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Science China Chemistry 2024年第4期67卷 1137-1160页

作者： Hui-min Xu Hong-Rui Zhu Chen-Jin Huang Zhi-Jie Zhang Ting-Yu Shuai Qi-Ni Zhan gao-Ren Li College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

Fe-nitrogen-carbon(Fe-N-C)-and Co-nitrogen-carbon(Co-N-C)-based electrocatalysts have been widely concerned because of their high OER/ORR activity,low metal cost,and simple *** exploration of Fe-N-C and Co-N-C single atombased catalysts with high activity and stability to overcome the slow kinetics of oxygen reduction and oxygen evolution reactions is also the key to the development of efficient electrolytic water,fuel cells,and rechargeable metal-air ***-N-C and Co-N-C single atom-based electrocatalysts have the advantages of a high utilization rate of metal atoms and high electrocatalytic activity,and are ideal catalysts for promoting electrochemical energy conversion and *** general principles of designing Fe-N-C and Co-N-C single atom-based electrocatalysts are reviewed in this ***,the strategies to improve the bifunctional catalytic activity and stability are ***,the challenges and prospects of Fe-N-C and Co-N-C single atom-based catalysts are well *** review will provide a reference for the directed optimization of Fe-N-C and Co-N-C single atom-based catalysts.

关键词： Fe-N-C Co-N-C single atom bifunctional oxygen electrocatalysts

Ultrasensitive detection of micro RNA-21 in human serum based on the confinement effect enhanced chemical etching of gold nanorods

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Chinese Chemical Letters 2024年第9期35卷 382-386页

作者： min Huang Ru Cheng Shuai Wen Liangtong Li Jie gao Xiaohui Zhao Chunmei Li Hongyan Zou Jian Wang Key Laboratory of Luminescence Analysis and Molecular Sensing(Southwest University) Ministry of EducationCollege of Pharmaceutical SciencesSouthwest UniversityChongqing 400715China Department of Biological and Chemical Engineering Chongqing University of EducationChongqing 400067China The Ninth People’s Hospital of Chongqing Chongqing 400700China

Natural enzymes,such as horseradish peroxidase(HRP),are a class of important biocatalysts with the high specificity,but their catalytic efficiency is usually ***,the higher catalytic efficiency induced by the confinement effect is promising in optical sensing *** this work,a dark-field light scattering sensing platform was fabricated by the confinement effect of HRP from hybridization chain reaction(HCR)and then released to solution by the toehold-mediated strand displacement reaction(TSDR).Then,HRP catalyzed the 3,3,5,5-tetramethylbenzidine(TMB)to TMB^(2+)with the assistance of hydrogen peroxide,which etched the gold nanorods(Au NRs)with the weakened light *** single-particle assay was established based on the decreased light scattering intensity of AuNRs under dark-field *** proposed assay revealed excellent analytical performance within a linear range from 25 pmol/L to 600 pmol/L,and a low limit of detection of 3.12 pmol/***,it also manifested satisfactory recovery of mi RNA-21 in human serum *** high sensitivity,excellent specificity,and universal applicability make this sensing platform promising for disease diagnosis.

关键词： Confinement effect Hybridization chain reaction Toehold-mediated strand displacement reaction MicroRNA-21 Gold nanorods Dark-field microscope

Metal-organic nanosheet assembly ions sieving membrane for precise lithium ion and anion/solvent separation toward robust lithium metal battery

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Science China Chemistry 2024年第10期67卷 3320-3327页

作者： Jian-Qiang Shen Tian-Tian Zhao Ying-Li Song Lingjuan Zhang ya-Nan gao Xiao-Nan Cui Peng Zhao Xian-ming Zhang Key Laboratory of Magnetic Molecules&Magnetic Information Materials Ministry of EducationSchool of Chemistry&Material ScienceShanxi Normal UniversityTaiyuan 030031China College of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024China

