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Rare Metals 2024年第9期43卷 4356-4366页

作者： Qin-Ke Tang Jiang-Chuan liu Rui Shi Yun-Feng Zhu Ji-Guang Zhang ya-na liu Jun Wang yao Zhang Xiao-Hui Hu Zhi-Bin liu Li-Quan Li College of Materials Science and Engineering Jiangsu Collaborative Innovation Centre for Advanced Inorganic Function CompositesNanjing Tech UniversityNanjing 211816China School of Materials Science and Engineering Southeast UniversityNanjing 211189China

Magnesium-based hydrides have been widely recognized as an appropriate choice for solid-state hydrogen ***,its undesirable thermodynamics and sluggish hydrogenation/dehydrogenation kinetics are major bottlenecks for its ***,a highly stable and highly dispersed Ni-based catalyst(Ni/Al_(2)O_(3)/GN)was fabricated to promote the hydrogen storage performance of MgH_(2)via the electrostatic effect of NiAl-LDH/GN precursor with a co-calcination reduction ***_(2)-5wt%Ni/Al_(2)O_(3)/GN exhibits excellent hydrogen storage performance,releasing about 5.7 wt%hydrogen in 3500 s at 250℃,and can reach a saturation hydrogen absorption of about 6.15 wt%in 3000 s at 100℃.Furthermore,it also shows low dehydrogenation apparent activation energy of 89.1 and 118.2 kJ·mol^(-1).Impressively,the catalyst ensures the stability of both the physical phase and structure during ball milling and cycling *** role of each phase in Ni/Al_(2)O_(3)/GN on the hydrogen storage performance of MgH_(2)was also discussed through experiments and theoretical calculation,and the synergistic catalytic mechanism of Ni/Al_(2)O_(3)/GN was clearly *** work provides a unique perspective for the preparation of highly stable and highly dispersible catalysts.

关键词： Magnesium hydride Ni/Al_(2)O_(3)/GN Hydrogen storage performance Catalytic mechanism

Influence of chloride salts on hydrogen generation via hydrolysis of MgH_2 prepared by hydriding combustion synthesis and mechanical milling

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Transactions of Nonferrous Metals Society of China 2017年第3期27卷 562-568页

作者： Shu LI De-yu GAN Yun-feng ZHU ya-na liu Ge ZHANG Li-quan LI College of Materials Science and Engineering Nanjing Tech University Nanjing 210009 China

The effects of chloride salts(naCl,MgCl2and NH4Cl)on the hydrolysis kinetics of MgH2prepared by hydridingcombustion synthesis and mechanical milling(HCS+MM)were discussed.X-ray diffraction(XRD)analyses show that high-purityMgH2was successfully prepared by *** performance test results indicate that the chloride salt added during the millingprocess is favorable to the initial reaction rate and hydrogen generation yield within60min.A MgH2?10%NH4Cl composite exhibitsthe best performance with the hydrogen generation yield of1311mL/g and a conversion rate of85.69%in60min at *** is suggested that the chloride salts not only play as grinding aids in the milling process,but also create fresh surface ofreactive materials,favoring the hydrolysis reaction.

关键词： MgH2 hydrogen generation yield hydrolysis reaction chloride salts hydriding combustion synthesis mechanical milling

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

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Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol na J.Jay liu Young-Ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang ya Gao Shuyue Li Cui Chang Xiang liu Guofeng yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,Dna,mRna,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

电针对脑缺血再灌注大鼠学习记忆障碍改善作用及机制研究

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中华行为医学与脑科学杂志 2018年第8期27卷 717-721页

作者：王海英林娜亚白柳刘文彦济宁医学院基础医学院生理学教研室济宁272067 济宁医学院基础医学院行为医学重点实验室济宁272067 济宁医学院基础医学院基础医学院机能实验室济宁272067

目的探讨电针对脑缺血再灌注大鼠学习记忆障碍的改善作用及其机制.方法简单随机抽样将90只用于跳台实验的SD大鼠随机分为正常对照组、单纯脑缺血再灌注7d、14d、30 d、60 d组（I/R）和脑缺血再灌注7d、14 d、30 d、60 d＋电针干预组（... 详细信息

