-2393页

作者： Qi-Feng Wang Zong-Wei Li Hai-Feng Zhou Kun-Zhong Zhu ya-Jing Wang ya-Qin Wang Yue-Wei zhang Department of Hepatobiliary Pancreatic Center Beijing Tsinghua Changgung Hospital Affiliated to Tsinghua UniversityBeijing 102218China Department of Hepatobiliary and Pancreatic Surgery Qinghai University Affiliated HospitalXining 810000Qinghai ProvinceChina

Hepatic artery infusion chemotherapy(HAIC)has good clinical efficacy in the treatment of advanced hepatocellular carcinoma(HCC);however,its efficacy *** review summarized the ability of various markers to predict the efficacy of HAIC and provided a reference for clinical *** of October 25,2023,51 articles have been retrieved based on keyword predictions and *** eligible articles were selected for inclusion in this *** literature analysis found that methods used to predict the efficacy of HAIC include serological testing,gene testing,and imaging *** above indicators and their combined forms showed excellent predictive effects in retrospective *** review summarized the strategies currently used to predict the efficacy of HAIC in middle and advanced HCC,analyzed each marker's ability to predict HAIC efficacy,and provided a reference for the clinical application of the prediction system.

关键词： Hepatocellular carcinoma Hepatic artery infusion chemotherapy Prediction Prognosis Imaging Biomarkers Genomics

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A Cross-matching Service for Data Center of Xinjiang Astronomical Observatory

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Research in Astronomy and Astrophysics 2024年第1期24卷 119-127页

作者： Hai-Long zhang Jie Wang Xin-Chen Ye Wan-Qiong Wang Jia Li ya-Zhou zhang Xu Du Han Wu Ting zhang Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

Cross-matching is a key technique to achieve fusion of multi-band astronomical catalogs. Due to different equipment such as various astronomical telescopes, the existence of measurement errors, and proper motions of the celestial bodies, the same celestial object will have different positions in different catalogs, making it difficult to integrate multi-band or full-band astronomical data. In this study, we propose an online cross-matching method based on pseudo-spherical indexing techniques and develop a service combining with high performance computing system(Taurus) to improve cross-matching efficiency, which is designed for the Data Center of Xinjiang Astronomical Observatory. Specifically, we use Quad Tree Cube to divide the spherical blocks of the celestial object and map the 2D space composed of R.A. and decl. to 1D space and achieve correspondence between real celestial objects and spherical patches. Finally, we verify the performance of the service using Gaia 3 and PPMXL catalogs. Meanwhile, we send the matching results to VO tools-Topcat and Aladin respectively to get visual results. The experimental results show that the service effectively solves the speed bottleneck problem of crossmatching caused by frequent I/O, and significantly improves the retrieval and matching speed of massive astronomical data.

关键词： virtual observatory tools astronomical databases:miscellaneous catalogs

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SGLT2 inhibitor monotherapy alleviates hyperglycemia in heredity severe insulin resistance syndrome

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Chinese Medical Journal 2024年第11期137卷 1372-1374页

作者： Huixuan Wu Junaid Iqbal Long Li Hongli Jiang Chen Chao Meibiao zhang ou Li Houde Zhou Department of Metabolism and Endocrinology National Clinical Research Center for Metabolic DiseasesHunan Provincial Key Laboratory for Metabolic Bone DiseasesKey Laboratory of Diabetes ImmunologyMinistry of EducationThe Second Xiangya Hospital of Central South UniversityChangshaHunan 410011China Department of Endocrinology and Metabolism The First People’s Hospital of HuaihuaHuaihuaHunan 418000China Department of Metabolism and Endocrinology San-Sui County Traditional Chinese Medicine HospitalQiandongnan Miao and Dong Autonomous PrefectureGuizhou 556000China

To the Editor:Hereditary severe insulin resistance syndrome(H-SIRS)shows a wide and variable clinical spectrum and results in severe complications in the endocrinological and cardiovascular *** treatments are recommended to control hyperglycemia in H-SIRS,including dietary intervention,insulin therapy,insulin sensitization,and recombinant human insulin-like growth factor-1(rhIGF-1)administration.[1]However,the heterogeneous etiology of H-SIRS leads to poor glycemic control in patients with different mutations,requiring multiple antihyperglycemic *** study described two cases diagnosed with H-SIRS and the treatment effect of multi-drug therapy and sodium-glucose cotransporter 2 inhibitor(SGLT2i)monotherapy.