Metal-organic nanosheets(MONs)as a novel material with tunable pore structures and low mass transfer resistance,have emerged as molecular sieves for the separation of gases and *** theory,they can also serve as ion sieves for lithium metal batteries(LMBs),realizing the high-energy and dendritic free ***,there are rarely relevant reports,because it is difficult to simultaneously balance efficient ion sieving ability,high ion passing rate and high electrochemical ***,we synthesized a stable ultrathin MON[Zn_(2)(Bim)_(4)]([Zn_(2)(Bim)_(4)]Nanosheet,HBim=benzimidazolate),which can achieve both efficient lithium ion sieving ability,high lithium ion passing rate and high electrochemical stability at the same *** separator assembled by this MON exhibits high Li^(+)transfer number of 0.81 due to the accurate lithium ion and anion/solvent *** battery containing such separator shows high lithium ionic conductivity of 0.74 m S cm^(-1)and low activation energy of 0.099 eV,which can be attributed to the nanometer level thickness and the ion sieving *** is more,we realized the application of MONs-based ion sieves in LMBs with intercalation cathodes for the first *** the LiFePO_(4)|Li battery with as-assembled separator demonstrates improved Coulombic efficiency(>99%)and significantly extended cycling life(>1600 cycles)with 80%capacity retention.

关键词： lithium sieving membrane metal-organic nanosheets lithium metal battery lithium ion and anion separation lithium ion and solvent separation

Differences and Correlations of Morphological and Hemodynamic Parameters between Anterior Circulation Bifurcation and Side-wall Aneurysms

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Current Medical Science 2024年第2期44卷 391-398页

作者： Kai-kai GUO Chang-ya LIU gao-hui LI Jian-ping XIANG Xiao-chang LENG Yi-ke CAI Xue-bin HU Department of Neurosurgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China Artery Flow Technology Co. Ltd.Hangzhou 310051China

Objective:The objective of this research was to explore the difference and correlation of the morphological and hemodynamic features between sidewall and bifurcation aneurysms in anterior circulation arteries,utilizing computational fluid dynamics as a tool for ***:In line with the designated inclusion criteria,this study covered 160 aneurysms identified in 131 patients who received treatment at Union Hospital of Tongji Medical College,Huazhong University of Science and Technology,China,from January 2021 to September *** follow-up digital subtraction angiography(DSA)data,these cases were classified into two distinct groups:the sidewall aneurysm group and the bifurcation aneurysm *** and hemodynamic parameters in the immediate preoperative period were meticulously calculated and examined in both groups using a three-dimensional DSA reconstruction ***:No significant differences were found in the morphological or hemodynamic parameters of bifurcation aneurysms at varied locations within the anterior ***,pronounced differences were identified between sidewall and bifurcation aneurysms in terms of morphological parameters such as the diameter of the parent vessel(Dvessel),inflow angle(θF),and size ratio(SR),as well as the hemodynamic parameter of inflow concentration index(ICI)(P0.5,P<0.001).Conclusions:The significant differences in certain morphological and hemodynamic parameters between sidewall and bifurcation aneurysms emphasize the importance to contemplate variances in threshold values for these parameters when evaluating the risk of rupture in anterior circulation *** it is a bifurcation or sidewall aneurysm,these disparities should be *** morphological parameter SR has the potential to be a val

关键词： sidewall bifurcation unruptured aneurysms computational fluid dynamics

Rosemary leaf powder improves egg quality, antioxidant status, gut barrier function, and cecal microbiota and metabolites of late-phase laying hens

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Animal Nutrition 2024年第2期17卷 325-334页