目的探讨电针对脑缺血再灌注大鼠学习记忆障碍的改善作用及其机制.方法简单随机抽样将90只用于跳台实验的SD大鼠随机分为正常对照组、单纯脑缺血再灌注7d、14d、30 d、60 d组（I/R）和脑缺血再灌注7d、14 d、30 d、60 d＋电针干预组（I/R＋EA）,n=10;70只用于分子生物学实验的SD大鼠随机分为正常对照组、单纯脑缺血再灌注3h、6h、12 h组（I/R）和脑缺血再灌注3h、6h、12 h＋电针干预组（VR＋EA）,n=10.采用线栓法制备大鼠脑缺血再灌注模型（MCAO）,取大鼠“百会”和“水沟”穴进行电针,终刺激强度为5 mA,持续时间为30 min.做跳台实验观察大鼠学习记忆的修复状况;Western blot检测大鼠脑组织procaspase-3、procaspase-12、PARP和iCAD蛋白的表达;免疫荧光组织化学方法检测GRP94阳性表达的细胞个数.结果跳台结果显示电针干预后大鼠学习记忆力得到明显改善,电针7d和14 d组大鼠触电潜伏期分别为[（90.60± 17.01）s、（128.80±8.85）s],与脑缺血再灌注7d和14 d组[（51.20±5.09）s、（105.00±10.39）s]相比明显升高,电针7d和14 d组大鼠单脚跳下错误次数分别为[（3.90±0.99）次、（2.70±0.67）次],与脑缺血再灌注7d和14d组[（9.20±1.61）次、（6.10±0.99）次]相比明显降低,差异有统计学意义（P＜0.01）;Western blot结果显示电针干预后procaspase-3、procaspase-12、PARP蛋白前体和iCAD蛋白的表达均上调（P＜0.01）;免疫荧光组织化学结果显示电针干预后3h、6h和12h组GRP94蛋白阳性细胞数与相应的I/R组比较明显减少（均P＜0.01）.结论电针干预可有效改善缺血再灌注大鼠的学习记忆能力,这可能与通过阻断内质网应激及炎性因子介导的凋亡通路来减少脑缺血再灌注损伤后的脑细胞凋亡有关.

关键词：电针缺血再灌注凋亡学习记忆大鼠

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微球状Co_3O_4修饰电极检测邻苯二酚

现代化工 2017年第10期37卷 134-137页

作者：武媛媛晋日亚乔怡娜刘晶敏周俊中北大学化工与环境学院山西太原030051

采用水热法在400℃的条件下煅烧并形成Co_3O_4微球,通过XRD粉末衍射、SEM等对Co_3O_4结构及形貌进行表征,并用循环伏安法(Cyclic Voltammetry,CV)和电化学阻抗谱法(Electrochemical Impedance Spectroscopy,EIS)对Co_3O_4的电化学性能进行表征。利用Co_3O_4修饰玻碳电极(Co_3O_4/GCE)并通过方波伏安法(Square wave voltammetry,SWV)检测邻苯二酚,在3.3~33μmol/L的浓度范围内,邻苯二酚浓度和峰电流值呈线性关系,回归方程的相关系数为0.995,检测限(LOD)为0.42μmol/L(3σ法),灵敏度为0.029μA·(μmol/L)-1。同时进行了电极的稳定性实验,经10次循环,其峰电流的相对标准偏差(RSD)为0.25%。还对实际水样进行加标回收实验,该电极对实际水样的检测呈现出良好的性能。

关键词：微球状Co3O4 电化学检测方波伏安法邻苯二酚

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-na liu Yu-Fan yang Zhi-Cheng Zhang Qi Dai Xiao-yan Bao Lin-Jie Wu ya-Xin Qin Xin Tan Xiao-yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China national Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering Rna(siRna)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRna to overcome the problem of siRna release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRna,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering Rna(siRna) doxorubicin