关键词： SIRS cardiovascular clinical

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Light-responsive Self-Immolative L-glutamic Acid-based Polyester Nanoparticles for Controlled Drug Release via Passerini Three-Component Polymerization

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Chinese Journal of Polymer Science 2024年第5期42卷 570-578,I0005页

作者： Xiao-Fei Sun Xu zhang Shu-Ping Song ya-Qun yao yan zhang Cheng-Liang Wang Jing-Jiang Sun Qing-Fu Wang Key Laboratory of Rubber-plastics Ministry of EducationSchool of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao266042China Qingdao Research Academy of Environmental Science Qingdao266012China

L-glutamic acid(LA)is a bio-based,non-toxic,environmentally friendly material derived from *** present study reports the application of Passerini three-component polymerization(P-3CP)for the straightforward preparation of LA-based light-responsive polyesters(PLTDs)under mild *** with molar masses up to 8500 g/mol and high yields exceeding 90%are *** chemical structures and light-responsive self-immolative behavior of PLTDs are comprehensively characterized by employing ultraviolet-visible(UV-Vis)spectroscopy,size exclusion chromatography(SEC),nuclear magnetic resonance(NMR)spectroscopy,and liquid chromatography mass spectrometry(LC-MS).Meanwhile,monodisperse PLTD-based doxorubicin-loaded nanoparticles(PLTD-DOX-NP)(size=193 nm,PDI=0.018)are formulated by nanoprecipitation *** light-induced depolymerization,the PLTD-DOX-NP undergoes rapid decomposition,resulting in a burst release of 80%cargo within 13 ***,according to biological toxicity tests,the PLTD-NP possesses adequate biosafety,both before and after ***,the incorporation of P-3CP with biorenewable LA-based monomer adheres to the principles of green chemistry,significantly simplifying the synthetic pathway of light-responsive polymers.

关键词： L-glutamic acid Passerini three-component polymerization Light-responsive Polyester Nanoparticles

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Selective photosynthesis of Z-olefins through crystalline metal-organic cage-initiated expeditious cascade reactions

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Carbon Energy 2024年第3期6卷 118-131页

作者： Jia-Ni Lu Yunze Huang Yuan-Sheng Xia Long-zhang Dong Lei zhang Jing-Jing Liu Lan-Gui Xie Jiang Liu ya-Qian Lan Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials ScienceJiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsNanjing Normal UniversityNanjingChina School of Chemistry South China Normal UniversityGuangzhouChina

The semi-hydrogenation of alkyne to form Z-olefins with high conversion and high selectivity is still a huge challenge in the chemical ***,flammable and explosive hydrogen as the common hydrogen source of this reaction increases the cost and danger of industrial ***,we connect the photocatalytic hydrogen evolution reaction and the semihydrogenation reaction of alkynes in series and successfully realize the high selective production of Z-alkenes using low-cost,safe,and green water as the proton *** the cascade reaction,a series of isomorphic metal–organic cage catalysts(Co_(x)Zn_(8−x)L_(6),x=0,3,4,5,and 8)are designed and synthesized to improve the yield of the photocatalytic hydrogen *** them,Co_(5)Zn_(3)L_(6) shows the highest photocatalytic activity,with a H_(2) generation rate of 8.81 mmol g^(−1) h^(−1).Then,Co_(5)Zn_(3)L_(6) is further applied in the above tandem reaction to efficiently reduce alkynes to Z-alkenes under ambient conditions,which can reach high conversion of>98%and high selectivity of>99%,and maintain original catalytic activity after multiple ***“one-pot”tandem reaction can achieve a highly selective and safe stepwise conversion from water into hydrogen into Z-olefins under mild reaction conditions.

