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Chinese Physics B 2020年第3期29卷 369-374页

作者： ya-lin li Pei Gong Xiao-Yong Fang Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan UniversityQinhuangdao 066004China

According to the one-dimensional quantum state distribution, carrier scattering, and fixed range hopping model, the structural stability and electron transport properties of N-, P-, and As-doped SiC nanowires(N-SiCNWs, P-SiCNWs, and As-SiCNWs) are simulated by using the first principles calculations. The results show that the lattice structure of NSiCNWs is the most stable in the lattice structures of the above three kinds of doped SiCNWs. At room temperature,for unpassivated SiCNWs, the doping effect of P and As are better than that of N. After passivation, the conductivities of all doped SiCNWs increase by approximately two orders of magnitude. The N-SiCNW has the lowest conductivity. In addition, the N-, P-, As-doped SiCNWs before and after passivation have the same conductivity–temperature characteristics,that is, above room temperature, the conductivity values of the doped SiCNWs all increase with temperature *** results contribute to the electronic application of nanodevices.

关键词： N-,P-,As-doped SiC nanowires transport properties first-principles theory

First Principle Study on Optical Properties of Tri-Group Doped(6,6) SiC Nanotubes

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Chinese Physics Letters 2018年第11期35卷 80-82页

作者： Pei GONG ya-lin li ya-Hui JIA Xiao-Yong FANG Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan University

The optical properties of tri-group（B, Al, Ga, In） doped（6,6） SiC nanotubes（SiCNTs） are studied from first principles. The results show that the main absorption and dispersion of SiCNTs caused by the intrinsic transition appear in the ultraviolet-visible region（below 500 nm）, and the tri-group doping increases the minimum dielectric constant value resulting in enhanced transmittance. In addition, the tri-group doping can introduce a weak absorption and dispersion region in the near-mid-infrared region, and the response peak blue shifts as the diameter of the doping atom increases. Comparative studies of reflectance, absorptivity, and transmittance show that the key factors affecting the transmittance of SiCNTs are reflectance（or refractive index） rather than absorption coefficient.

关键词： Ga Al Ts First Principle Study on Optical Properties of Tri-Group Doped SiC Nanotubes

Conductance and dielectric properties of hydrogen and hydroxyl passivated SiCNWs

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Chinese Physics B 2021年第10期30卷 609-616页

作者： Wan-Duo Ma ya-lin li Pei Gong ya-Hui Jia Xiao-Yong Fang Key Laboratory for Microstructural Material Physics of Hebei Province School of ScienceYanshan UniversityQinhuangdao 066004China

Based on the transport theory and the polarization relaxation model,the effects of hydrogen and hydroxyl passivation on the conductivity and dielectric properties of silicon carbide nanowires(SiCNWs)with different sizes are numerically *** results show that the variation trend of conductivity and band gap of passivated SiCNWs are opposite to the scenario of the size effect of bare *** the influencing factors of conductivity,the carrier concentration plays a leading *** the dielectric properties,the bare SiCNWs have a strong dielectric response in the blue light region,while passivated SiCNWs show a more obvious dielectric response in the far ultraviolet-light *** particular,hydroxyl passivation produces a strong dielectric relaxation in the microwave band,indicating that hydroxyl passivated SiCNWs have a wide range of applications in electromagnetic absorption and shielding.

关键词： silicon carbide nanowires passivation conductance properties dielectric relaxation

Inhibition of Obtusifolin on retinal pigment epithelial cell growth under hypoxia

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1539-1547页

作者： li-Fei Wang Zhong-yang yan ya-lin li yan-Hui Wang Sheng-Juan Zhang Xin Jia Lu Lu yan-Xia Shang Xin Wang Yun-Huan li Shan-Yu li Fundus Surgery Ward Hebei Provincial Eye HospitalXingtai054001Hebei ProvinceChina Diabetic Eye Disease Ward Hebei Provincial Eye HospitalXingtai054001Hebei ProvinceChina Corneal Disease Ward Hebei Provincial Eye HospitalXingtai054001Hebei ProvinceChina

AIM: To explore the effect of Obtusifolin on retinal pigment epithelial cell growth under ***: In vitro chemical hypoxia model of ARPE-19 cells was established using cobalt chloride(CoCl2). Cell viability was tested by cell counting kit-8(CCK-8) assay. Western blot and real-time quantitative polymerase chain reaction were applied to detect proteins and mRNAs respectively. Flow cytometry was used to examine the cell cycle. Secretion of vascular endothelial growth factor(VEGF) was tested by using enzyme linked immunosorbent assay(EliSA).RESULTS: Under the chemical hypoxia model established by CoCl2, hypoxia inducible factor-1α(HIF-1α) mRNA and protein levels was up-regulated. Cell viability was increased and the proportion of S phase was higher. Obtusifolin could reduce cell viability under hypoxic conditions and arrest cells in G1 phase. Obtusifolin reduced the expression of Cyclin D1 and proliferating cell nuclear antigen(PCNA) in the hypoxic environment and increased the expression of p53 and p21. The levels of VEGF, VEGFR2 and eNOS proteins and mRNA were significantly increased under hypoxia while Obtusifolin inhibited the ***: Obtusifolin can inhibit cell growth under hypoxic conditions and down-regulate HIF-1/VEGF/eNOS secretions in ARPE-19 cells.