作者： Lianhua Zhang Junwei Ge Fei gao min yang Hui Li Fei Xia Hongtong Bai Xiangshu Piao Zhiying Sun Lei Shi Key Laboratory of Plant Resources Institute of Botany Chinese Academy of Sciences China National Botanical Garden State Key Laboratory of Animal Nutrition Institute of Animal Science Chinese Academy of Agricultural Sciences College of Pharmacy Shandong University of Traditional Chinese Medicine University of Chinese Academy of Sciences Beijing Jingwa Agricultural Science&Technology Innovation Center State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University

his study sought to determine the effects of rosemary leaf powder(RP) on laying performance, egg quality, serum indices, gut barrier function, and cecal microbiota and metabolites of late-phase laying hens. A total of 84 “Jing Tint 6” laying hens at 65-week old were randomly divided into 2 groups and fed either a basal diet(CON) or a basal diet supplemented with 0.3% RP. Our study revealed that RP improved the Haugh unit and decreased yolk n-6/n-3 polyunsaturated fatty acid(PUFA) ratio of laying hens,increased serum superoxide dismutase(SOD), jejunal activities of SOD and catalase(CAT), and jejunal zonula occludens-1(ZO-1) expression, as well as decreased serum tumor necrosis factor-a(TNF-a) level and jejunal TNF-a m RNA expression. Rosemary leaf powder markedly enhanced(P minomutase, β-lysine 5,6-aminomutase, and 3-oxoacid Co A-transferase. Together, 0.3% RP has the potential to enhance egg quality by partially modulating serum antioxidant status, jejunal barrier function, and cecal microbiota structure and metabolites,indicating that RP could be considered a promising feed additive to promote the production performance of late-phase laying hens.

关键词： Rosemary leaf powder Production Antioxidant status Gut health Microbial community Laying hen

Multi-omics analyses provide insights into the evolutionary history and the synthesis of medicinal components of the Chinese wingnut

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Plant Diversity 2024年第3期46卷 309-320页

作者： Zi-yan Zhang He-Xiao Xia Meng-Jie Yuan Feng gao Wen-Hua Bao Lan Jin min Li Yong Li College of Life Science and Technology Inner Mongolia Normal UniversityHohhot 010020China Key Laboratory of Biodiversity Conservation and Sustainable Utilization in Mongolian Plateau for College and University of Inner Mongolia Autonomous Region Hohhot 010022China College of Landscape and Art Henan Agricultural UniversityZhengzhou 450002China State Key Laboratory of Tree Genetics and Breeding Chinese Academy of ForestryBeijing 100091China

Chinese wingnut(Pterocarya stenoptera)is a medicinally and economically important tree species within the family ***,the lack of high-quality reference genome has hindered its in-depth *** this study,we successfully assembled its chromosome-level genome and performed multiomics analyses to address its evolutionary history and synthesis of medicinal components.A thorough examination of genomes has uncovered a significant expansion in the Lateral Organ Boundaries Domain gene family among the winged group in *** notable increase may be attributed to their frequent exposure to flood-prone *** further differentiation between Chinese wingnut and Cyclocarya paliurus,significant positive selection occurred on the genes of NADH dehydrogenase related to mitochondrial aerobic respiration in Chinese wingnut,enhancing its ability to cope with waterlogging *** genomic analysis revealed Chinese wingnut evolved more unique genes related to arginine synthesis,potentially endowing it with a higher capacity to purify nutrient-rich water *** of terpene synthase families enables the production of increased quantities of terpenoid volatiles,potentially serving as an evolved defense mechanism against herbivorous *** combined transcriptomic and metabolomic analysis,we identified the candidate genes involved in the synthesis of terpenoid *** study offers essential genetic resources for Chinese wingnut,unveiling its evolutionary history and identifying key genes linked to the production of terpenoid volatiles.

关键词： Genome Medicinal components Metabolome Pterocarya stenoptera Transcriptome

Anti-osteosarcoma trimodal synergistic therapy using NiFe-LDH and MXene nanocomposite for enhanced biocompatibility and efficacy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1329-1344页