关键词： alkyne semi-hydrogenation hydrogen evolution reaction metal-organic cages photocatalysis Z-olefins

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Clinical analysis of 12 cases of ovarian neuroendocrine carcinoma

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World Journal of Clinical Cases 2024年第6期12卷 1111-1119页

作者： Xiao-Yu Xing Wei zhang Li-ya Liu Li-Ping Han Department of Gynecology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina

BACKGRouND Neuroendocrine neoplasms of the female genital tract are *** To enhance our clinical understanding of neuroendocrine carcinoma(NEC)of the *** A retrospective review was conducted on 12 patients diagnosed with NEC of the ovary,analyzing clinicopathological characteristics,treatment modalities,and survival *** The median age at diagnosis was 34.5 years(range:20 to 62 years).Among the 12 cases,9 were small cell carcinoma of the ovary and 3 were large cell *** cases were stage I tumors,one case was stage IV,and six cases were stage *** patients underwent surgery as part of their *** patients received adjuvant *** the 12 patients,one patient received radiotherapy,and one patient with a BRCA2 mutation was administered PARP inhibitor maintenance after *** median progression-free survival was 13 months,and the median overall survival was 19.5 *** cases remained disease-free,while eight cases experienced tumor recurrence,including three cases that resulted in death due to disease *** NEC of the ovary is a rare condition that is more common in women of childbearing age and is associated with aggressive behavior and poor clinical *** resection remains the mainstay of treatment,with some patients benefiting from adjuvant chemoradiation therapy.

关键词： Neuroendocrine carcinoma Ovary Pathology Treatment

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Role of feline ANP32 proteins in regulating polymerase activity of influenza A virus

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Journal of Integrative Agriculture 2024年第9期23卷 3145-3158页

作者： Gang Lu Feiyan Zheng Yuqing Xiao Ran Shao Jiajun ou Xin Yin Shoujun Li Guihong zhang College of Veterinary Medicine South China Agricultural UniversityGuangzhou 510642China State Key Laboratory for Animal Disease Control and Prevention Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150000China Maoming Branch Guangdong Laboratory for Lingnan Modern AgricultureMaoming 525000China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China

Recently,increasing natural infection cases and experimental animal challenge studies demonstrated domestic cats are susceptible to multiple subtypes influenza A virus(IAV)***,some subtype IAV strains could circulate in domestic cats after cross-species transmission and even infected humans,posing a threat to public *** factors related to viral polymerase activity could determine host range of IAV and acidic nuclear phosphoprotein 32(ANP32)is the most important one among ***,role of cat-derived ANP32 on viral polymerase activity and host range of IAV is still *** the present study,a total of 10 feline ANP32(feANP32)splice variants(including 5 feANP32A,3 feANP32B,and 2 feANP32E)were obtained from domestic cats by *** alignment results demonstrated amino acid deletions and/or insertions occurred among feANP32 variants,but all feANP32 proteins were primarily localized to cell *** replication systems for several representative IAV strains were established and the support ability of feANP32 on IAV polymerase activity was *** results indicated that most feANP32A and feANP32B splice variants were able to support all the tested IAV strains,though the support activity of a single feANP32 protein on polymerase activity varied among different IAV *** addition,the role of feANP32 in supporting H3N2 canine influenza virus was determined by investigating viral replication in ***,our study systematically investigated the support activity of feANP32 on IAV,providing a clue for further exploring the mechanism of susceptibility of cats to IAV.

关键词： ANP32 influenza A virus feline cross-species transmission

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Peroxisome Proliferator-Activated Receptor-γCoactivator-1αin the Spotlight with Multiple Sclerosis

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Neuroscience Bulletin 2024年第2期40卷 268-272页

作者： ya-Na yang Mao-Qing zhang Feng-Lin Yu Bing Han Ming-Yue Bao yan He Xing Li Yuan zhang Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry(Shaanxi Normal University) The Ministry of EducationXi’an 710119China College of Life Sciences Shaanxi Normal UniversityXi’an 710119China

Multiple sclerosis(MS)is a chronic and incurable autoimmune disease of the central nervous system(CNS)that results in neuro-inflammation and *** therapies for MS alleviate symptoms to some extent but fail to realize myelin ***,it is crucial to identify effective targets to promote *** a widely expressed transcriptional regulator,peroxisome proliferatoractivated receptor-coactivator-1α(PGC-1α)expresses in different cells with high energy consumption,including skeletal muscle cells,brown fat cells,neurons,astrocytes,and oligodendrocyte precursor cell(OPC)[1].Targeting PGC-1αmay be beneficial for CNS development and various neurodegenerative diseases.

关键词： inflammation myelin autoimmune

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