关键词： retinal pigment epithelial cells Obtusifolin vascular endothelial growth factor hypoxia

Trial characteristics and treatment effect estimates in randomized controlled trials of Chinese herbal medicine: A meta-epidemiological study

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Journal of Integrative Medicine 2024年第3期22卷 223-234页

作者： Betty H.Wang ya-li lin Yin-yan Gao Jin-lu Song Lang Qin ling-qi li Wen-qi liu Claire C.W.Zhong Mary Y.Jiang Chen Mao Xiao-bo yang Vincent C.H.Chung Irene X.Y.Wu Jockey Club School of Public Health and Primary Care the Chinese University of Hong KongHong Kong 999077China Xiangya School of Public Health Central South UniversityChangsha 410006Hunan ProvinceChina School of Chinese Medicine the Chinese University of Hong KongHong Kong 999077China School of Public Health Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina State Key Laboratory of Dampness Syndrome of Chinese Medicine the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Chinese Medicine Syndrome Research Team the Second Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou 510120Guangdong ProvinceChina Hunan Provincial Key Laboratory of Clinical Epidemiology Central South UniversityChangsha 410006Hunan ProvinceChina

Background:Previously published meta-epidemiological studies focused on Western medicine have identified some trial characteristics that impact the treatment effect of randomized controlled trials(RCTs).Nevertheless,it remains unclear if similar associations exist in RCTs on Chinese herbal medicine(CHM).Further,Chinese medicine-related characteristics have not been explored ***:To investigate trial characteristics related to treatment effect estimates on CHM *** strategy:This meta-epidemiological study searched 5 databases for systematic reviews on CHM treatment published between January 2011 and July *** criteria:An eligible systematic review should only include RCTs of CHM and conduct at least one *** extraction and analysis:Two reviewers independently conducted data extraction on general characteristics of systematic reviews,meta-analyses and included *** also assessed the risk of bias of RCTs using the Cochrane risk of bias tool.A two-step approach was used for data *** ratio of odds ratios(ROR) and difference in standardized mean differences (dSMD) with 95%confidence interval (CI) were applied to present the difference in effect estimates for binary and continuous outcomes,***:Ninety-one systematic reviews,comprising 1338 RCTs were *** binary outcomes,RCTs incorporated with syndrome differentiation (ROR:1.23;95%CI:[1.07,1.39]),adopting Chinese medicine formula (ROR:1.19;95%CI:[1.03,1.34]),with low risk of bias on incomplete outcome data (ROR:1.29;95%CI:[1.06,1.52]) and selective outcome reporting (ROR:1.12;95%CI:[1.01,1.24]),as well as a trial size≥100 (ROR:1.23;95%CI:[1.04,1.42]) preferred to show larger effect *** for continuous outcomes,RCTs with Chinese medicine diagnostic criteria (dSMD:0.23;95%CI:[0.06,0.41]),judged as high/unclear risk of bias on allocation concealment (dSMD:-0.70;95%CI:[-0.99,-0.42]),with low risk of bias on incomplete outcome data (dSMD:0.30

关键词： Chinese herbal medicine Randomized controlled trial Risk of bias Meta-epidemiological study Effect estimates

Construction of the Subtracted cDNA library of Striatal Neurons Treated with Long-term Morphine

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Chinese Medical Sciences Journal 2011年第1期26卷 54-59页

作者： Bo Bai Hai-qing liu Jing Chen ya-lin li Hui Du Hai Lu Peng-li Yu Department of Neurobiology Jining Medical College Jining 272067 China Department of Physiology Taishan Medical College Taian 271000 China