喘息婴幼儿外周血白介素-17、白介素-23、趋化因子配体10的测定及意义

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中国现代医学杂志 2016年第21期26卷 97-99页

作者：孟永胜刘亚娜何宏蕴石宏李相磊河南省开封市中心医院儿科河南开封475000

目的探讨喘息婴幼儿外周血白介素-17(IL-17)、白介素-23(IL-23)、趋化因子配体10(CXCL10)的变化及其意义。方法酶联免疫吸附法测定36例喘息患儿、24例非喘息患儿及20例健康组外周血IL-17、IL-23、CXCL10的含量,并进行两两比较。结果喘... 详细信息

目的探讨喘息婴幼儿外周血白介素-17(IL-17)、白介素-23(IL-23)、趋化因子配体10(CXCL10)的变化及其意义。方法酶联免疫吸附法测定36例喘息患儿、24例非喘息患儿及20例健康组外周血IL-17、IL-23、CXCL10的含量,并进行两两比较。结果喘息组、非喘息组和健康组的外周血IL-17、IL-23、CXCL10的含量,采用单因素方差分析,差异有统计学意义(P0.05)。结论 IL-17、IL-23及CXCL10在喘息患儿外周血中的含量表达升高,可能参与婴幼儿喘息的发病机制。

关键词：婴幼儿喘息白细胞介素趋化因子

Rational modulation of fluorophosphate cathode by anionic groups to reduce the polarization behavior for fast-charging sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 509-521页

作者： Xinyuan Wang Fan Zhang Xingyu Zhou Qian Wang Changyu liu yangyang liu Hui Wang Xiaojie liu Key Laboratory of Synthetic and natural Functional Molecule of the Ministry of Education College of Chemistry & Materials Science Northwest University

na3V2（PO4）2O2F （VP） is recognized as a promising cathode material for sodium-ion batteries due to its stable structural framework and high specific *** functional theory （DFT） and finite element simulations show that incorporating SO42-into VP decreases its band gap,lowers the migration energy barrier,and ensures a uniform na+concentration gradient and stress distribution during charge and discharge ***,the average na+diffusion coefficient of na3V2（PO4）1.95（SO4）0.05O2F（VPS-1） is roughly double that of VP,leading to enhanced rate capability (80 C,75.5 mAh g-1) and cycling stability (111.0 mAh g-1capacity after 1000 cycles at 10 C current density) for ***-1 exhibits outstanding fast-charging capabilities,achieving an 80%state of charge in just 8.1 *** assembled VPS-1//SbSn/NPC full cell demonstrated stable cycling over 200 cycles at a high 5 C current,maintaining an average coulombic efficiency of 95.35%.

关键词： Anionic group modulation Polarization behavior Fast-charging Sodium-ion battery Fluorophosphate Cathode

Role of the Greenland Sea ice anomaly in the late-spring drought over Northwest China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 1-5页

作者： yang liu Huopo Chen nansen-Zhu International Research Centre Institute of Atmospheric Physics Chinese Academy of SciencesBeijingChina Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University for Information Science and TechnologyNanjingChina

Drought across Northwest China in late spring has exerted a vital effect on the local climate and agricultural production,and has been alleviated during the past *** study explored the influence of the preceding Arctic sea ice on the May drought in Northwest China caused by the precipitation *** analysis indicated that when the Greenland Sea ice concentration is abnormally high during February to April,the dry conditions in Northwest China tend to be *** increase of sea ice in the Greenland Sea can excite a meridional circulation,which causes sea surface temperature(SST)anomalies in the North Atlantic via the sea-air interaction,manifested as significant warm SST anomalies over the south of Greenland and the subtropical North Atlantic,but negative SST anomalies over the west of the *** abnormal SST pattern maintains to May and triggers a zonal wave train from the North Atlantic through Scandinavia and Central Asia to Northwest China,leading to abnormal cyclones in Northwest ***,Northwest China experiences a more humid climate than usual.

关键词： Arctic sea ice Greenland Sea North Atlantic SST Drought Northwest China