作者： yani Xu Lan yang min Li Haozhou Shu Na Jia Yunzhen gao Rongying Shi Xiaojia yang Zhirong Zhang Ling Zhang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Osteosarcoma is usually resistant to immunotherapy and,thus primarily relies on surgical resection and high-dosage ***,less invasive or toxic therapies such as photothermal therapy(PTT)and chemodynamic therapy(CDT)generally failed to show satisfactory *** multimodal therapies with proper safety profiles may provide better solutions for ***,a simple nanocomposite that synergistically combines CDT,PTT,and chemotherapy for osteosarcoma treatment was *** this composite,small 2D Ni Fe-LDH flakes were processed into 3D hollow nanospheres via template methods to encapsulate 5-Fluorouracil(5-FU)with high loading *** nanospheres were then adsorbed onto larger 2D Ti3C2MXene monolayers and finally shielded by bovine serum albumin(BSA)to form 5-FU@Ni Fe-LDH/Ti3C2/BSA nanoplatforms(5NiTiB).Both in vitro and in vivo data demonstrated that the 5-FU induced chemotherapy,Ni Fe-LDH driven chemodynamic effects,and MXene-based photothermal killing collectively exhibited a synergistic“all-in-one”anti-tumor effect.5NiTiB improved tumor suppression rate fromminimizing side ***,the composite is simple to produce,enabling the fine-tuning of dosages to suit different ***,the platform is versatile and efficient,with potential for further development.

关键词： Osteosarcoma NiFe-LDH MXene Chemodynamic therapy Photothermal therapy Chemotherapy 5-Fluorouracil Nanocomposite

Enhancing cartilage regeneration and repair through bioactive and biomechanical modification of 3D acellular dermal matrix

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Regenerative Biomaterials 2024年第3期3卷 105-121页

作者： Wei gao Tan Cheng Zhengya Tang Wenqiang Zhang Yong Xui min Han Guangdong Zhou Chunsheng Tao Ning Xu Huitang Xia Weijie Sun Qingdao Medical College of Qingdao University Qingdao266071China Department of Infectious Diseases The First Affliated Hospital of Anhui Medical UniversityShushanHefei230022China Department of Orthopaedic Surgery Shanghai Sixth People's Hospital Affliated to Shanghai jiao Tong University School of MedicineShanghai200025China Department of Orthopedic Surgery Shanghai Eighth People's HospitalShanghai200235China Department of PlasticSurgery&Jinan ClinicalResearch Center for Tissue Engineering Skin Regeneration and Wound Repair The First Affliated Hospital of Shandong First Medical UniversityJinan266299China Department of Orthopaedics Ninety-seventh Hospital of the Chinese People's Liberation Army NavyQingdao266071China Department of Orthopaedics The First Affliated Hospital of Shandong First Medical UniversityJinan266299China Department of Plastic surgery Shanghai Key Laboratory of Tissue EngineeringShanghai Ninth People's HospitalShanghai jiao Tong University School of MedicineShanghai200023China Department of Thoracic Surgery Shanghai Children's HospitalShanghai Jiao Tong University School of MedicineShaghai200040China Department of Thoracic Surgery Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghai200433China

Acellular dermal matrix(ADM)shows promise for cartilage regeneration and ***,an effective decellularization technique that removes cellular components while preserving the extracellular matrix,the transformation of 2D-ADM into a suitable 3D scaffold with porosity and the enhancement of bioactive and biomechanical properties in the 3D-ADM scaffold are yet to be fully *** this study,we present an innovative decellularization method involving 0.125%trypsin and 0.5%SDS and a 1%Triton X-100 solution for preparing ADM and converting 2D-ADM into 3D-ADM *** scaffolds exhibit favorable physicochemical properties,exceptional biocompatibility and significant potential for driving cartilage regeneration in vitro and in *** further enhance the cartilage regeneration potential of 3D-ADM *** incorporated porcine-derived small intestinal submucosa(SIS)for bioactivity and calcium sulfate hemihydrate(CSH)for biomechanical *** resulting 3D-ADM+SIS scaffolds displayed heightened biological activity,while the 3D-ADM+CSH scaffolds notably bolstered biomechanical *** scaffold types showed promise for cartilage regeneration and repair in vitro and in vivo,with considerable improvements observed in repairing cartilage defects within a rabbit articular cartilage *** summary,this research introduces a versatile 3D-ADM scaffold with customizable bioactive and biomechanical properties,poised to revolutionize the field of cartilageregeneration.