Objective To construct a morphine tolerance model in primarily cultured striatal neurons, and screen the differentially expressed genes in this model using suppression subtractive hybridization （SSH）. Methods Sbtracted cDNA libraries were constructed using SSH from normal primarily cultured striatal neurons and long-term morphine treated striatal neurons （10^-5 mol/L for 72 hours）. To check reliability of the cell culture model, RT-PCR was performed to detect the cAMP-responsive element-binding protein （CREB） mRNA expression. The subtracted clones were prescreened by PCR. The clones containing inserted fragments from forward libraries were sequenced and submitted to GenBank for homology analysis. And the expression levels of genes of interest were confirmed by RT-PCR. Results CREB mRNA expression showed a significant increase in morphine treated striatal neurons （62.85± 1.98） compared with normal striatal neurons （28.43 ± 1.46, P〈0.01）. Thirty-six clones containing inserted fragments were randomly chosen for sequence analysis. And the 36 clones showed homology with 19 known genes and 2 novel genes. The expression of 2 novel genes, mitochondrial carrier homolog 1 （Mtchl ; 96.81±2.04 vs. 44.20±1.31, P〈0.01） and thyrnoma viral proto-oncogene 1 （Akt1 ; 122.10±2.17 vs 50.11±2.01, P〈0.01）, showed a significant increase in morphine-treated striatal neurons compared with normal striatal neurons. Conclusions A reliable differential cDNA library of striatal neurons treated with long-term morphine is constructed. Mtchl and Aktl might be the candidate genes for the development of morphine tolerance.

关键词： neuron morphine tolerance suppression subtractive hybridization subtracted cDNA library differential gene expression

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一类中立型泛函微分系统周期解存在性问题

数学学报（中文版） 2007年第6期50卷 1231-1242页

作者：鲁世平李亚林南京财经大学应用数学系南京210046 安徽师范大学数学系芜湖241000

首先对线性差分算子M:[Mx](t)=z(t)-Cx(t-r)的性质进行了研究,在此基础上利用Mawhin重合度拓展定理研究了一类具偏差变元的中立型泛函微分系统的周期解问题,得到了周期解存在性的新结论.本文的矩阵C仅为一般的实方阵,不必为实对称阵,因... 详细信息

首先对线性差分算子M:[Mx](t)=z(t)-Cx(t-r)的性质进行了研究,在此基础上利用Mawhin重合度拓展定理研究了一类具偏差变元的中立型泛函微分系统的周期解问题,得到了周期解存在性的新结论.本文的矩阵C仅为一般的实方阵,不必为实对称阵,因而结果改进和推广了已有工作.此外,本文周期解先验界估计方法与已有工作也不相同.

关键词：重合度拓展定理中立型微分系统偏差变元

Postoperative subacute static progressive stretch does not increase the risk of distal lower limb venous thromboembolism

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Chinese Journal of Traumatology 2023年第3期26卷 178-182页

作者： Jun-Kun Zhu Feng-Feng Wu Rui-Feng yang Fen-Fen Xu ya-li lin Miao-Fang Ye Orthopedics Rehabilitation Department Lishui Central HospitalLishuiZhejiang Province323020China Rehabilitation Department Huzhou Central HospitalHangzhou310020China Orthopedics and Trauma Department Lishui Central HospitalLishuiZhejiang Province323020China

Purpose:Static progressive stretch(SPS)can be applied to treat chronic joint ***,the impacts of subacute application of SPS to the distal lower limbs,where deep vein thrombosis(DVT)is common,on venous thromboembolism remain *** study aims to explore the risk of venous thromboembolism events following subacute application of ***:A retrospective cohort study was conducted on patients diagnosed with DVT following a lower extremity orthopedic surgery before being transferred to the rehabilitation ward from May 2017 to May *** with unilateral lower limb comminuted para-articular fractures,transferred to rehabilitation ward for further treatment within 3 weeks after operation,followed up more than 12 weeks since initial manual physiotherapy,and diagnosed DVT by ultrasound before rehabilitation course were included in the *** with polytrauma,without evidence of previous peripheral vascular disease or incompetence,had medication for thrombosis treatment or prophylaxis before the operation,detected with paralysis due to nervous system impairment,infected after operation during the regime,or with acute progression of DVT were *** included patients were randomized to the standard physiotherapy and the SPS integrated groups for *** DVT and pulmonary embolism data were collected during the physiotherapy course to compare the *** 28.0 and GraphPad Prism 9 were used for data ***lism incidence(OR=0.

关键词： Trauma Deep vein thrombosis Rehabilitation Musculoskeletal manipulations Physical therapy modalities

Fine-tuning the spatial allocation of phytohormones for smart canopy, smart breeding, and smart agriculture

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Science China life Sciences 2025年第1期 309-310页

作者： Tao Zhou lin li National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University HuBei HongShan Laboratory

The dual challenges of global climate change and population growth have increased demand for higher crop yields per unit area. The innovative technology of smart agriculture aims to synergize breeding, cultivation, and production through the application of biological and informatics technologies. Historically, the “Green Revolution” introduced semidwarf varieties of certain key crops by utilizing mutations affecting gibberellin pathways, which significantly increased planting densities and yields.

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期 233-240页

作者： Peipei liu yantong li Meng-Xiang Wu Hao Kang Xiao-li Zhao lin Xu linlin liu Xiaodong li Junfeng Fang Zhiwei Fang ya Cheng Hai-Bo yang Huakang Yu Xueliang Shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

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