关键词： acellular dermal matrix three-dimensional scaffolds cartilage regeneration small intestinal submucosa calcium sulfate hemihydrate

Blind Recognition of Non-Binary LDPC Codes Based on Ant Colony Optimization

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China Communications 2024年第10期21卷 59-69页

作者： Guan Mengsheng gao Wanting Chen Qi Zhu min Bai Baoming State Key Laboratory of Integrated Services Networks Xidian UniversityXi'an 710071China

This paper introduces a novel blind recognition of non-binary low-density parity-check(LDPC)codes without a candidate set,using ant colony optimization(ACO)algorithm over additive white Gaussian noise(AWGN)***,the scheme that effectively combines the ACO algorithm and the non-binary elements over finite fields is ***,an improved,simplified elitist ACO algorithm based on soft decision reliability is introduced to recognize the parity-check matrix over noisy *** results show that the recognition rate continuously increases with an increased signalto-noise ratio(SNR)over the AWGN channel.

关键词： ACO blind recognition non-binary LDPC codes open-set

Electroacupuncture activates AMPKα1 to improve learning and memory in the APP/PS1 mouse model of early Alzheimer’s disease by regulating hippocampal mitochondrial dynamics

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Journal of Integrative Medicine 2024年第5期22卷 588-599页

作者： Wei-wei Jia Hua-wei Lin min-guang yang ya-ling Dai yan-yi Ding Wen-shan Xu Si-nuo Wang ya-jun Cao Sheng-xiang Liang Zhi-fu Wang Cong Chen Wei-lin Liu College of Rehabilitation Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina The Institute of Rehabilitation Industry Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina National-Local Joint Engineering Research Center of Rehabilitation Medicine Technology Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina Traditional Chinese Medicine Rehabilitation Research Center of State Administration of Traditional Chinese Medicine Fujian University of Traditional Chinese MedicineFuzhou 350122Fujian ProvinceChina

Objective Studies have shown that electroacupuncture(EA)can alleviate cognitive impairments from Alzheimer’s disease(AD)by regulating the expression of adenosine monophosphate-activated protein kinase(AMPK),but the specific mechanism involved remains to be ***,this study explores the potential mechanism by which EA improves cognitive function from the perspective of mitochondrial *** The four-month-old transgenic mice with amyloid precursor protein(APP)/presenilin 1(PS1)and AMPKα1-subunit conditional knockout(AMPKα1-cKO)were used for *** evaluate the effects of EA treatment on cognitive function,the T-maze and Morris water maze were *** addition,chemical exchange saturation transfer,thioflavin staining,transmission electron microscopy,mitochondrial membrane potential,and Western blotting were used to examine the potential mechanisms underlying the effects of EA on APP/PS1 *** Both APP/PS1 mice and AMPKα1-cKO mice exhibited dysfunction in mitochondrial dynamics accompanied by learning and memory *** of the AMPK/peroxisome proliferator-activated receptor-γcoactivator-1α(PGC-1α)pathway increased pathological amyloid-β(Aβ)deposition and aggravated the dysfunction in mitochondrial *** addition,EA rescued learning and memory deficits in APP/PS1 mice by activating the AMPK/PGC-1αpathway,specifically by reducing pathological Aβdeposition,normalizing energy metabolism,protecting the structure and function of mitochondria,increasing the levels of mitochondrial fusion proteins,and downregulating the expression of fission ***,the therapeutic effect of EA on cognition in APP/PS1 mice was hindered by AMPKα1 *** The regulation of hippocampal mitochondrial dynamics and reduction in Aβdeposition via the AMPK/PGC-1αpathway are critical for the ability of EA to ameliorate cognitive impairment in APP/PS1 mice.

关键词： Adenosine monophosphate-activated protein kinase Alzheimer’s disease Cognitive impairment Electroacupuncture Hippocampus Mitochondrial dynamics